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| 1 | Dissection of genetic overlap of salt tolerance QTLs at the seedling and tillering stages using backcross introgression lines in rice显示文摘QTLs for salt-tolerance(ST)related traits at the seedling and tillering stages were identified using 99 BC2F8 introgression lines(IL)derived from a cross between IR64(indica)as a recurrent parent and Binam(japonica)from Iran as the donor parent.Thirteen QTLs affecting survival days of seedlings(SDS), score of salt toxicity of leaves(SST),shoot K + concentration(SKC)and shoot Na + concentration(SNC) at the seedling stage and 22 QTLs underlying fresh weight of shoots(FW),tiller number per plant(TN) and plant height(PH)at the tillering stage were identified.Most QTLs detected at the tillering stage showed obvious differential expression to salt stress and were classified into three types based on their differential behaviors.Type I included 11 QTLs which were expressed only under the non-stress condition.Type II included five QTLs expressed in the control and the salt stress conditions,and three of them(QPh5,QPh8 and QTn9)had similar quantity and the same direction of gene effect,suggesting their expression was less influenced by salt stress.Type III included six QTLs which were detectable only under salt stress,suggesting that these QTLs were apparently induced by the stress.Thirteen QTLs affecting trait difference or trait stability of ILs between the stress and non-stress conditions were identified and the Binam alleles at all loci except QPh4,QTn2 and QFw2a decreased trait difference.The three QTLs less influenced by the stress and 13 QTLs affecting trait stability were considered as ST QTLs which contributed to ST.Comparing the distribution of QTLs detected at the seedling and tillering stages,most(69%)of them were genetically independent.Only four were the same or adjacent regions on chromosomes 1,2,8 and 11 harboring ST QTLs detected at the two stages,suggesting that partial genetic overlap of ST across the two stages occurs.It is likely,therefore,to develop ST rice variety for both stages by pyramiding of ST QTLs of different stages or selection against the overlapping QTLs between the two stages via marker-assisted selection(MAS). | ZANG JinPing 1 ,SUN Yong 1 ,WANG Yun 1 ,YANG Jing 1 ,LI Fang 1 ,ZHOU YongLi 1 ,ZHU LingHua 1 , Reys JESSICA2,Fotokian MOHAMMADHOSEIN 2,XU JianLong 1&LI ZhiKang 1,2 1Institute of Crop Sciences/National Key Facility for Crop Gene Resources&Genetic Improvement,Chinese Academy of Agricul- tural Sciences,Beijing 100081,China 2International Rice Research Institute,DAPO Box 7777,Metro Manila,Philippines | 2008 | Science China(Life Sciences)2008，51，7： | 32 |
| 2 | An operational two-layer remote sensing model to estimate surface flux in regional scale: Physical background显示文摘Based on the improved interaction mechanism of two-layer model, this paper proposed Pixel Component Arranging and Comparing Algorithm (PCACA) and theoretically positioning algorithm, estimated the true temperature of mixed pixel in four extreme points in combination with the measurements of dry and wet points in calibration fields and improved the reliability of positioning dry and wet line. A new two-layer energy-separation algorithm was proposed,which was simple and direct without resistance network parameters for each pixel. We also proposed a new thought about the effect of advection. The albedo of mixed pixel was also separated with PCACA. In combination with two-layer energy-separation algorithm, the net radiation of mixed pixel was separated to overcome the uncertainty of conventional energy-separation algorithm using Beer's Law. Through the validation of retrieval result, this method is proved to be feasible and operational. At the same time, the uncertainty of this algorithm was objectively analyzed. | ZHANG Renhua SUN Xiaomin WANG Weimin XU Jinping ZHU Zhilin TIAN Jing | 2005 | Science China Earth Sciences2005，48，z1： | 16 |
| 3 | ZmMs30 Encoding a Novel GDSL Lipase Is Essential for Male Fertility and Valuable for Hybrid Breeding in Maize显示文摘Genic male sterility (GMS) is very useful for hybrid vigor utilization and hybrid seed production. Although a large number of GMS genes have been identified in plants, little is known about the roles of GDSL lipase members in anther and pollen development. Here, we report a maize GMS gene, ZmMs30, which encodes a novel type of GDSL lipase with diverged catalytic residues. Enzyme kinetics and activity assays show that ZmMs30 has lipase activity and prefers to substrates with a short carbon chain. ZmMs30 is specifically expressed in maize anthers during stages 7-9. Loss of ZmMs30 function resulted in defective anther cuticle, irregular foot layer of pollen exine, and complete male sterility. Cytological and lipidomics analyses demonstrate that ZmMs30 is crucial for the aliphatic metabolic pathway required for pollen exine formation and anther cuticle development. Furthermore, we found that male sterility caused by loss of ZmMs30 function was stable in various inbred lines with different genetic background, and that it didn't show any negative effect on maize heterosis and production, suggesting that ZmMs30 is valuable for crossbreeding and hybrid seed production. We then developed a new multi-control sterility system using ZmMs30 and its mutant line, and demonstrated it is feasible for generating desirable GMS lines and valu. able for hybrid maize seed production. Taken together, our study sheds new light on the mechanisms of anther and pollen development, and provides a valuable male-sterility system for hybrid breeding maize. | Xueli An Zhenying Dong Youhui Tian Ke Xie Suowei Wu Taotao Zhu Danfeng Zhang Van Zhou Canfang Niu Biao Ma Quancan Hou Jianxi Bao Simiao Zhang Ziwen Li Yanbo Wang Tingwei Yan Xiaojing Sun Yuwen Zhang Jinping Li Xiangyuan Wan | 2019 | Molecular Plant2019，12，3： | 15 |
| 4 | A GTD model and state space approach based method for extracting the UWB scattering center of moving target显示文摘Movements of the scattering center on the condition of ultra-wideband(UWB)will impact the extraction of parameters.This paper presents an approach for extracting the moving targets'UWB scattering center parameters based on the geometrical theory of diffraction(GTD)model and the state space approach. Firstly,the UWB GTD scattering model is transformed into state-space equations in order to estimate the range and range rate through the singular value decomposition.Secondly,the type parameter in the whole bandwidth is indicated dimension-reducedly by orthonormalized basis and estimated by traversal algorithm and minimumnorm algorithm.Finally,the intensity of scattering center is worked out based on the least square method.The paper provides the Cramer-Rao bound(CRB)for parameter estimation.The effectiveness of the approach is verified by computer simulation.The approach can estimate range,range rate,reflection intensity and type parameter simultaneously in order to improve the track of scattering centers and the target identification. | WANG Jun WEI ShaoMing SUN JinPing MAO ShiYi | 2011 | Science China(Information Sciences)2011，54，1： | 11 |
| 5 | Correcting method of eddy covariance fluxes over non-flat surfaces and its application in ChinaFLUX显示文摘Although Eddy Covariance (EC) technique is one of the best methods for estimating the energy and mass exchanges between underlying surface and atmosphere in micrometeorology, errors and uncertainties still exist without necessary corrections. In this paper, we will focus on the effect of coordinate system on the eddy fluxes. Based on the data observed over four sites (one farmland site, one grassland site and two forest sites), the effects of three coordinate system transforming methods (Double Rotation-DR, Triple Rotation-TR and Planar Fit-PF)on the turbulent fluxes are analyzed. It shows that (i) the corrected fluxes are more or less than the uncorrected fluxes, which is related mainly to the sloping degree of surface, wind speed and wind direction; and (ii) pitch angle has a sinusoidal dependence on wind direction, especially in the regular sloping terrain; and (iii) PF method is something like the simplification of TR or DR,and there are not obvious distinctions in correction in sloping grassland and flat farmland, but PF method is not suitable for uneven and irregular forest sites. | ZHU Zhilin, SUN Xiaomin, ZHOU Yanlian, XU Jinping, YUAN Guofu & ZHANG Renhua Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China Graduate School of the Chinese Academy of Sciences, Beijing 100039, China | 2005 | Science China Earth Sciences2005，48，z1： | 10 |
| 6 | On the TOPS mode spaceborne SAR显示文摘TOPS (terrain observation by progressive scans) is a recently proposed SAR mode for wide swath acquisition, which aims at achieving the same coverage and resolution as the SCAN mode besides creating scalloping-free images. In this paper, a general SAR imaging model used in TOPS and other SAR modes is introduced, where the antenna sweep rate, Doppler centroid rate, illumination time and azimuth resolution are described by a parameter defined as the 'mode factor'. After analyzing the characteristics of TOPS signal, an algorithm based on chirp-z transform is proposed, in which a new de-rotation function is used. Simulation results validate the proposed algorithm. | BAI Xia SUN JinPing HONG Wen MAO ShiYi | 2010 | Science China(Information Sciences)2010，53，2： | 7 |
| 7 | Molecular dissection of plant height QTLs using recombinant inbred lines from hybrids between common wheat (Triticum aestivum L.) and spelt wheat (Triticum spelta L.)显示文摘In wheat, plant height is an important agronomic trait, and a number of quantitative trait loci (QTLs) controlling plant height have been located. In this study, using the conditional and unconditional QTL mapping methods, combined with data from five different growth stages over two years of field trials, the developmental behavior for plant height in wheat was dissected. Nine unconditional QTLs and 8 conditional QTLs were identified, of which 6 were detected by both methods. None of the 11 QTLs was detected at all of the 5 investigated developmental stages, but 7 QTLs were detected at certain stages in both years. Further analysis identified 9 unconditional QTLs at different stages, which could explain the phenotypic variation from 4.81% to 17.35%. It was noteworthy that one major QTL designated QHt-4B-2, which was located on chromosome 4B, was detected on May 18 and 25 in both years, and its genetic contributions to plant height ranged from 13.42% to 16.13%. Moreover, of the 8 conditional QTLs identified, six were detected in both years, in the order of QHt-3B→QHt-4B-1→QHt-4B-2→QHt-4D→QHt-5A and QHt-2B expressed at the same developmental stage. The results indicate that QTL expression during plant height development is selective and in a temporal order. | LIU Gang XU ShengBao NI ZhongFu XIE ChaoJie QIN DanDan LI Jing LU LaHu ZHANG JinPing PENG HuiRu SUN QiXin | 2011 | Chinese Science Bulletin2011，56，18： | 6 |
| 8 | Knowledge-based bridge detection from SAR images显示文摘Automatic bridge detection is an important application of SAR images.Differed from the classical CFAR method,a new knowledge-based bridge detection approach is proposed.The method not only uses the backscattering intensity difference between targets and background but also applies the contextual information and spatial relationship between objects.According to bridges' special characteristics and scattering properties in SAR images,the new knowledge-based method includes three processes:river segmentation,potential bridge areas detection and bridge discrimination.The application to AIRSAR data shows that the new method is not sensitive to rivers' shape.Moreover,this method can detect bridges successfully when river segmentation is not very exact and is more robust than the radius projection method. | Wang Wenguang Sun Jinping Hu Rui Mao Shiyi | 2009 | Journal of Systems Engineering and Electronics2009，20，5： | 5 |
| 9 | Hierarchical Feature-Based Detection Method for SAR Targets Under Complex Environment显示文摘A reliable target detection method for Synthetic aperture radar(SAR)images is needed urgently with the wide application of SAR systems.The performance of conventional detection algorithms,such as Constant false alarm rate(CFAR),degrade significantly in low SCR or complex regions while the Human visual system(HVS)can identify targets of interest without knowing characteristics of the background even in complicated environment.The combination of HVS with the SAR-ATR system may effectively achieve real-time multi-target detection in complex occlusion scenes.A new effective target detection algorithm is put forward using hierarchical characteristics of targets.Inspired by different roles of the retina and visual cortex in the HVS,this detection algorithm is divided into coarse detection and fine detection stage.Two kinds of features based on the correlation between target features and suspicious targets,namely overall feature and refined feature,are used in these two stages respectively to extract real targets.Experimental results verify its correctness and effectiveness in complex environment. | GAO Fei MA Fei LUO Xiling WANG Jun SUN Jinping | 2017 | Chinese Journal of Electronics2017，26，3： | 4 |
| 10 | A novel spaceborne SAR wide-swath imaging approach based on Poisson disk-like nonuniform sampling and compressive sensing显示文摘Since the range swath width in the conventional single channel spaceborne synthetic aperture radar(SAR)is restricted by the system parameters,there is a trade-off between the azimuth resolution and the swath width in order to satisfy the Nyquist sampling criterion.In this paper,we propose a novel spaceborne SAR wide-swath imaging scheme based on compressive sensing(CS)for the sparse scene.The proposed method designs a Poisson disk-like nonuniform sampling pattern in the azimuth direction,which meets the demand of wider swath by restricting the smallest time interval between any two azimuth samples,with the conventional sampling pattern preserved in the range direction.By a similar way to the processing procedure of spectral analysis(SPECAN)algorithm,the linear range migration correction(RMC)is realized while carrying out range compression,which can meet the demand for focusing with middle level resolution.To reduce the computation load of CS reconstruction,we propose a novel fast reconstruction algorithm based on nonuniform fast Fourier transform(NUFFT),which greatly reduces the computation complexity from O(2M N)to O(4N log N).Experiment results validate the effectiveness of the proposed methods via the point target simulation and the Radarsat-1 raw data processing in F2 mode. | SUN JinPing ZHANG YuXi TIAN JiHua WANG Jun | 2012 | Science China(Information Sciences)2012，55，8： | 4 |
| 11 | Factor graph aided multiple hypothesis tracking显示文摘Since closely moving targets exist extensively in the ground moving target tracking,the uncertainty of data association greatly increases making the measurement-to-track association more difcult.Especially,traditional multiple hypothesis tracking(MHT)has high false tracking rate and track swap.This paper frst investigates the measurement based factor graph in data association,and gives the corresponding message passing algorithm.Then,a factor graph aided multiple hypothesis tracking(FGA-MHT)method is proposed,which introduces factor graph based m-best hypothesis producing technique and exploits factor graph based probability refnement algorithm to reduce the uncertainty of measurement-to-track association.Experiment results demonstrate that FGA-MHT reduces times of track swap and increases the correct data association rate in closely moving target tracking. | WANG Huan SUN JinPing LU SongTao WEI ShaoMing | 2013 | Science China(Information Sciences)2013，56，10： | 4 |
| 12 | De-colorization of Reactive Brilliant Orange X-GN by a novel rotating electrochemical disc process显示文摘A novel electrochemical setup for wastewater treatment-rotating electrochemical disc process(RECDP)was developed in this article. The anode and cathode are distributed alternatively and evenly on a flat round disc,which was designed to improve mass transfer of organics from bulk solution to electrode surface,while at the same time increasing oxygen transfer from air to the liquid to benefit the organics oxidization.The color removal of dye Reactive Brilliant Orange X-GN(RBO)was experimentally investigate... | Zhong Dengjie Yang Ji Xu Yunlan Jia Jinping Wang Yalin Sun Tonghua | 2008 | Journal of Environmental Sciences2008，20，8： | 3 |
| 13 | Discovery of Novel Androgen Receptor Ligands by Structure-based Virtual Screening and Bioassays显示文摘Androgen receptor(AR) is a ligand-activated transcription factor that plays a pivotal role in the development and progression of many severe diseases such as prostate cancer, muscle atrophy, and osteoporosis. Binding of ligands to AR triggers the conformational changes in AR that may affect the recruitment of coactivators and downstream response of AR signaling pathway.Therefore, AR ligands have great potential to treat these diseases. In this study, we searched for novel AR ligands by performing a docking-based virtual screening(VS) on the basis of the crystal structure of the AR ligand binding domain(LBD) in complex with its agonist. A total of 58 structurally diverse compounds were selected and subjected to LBD affinity assay, with five of them(HBP1-3, HBP1-17, HBP1-38, HBP1-51, and HBP1-58) exhibiting strong binding to AR-LBD. The IC50 values of HBP1-51 and HBP1-58 are 3.96 m M and 4.92 m M, respectively, which are even lower than that of enzalutamide(Enz, IC50= 13.87 m M), a marketed second-generation AR antagonist. Further bioactivity assays suggest that HBP1-51 is an AR agonist, whereas HBP1-58 is an AR antagonist. In addition, molecular dynamics(MD) simulations and principal components analysis(PCA) were carried out to reveal the binding principle of the newlyidentified AR ligands toward AR. Our modeling results indicate that the conformational changes of helix 12 induced by the bindings of antagonist and agonist are visibly different. In summary,the current study provides a highly efficient way to discover novel AR ligands, which could serve as the starting point for development of new therapeutics for AR-related diseases. | Wenfang Zhou Mojie Duan Weitao Fu Jinping Pang Qin Tang Huiyong Sun Lei Xu Shan Chang Dan Li Tingjun Hou | 2018 | Genomics, Proteomics & Bioinformatics2018，16，6： | 3 |
| 14 | Study on the Improvement of the Application of Complete Ensemble Empirical Mode Decomposition with Adaptive Noise in Hydrology Based on RBFNN Data Extension Technology显示文摘The complex nonlinear and non-stationary features exhibited in hydrologic sequences make hydrological analysis and forecasting difficult.Currently,some hydrologists employ the complete ensemble empirical mode decomposition with adaptive noise(CEEMDAN)method,a new time-frequency analysis method based on the empirical mode decomposition(EMD)algorithm,to decompose non-stationary raw data in order to obtain relatively stationary components for further study.However,the endpoint effect in CEEMDAN is often neglected,which can lead to decomposition errors that reduce the accuracy of the research results.In this study,we processed an original runoff sequence using the radial basis function neural network(RBFNN)technique to obtain the extension sequence before utilizing CEEMDAN decomposition.Then,we compared the decomposition results of the original sequence,RBFNN extension sequence,and standard sequence to investigate the influence of the endpoint effect and RBFNN extension on the CEEMDAN method.The results indicated that the RBFNN extension technique effectively reduced the error of medium and low frequency components caused by the endpoint effect.At both ends of the components,the extension sequence more accurately reflected the true fluctuation characteristics and variation trends.These advances are of great significance to the subsequent study of hydrology.Therefore,the CEEMDAN method,combined with an appropriate extension of the original runoff series,can more precisely determine multi-time scale characteristics,and provide a credible basis for the analysis of hydrologic time series and hydrological forecasting. | Jinping Zhang Youlai Jin Bin Sun Yuping Han Yang Hong | 2021 | Computer Modeling in Engineering & Sciences2021，，2： | 3 |
| 15 | Determination of averaging period parameter and its effects analysis for eddy covariance measurements显示文摘It is more and more popular to estimate the exchange of water vapor, heat and CO2fluxes between the land surface and the atmosphere using the eddy covariance technique. To get believable fluxes, it is necessary to correct the observations based on the different surface conditions and to determine relevant techinical parameters. The raw 10 Hz eddy covariance data observed in the Yucheng and Changbai Mountains stations were recalculated by various averaging periods (from 1 to 720 min) respectively, and the recalculated results were compared with the results calculated by the averaging period of 30 mins. Meanwhile, the distinctions of fluxes calculated by different averaging periods were analyzed. The continuous 15 days observations over wheat fields in the Yucheng station were mainly analyzed. The results are shown that: (i) In the Yucheng station, compared with the observations by 30 min, when the averaging period changes from 10 to 60 min, the variations of the eddy-covariance estimates of fluxes were less than 2%; when the averaging period changes less than 10 min, the estimate of fluxes reduced obviously with the reduction of the averaging period (the max relative error was -12%); and when the averaging period exceeds 120 min, the eddy covariance estimates of fluxes will be increased and become unsteady (the max relative error is over 10%); (ii) the eddy covariance estimates of fluxes over wheat field in the Yucheng station suggusted that it is much better to take 10 min as an averaging period in studying diurnal change of fluxes, and take 30min for a long-term flux observation; and (iii) normalized ratio was put forward to determine the range of averaging period of eddy covariance measurements. By comparing the observations over farmlands and those over forests, it is indicated that the increase of eddy covariance estimates over tall forest was more than that over short vegetation when the averaging period increased. | SUN Xiaomin, ZHU Zhilin, XU Jinping, YUAN Guofu , ZHOU Yanlian & ZHANG Renhua Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China Graduate School of the Chinese Academy of Sciences, Beijing 100039, China | 2005 | Science China Earth Sciences2005，48，z1： | 3 |
| 16 | Chokeberry(Aronia melanocarpa)as a new functional food relationship with health:an overview显示文摘As a consumer product,black chokeberry(Aronia melanocarpa)is diffi cult to consume due to its pungent taste.It is mainly used in various food industries to produce a variety of juices,preserves,extracts,fruit teas and nutritional supplements.Traditionally,Potawatomi Native Americans used black chokeberry to treat colds,coughs and fever.It has been found to contain numerous active ingredients.Currently,there are many health and medical products that contain black chokeberry.The purpose of this review is to understand the nutritional benefi ts of black chokeberry and to explore its benefi cial effects on biological systems in vitro,thereby emphasizing its therapeutic prospects. | Yiwen Zhang Yingchun Zhao Xinglong Liu Xueyan Chen Chuanbo Ding Ling Dong Jinping Zhang Shuwen Sun Qiteng Ding Sadia Khatoom Zhiqiang Cheng Wencong Liu Liqian Shen Fengyan Xiao | 2021 | Journal of Future Foods2021，1，2： | 3 |
| 17 | Origin and future distribution of the new A (H1N1) influenza virus emerging in North America in 2009显示文摘The origin of the new A (H1N1) influenza virus recently emerging in North America is a hot controversial topic of significance in disease control and risk assessment.Some experts claimed that it was an unusually mongrelized mix of human,avian and swine influenza viruses,while some others concluded that it was totally a simple re-assortment hybrid of two lineages of swine influenza viruses.Here the phylogenetic diversity of the viral PB1,PA and PB2 gene sequences using online web servers,and the results suggest that all the 8 genetic segments of the new virus were possibly from two lineages of swine influenza viruses,and one of the lineage was a mongrelized mix of human,avian and swine influenza viruses emerging in the world approximately 10 years ago.Considering the recent epidemiological trends of the new virus,we believe it will spread more widely in the world and persist long in human populations.It also could spread among swine populations.The future wide spreading of the new virus may coincide the disappearance of a subtype of previous human influenza A virus. | CHEN JiMing SUN YingXue LIU Shuo JIANG WenMing CHEN Jie HOU GuangYu LI JinPing | 2009 | Chinese Science Bulletin2009，54，13： | 3 |
| 18 | Rhodojaponin Ⅵ indirectly targets Cav2.2 channels via N-ethylmaleimide-sensitive fusion protein to alleviate neuropathic pain显示文摘Neuropathic pain is a chronic disease that severely afflicts the life and emotional status of patients,but currently available treatments are often ineffective.Novel therapeutic targets for the alleviation of neuropathic pain are urgently needed.Rhodojaponin Ⅵ,a grayanotoxin from Rhododendron molle,showed remarkable antinociceptive efficacy in models of neuropathic pain,but its biotargets and mechanisms are unknown.Given the reversible action of rhodojaponin Ⅵ and the narrow range over which its structure can be modified,we perforwmed thermal proteome profiling of the rat dorsal root ganglion to determine the protein target of rhodojaponin Ⅵ.N-Ethylmaleimide-sensitive fusion(NSF) was confirmed as the key target of rhodojaponin Ⅵ through biological and biophysical experiments.Functional validation showed for the first time that NSF facilitated trafficking of the Cav2.2 channel to induce an increase in Ca2+current intensity,whereas rhodojaponin Ⅵ reversed the effects of NSF.In conclusion,rhodojaponin Ⅵ represents a unique class of analgesic natural products targeting Cav2.2 channels via NSF. | Keliang Chen Tao Wang Yong Li Jun Wu Cheng-Xiao Zhao Sheng Liu Fengrun Sun Yehong Fang Jiahuan Hu Jinping Hu Chong-Jing Zhang Haibo Yu Chao Ma Shi-Shan Yu | 2023 | Acta Pharmaceutica Sinica B2023，13，3： | 2 |
| 19 | Multiple hypothesis tracking based on the Shiryayev sequential probability ratio test显示文摘To date, Wald sequential probability ratio test(WSPRT) has been widely applied to track management of multiple hypothesis tracking(MHT). But in a real situation, if the false alarm spatial density is much larger than the new target spatial density, the original track score will be very close to the deletion threshold of the WSPRT. Consequently, all tracks, including target tracks, may easily be deleted, which means that the tracking performance is sensitive to the tracking environment. Meanwhile, if a target exists for a long time, its track will have a high score, which will make the track survive for a long time even after the target has disappeared. In this paper, to consider the relationship between the hypotheses of the test, we adopt the Shiryayev SPRT(SSPRT) for track management in MHT. By introducing a hypothesis transition probability, the original track score can increase faster, which solves the first problem. In addition, by setting an independent SSPRT for track deletion, the track score can decrease faster, which solves the second problem. The simulation results show that the proposed SSPRT-based MHT can achieve better tracking performance than MHT based on the WSPRT under a high false alarm spatial density. | Jinbin FU Jinping SUN Songtao LU Yingjing ZHANG | 2016 | Science China Earth Sciences2016，59，12： | 2 |
| 20 | Low sample volume origami-paper-based graphene-modified aptasensors for label-free electrochemical detection of cancer biomarker-EGFR显示文摘In this work,an electrochemical paper-based aptasensor was fabricated for label-free and ultrasensitive detection of epidermal growth factor receptor(EGFR)by employing anti-EGFR aptamers as the bio-recognition element.The device used the concept of paper-folding,or origami,to serve as a valve between sample introduction and detection,so reducing sampling volumes and improving operation convenience.Amino-functionalized graphene(NH 2-GO)/thionine(THI)/gold particle(AuNP)nanocomposites were used to modify the working electrode not only to generate the electrochemical signals,but also to provide an environment conducive to aptamer immobilization.Electrochemical characterization revealed that the formation of an insulating aptamer–antigen immunocomplex would hinder electron transfer from the sample medium to the working electrode,thus resulting in a lower signal.The experimental results showed that the proposed aptasensor exhibited a linear range from 0.05 to 200 ngmL^(−1)(R^(2)=0.989)and a detection limit of 5pgmL^(−1) for EGFR.The analytical reliability of the proposed paper-based aptasensor was further investigated by analyzing serum samples,showing good agreement with the gold-standard enzyme-linked immunosorbent assay. | Yang Wang Shuai Sun Jinping Luo Ying Xiong Tao Ming Juntao Liu Yuanyuan Ma Shi Yan Yue Yang Zhugen Yang Julien Reboud Huabing Yin Jonathan MCooper Xinxia Cai | 2020 | Microsystems & Nanoengineering2020，6，1： | 2 |
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