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| 1 | Prevalence of Helicobacter pylori infection and intestinal metaplasia in subjects who had undergone surgery for gastric adenocarcinoma in Northwest Italy显示文摘AIM: To investigate the seroprevalence of Helicobacter pylori(H pylorri) infection and its more virulent strains as well as the correlation with the histologic features among patients who had undergone surgery for gastric cancer (GC).METHODS: Samples from 317 (184 males, 133females, mean age 69±3.4 years) consecutive patients who had undergone surgery for gastric non-cardia adenocarcinoma were included in the study. Five hundred and fifty-five (294 males, 261 females, mean age 57.3±4.1 years) patients consecutively admitted to the Emergency Care Unit served as control. Histological examination of tumor, lymph nodes and other tissues obtained at the time of surgery represented the diagnostic 'gold standard'. An enzyme immunosorbent assay was used to detect serum anti-H pylori(IgG)antibodies and Western blotting technique was utilized to search for anti-CagA protein (IgG).RESULTS: Two hundred and sixty-one of three hundred and seventeen (82.3%) GC patients and 314/555 (56.5%)controls were seropositive for anti-H pylori (P<0.0001;OR, 3.58; 95%CI, 2.53-5.07). Out of the 317 cases, 267(84.2%) were seropositive for anti-CagA antibody vs 100 out of 555 (18%) controls (P<0.0001; OR, 24.30;95%CI, 16.5-35.9). There was no difference between the frequency of H pyloriin intestinal type carcinoma (76.2%) and diffuse type cancer (78.8%). Intestinal metaplasia (IM) was more frequent but not significant in the intestinal type cancer (83.4% vs 75.2% in diffuse type and 72.5% in mixed type). Among the patients examined for IM, 39.8% had IM type Ⅰ, 8.3% type Ⅱ and 51.9% type Ⅲ (type Ⅲ vs others, P = 0.4).CONCLUSION; This study confirms a high seroprevalence of H pyloriinfection in patients suffering from gastric adenocarcinoma and provides further evidence that searching for CagA status over H pylori infection might confer additional benefit in identifying populations at greater risk for this tumor. | Giorgio Palestro Rinaldo Pellicano Gian Ruggero Fronda Guido Valente Marco De Giuli Tito Soldati Agostino Pugliese Stefano Taraglio Mauro Garino Donata Campra Miguel Angel Cutufia Elena Margaria Giancarlo Spinzi Aldo Ferrara Giorgio Marenco Mario Rizzetto Antonio Ponzetto | 2005 | World Journal of Gastroenterology2005，11，45： | 5 |
| 2 | Constipation in the elderly:management strategies显示文摘 | Spinzi G Amato A Imperiali G | 2009 | Drug Aging2009，26，： | 1 |
| 3 | Computed tomographic colonography and conventional colonoscopy for colon diseases: a prospective, blinded study显示文摘 | Spinzi G Belloni G Martegani A | 2001 | Am J Gastroenterol2001，96，2： | 1 |
| 4 | Hyoscine N-butylbromide for adenoma detection during colonoscopy: A randomized, double-blind, placebo-controlled study显示文摘 | Emanuele Rondonotti Franco Radaelli Silvia Paggi Arnaldo Amato Gianni Imperiali Vittorio Terruzzi G. Mandelli Nicoletta Lenoci Natalia L. Terreni Alessandra Baccarin Giancarlo Spinzi | 2013 | Digestive and Liver Disease2013，，： | 1 |
| 5 | Effectiveness of a continuous quality improvement program on colonoscopy practice显示文摘 | G. Imperiali G. Minoli G. M. Meucci G. Spinzi E. Strocchi V. Terruzzi F. Radaelli | 2007 | Endoscopy2007，，04： | 1 |
| 6 | Helicobacter pylori seroprevalence in hepatitis C virus positive patients with cirrhosis: the Como cross-sectional study显示文摘 | Spinzi G Pellicano R Minoli G | 2001 | Panminerva Med2001，43，2： | 1 |
| 7 | Constipation in the elderly: Man- agement strategies显示文摘 | Spinzi G Amato A Impefiali G | 2009 | Drugs Aging2009，26，6： | 1 |
| 8 | Hyoscine N-butylbromide for adenoma detection during colonoscopy: A randomized, double-blind, placebo-controlled study显示文摘 | Emanuele Rondonotti Franco Radaelli Silvia Paggi Arnaldo Amato Gianni Imperiali Vittorio Terruzzi G. Mandelli Nicoletta Lenoci Natalia L. Terreni Alessandra Baccarin Giancarlo Spinzi | 2013 | Digestive and Liver Disease2013，，： | 1 |
| 9 | Unsedated colonoscopy: an option for some but not for all显示文摘 | Silvia Paggi Franco Radaelli Arnaldo Amato Gianmichele Meucci Giancarlo Spinzi Emanuele Rondonotti Vittorio Terruzzi | 2012 | Gastrointestinal Endoscopy2012，，2： | 1 |
| 10 | Bowel care in the elderly 显示文摘 | Spinzi GC | 2007 | Dig Dis2007，25，2： | 1 |
| 11 | Constipation elderly:Man agement st rategies显示文摘 | Spinzi G Amato A Imperiali G | | Drugs Aging0，20，6： | 1 |
| 12 | Lack of colonic neoplastic lesions in patients under 50 yr of age with hematochezia: a muhicen prospective study 显示文摘 | Spinzi G Fante MD Masci E | 2007 | Am J Gastroenterol2007，102，： | 1 |
| 13 | Re- processing in digestive endoscopy units in Lombardy: results of a regional surve显示文摘 | SPINZI G FASOLI R CENTENARO R | 2008 | Dig Liver Dis2008，40，11： | 1 |
| 14 | Constipation in the elderly: Management strategies 显示文摘 | Spinzi G Amato A Imperiali G | 2009 | Drugs Aging2009，26，6： | 1 |
| 15 | Reprocessing in Diges- tive Endoscopy Units in Lombardy: Results of a Regiona Sur- vey显示文摘 | Spinzi G Fasoli R Centenaro R | 2008 | Dig Liver Dis2008，40，11： | 1 |
| 16 | Constipation in the elderly: management strategies 显示文摘 | Spinzi G Amato A Imperiali G | 2009 | Drugs Aging2009，26，6： | 1 |
| 17 | Diagnosis, treatment and survival of patients with hepatorenal syndrome: A survey on daily medical practice显示文摘 | Francesco Salerno Massimo Cazzaniga Manuela Merli Giancarlo Spinzi Simone Saibeni Andrea Salmi Stefano Fagiuoli Antonio Spadaccini Elisa Trotta Giacomo Laffi Maurizio Koch Oliviero Riggio Sergio Boccia Martina Felder Simona Balzani Savino Bruno Paolo Ange | 2011 | Journal of Hepatology2011，，6： | 1 |
| 18 | Computed tomographic colonography and conventional colonoscopy for colon diseases:a prospective,blinded study显示文摘 | Spinzi G Bellani G Martegani A | 2001 | Am J Gastroenterol2001，96，2： | 1 |
| 19 | Bowel care in the elderly显示文摘 | Spinzi GC | 2007 | Dig Dis2007，25，2： | 1 |
| 20 | Comparison of omeprazole and lansoprazole in short time triple therapy for helicobacter pylori显示文摘 | SPINZI GC BIERTI L BORTOLI A | 1998 | Aliment Pharmacol Ther1998，12，： | 1 |
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