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| 1 | Roles of the MEK1/2 and AKT pathways in CXCL12/CXCR4 induced cholangiocarcinoma cell invasion显示文摘AIM:To evaluate the expression of C-X-C motif chemokine receptor 4(CXCR4)and its signaling cascades,which were previously identified as a key factor for cancer cell progression and metastasis,in cholangiocarcinoma cell lines.METHODS:The expression of CXCR4 and its signaling cascades were determined in the cholangiocarcinoma cell lines(RMCCA1 and KKU100)by Western blotting.The invasion assays and the detection of actin polymerization were tested in these cholangiocarcinoma cells treated with CXC chemokine ligand-12(CXCL12).RESULTS:Expression of CXCR4 was detected in both cholangiocarcinoma cell lines and activation of CXCR4 with CXCL12 triggered the signaling via the extracellular signal-regulated kinase-1/2(ERK1/2)and phosphoinositide 3-kinase(PI3K)and induction of cholangiocarcinoma cell invasion,and displayed high levels of actin polymerization.Addition of CXCR4 inhibitor(AMD3100)abrogated CXCL12-induced phosphorylation of MEK1/2 and Akt in these cells.Moreover,treatment with MEK1/2 inhibitor(U0126)or PI3K inhibitor(LY294 002)also attenuated the effect of CXCL12-induced cholangiocarcinoma cell invasion.CONCLUSION:These results indicated that the activation of CXCR4 and its signaling pathways(MEK1/2 and Akt)are essential for CXCL12-induced cholangiocarcinoma cell invasion.This rises Implications on a potential role for the inhibition of CXCR4 or its signal cascades in the treatment of cholangiocarcinoma. | Kawin Leelawat Surang Leelawat Siriluck Narong Suradej Hongeng | 2007 | World Journal of Gastroenterology2007，13，10： | 27 |
| 2 | Circulating hTERT mRNA as a tumor marker in cholangiocarcinoma patients显示文摘瞄准:调查人的 telomerase 颠倒 transcriptase (hTERT ) 在 cholangiocarcinoma 病人的浆液的 mRNA。方法:三十三个 cholangiocarcinoma 病人,四十一个良性的胆道疾病病人和十个健康志愿者的浆液为由即时反向的 transcriptase 聚合酶链反应(RT-PCR ) 的 hTERT mRNA 的表示镇定、分析。我们然后检验了在浆液 hTERT mRNA 的价值和 cholangiocarcinoma 的病理学的阶段之间的关联。结果:hTERT mRNA 在 33 中的 28 个被检测(84.85%) 从 cholangiocarcinoma 浆液获得了病人,(21.9%) 41 中的 9 个从良性的胆道疾病病人浆液获得了。hTERT mRNA 没在从健康志愿者获得的任何浆液被检测。在另一方面普通肿瘤标记, CA19-9 在 33 中的 20 个被检测(60.6%) 从 cholangiocarcinoma 浆液获得了病人,(19.5%) 41 中的 8 个从良性的胆道疾病病人浆液获得了。然而,没有关联浆液 hTERT mRNA 和肿瘤阶段在礼品之间被发现。结论:这些结果显示传播 hTERT mRNA 的察觉在几乎所有 cholangiocarcinoma 病人被识别。它提供一个新奇肿瘤标记,它能为 cholangiocarcinoma 的诊断被用作互补研究。 | Kawin Leelawat Surang Leelawat Thawee Ratanachu-Ek Somboon Trubwongchareon Jerasak Wannaprasert Saad Tripongkaruna Suchart Chantawibul Panadda Tepaksorn | 2006 | World Journal of Gastroenterology2006，12，26： | 10 |
| 3 | Frontiers in antibiotic alternatives for Clostridioides difficile infection显示文摘Clostridioides difficile(C.difficile)is a gram-positive,anaerobic spore-forming bacterium and a major cause of antibiotic-associated diarrhea.Humans are naturally resistant to C.difficile infection(CDI)owing to the protection provided by healthy gut microbiota.When the gut microbiota is disturbed,C.difficile can colonize,produce toxins,and manifest clinical symptoms,ranging from asymptomatic diarrhea and colitis to death.Despite the steady-if not risingprevalence of CDI,it will certainly become more problematic in a world of antibiotic overuse and the post-antibiotic era.C.difficile is naturally resistant to most of the currently used antibiotics as it uses multiple resistance mechanisms.Therefore,current CDI treatment regimens are extremely limited to only a few antibiotics,which include vancomycin,fidaxomicin,and metronidazole.Therefore,one of the main challenges experienced by the scientific community is the development of alternative approaches to control and treat CDI.In this Frontier article,we collectively summarize recent advances in alternative treatment approaches for CDI.Over the past few years,several studies have reported on natural product-derived compounds,drug repurposing,highthroughput library screening,phage therapy,and fecal microbiota transplantation.We also include an update on vaccine development,pre-and probiotics for CDI,and toxin antidote approaches.These measures tackle CDI at every stage of disease pathology via multiple mechanisms.We also discuss the gaps and concerns in these developments.The next epidemic of CDI is not a matter of if but a matter of when.Therefore,being well-equipped with a collection of alternative therapeutics is necessary and should be prioritized. | Matthew Phanchana Phurt Harnvoravongchai Supapit Wongkuna Tanaporn Phetruen Wichuda Phothichaisri Supakan Panturat Methinee Pipatthana Sitthivut Charoensutthivarakul Surang Chankhamhaengdecha Tavan Janvilisri | 2021 | World Journal of Gastroenterology2021，27，42： | 2 |
| 4 | Occurrence of salt, pH and temperature tolerant, phosphatic solu- bilizing bacteria in alkaline soils显示文摘 | Johri J K Surange S Nautiyal C S | 1999 | Current Microbi- ology1999，39，： | 1 |
| 5 | An anti-herpes simplex virus-type 1 agent from Xylaria mellisii(BCC 1005) 显示文摘 | Pattama P Rapheephat S Surang T | 2005 | Tetrahedron Letters2005，46，3： | 1 |
| 6 | Multiloculated peritoneal inclusion cyst treated successfully with laparoscopic surgery显示文摘 | Vorapong P Wirach W Surang T | 2005 | Gynecol Surg2005，2，： | 1 |
| 7 | Phosphate solubilization under varying pH by Rhi zobium from tree legumes显示文摘 | Kumar N 1993 | 1993 | Indian J Exp Biol1993，31，： | 1 |
| 8 | Kidney transplantation into an ileal conduit: a single center experience of 59 cases显示文摘 | Johnson R W G Tavakoli A | 2003 | J Urol2003，170，5： | 1 |
| 9 | An anti-herpes simplex virus-type 1 agent from Xylaria mellisii(BCC 1005)显示文摘 | PATTAMA P RAPHEEPHAT S SURANG T | 2005 | Tetrahedron Letters2005，46，： | 1 |
| 10 | Screening for Intestinal Parasitic Infections Among Myanmar Migrant Workers in Thai Food Industry: A High-Risk Transmission显示文摘 | Surang Nuchprayoon Vivornpun Sanprasert Sakchai Kaewzaithim Wilai Saksirisampant | 2009 | Journal of Immigrant and Minority Health2009，，2： | 1 |
| 11 | Occurrence of salt,pH,and temperature-tolerant, phosphate-solubilizing bacteria in alkaline soils显示文摘 | Johri J K Surange S Nautiyal C S | 1999 | Current Microbiology1999，39，2： | 1 |
| 12 | Effects of clomiphene citrate on the endometrium of regularly cycling women显示文摘 | Wisan Sereepapong Somchai Suwajanakorn Surang Triratanachat Pichet Sampatanukul Kamthorn Pruksananonda Wisut Boonkasemsanti Damrong Reinprayoon | 2000 | Fertility and Sterility2000，，2： | 1 |
| 13 | Occurrence of salt pH and temperature-tolerant phosphate-solubilizing bacteria in alkaline soils显示文摘 | Johri J K Surange S Natiyal C S | 1999 | Curr Microbiol1999，39，： | 1 |
| 14 | Impact of stents on urological complications and health care expenditure in renal transplant recipients: results of a prospective, randomized clinical trial显示文摘 | Tavakoli A Surange RS Pearson RC | 2007 | J Urol2007，177，6： | 1 |
| 15 | Occurrence of Salt, pH, and Temperature-tolerant, Phosphate-solubilizing Bacteria in Alkaline Soil显示文摘 | AYANDRA KUMAR JOHRI SAN JAY SURANGE | 1999 | Current Microbiology1999，39，： | 1 |
| 16 | Mosquito distribution and Japanese encephalitis virus infection in the immigration bird (Asian open-billed stork) nested area in Pathum Thani province, central Thailand显示文摘 | Sonthaya Tiawsirisup Surang Nuchprayoon | 2010 | Parasitology Research2010，，4： | 1 |
| 17 | Prostate specific antigen ratio:for diagnosis and assessment of aggressiveness of malignancy of prostate显示文摘 | KAPOOR N JAIN R SURANGE S | 2006 | Indian J Pathol Microbiol2006，49，2： | 1 |
| 18 | Receptor-binding cancer antigen expressed on SiSo cells can be detected in metastatic lymph nodes from gastrointestinal cancers显示文摘AIM: To investigate the expression of receptor-binding cancer antigen expressed on SiSo cells (RCAS1) in metastatic lymph nodes from gastrointestinal cancer.METHODS: Metastatic lymph nodes from gastrointestinal cancer were detected for RCAS1 by immunohistochemical staining and mRNA in situ hybridization.RESULTS: A total of 102 metastatic lymph nodes from bile duct, gastric, colon, and pancreatic cancer were investigated for RCAS1 expression. The immunoreactivity of RCAS1 was identified in 100% of metastatic lymph nodes. Both local and distant metastatic lymph nodes showed RCAS1 expression. On the contrary, specimens of non-cancerous lymph nodes were negative for RCAS1.The result of mRNA in situ hybridization was also confirmed by the finding of immunohistochemical staining. RCAS1 mRNA was detected in all tumor cells that metastasized to lymph nodes.CONCLUSION: All metastatic lymph nodes express RCAS1 in tumor cells at both protein and mRNA levels,and RCAS1 should be used as a complementary factor for identification of metastatic lymph nodes from gastrointestinal cancers. | Kawin Leelawat Surang Engprasert Supathip Tujinda Cheepsumon Suthippintawong Munechika Enjoji Manabu Nakashima Takeshi Watanabe Vijittra Leardkamolkarn | 2005 | World Journal of Gastroenterology2005，11，38： | 1 |
| 19 | Detection of PTEN immunoreactivity in endometrial hyperplasia and adenocarcinoma显示文摘 | Patou Tantbirojn Surang Triratanachat | 2008 | Med Assoc Thai2008，91，8： | 1 |
| 20 | Genotypic profile of Strepto- coccus suis serotype 2 and clinical features of infection in humans, Thai- land 显示文摘 | Anusak K Surang D Parichart P | 2011 | Emerg Infect Dis2011，17，5： | 1 |
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