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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | Acute fatty liver of pregnancy associated with severe acute pancreatitis:A case report显示文摘Acute fatty liver of pregnancy is a rare disease that affects women in the third trimester of pregnancy. Although infrequent, the disease can cause maternal mortality. The diagnosis is not always clear until the pregnancy is terminated, and significant complications, such as acute pancreatitis, can occur. Pancreatic involvement typically only occurs in severe cases after the development of hepatic and renal impairment. To date, little knowledge is available regarding how the disease causes pancreatitis. Treatment involves supportive measures and pregnancy interruption. In this report, we describe a case of a previously healthy 26-year-old woman at a gestational age of 27 wk and 6 d who was admitted with severe abdominal pain and vomiting. This case illustrates the clinical and laboratory overlap between acute fatty liver of pregnancy and pancreatitis, highlighting the difficulties in differentiating each disease. Furthermore, the hypothesis for this overlapping is presented, and the therapeutic options are discussed. | Cássio Vieira de Oliveira Alecsro Moreira Julio P Baima Leticia de C Franzoni Talles B Lima Fabio da S Yamashiro Kunie Yabuki Rabelo Coelho Ligia Y Sassaki Carlos Antonio Caramori Ferno G Romeiro Giovanni F Silva | 2014 | World Journal of Hepatology2014，6，7： | 3 |
| 3 | 由磁共振成像评估的主动脉弓脉搏波传导速度是心血管事件的预测因子:多种族动脉粥样硬化研究显示文摘通过磁共振成像评估的主动脉弓脉搏波传导速度(pulse wave velocity,PWV)对心血管病事件的预测价值尚未完全确定。为了评估多种族动脉粥样硬化研究(multi-ethnic study of atherosclerosis,MESA)受试者中主动脉弓PWV与心血管病的关系,Ohyama等纳入3527例MESA受试者[基线时平均年龄为(62±10)岁,47%为男性], | 刘莉 叶鹏 Ohyama Y Ambale-Venkatesh B Noda C Kim JY Tanami Y Teixido-Tura G Chugh AR Redheuil A Liu CY Wu CO Hundley WG Bluemke DA Guallar E Lima JAC | 2017 | 中华高血压杂志2017，25，8： | 2 |
| 4 | Effect of bore liquid temperature and dope concentration on mechanical properties 显示文摘 | DA G Y WEN L C YANG B | 2006 | Separation and Purication Technology2006，51，： | 1 |
| 5 | Synthesis of 1-aryloxyacetyl-4- ( 5-( 4-chlorophenyl )-2-furoyl ) - semicarbazides显示文摘 | Li Z Wang X C Da Y X | 2001 | Synth Commun2001，31，9： | 1 |
| 6 | Antioxidant activity of anthraquinones and anthrone显示文摘 | GOW C Y PIN D D DA Y C | 2000 | Food Chemistry2000，70，： | 1 |
| 7 | Microstructure evolution of underconling iron-copper hypopefitectic alloys显示文摘 | Da X Y Cao C D | 2001 | Materials Science and Engineering A2001，313，： | 1 |
| 8 | Ordinal pattern based similarity analysis for EEG recordings显示文摘 | OUNYANG G X DANG C Y RICHARDS DA | 2010 | Clin- ical Neurophysiology2010，121，5： | 1 |
| 9 | Molecular genetic analysis of PRKAG2 in sporadic Wolff-Parkinson-White syndrome 显示文摘 | Vaughan C J Horn Y Okin DA | 2003 | J Cardiovasc Electrophysiol2003，14，3： | 1 |
| 10 | 查看详情显示文摘 | Quan Z -J Hu W -H Jia X -D Zhang Z Da Y -X Wang X -C | | 0，，： | 1 |
| 11 | Laparoscopic liver resections显示文摘 | Are C Fong Y Geller DA | 2005 | Adv Surg2005，39，： | 1 |
| 12 | Negative refractive index of layered nonmagnetic/magnetic composites显示文摘 | Da H X Xu C Li Z Y | 2005 | J Magn Magn Mater2005，285，： | 1 |
| 13 | 查看详情显示文摘 | Wang X C Yang G J Jia X D Zhang Z Da Y X Quan Z J | | 0，，： | 1 |
| 14 | Sex-specific genetic architecture of human disease显示文摘 | Ober C Loisel DA Gilad Y | 2008 | Nat Rev Genet2008，9，12： | 1 |
| 15 | Laparoscopic liver resections显示文摘 | Are C Fong Y Geller DA | 2005 | Adv Surg2005，39，： | 1 |
| 16 | Valuation of dynamic reactive power support services for transmission access 显示文摘 | Xu W Zhang Y Da Silva L C P et at | 2001 | IEEE Trans on Power Systems2001，16，4： | 1 |
| 17 | Non-polymer-based paclitaxel-coated coronary stents for the treatment of patients with de novo coronary lesions: angiographic follow-up of the DELIVER clinical trial显示文摘 | Lansky AJ Costa RA Mintz GS Tsuchiya Y Midei M Cox DA O'Shaughnessy C Applegate RA Cannon LA Mooney M Farah A Tannenbaum MA Yakubov S Kereiakes DJ Wong SC Kaplan B Cristea E Stone GW Leon MB Knopf WD O'Neill WW DELIVER Clinical Trial Investigators | 2004 | Circulation2004，109，16： | 1 |
| 18 | Numerical simulation for parameter optimization of silicon purification by electron beam melting 显示文摘 | Tan Y Wen S T Shi S Da C J Wei D Xiao L G | 2013 | Vacuum2013，95，： | 1 |
| 19 | 查看详情显示文摘 | Fan H Y Da C | | 0，，： | 1 |
| 20 | Reduced bovine leukaemia virus proviral load in genetically resistant cattle显示文摘 | Mirsky M L Olmstead C Da Y | 1998 | Anim Genet1998，29，4： | 1 |
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