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| 1 | A reappraisal of CTLA-4 checkpoint blockade in cancer immunotherapy显示文摘anti-CTLA-4 抗体由阻止 B7-CTLA-4 相互作用接近否定发信号引起肿瘤拒绝,这被假定。在比临床上有效的 dosing 完成的血浆层次更加高的集中,令人惊讶地, anti-CTLA-4 抗体 Ipilimumab 不由 CTLA-4 也不 CTLA-4 绑定堵住任何一 B7 trans-endocytosis 到使不能调动或联系房间的 B7。因而, Ipilimumab 不从人性化的任何一个 CTLA4 基因在树枝状的房间(DC ) 上增加 B7 (Ctla4 h/h ) 或人的 CD34 + 茎重新组成房间的 NSG 老鼠。在 Ctla4 高效地表示人和老鼠 CTLA4 基因,绑在人的 anti-CTLA-4 抗体然而并非老鼠 CTLA-4 的 h/m 老鼠导致 Treg 弄空和 Fc 受体依赖者肿瘤拒绝。堵住的抗体 L3D10 比得上在引起肿瘤拒绝的非阻塞的 Ipilimumab。显著地,输在人类化期间堵住活动的 L3D10 子孙在导致 Treg 弄空和肿瘤拒绝仍然保持充分能干。有效地在淋巴的器官堵住 CD4 T 细胞激活和 de novo CD8 T 细胞 priming 的 Anti-B7 抗体否定地不影响 Ipilimumab 的 immunotherapeutic 效果。因此,临床上有效的 anti-CTLA-4 mAb 由独立于检查点封锁的机制引起肿瘤拒绝但是依赖于主人 Fc 受体。我们为 CTLA-4 检查点的一个重评价的数据电话封锁假设并且为安全、有效的 anti-CTLA-4 mAbs 的下一代提供新卓见。 | Xuexiang Du Fei Tang Mingyue Liu Juanjuan Su Yan Zhang Wei Wu Martin Devenport Christopher A Lazarski Peng Zhang Xu Wang Peiying Ye Changyu Wang Eugene Hwang Tinghui Zhu Ting Xu Pan Zheng Yang Liu | 2018 | Cell Research2018，28，4： | 25 |
| 2 | 堪察加地区现今地壳运动与变形特征研究显示文摘利用俄罗斯堪察加地区1995~2005年的 GPS 观洲数据,研究了该区现今地壳水平运动速度场特征.在球坐标系中解算了各应变率分量,分析了应变率场的空间分布特征.并与地震学和地质学研究结果进行了综合对比分析.结果表明.堪察加半岛北部的微板块边界并不明显.堪察加南部测站运动速度大于中部和北部地区.愈靠近东部板块汇聚区,测站速度越大.从东海岸到西海岸,测站水平速度存在明显的梯度衰减特征,水平运动方向与太平洋板块向西北的俯冲方向基本一致.各应变率分量具有东部海岸大于中部和西海岸、从东至西呈梯度衰减的特点.堪察加大部分地区处于 EW 和 NS 向压缩状念.局部存在拉张.面应变率结果显示绝大部分为压缩区;刚性转动结果表明大部分地区表现为顺时针转动,北部地区和南端顺时针旋转性明显.东部有效应变率明显大于西部地区,东西向梯度衰减关系明显.主压应变率明显大于主张应变率.特别是在东海岸地区.主压应变率方向与中等以上地震的主压应力轴在水平方向的投影方向基本一致.地壳变形场在空间分布上的不一致性主要与太平洋板块在堪察加半岛东南侧的俯冲深度、俯冲方位角、俯冲倾角和俯冲带的耦合强度有关. | 孟国杰 申旭辉 Vladimir Smirnov Eugene A Rogozhin 伍吉仓 | 2009 | 地球物理学报2009，52，3： | 12 |
| 3 | 东北地区现今地壳形变特征研究显示文摘利用东北地区37个GPS测站1997~2005年的观测数据研究了该区现今地壳形变特征。结果显示:东北地区相对欧亚板块的位移速率矢量较小,平均为1.58mm/a,表明该区总体上比较稳定;有5个测站的水平位移速率在95%的置信水平上具有显著性,而其他测站则并不显著;辽西地区的几个测站显示出一致性的东南运动,可能是青藏高原东向运动的远程效应;靠近1999年Mw7.1和2002年Mw7.3深源地震震中的测站速率较小,说明这两次深源地震对地表造成的形变并不明显。黑龙江东北部测站运动可能反映了北美板块向南楔入对欧亚板块的影响。 | 孟国杰 申旭辉 伍吉仓 任金卫 Eugene A Rogozhin | 2007 | 大地测量与地球动力学2007，27，1： | 8 |
| 4 | GPS揭示的贝加尔湖地区现今地壳形变特征显示文摘利用贝加尔湖地区GPS监测网测站坐标,根据边长尽量相等的原则,形成了11个Delaunay三角形,计算了各三角形的形状因子,结果表明有9个三角形的形状因子大于0.1。利用3期GPS观测结果,通过对位移速率和应变分量的分析,初步得到以下基本认识贝加尔湖地区目前整体上处于拉张状态,拉张速度约为4.5±1.2mm/a,拉张方向为NW-SE方向;地壳应变是不均匀的,应变分量存在区域上的差异性。东部和西部主张应变均为NW向,但主压应变方向表现不一致,监测网东西两端的应变大于中部地区,最大应变为5.4×10-8,最小应变为-2.6×10-8。贝加尔湖东南部地壳处于压缩状态,压缩方向为NNW向和NNE向;东西部剪切应变比中部大,东西部剪切应变方向基本一致,表现为近南北向;7个三角形的面应变计算结果显示地壳为膨胀状态,2个三角形显示为压缩状态。大地转动结果表明,东北部表现为顺时针的旋转,而西部地区和中部显示为逆时针的旋转。GPS揭示的应变结果与地质和地震学结果基本一致。 | 孟国杰 申旭辉 伍吉仓 任金卫 Eugene A Rogozhin | 2006 | 大地测量与地球动力学2006，26，1： | 6 |
| 5 | STIRPAT, IPAT and ImPACT: analytic tools for unpacking the driving forces of environmental impacts显示文摘 | Richard York Eugene A Rosa Thomas Dietz | 2003 | Ecological Economics2003，，3： | 5 |
| 6 | Risk for emerging bipolar disorder, variants, and symptoms in children with attention deficit hyperactivity disorder, now grown up显示文摘AIM: To determine the prevalence of bipolar disorder(BD) and sub-threshold symptoms in children with attention deficit hyperactivity disorder(ADHD) through 14 years' follow-up, when participants were between 21-24 years old.METHODS: First, we examined rates of BD type Ⅰ?and Ⅱ diagnoses in youth participating in the NIMH-funded Multimodal Treatment Study of ADHD(MTA). We used the diagnostic interview schedule for children(DISC), administered to both parents(DISC-P) and youth(DISCY). We compared the MTA study subjects with ADHD(n = 579) to a local normative comparison group(LNCG, n = 289) at 4 different assessment points: 6, 8, 12, and 14 years of follow-ups. To evaluate the bipolar variants, we compared total symptom counts(TSC) of DSM manic and hypomanic symptoms that were generated by DISC in ADHD and LNCG subjects. Then we sub-divided the TSC into pathognomonic manic(PM) and non-specific manic(NSM) symptoms. We compared the PM and NSM in ADHD and LNCG at each assessment point and over time. We also evaluated the irritability as category A2 manic symptom in both groups and over time. Finally, we studied the irritability symptom in correlation with PM and NSM in ADHD and LNCG subjects.RESULTS: DISC-generated BD diagnosis did not differ significantly in rates between ADHD(1.89%) and LNCG 1.38%). Interestingly, no participant met BD diagnosis more than once in the 4 assessment points in 14 years. However, on the symptom level, ADHD subjects reported significantly higher mean TSC scores: ADHD 3.0; LNCG 1.7; P < 0.001. ADHD status was associated with higher mean NSM: ADHD 2.0 vs LNCG 1.1; P < 0.0001. Also, ADHD subjects had higher PM symptoms than LNCG, with PM means over all time points of 1.3 ADHD; 0.9 LNCG; P = 0.0001. Examining both NSM and PM, ADHD status associated with greater NSM than PM. However, Over 14 years, the NSM symptoms declined and changed to PM over time(df 3, 2523; F = 20.1; P < 0.0001). Finally, Irritability(BD DSM criterion-A2) rates were significantly higher in ADHD than LNCG(χ2 = 122.2, P < 0.0001), but irritability was associated more strongly with NSM than PM(df 3, 2538; F = 43.2; P < 0.0001).CONCLUSION: Individuals with ADHD do not appear to be at significantly greater risk for developing BD, but do show higher rates of BD symptoms, especially NSM. The greater linkage of irritability to NSM than to PM suggests caution when making BD diagnoses based on irritability alone as one of 2(A-level) symptoms for BD diagnosis, particularly in view of its frequent presentation with other psychopathologies. | Ahmed Z Elmaadawi Peter S Jensen L Eugene Arnold Brooke SG Molina Lily Hechtman Howard B Abikoff Stephen P Hinshaw Jeffrey H Newcorn Laurence Lee Greenhill James M Swanson Cathryn A Galanter | 2015 | World Journal of Psychiatry2015，5，4： | 3 |
| 7 | MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors显示文摘 | Liu Xi Sempere Lorenzo F Ouyang Haoxu Memoli Vincent A Andrew Angeline S Luo Yue Demidenko Eugene Korc Murray Shi Wei Preis Meir Dragnev Konstantin H Li Hua DiRenzo James Bak Mads Freemantle Sarah J Kauppinen Sakari Dmitrovsky Ethan | 2010 | Journal of Clinical Investigation2010，，4： | 3 |
| 8 | Long-term safety of lamivudine treatment in patients with chronic hepatitis B显示文摘 | Anna S.F Lok Ching-Lung Lai Nancy Leung Guang-Bi Yao Zhen-Yu Cui Eugene R Schiff Jules L Dienstag E.Jenny Heathcote Nancy R Little Dorothea A Griffiths Stephen D Gardner Mary Castiglia | 2003 | Gastroenterology2003，，6： | 3 |
| 9 | STIRPAT, IPAT and ImPACT: analytic tools for unpacking the driving forces of environmental impacts显示文摘 | Richard York Eugene A Rosa Thomas Dietz | 2003 | Ecological Economics2003，，3： | 2 |
| 10 | Long-term safety of lamivudine treatment in patients with chronic hepatitis B显示文摘 | Anna S.F Lok Ching-Lung Lai Nancy Leung Guang-Bi Yao Zhen-Yu Cui Eugene R Schiff Jules L Dienstag E.Jenny Heathcote Nancy R Little Dorothea A Griffiths Stephen D Gardner Mary Castiglia | 2003 | Gastroenterology2003，，6： | 2 |
| 11 | Identification of influential spreaders in complex networks显示文摘 | Kitsak Maksim Gallos Lazaros K Havlin Shlomo Liljeros Fredrik Muchnik Lev Stanley H Eugene Makse Hernán A | 2010 | Nature Physics2010，，11： | 2 |
| 12 | Trabecular Bone Score: A Noninvasive Analytical Method Based Upon the DXA Image显示文摘 | Barbara C Silva William D Leslie Heinrich Resch Olivier Lamy Olga Lesnyak Neil Binkley Eugene V McCloskey John A Kanis John P Bilezikian | 2014 | J Bone Miner Res2014，，3： | 2 |
| 13 | Identification of influential spreaders in complex networks显示文摘 | Kitsak Maksim Gallos Lazaros K Havlin Shlomo Liljeros Fredrik Muchnik Lev Stanley H Eugene Makse Hernán A | 2010 | Nature Physics2010，，11： | 2 |
| 14 | Captopril: An update of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in hypertension and congestive heart failure显示文摘 | Brogden Rex N Todd Peter A Sorkin Eugene M | 1988 | Drugs1988，36，5： | 1 |
| 15 | Toxicity of the antiandrogen flutamide in isolated rat hepatocytes 显示文摘 | FAU D EUGENE D BERSON A | 1994 | J Pharmacol Exp Ther1994，269，3： | 1 |
| 16 | Metallic Glasses from ' Alchemy' to Pure Sci- ence: Present and Future of Design, Processing and Appli- cations of Glassy Metals 显示文摘 | EUGEN A | 2012 | Materials and Design2012，35，： | 1 |
| 17 | Vorapaxar for secondary prevention of thrombotic events for patients with previous myocardial infarction: a prespecified subgroup analysis of the TRA 2°P-TIMI 50 trial显示文摘 | Benjamin M Scirica Marc P Bonaca Eugene Braunwald Gaetano M De Ferrari Daniel Isaza Basil S Lewis Felix Mehrhof Piera A Merlini Sabina A Murphy Marc S Sabatine Michal Tendera Frans Van de Werf Robert Wilcox David A Morrow | 2012 | The Lancet . 2012 (9850)2012，，9850： | 1 |
| 18 | Chemokine receptors CCR6 and CXCR3 are necessary for CD4 + T cell mediated ocular surface disease in experimen- tal dry eye disease显示文摘 | TERRY G NIRAL B EUGENE A STEPHEN C CINTIA S | 2013 | PLoS One2013，8，78： | 1 |
| 19 | STIRPAT,IPAT and ImPACT:analytic tool for unpacking the driving forces of environmental impacts显示文摘 | Eugene A Rosa Thomas Dietz | 2003 | Ecological Economics2003，，46： | 1 |
| 20 | Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer显示文摘 | Eugen Ruckh(a)berle Achim Rody | 2008 | Breast Cancer Res Treat2008，112，： | 1 |
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