|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Accelerated evolution of an Lhx2 enhancer shapes mammalian social hierarchies显示文摘Social hierarchies emerged during evolution,and social rank influences behavior and health of individuals.However,the evolutionary mechanisms of social hierarchy are still unknown in amniotes.Here we developed a new method and performed a genome-wide screening for identifying regions with accelerated evolution in the ancestral lineage of placental mammals,where mammalian social hierarchies might have initially evolved.Then functional analyses were conducted for the most accelerated region designated as placental-accelerated sequence 1(PAS1,P=3.15 × 10^-18).Multiple pieces of evidence show that PAS1 is an enhancer of the transcription factor gene Lhx2 involved in brain development.PAS1s isolated from various amniotes showed different c/s-regulatory activity in vitro,and affected the expression of Lhx2 differently in the nervous system of mouse embryos.PAS1 knock-out mice lack social stratification.PAS1 knock-in mouse models demonstrate that PAS1s determine the social dominance and subordinate of adult mice,and that social ranks could even be turned over by mutated PAS1.All homozygous mutant mice had normal huddled sleeping behavior,motor coordination and strength.Therefore,PAS1-Lhx2 modulates social hierarchies and is essential for establishing social stratification in amniotes,and positive Darwinian selection on PAS1 plays pivotal roles in the occurrence of mammalian social hierarchies. | Yuting Wang Guangyi Dai Zhili Gu Guopeng Liu Ke Tang Yi-Hsuan Pan Yujie Chen Xin Lin Nan Wu Haoshan Chen Su Feng Shou Qiu Hongduo Sun Qian Li Chuan Xu Yanan Mao Yong Edward Zhang Philipp Khaitovich Yan-Ling Wang Qunxiu Liu Jing-Dong Jackie Han Zhen Shao Gang Wei Chun Xu Naihe Jing Haipeng Li | 2020 | Cell Research2020，30，5： | 4 |
| 2 | Inhibition of CDK9 by voruciclib synergistically enhances cell death induced by the Bcl-2 selective inhibitor venetoclax in preclinical models of acute myeloid leukemia显示文摘Venetoclax,an FDA-approved Bcl-2 selective inhibitor for the treatment of chronic lymphocytic leukemia and acute myeloid leukemia(AML),is tolerated well in elderly patients with AML and has good overall response rates;however,resistance remains a concern.In this study,we show that targeting CDK9 with voruciclib in combination with venetoclax results in synergistic antileukemic activity against AML cell lines and primary patient samples.CDK9 inhibition enhances venetoclax activity through downregulation of Mcl-1 and c-Myc.However,downregulation of Mcl-1 is transient,which necessitates an intermittent treatment schedule to allow for repeated downregulation of Mcl-1.Accordingly,an every other day schedule of the CDK9 inhibitor is effective in vitro and in vivo in enhancing the efficacy of venetoclax.Our preclinical data provide a rationale for an intermittent drug administration schedule for the clinical evaluation of the combination treatment for AML. | Daniel A.Luedtke Yongwei Su Jun Ma Xinyu Li Steven ABuck Holly Edwards Lisa Polin Juiwanna Kushner Sijana HDzinic Kathryn White Hai Lin Jeffrey WTaub Yubin Ge | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 3 |
| 3 | The reference genetic linkage map for the multinational Brassica rapa genome sequencing project显示文摘 | Su Ryun Choi Graham R. Teakle Prikshit Plaha Jeong Hee Kim Charlotte J. Allender Elena Beynon Zhong Yun Piao Pilar Soengas Tae Ho Han Graham J. King Guy C. Barker Paul Hand Derek J. Lydiate Jacqueline Batley David Edwards Dal Hoe Koo Jae Wook Bang Beom-Se | 2007 | Theoretical and Applied Genetics2007，，6： | 2 |
| 4 | A Phase I Study of the Chinese Herbal Medicine PHY906 as a Modulator of Irinotecan-based Chemotherapy in Patients with Advanced Colorectal Cancer显示文摘 | Shivaani Kummar M. Sitki Copur Michal Rose Scott Wadler Joe Stephenson Mark O’Rourke Wayne Brenckman Robert Tilton Shwu-Huey Liu Zaoli Jiang Tahmun Su Yung-chi Cheng Edward Chu | 2011 | Clinical Colorectal Cancer2011，，2： | 1 |
| 5 | Demonstration of an Area - Enclosing Guided - atom Interferometer for Ro- tation Sensing 显示文摘 | Saijun Wu Edward Su Mara Prentiss | 2007 | Physical Review Letters2007，99，17： | 1 |
| 6 | Late gadolinium enhancement: precursor to cardiomyopathy in Duchenne muscular dystrophy?显示文摘 | Michael D. Puchalski Richard V. Williams Bojana Askovich C. Todd Sower Kan H. Hor Jason T. Su Nathan Pack Edward Dibella William M. Gottliebson | 2009 | The International Journal of Cardiovascular Imaging2009，，1： | 1 |
| 7 | A randomized controlled trial of self‐management programme improves health‐related outcomes of older people with heart failure显示文摘 | Jung‐Hua Shao Anne M. Chang Helen Edwards Yea‐Ing Lotus Shyu Su‐Hui Chen | 2013 | J Adv Nurs2013，，11： | 1 |
| 8 | Demonstration of an area-enclosing guided-atom interferometer for rotation sensing显示文摘 | Wu Saijun Su Edward Prentiss Mara | 2007 | Physical Review Letters2007，，99： | 1 |
| 9 | Treatment of Complex Tibial Plateau Fractures using the less invasive stabilization system plate;Clincal Experience and a laboratory comparsion with double plating显示文摘 | Egol Kenneth A MD Su Edward MD Te Jwani | 2004 | The Journal of Trauma2004，57，2： | 1 |
| 10 | Assessing Singapore's Export Competitiveness through Dynamic Shift-Share Analysis显示文摘 | Peter Wilson Ting Su Chern Tu Suh Ping and Edward Robinson | 2005 | ASEAN Economic Bulletin2005，22，2： | 1 |
| 11 | The 2007 water crisis in Wuxi, China: Analysis of the origin显示文摘 | Xiao-jian Zhang Chao Chen Jian-qing Ding Aixin Hou Yong Li Zhang-bin Niu Xiao-yan Su Yan-juan Xu Edward A. Laws | 2010 | Journal of Hazardous Materials2010，，1： | 1 |
| 12 | Induction of endometrial mesenchymal stem ceils into tissue-forming cells suitable for fascial repair显示文摘 | Su Kj Edwards SL Tan KS | 2014 | Acta Biomaterialia2014，10，12： | 1 |
| 13 | Treatment of Complex Tibial Plateau Fractures Using the Less Invasive Stabilization System Plate: Clinical Experience and a Laboratory Comparison with Double Plating显示文摘 | Kenneth A. Egol Edward Su Nirmal C. Tejwani Stephen H. Sims Frederick J. Kummer Kenneth J. Koval | 2004 | The Journal of Trauma: Injury Infection and Critical Care2004，，2： | 1 |
| 14 | Micro/Nanometer‐Scale Fiber with Highly Ordered Structures by Mimicking the Spinning Process of Silkworm显示文摘 | Su‐Kyoung Chae Edward Kang Ali Khademhosseini Sang‐Hoon Lee | 2013 | Adv. Mater2013，，22： | 1 |
| 15 | Fate and transport of elemental copper (Cu 0 ) nanoparticles through saturated porous media in the presence of organic materials显示文摘 | Edward H. Jones Chunming Su | 2012 | Water Research2012，，7： | 1 |
| 16 | The reference genetic linkage map for the multinational Brassica rapa genome sequencing project显示文摘 | Su Ryun Choi Graham R. Teakle Prikshit Plaha Jeong Hee Kim Charlotte J. Allender Elena Beynon Zhong Yun Piao Pilar Soengas Tae Ho Han Graham J. King Guy C. Barker Paul Hand Derek J. Lydiate Jacqueline Batley David Edwards Dal Hoe Koo Jae Wook Bang Beom-Se | 2007 | Theoretical and Applied Genetics2007，，6： | 1 |
| 17 | Human endometrial mesenehymal stem cells modulate the tissue response and mechanical behavior of polyamide mesh implants for pelvic organ prolapse repair显示文摘 | Ulrich D Edwards SL Su K | 2014 | Tissue Eng Part A2014，20，34： | 1 |
| 18 | Bayesian stochastic search for VARmodelrestrictions 显示文摘 | Edward George Dongchu Su~ Shawn Ni | 2008 | JournalofEconometrics2008，，1： | 1 |
| 19 | Assessing Singapore's Export Competitiveness through Dynamic Shift -Share Analysis 显示文摘 | Peter Wilson Ting Su Chern Tu Suh Ping and Edward Robinson | 2005 | ASEAN Economic Bulletin2005，22，2： | 1 |
| 20 | 教学研究:鼓励发现显示文摘什么东西可以让一个学习者转变成发现者,或者让一名教师转变成合作探险者呢?大量的经验——从讲授中学数学课到带大学生进行研究——改变了我回答这些问题的方式.我所学到的一些经验令我惊讶. | Francis Edward Su 袁钧(译) 袁向东(校) | 2011 | 数学译林2011，30，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员