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| 1 | Effects of alkaline-electrolyzed and hydrogen-rich water,in a high-fat-diet nonalcoholic fatty liver disease mouse model显示文摘AIM To identify the effect of hydrogen-rich water(HRW) and electrolyzed-alkaline water(EAW) on high-fat-induced non-alcoholic fatty acid disease in mice.METHODS Mice were divided into four groups:(1) Regular diet(RD)/regular water(RW);(2) high-fat diet(HFD)/RW;(3) RD/EAW; and(4) HFD/EAW. Weight and body composition were measured. After twelve weeks, animals were sacrificed, and livers were processed for histology and reverse-transcriptase polymerase chain reaction. A similar experiment was performed using HRW to determine the influence and importance of molecular hydrogen(H2) in EAW. Finally, we compared the response of hepatocytes isolated from mice drinking HRW or RW to palmitate overload.RESULTS EAW had several properties important to the study:(1) pH = 11;(2) oxidation-reduction potential of-495 mV; and(3) H2 = 0.2 mg/L. However, in contrast to other studies, there were no differences between the groups drinking EAW or RW in either the RD or HFD groups. We hypothesized that the null result was due to low H2 concentrations. Therefore, we evaluated the effects of RW and low and high HRW concentrations(L-HRW = 0.3 mg H2/L and H-HRW = 0.8 mg H2/L, respectively) in mice fed an HFD. Compared to RW and L-HRW, H-HRW resulted in a lower increase in fat mass(46% vs 61%), an increase in lean body mass(42% vs 28%), and a decrease in hepatic lipid accumulation(P < 0.01). Lastly, exposure of hepatocytes isolated from mice drinking H-HRW to palmitate overload demonstrated a protective effect from H2 by reducing hepatocyte lipid accumulation in comparison to mice drinking regular water.CONCLUSION H2 is the therapeutic agent in electrolyzed-alkaline water and attenuates HFD-induced nonalcoholic fatty liver disease in mice. | Karen Jackson Noa Dressler Rotem S Ben-Shushan Ari Meerson Tyler W LeBaron Snait Tamir | 2018 | World Journal of Gastroenterology2018，24，45： | 9 |
| 2 | Adverse events of upper GI endoscopy显示文摘 | Tamir Ben-Menachem G. Anton Decker Dayna S. Early Jerry Evans Robert D. Fanelli Deborah A. Fisher Laurel Fisher Norio Fukami Joo Ha Hwang Steven O. Ikenberry Rajeev Jain Terry L. Jue Khalid M. Khan Mary L. Krinsky Phyllis M. Malpas John T. Maple Ravi N. S | 2012 | Gastrointestinal Endoscopy2012，，4： | 2 |
| 3 | Analysis and design of grating couplers 显示文摘 | Tamir T Peng S T | 1977 | Applied Physics1977，14，： | 1 |
| 4 | NAF-1 and mitoNEET are central to human breast cancer proliferation by maintaining mitochondrial homeostasis and promoting tumor growth显示文摘 | Sohn YS Tamir S Song LH | 2013 | Proc Natl Acad Sci U S A2013，110，14： | 1 |
| 5 | 显示文摘 | Handa K Peng S T Tamir T | 1975 | Applied Physics1975，，1： | 1 |
| 6 | Obstetricians' opinions regarding patient choice in cesarean delivery显示文摘 | Gonen R Tamir A Degani S | 2002 | Obstet Gynecol2002，99，4： | 1 |
| 7 | Endothelial dysfunction is revers- ible in Helicobacter pylori-positive subjects显示文摘 | Blum A Tamir S Mualem K | 2011 | Am J Med2011，124，12： | 1 |
| 8 | Nutrient-Deprivation autophagy factor-1 (NAF-1): biochemical properties of a novel cellular target for Anti-Diabetic drugs显示文摘 | Tamir S Zuris JA Agranat L | 2013 | PLoS One2013，8，61： | 1 |
| 9 | Effect of stubble height and successive harvest on yield and quality of alfalfa forage in North Central Ethiopia显示文摘 | Seid A Tamir B Melaku S | 2005 | Tropic Science2005，45，： | 1 |
| 10 | Approximation algorithms for maximum dispersion显示文摘 | Hassin R Rubinstein S Tamir A | 1997 | Operations Research Letters1997，21，3： | 1 |
| 11 | Frequency selective reflection and transmission by a periodic dielectric layer显示文摘 | Bertoni H L Cheo L S Tamir T | 1989 | IEEE Trans Antennas Propagt1989，37，： | 1 |
| 12 | The role of nitric oxide (NO-) in the carcinogenic process 显示文摘 | Tamir S Tannenbaum SR | 1996 | Biochim Biophys Acta (BBA)-Rev Cancer1996，1288，2： | 1 |
| 13 | Performance characteristics of a gas burner with a swirling central flame显示文摘 | TAMIR A ELPERIN I YOTZER S | 1989 | Energy1989，14，7： | 1 |
| 14 | Endothelial dysfunction is reversible in Helicobacter pylori-positive subjects 显示文摘 | Blum A Tamir S Mualem K | 2011 | Am J Med2011，124，12： | 1 |
| 15 | Inhibition of serotonin re-uptake by licorice constituents显示文摘 | Ofir R Tamir S Khatib S Vaya J | 2003 | J Mol Neurosci2003，20，2： | 1 |
| 16 | Cutaneous manifestations of internal malignancies显示文摘 | Brenner S Tamir E Maharshak N | 2001 | Clin Dermatol2001，19，3： | 1 |
| 17 | Nitric oxide induces oxidative damage in addition to deamination in macrophage DN A 显示文摘 | de Rojas-Walker T Tamir S Schooeder H | 1995 | Chem Res Toxicol1995，8，： | 1 |
| 18 | Cutaneous manifestations of internal malignancies显示文摘 | Brenner S Tamir E Maharshak N | 2001 | Clin Dermatol2001，19，3： | 1 |
| 19 | Does hysteroscopy affect prognosis in apparent early-stage endometrial cancer?显示文摘 | Ben-Arie A Tamir S Dubnik s | 2008 | Int J Gynecol Cancer2008，18，4： | 1 |
| 20 | New aspects on pulsed laser deposition of aligned carbon nanotubes显示文摘 | Tamir S | 2006 | Applied Surface Science2006，252，： | 1 |
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