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| 1 | Aspirin, cyclooxygenase inhibition and colorectal cancer显示文摘Colorectal cancer(CRC)is the third most common type of cancer worldwide.Screening measures are far from adequate and not widely available in resourcepoor settings.Primary prevention strategies therefore remain necessary to reduce the risk of developing CRC.Increasing evidence from epidemiological studies,randomized clinical trials and basic science supports the effectiveness of aspirin,as well as other non-steroidal anti-inflammatory drugs,for chemoprevention of several types of cancer,including CRC.This includes the prevention of adenoma recurrence and reduction of CRC incidence and mortality.The detectable benefit of daily low-dose aspirin(at least 75 mg),as used to prevent cardiovascular disease events,strongly suggests that its antiplatelet action is central to explaining its antitumor efficacy.Daily low-dose aspirin achieves complete and persistent inhibition of cyclooxygenase(COX)-1 in platelets(in pre-systemic circulation)while causing alimited and rapidly reversible inhibitory effect on COX-2and/or COX-1 expressed in nucleated cells.Aspirin has a short half-life in human circulation(about 20 minutes);nucleated cells have the ability to resynthesize acetylated COX isozymes within a few hours,while platelets do not.COX-independent mechanisms of aspirin have been suggested to explain its chemopreventive effects but this concept remains to be demonstrated in vivo at clinical doses. | Carlos Sostres Carla Jerusalen Gargallo Angel Lanas | 2014 | World Journal of Gastrointestinal Pharmacology and Therapeutics2014，5，1： | 8 |
| 2 | Interaction between Helicobacter pylori infection, nonsteroidal anti-inflammatory drugs and/or low-dose aspirin use: Old question new insights显示文摘Previous reports clearly demonstrated that Helicobacter pylori(H.pylori)infection,nonsteroidal anti-inflammatory drugs(NSAID)or low dose aspirin(ASA)use significantly and independently increased the risk for the development of peptic ulcer disease.Today,the presence of H.pylori infection associated with low dose ASA and/or NSAID use in the same patient is becoming more frequent and therefore the potential interaction between these factors and the consequences of it has important implications.Whether NSAID intake in the presence of H.pylori infection may further increase the risk of peptic ulcer carried by the presence of only one risk factor is still a matter of debate.Studies on the interaction between the two risk factors yielded conflicting data and no consensus has been reached in the last years.In addition,the interaction between H.pylori infection and low-dose ASA remains even more controversial.In real clinical practice,we can find different clinical scenarios involving these three factors associated with the presence of different gastrointestinal and cardiovascular risk factors.These huge variety of possible combinations greatly hinder the decision making process of physicians. | Carlos Sostres Carla Jerusalen Gargallo Angel Lanas | 2014 | World Journal of Gastroenterology2014，20，28： | 8 |
| 3 | Helicobacter pylori and Nonmalignant Diseases显示文摘 | Wouter J. den Hollander Carlos Sostres Ernst J. Kuipers Angel Lanas | 2013 | Helicobacter2013，，： | 1 |
| 4 | Identification of the novel antimicrobial fatty acid ( 5Z, 9Z ) -14-methyl-5,9-pentadecadienoic acid in Eunicea succinea显示文摘 | Carballeira N M Reyes E D Sostre A | 1997 | J Nat Prod1997，60，： | 1 |
| 5 | Sonographic diagnosis and grading of Hashimoto's thyroiditis显示文摘 | Sostre S Reyes MM | 1991 | J Endocrinol Invest1991，14，2： | 1 |
| 6 | Acute necrotizing pancreatitis and severe hepatic failure:description of three cases显示文摘 | Bernal Monterde V Campillo Arregui A Sostres Homedes C | 2008 | Transplant Proc2008，40，9： | 1 |
| 7 | Intrasphincteric botulinum toxin for the treatment of achalasia 显示文摘 | Pasricha PJ Ravich WJ Hendrix TR Sostre S Jones B Kalloo AN | 1995 | N Engl J Med1995，332，12： | 1 |
| 8 | Sonographic diagnosis and grading of Hashimoto's thyroiditis显示文摘 | Reyes M | 1991 | Jendocrinal Invest1991，14，1： | 1 |
| 9 | Identification of the novel antimicrobial fatty acid (5Z, 9Z)-14-methyl-5, 9- pentadeca-dienoic acid in Eunicea succinea 显示文摘 | Carballeira N M Reyes E D Sostre A | 1997 | J Nat Prod1997，60，： | 1 |
| 10 | Clinical utility of posttreatment radioiodine scans in the management of patients with thyroid carcinoma显示文摘 | Sherman S I Tielens E T Sostre S | 1994 | J Clin Endocrinol Metab1994，78，3： | 1 |
| 11 | A noninvasive test of Sphincter of Oddi dysfunction in postcholecystectomy patients: the scintgraphic score显示文摘 | Sostre S Kalloo AN Spiegler EJ | 1992 | J Nucl Med1992，33，6： | 1 |
| 12 | Global and regional cerebral metabolic rate of 2- fluoro-2-deoxy-D-glucose in the presence of ofloxacin, a gammaaminobutyric acid a receptor antagonist 显示文摘 | Camargo E E Sostre S Sadzot B | 1991 | Antimicrob Agents Chemother1991，35，4： | 1 |
| 13 | Sonographic diagnosis and grading of Hashimoto's thyroiditis显示文摘 | Sostre S Reyes M | 1991 | J Endocrinal Invest1991，14，： | 1 |
| 14 | Epidemiology and Demographics of Upper Gastrointestinal Bleeding: Prevalence, Incidence, and Mortality显示文摘 | Carlos Sostres Angel Lanas | 2011 | Gastrointestinal Endoscopy Clinics of North Americ2011，，4： | 1 |
| 15 | The various scintigraphic patterns of Warthin's tumor显示文摘 | Sostre S Medina L de Arellano GR | 1987 | Clin Nuc Med1987，12，： | 1 |
| 16 | Gastrointestinal effects of aspirin显示文摘 | Sostres C Lanas A | 2011 | Nat Rev Gastroenterol Hepatol2011，8，7： | 1 |
| 17 | Adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs,aspirin and coxibs) on upper gastrointestinal tract显示文摘 | Sostres C Gargallo CJ Arroyo MT | 2010 | Best Pract Res Clin Gastroenterol2010，24，2： | 1 |
| 18 | Global and regional cerebral metabolic rate of 2- fluoro-2-deoxy-D-glueose in the presence of ofloxacin, a gamma-aminobutyric acid a receptor antagonist显示文摘 | Camargo E E Sostre S Sadzot B | 1991 | Antimicrob Agents Chemother1991，35，4： | 1 |
| 19 | Sonographic diagnosis and grading of Hashimoto's thyroidkis 显示文摘 | Sostre S Reyes MM | 1991 | J Endocrinol Invest1991，14，2： | 1 |
| 20 | Ossifying renal cell carcinoma 显示文摘 | Sostre G Johnson Ⅲ JF Cho M | 1998 | Pediatr Radiol1998，28，6： | 1 |
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