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| 1 | Maintenance infliximab for Crohn’s disease: the ACCENT I randomised trial显示文摘 | Stephen B Hanauer Brian G Feagan Gary R Lichtenstein Lloyd F Mayer S Schreiber Jean Frederic Colombel Daniel Rachmilewitz Douglas C Wolf Allan Olson Weihang Bao Paul Rutgeerts | 2002 | The Lancet2002，，9317： | 6 |
| 2 | Robust Minimum Variance Beamforming显示文摘 | Robert G L Stephen P B | 2005 | IEEE Trans on Signal Processing2005，53，5： | 1 |
| 3 | Chemokine receptors CCR6 and CXCR3 are necessary for CD4 + T cell mediated ocular surface disease in experimen- tal dry eye disease显示文摘 | TERRY G NIRAL B EUGENE A STEPHEN C CINTIA S | 2013 | PLoS One2013，8，78： | 1 |
| 4 | Theory and history of suspension bridge design from 1823 to 1940显示文摘 | STEPHEN G B DAVID P B | 1993 | J Struct Eng1993，119，3： | 1 |
| 5 | Transgenic pigs as bioreactors: a comparison ofgamma-carboxylation of glutamic acid in recombinant humanprotein C and factor Ⅸ by the mammary gland显示文摘 | KEVIN E V C STEPHEN P B CHRISTOPHER G R | 1999 | Genetic Analysis: Biomolecular Engineering1999，15，： | 1 |
| 6 | The effect of temperature varia- tion on spontaneous potential production from explants of brain tissue in culture 显示文摘 | Cunningham A W B Stephens S G | 1962 | Experientia1962，18，1： | 1 |
| 7 | Investigation of benzene oxide in bone marrow and other tissues of F344 rats following metabolism of benzene in vitro and in vivo 显示文摘 | Andrew B L Karen YO C Suramya W Thomas A M Bernard T G Stephen M R | 1998 | Chemical Research in Toxicology1998，11，4： | 1 |
| 8 | Observations on the experimental destruction and substructural organisation of the pollen wall of some selected Gymnosperms and Angiosperms显示文摘 | NINA I G STEPHEN B JOHN R R | 2003 | Review of Palaeobotany and Palynology2003，124，： | 1 |
| 9 | Neuroretinal hypoxic signaling in a new preclinical murine model for proliferative diabetic retinopathy显示文摘Diabetic retinopathy(DR)affects approximately one-third of diabetic patients and,if left untreated,progresses to proliferative DR(PDR)with associated vitreous hemorrhage,retinal detachment,iris neovascularization,glaucoma and irreversible blindness.In vitreous samples of human patients with PDR,we found elevated levels of hypoxia inducible factor 1 alpha(HIF1α).HIFs are transcription factors that promote hypoxia adaptation and have important functional roles in a wide range of ischemic and inflammatory diseases.To recreate the human PDR phenotype for a preclinical animal model,we generated a mouse with neuroretinal-specific loss of the von Hippel Lindau tumor suppressor protein,a protein that targets HIF1αfor ubiquitination.We found that the neuroretinal cells in these mice overexpressed HIF1αand developed severe,irreversible ischemic retinopathy that has features of human PDR.Rapid progression of retinopathy in these mutant mice should facilitate the evaluation of therapeutic agents for ischemic and inflammatory blinding disorders.In addition,this model system can be used to manipulate the modulation of the hypoxia signaling pathways,for the treatment of non-ocular ischemic and inflammatory disorders. | Katherine J Wert Vinit B Mahajan Lijuan Zhang Yuanqing Yan Yao Li Joaquin Tosi Chun Wei Hsu Takayuki Nagasaki Kerstin M Janisch Maria B Grant MaryAnn Mahajan Alexander G Bassuk Stephen H Tsang | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 1 |
| 10 | Decadal climatic variability, trends, and future scenarios for the Noah China Plain 显示文摘 | Fu G B Stephen P C Yu J J | 2009 | Journal of Climate2009，22，： | 1 |
| 11 | Decadal climatic variability,trends, and future scenarios for the North China Plain显示文摘 | Fu G B Stephen P C Yu J J | 2009 | Journal of Climate2009，22，： | 1 |
| 12 | Gene selection for cancer classification using support vector machines显示文摘 | Isabelle G Jason W Stephen B | 2002 | Machine Learning2002，46，1： | 1 |
| 13 | Tacrolimus for the treatment of fistulas in patients with crohn’s disease: a randomized, placebo-controlled trial显示文摘 | William J Sandborn Daniel H Present Kim L Isaacs Douglas C Wolf Eugene Greenberg Stephen B Hanauer Brian G Feagan Lloyd Mayer Therese Johnson Joseph Galanko Christopher Martin Robert S Sandler | 2003 | Gastroenterology2003，，2： | 1 |
| 14 | Drueke parathyroid hormone,Vitamin D and Cardiovascular disease in CRF显示文摘 | Stephen G Rostand Tilman B | 1999 | Kidney Int1999，56，： | 1 |
| 15 | Medication, aller-gy, and adverse drug event discrepancies in ambulatorycare显示文摘 | Stephens M Fox B Kukulka G | 2008 | iraw2008，40，2： | 1 |
| 16 | Coded aperture imaging in X-and gamma-ray astronomy显示文摘 | Caroli E Stephen J B Cocco G D | 1987 | Space Science Reviews1987，45，： | 1 |
| 17 | Self-agglomerating fluidized bed reduction 显示文摘 | Langston B G Stephens F M | 1960 | Journal of Metals1960，12，4： | 1 |
| 18 | New managerial challenges form supply chain opportunities 显示文摘 | Ronald H B Stephen M G Askok M | 2000 | IEEE Engineering Management Review2000，，3： | 1 |
| 19 | Widespread distribution of a tet W determinant among tetracycline-resistant isolates of the animal pathogen arcanobacterium pyogenes显示文摘 | Stephen J B Songer J G Jost B H | 2002 | Antimi- crobial Agents and Chemotherapy2002，46，5： | 1 |
| 20 | Robust minimum variance beamforming显示文摘 | Robert G L Stephen P B | 2005 | IEEE Transactions on Signal Processing2005，53，5： | 1 |
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