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| 1 | Transient receptor potential vanilloid 4-dependent calcium influx and ATP release in mouse and rat gastric epithelia显示文摘AIM: To explore the expression of transient receptor potential vanilloid 4(TRPV4) and its physiological meaning in mouse and rat gastric epithelia. METHODS: RT-PCR and immunochemistry were used to detect TRPV4 m RNA and protein expression in mouse stomach and a rat normal gastric epithelial cell line(RGE1-01), while Ca2+-imaging and electrophysiology were used to evaluate TRPV4 channel activity. ATP release was measured by a luciferin-luciferase assay. Gastric emptying was also compared between WT and TRPV4 knockout mice. RESULTS: TRPV4 m RNA and protein were detected in mouse tissues and RGE1-01 cells. A TRPV4-specific agonist(GSK1016790A) increased intracellular Ca2+ concentrations and/or evoked TRPV4-like current activities in WT mouse gastric epithelial cells andRGE1-01 cells, but not TRPV4 KO cells. GSK1016790 A or mechanical stimuli induced ATP release from RGE1-01 cells while TRPV4 knockout mice displayed delayed gastric emptying in vivo. CONCLUSION: TRPV4 is expressed in mouse and rat gastric epithelium and contributes to ATP release and gastric emptying. | Hiroshi Mihara Nobuhiro Suzuki Ammar Abdullkader Boudaka Jibran Sualeh Muhammad Makoto Tominaga Yoshiaki Tabuchi Toshiro Sugiyama | 2016 | World Journal of Gastroenterology2016，22，24： | 5 |
| 2 | Anti-inflammatory and cytoprotective effects of selected Pakistani medicinal plants in Helicobacter pylori -infected gastric epithelial cells显示文摘 | Syed Faisal Zaidi Jibran Sualeh Muhammad Saeeda Shahryar Khan Usmanghani Anwarul-Hassan Gilani Wasim Jafri Toshiro Sugiyama | 2012 | Journal of Ethnopharmacology2012，，1： | 3 |
| 3 | Anti-inflammatory and cytoprotective effects of selected Pakistani medicinal plants in Helicobacter pylori-infected gastric epithelial cells显示文摘 | Syed Faisal Zaidi Jibran Sualeh Muhammad Saeeda Shahryar | 2012 | Journal of Ethnopharmacology2012，141，1： | 1 |
| 4 | Long term outcomes of Cohen’s cross trigonal reimplantation for primary vesicoureteral reflux in poorly functioning kidney显示文摘BACKGROUND Open ureteric reimplantation by cross trigonal technique described by Cohen is considered a common surgical option for correction of vesicoureteral reflux(VUR). There is a lack of evidence in literature though for what happens to such kidneys, in the long run, particularly those which are poorly functioning.AIM To assess the long-term outcomes of ureteric reimplantation in poorly functioning kidneys in children with unilateral primary VUR.METHODS Children with unilateral primary VUR and a relative renal function of less than 35% who underwent open or laparoscopic ureteric reimplantation between January 2005 and January 2017 were included in the study. Patients who had a follow up of less than five years were excluded. Preoperative evaluation consisted of a voiding cystourethrogram and Dimercaptosuccinic acid(DMSA) scan. In the follow-up period, patients underwent a diuretic scan at 6 weeks and 6 months.Follow up ultrasound was done for change in grade of hydronephrosis and retrovesical ureteric diameter. Subsequent follow up was done at 6 monthly intervals with evaluation for proteinuria and hypertension and any recurrent urinary tract infection(UTI). For assessment of cortical function, DMSA was repeated annually for 5 years after surgery. A paired-samples t-test was used to test the mean difference of DMSA between pre-post observations.RESULTS During this period, 36 children underwent ureteric reimplantation for unilateral primary VUR. After excluding those with insufficient follow-up, 31 were included in the analysis. Most of the patients were males(n = 26/31, 83.8%). Patient’s age(mean ± SD, range) was 5.21 ± 3.71, 1-18 years. The grades of VUR were grade Ⅱ(1patient), grade Ⅲ(8 patients), grade Ⅳ(10 patients), and grade Ⅴ(12 patients). The pre and postoperative DMSA was 24.064 ± 12.02 and 24.06 ± 10.93, which was almost the same(statistically equal, paired-samples t-test: P = 0.873). The median(range) follow-up duration was 82(60-120)mo. One patient had persistent reflux after surgery(preoperative: grade Ⅳ, postoperative: grade Ⅲ), and the very same patient developed recurrent UTI. The difference in the preoperative and postoperative DRF was less than 10% in 29 patients. In one patient, the DRF decreased by 17%(22% to 05%) while in another patient, the DRF increased by 12%(25% to 37%) after surgery. None of the patients had an increase in scarring after surgery. 15% of patients were hypertensive before surgery and all of them continued to be hypertensive after surgery while none developed hypertension after surgery. None of the patients had significant proteinuria(> 150 mg/d) during the follow-up period.CONCLUSION Children with unilateral primary VUR and poorly functioning kidney maintain the renal function over the long term in most cases. Hypertension and proteinuria do not progress over time in these patients. | Mohd Sualeh Ansari Ravi Banthia Shrey Jain Vinay N Kaushik Nayab Danish Priyank Yadav | 2023 | World Journal of Clinical Cases2023，11，16： | 0 |
| 5 | Ins and outs of Helicobacter pylori association with autoimmune rheumatic diseases显示文摘Helicobacter pylori(H.pylori) infection is widely prevalent throughout worldwide.H.pylori manage a long-term survival in hostile environment of human stomach leading to peptic ulcer diseases and gastric cancer.But mostly infected person remains asymptomatic.Its chronic interaction with immune system makes H.pylori as an attractive candidate for the researchers to study its association with autoimmune diseases.This article presents a review of the literature on the association of H.pylori infection in selective autoimmune rheumatic diseases(RD).The authors used Me SH terms 'Helicobacter pylori ' with 'rheumatoid arthritis,' 'systemic lupus erythematosus,' or 'fibromyalgia' to search Pub Med database.All relevant studies identified were included.Despite extensive medical advancement many questions on role of H.pylori infection in autoimmune RD still remain unanswered.Further studies are therefore needed to address the role of H.pylori in pathogenesis of RD. | Jibran Sualeh Muhammad Syed Faisal Zaidi Muhammad Ishaq | 2015 | World Journal of Rheumatology2015，5，2： | 0 |
| 6 | Predictors of severe and critical COVID-19:A systematic review显示文摘BACKGROUND Coronavirus disease 2019(COVID-19)has emerged as a public health crisis that was declared as a global pandemic by the World Health Organization.Although most cases have no or mild symptoms,around 10%of patients develop severe or critical illness that necessitates hospitalization and intensive care unit admission.AIM To assess the literature for the predictive factors that can identify patients having severe/critical COVID-19 disease.METHODS A Preferred Reporting Items for Systematic Reviews and Meta-Analysescompliant systematic search of the literature was conducted.Electronic databases including PubMed/MEDLINE,Scopus,and Cochrane Library were queried.The main outcome measures were the predictors of severe/critical COVID-19 and mortality.RESULTS Five studies including 583 patients of a median age of 50.5 years were reviewed.Patients were 346(59.4%)male and 237(40.6%)female.Of 583 hospitalized patients,242(41.5%)had critical illness.Acute respiratory distress disease occurred in 291 patients,accounting for 46.7%of total complications.Onehundred(17.1%)mortalities were recorded.The most commonly reported predictors of severe COVID-19 were older age,medical comorbidities,lymphopenia,elevated C-reactive protein,increased D-dimer,and increased neutrophil ratio.Findings on computed tomography(CT)scanning predictive of severe disease were bronchial wall thickening,CT score>7,linear opacities,consolidation,right upper lobe affection,and crazy paving pattern.CONCLUSION Several demographic,clinical,laboratory,and radiologic factors can help predict severe and critical COVID-19 along with the potential need for mechanical ventilation.Factors that were more commonly reported were older age,medical comorbidities,lymphopenia,increased neutrophil ratio,elevated C-reactive protein,and increased D-dimer. | Sameh Hany Emile Sualeh Muslim Khan | 2020 | World Journal of Clinical Infectious Diseases2020，10，2： | 0 |
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