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| 1 | Colorectal cancer population screening programs worldwide in 2016: An update显示文摘Colorectal cancer(CRC)is the third most commonly diagnosed cancer in the world.The incidence and mortality show wide geographical variations.Screening is recommended to reduce both incidence and mortality.However,there are significant differences among studies in implementation strategies and detection.This review aimed to present the results and strategies of different screening programs worldwide.We reviewed the literature on national and international screening programs published in Pub Med,on web pages,and in clinical guidelines.CRC Screening programs are currently underway in most European countries,Canada,specific regions in North and South America,Asia,and Oceania.The most extensive screening strategies were based on fecal occult blood testing,and more recently,the fecal immunochemical test(FIT).Participation in screening has varied greatly among different programs.The Netherlands showed the highest participation rate(68.2%)and some areas of Canada showed the lowest(16%).Participation rates were highest among women and in programs that used the FIT test.Men exhibited the greatest number of positive results.The FIT test has been the most widely used screening program worldwide.The advent of this test has increased participation rates and the detection of positive results. | Mercedes Navarro Andrea Nicolas Angel Ferrandez Angel Lanas | 2017 | World Journal of Gastroenterology2017，23，20： | 43 |
| 2 | Role of gastrin-peptides in Barrett's and colorectal carcinogenesis显示文摘Gastrin is the main hormone responsible for the stimulation of gastric acid secretion;in addition,gastrin and its derivatives exert proliferative and antiapoptotic effects on several cell types.Gastrin synthesis and secretion are increased in certain situations,for example,when proton pump inhibitors are used.The impact of sustained hypergastrinemia is currently being investigated.In vitro experiments and animal models have shown that prolonged hypergastrinemia may be related with higher cancer rates;although,this relationship is less clear in human beings.Higher gastrin levels have been shown to cause hyperplasia of several cell types;yet,the risk for developing cancer seems to be the same in normo-and hypergastrinemic patients.Some tumors also produce their own gastrin,which can act in an autocrine manner promoting tumor growth.Certain cancers are extremely dependent on gastrin to proliferate.Initial research focused only on the effects of amidated gastrins,but there has been an interest in intermediates of gastrin in the last few decades.These intermediates aren't biologically inactive;in fact,they may exert greater effects on proliferation and apoptosis than the completely processed forms.In certain gastrin overproduction states,they are the most abundant gastrin peptides secreted.The purpose of this review is to examine the gastrin biosynthesis process and to summarize the results from different studies evaluating the production,levels,and effects of the main forms of gastrin in different overexpression states and their possible relationship with Barrett's and colorectal carcinogenesis. | Eduardo Chueca Angel Lanas Elena Piazuelo | 2012 | World Journal of Gastroenterology2012，18，45： | 19 |
| 3 | Protons pump inhibitor treatment and lower gastrointestinal bleeding: Balancing risks and benefits显示文摘Proton pump inhibitors(PPIs) represent a milestone in the treatment of acid-related diseases, and are the mainstay in preventing upper gastrointestinal bleeding in high-risk patients treated with nonsteroidal antiinflammatory drugs(NSAIDs) or low-dose aspirin. However, this beneficial effect does not extend to the lower gastrointestinal tract. PPIs do not prevent NSAID or aspirin-associated lower gastrointestinal bleeding(LGB). PPIs may increase both small bowel injury related to NSAIDs and low-dose aspirin treatment and the risk of LGB. Recent studies suggested that altering intestinal microbiota by PPIs may be involved in the pathogenesis of NSAID-enteropathy. An increase in LGB hospitalization rates may occur more frequently in older patients with more comorbidities and are associated with high hospital resource utilization, longer hospitalization, and increased mortality. Preventive strategies for NSAID and aspirin-associated gastrointestinal bleeding should be directed toward preventing both upper and lower gastrointestinal damage. Future research should be directed toward identifying patients at low-risk for gastrointestinal events associated with the use of NSAIDs or aspirin to avoid inappropriate PPI prescribing. Alternatively, the efficacy of new pharmacologic strategies should be evaluated in high-risk groups, with the aim of reducing the risk of both upper and lower gastrointestinal bleeding in these patients. | Alberto Lué Angel Lanas | 2016 | World Journal of Gastroenterology2016，22，48： | 9 |
| 4 | Aspirin, cyclooxygenase inhibition and colorectal cancer显示文摘Colorectal cancer(CRC)is the third most common type of cancer worldwide.Screening measures are far from adequate and not widely available in resourcepoor settings.Primary prevention strategies therefore remain necessary to reduce the risk of developing CRC.Increasing evidence from epidemiological studies,randomized clinical trials and basic science supports the effectiveness of aspirin,as well as other non-steroidal anti-inflammatory drugs,for chemoprevention of several types of cancer,including CRC.This includes the prevention of adenoma recurrence and reduction of CRC incidence and mortality.The detectable benefit of daily low-dose aspirin(at least 75 mg),as used to prevent cardiovascular disease events,strongly suggests that its antiplatelet action is central to explaining its antitumor efficacy.Daily low-dose aspirin achieves complete and persistent inhibition of cyclooxygenase(COX)-1 in platelets(in pre-systemic circulation)while causing alimited and rapidly reversible inhibitory effect on COX-2and/or COX-1 expressed in nucleated cells.Aspirin has a short half-life in human circulation(about 20 minutes);nucleated cells have the ability to resynthesize acetylated COX isozymes within a few hours,while platelets do not.COX-independent mechanisms of aspirin have been suggested to explain its chemopreventive effects but this concept remains to be demonstrated in vivo at clinical doses. | Carlos Sostres Carla Jerusalen Gargallo Angel Lanas | 2014 | World Journal of Gastrointestinal Pharmacology and Therapeutics2014，5，1： | 8 |
| 5 | Interaction between Helicobacter pylori infection, nonsteroidal anti-inflammatory drugs and/or low-dose aspirin use: Old question new insights显示文摘Previous reports clearly demonstrated that Helicobacter pylori(H.pylori)infection,nonsteroidal anti-inflammatory drugs(NSAID)or low dose aspirin(ASA)use significantly and independently increased the risk for the development of peptic ulcer disease.Today,the presence of H.pylori infection associated with low dose ASA and/or NSAID use in the same patient is becoming more frequent and therefore the potential interaction between these factors and the consequences of it has important implications.Whether NSAID intake in the presence of H.pylori infection may further increase the risk of peptic ulcer carried by the presence of only one risk factor is still a matter of debate.Studies on the interaction between the two risk factors yielded conflicting data and no consensus has been reached in the last years.In addition,the interaction between H.pylori infection and low-dose ASA remains even more controversial.In real clinical practice,we can find different clinical scenarios involving these three factors associated with the presence of different gastrointestinal and cardiovascular risk factors.These huge variety of possible combinations greatly hinder the decision making process of physicians. | Carlos Sostres Carla Jerusalen Gargallo Angel Lanas | 2014 | World Journal of Gastroenterology2014，20，28： | 8 |
| 6 | Education-based approach to addressing non-evidence-based practice in preventing NSAID-associated gastrointestinal complications显示文摘AIM:To evaluate an evidence-based educational program for improving strategies for prevention of non-steroidal anti-inflammatory drug(NSAID)-associated gastrointestinal(GI)complications. METHODS:Four hundred and fifty-six specialists replied to a questionnaire that covered issues related to NSAID-induced adverse effects.They also collected data from their last five consecutive patients before and after they had attended an evidence-based seminar on GI prevention strategies. RESULTS:Four hundred and forty-one of 456 specialists(96.7%)participated in the survey,and 382(83.7%)in the education-based study that recorded data from 3728 patients.The specialists overestimated the risk of GI complications with NSAIDs,underestimated the GI safety profile of coxibs,but were aware of the risk factors and of the current prevention strategies.Proton pump inhibitors were co-prescribed with NSAIDs in>80% of patients with and without risk factors.The educational program had little impact on prescribing habits.CONCLUSION:Specialists are informed of advances in NSAID-associated adverse effects and have high rates of GI-prevention therapy.Our educational program did not alter these rates. | Angel Lanas Juan V Esplugues Javier Zapardiel Eduardo Sobreviela | 2009 | World Journal of Gastroenterology2009，15，47： | 5 |
| 7 | Superoxide dismutase prevents development of adenocarcinoma in a rat model of Barrett's esophagus显示文摘AIM: To test whether antioxidant treatment could prevent the progression of Barrett's esophagus to adenocarcinoma.METHODS: In a rat model of gastroduodenoesophageal reflux by esophagojejunal anastomosis with gastric preservation, groups of 6-10 rats were randomized to receive treatment with superoxide dismutase (SOD) or vehicle and followed up for 4 mo. Rat's esophagus was assessed by histological analysis, superoxide anion and peroxinitrite generation, SOD levels and DNA oxidative damage.RESULTS: All rats undergoing esophagojejunostomy developed extensive esophageal mucosal ulceration and inflammation by mo 4. The process was associated with a progressive presence of intestinal metaplasia beyondthe anastomotic area (9% 1st mo and 50% 4th mo) (94% at the anastomotic level) and adenocarcinoma(11% 1st mo and 60% 4th mo). These changes were associated with superoxide anion and peroxinitrite mucosal generation, an early and significant increase of DNA oxidative damage and a significant decrease in SOD levels (P<0.05). Exogenous administration of SOD decreased mucosal superoxide levels, increased mucosal SOD levels and reduced the risk of developing intestinal metaplasia beyond the anastomotic area (odds ratio = 0.326; 95%CI: 0.108-0.981; P = 0.046),and esophageal adenocarcinoma (odds ratio = 0.243;95%CI: 0.073-0.804; P = 0.021).CONCLUSION: Superoxide dismutase prevents the progression of esophagitis to Barrett's esophagus and adenocarcinoma in this rat model of gastrointestinal reflux, supporting a role of antioxidants in the chemoprevention of esophageal adenocarcinoma. | Elena Piazuelo Carmelo Cebrián Alfredo Escartín Pilar Jiménez Fernando Soteras Javier Ortego Angel Lanas | 2005 | World Journal of Gastroenterology2005，11，47： | 5 |
| 8 | Esomeprazole for Prevention and Resolution of Upper Gastrointestinal Symptoms in Patients Treated With Low-dose Acetylsalicylic Acid for Cardiovascular Protection: The OBERON Trial显示文摘 | James M. Scheiman Johan Herlitz Sander J. Veldhuyzen van Zanten Angel Lanas Stefan Agewall Emma C. Nauclér Lars-Erik Svedberg Péter Nagy | 2013 | Journal of Cardiovascular Pharmacology2013，，： | 1 |
| 9 | Helicobacter pylori and Nonmalignant Diseases显示文摘 | Wouter J. den Hollander Carlos Sostres Ernst J. Kuipers Angel Lanas | 2013 | Helicobacter2013，，： | 1 |
| 10 | Nonsteroidal Anti-Inflammatory Drugs and Lower Gastrointestinal Complications显示文摘 | Angel Lanas Federico Sopena | 2009 | Gastroenterology Clinics of North America2009，38，2： | 1 |
| 11 | Nonsteroidal anti-inflammatory drugs and cyclooxygenase inhibition in the gastrointestinal tract:a trip from petic ulcer to colon cancer显示文摘 | Lanas Angel M D | 2009 | Am J Med Sci2009，338，2： | 1 |
| 12 | Gastrointestinal bleeding associated with low-dose aspirin use: relevance and management in clinical practice显示文摘 | Angel Lanas | 2011 | Expert Opinion on Drug Safety2011，，1： | 1 |
| 13 | Short-Term Acetylsalicylic Acid(Aspirin) Use for Pain,Fever,or Cold-Gastrointertinal Adverse Effectsa Meta-Analysis of Randomize Clinical Trial显示文摘 | ANGEL LANAS DENIS MCCARTHY MICHEAL VOELKER | 2011 | Orignal Researrch Article2011，11，3： | 1 |
| 14 | A Randomized Trial of Rofecoxib for the Chemoprevention of Colorectal Adenomas显示文摘 | John A. Baron Robert S. Sandler Robert S. Bresalier Hui Quan Robert Riddell Angel Lanas James A. Bolognese Bettina Oxenius Kevin Horgan Susan Loftus Dion G. Morton | 2006 | Gastroenterology2006，，： | 1 |
| 15 | Epidemiology and Demographics of Upper Gastrointestinal Bleeding: Prevalence, Incidence, and Mortality显示文摘 | Carlos Sostres Angel Lanas | 2011 | Gastrointestinal Endoscopy Clinics of North Americ2011，，4： | 1 |
| 16 | Superoxide Anion and Nitric Oxide in High-Grade Esophagitis Induced by Acid and Pepsin in Rabbits显示文摘 | Angel Lanas Fernando Soteras Pilar Jimenez Isabel Fiteni Elena Piazuelo Yolanda Royo Javier Ortego Pedro I?arrea Francisco Esteva | 2001 | Digestive Diseases and Sciences2001，，12： | 1 |
| 17 | Shortterm acetylsalicylic acid (Aspirin)use for pain,fever,or cold-gastrointertinal adverse effectsa meta-Analysis of randomize clinical trial显示文摘 | ANGEL LANAS DENIS MCCARTHY MICHEAL VOELKER | 2011 | Orignal Res earrch Article2011，11，3： | 1 |
| 18 | One year intermittent rifaximin plus fibre supplementation vs. fibre supplementation alone to prevent diverticulitis recurrence: A proof-of-concept study显示文摘 | Angel Lanas Julio Ponce Angelo Bignamini Fermín Mearin | 2012 | Digestive and Liver Disease2012，，： | 1 |
| 19 | Superoxide Anion and Nitric Oxide in High-Grade Esophagitis Induced by Acid and Pepsin in Rabbits显示文摘 | Angel Lanas Fernando Soteras Pilar Jimenez Isabel Fiteni Elena Piazuelo Yolanda Royo Javier Ortego Pedro I?arrea Francisco Esteva | 2001 | Digestive Diseases and Sciences2001，，12： | 1 |
| 20 | Nitric Oxide and Superoxide Anion in Low-Grade Esophagitis Induced by Acid and Pepsin in Rabbits显示文摘 | Fernando Soteras Angel Lanas Isabel Fiteni Yolanda Royo Pilar Jimenez Pedro I?arrea Javier Ortego Francisco Esteva | 2000 | Digestive Diseases and Sciences2000，，9： | 1 |
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