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| 1 | Elevation of the glycated albumin to glycated hemoglobin ratio during the progression of hepatitis C virus related liver fibrosis显示文摘AIM: To analyze the relationship between the glycated albumin (GA) to glycated hemoglobin (HbA1c) ratio and the histological grading of liver fibrosis.METHODS: The study retrospectively included consecutive hepatitis C virus positive chronic liver disease patients (n = 142) who had undergone percutaneous liver biopsy between January 2008 and March 2010 at our institution. The ratios of GA/HbA1c were calculated in all patients to investigate the relationship with the degree of the liver fibrosis. The values of the aspartate aminotransferase-to-platelet ratio index (APRI), an excellent marker for the evaluation of liver fibrosis, were also calculated. In addition, we combined the ratio of GA/HbA1c and the APRI in order to improve our ability to detect the presence of significant liver fibrosis. RESULTS: Sixty-one (43%) patients had either no fibrosis or minimal fibrosis (METAVIR score: F0-F1), while 25 (17%) had intermediate fibrosis (F2). Fifty-six (39%) patients had severe fibrosis (F3-F4) and 27 of them had cirrhosis (F4). The mean values of the GA/HbA1c increased with the progression of the fibrosis (F0-1: 2.83 ± 0.24, F2: 2.85 ± 0.24, F3: 2.92 ± 0.35, F4: 3.14 ± 0.54). There was a significant dif- ference between the F0-F1 vs F4, F2 vs F4, and F3 vs F4 groups (P < 0.01, P < 0.01, P < 0.01 and P < 0.05, respectively). The GA/HbA1c ratio was significantly higher in the patients with cirrhosis (F4) than in those without cirrhosis (F0-F3) (3.14 ± 0.54 vs 2.85 ± 0.28, P < 0.0001). The GA/HbA1c ratio was also significantly higher in the patients with severe fibrosis (F3-F4) than in those without severe liver fibrosis (F0-F2) (3.03 ± 0.41 vs 2.84 ± 0.24, P < 0.001). Furthermore, the GA/ HbA1c ratio was also significantly higher in the patients with significant fibrosis (F2-F4) than in those without significant liver fibrosis (F0-F1) (2.98 ± 0.41 vs 2.83 ± 0.24, P < 0.001). The diagnostic performance of the increased GA/HbA1c ratio (> 3.0) was as follows: its sensitivity and specificity for the detection of liver cirrhosis (F4) were 59.3% and 70.4%, respectively and its sensitivity and specificity for the detection of severe liver fibrosis (F3-F4) were 50.0% and 74.4%,respectively. With regard to the detection of significant fibrosis (F2-F4), its sensitivity was 44.4% and its specificity was 77.0%. Although even the excellent marker APRI shows low sensitivity (25.9%) for distinguishing patients with or without significant fibrosis, the combination of the APRI and GA/HbA1c ratio increased the sensitivity up to 42.0%, with only a modest decrease in the specificity (from 90.2% to 83.6%). CONCLUSION: The GA/HbA1c ratio increased in line with the histological severity of liver fibrosis, thus suggesting that this ratio is useful as a supportive index of liver fibrosis. | Nobuhiro Aizawa Hirayuki Enomoto Hiroyasu Imanishi Masaki Saito Yoshinori Iwata Hironori Tanaka Naoto Ikeda Yoshiyuki Sakai Tomoyuki Takashima Takashi Iwai Ei-ichiro Moriwaki Soji Shimomura Hiroko Iijima Hideji Nakamura Shuhei Nishiguchi | 2012 | World Journal of Hepatology2012，4，1： | 10 |
| 2 | Egress route of emulsified 20 centistokes sili- cone oil from anterior chamber of rabbit 显示文摘 | Ohira A Chihara E Soji T | 1994 | Curt Eye Res1994，13，7： | 1 |
| 3 | Short-term and long-term outcome of endoluminal gastroplication for the treatment of GERD: the first multicenter trial in Japan显示文摘 | Soji Ozawa Koichiro Kumai Kazuhide Higuchi Tetsuo Arakawa Mototsugu Kato Masahiro Asaka Natsuya Katada Hiroyuki Kuwano Masaki Kitajima | 2009 | Journal of Gastroenterology2009，，7： | 1 |
| 4 | Urban Restructing:an Anlysis of Social and Spatial Change in Los Angeles显示文摘 | Edward Soji Rebecca Morales Goetz Wolff | 1983 | Economic Geography1983，59，2： | 1 |
| 5 | Development of a New Aluminium Alloy Beating for Small - sized Diesel Engines 显示文摘 | Toru Desaki Soji Kamiya | 2000 | JSAE Review2000，21，： | 1 |
| 6 | Urban Restructing:an Anlysis of Social and Spatial Change in Los Angeles显示文摘 | Edward Soji Rebecca Morales Goetz Wolff | 1983 | Economic Geography1983，59，2： | 1 |
| 7 | Effects of HC on the formation of gap junctions and the abnormal growth of cilia within the rat anterior pituitary gland显示文摘 | Sakuma E Soji T Herbert D C | 2001 | Anatomical Record2001，262，2： | 1 |
| 8 | Long-Term (>10 Years) Clinical Outcomes of First-in-Human Biodegradable Poly-l-Lactic Acid Coronary Stents: Igaki-Tamai Stents显示文摘 | Soji Nishio Kunihiko Kosuga Keiji Igaki Masaharu Okada Eisho Kyo Takafumi Tsuji Eiji Takeuchi Yasutaka Inuzuka Shinsaku Takeda Tatsuhiko Hata Yuzo Takeuchi Yoshitaka Kawada Takeshi Harita Junya Seki Shunji Akamatsu Shinichi Hasegawa Nico Bruining Salvator | 2012 | Circulation2012，，19： | 1 |
| 9 | Mechanical properties of polypropylene filled with calcium carbonate显示文摘 | Kazuta Mitsuishi Soji Kouama Hitoshi Kawasaki | 1985 | Polymer Engineering and Science1985，25，17： | 1 |
| 10 | Improvement in the Results of Surgical Treatment of Advanced Squamous Esophageal Carcinoma During 15 Consecutive Years显示文摘 | Nobutoshi Ando Soji Ozawa Yuko Kitagawa Yotaro Shinozawa Masaki Kitajima | 2000 | Annals of Surgery2000，，2： | 1 |
| 11 | Clinicopathological,immunohistochemical factors and recurrence associated with extrathyroidal extension in papillary thyroid microcarcinoma显示文摘 | Kim WY Kim HY Soji GS | 2014 | J Cancer Res Ther2014，10，1： | 1 |
| 12 | Anti-High-Mobility Group Box Chromosomal Protein 1 Antibodies Improve Survival of Rats with Sepsis显示文摘 | Koichi Suda Yuko Kitagawa Soji Ozawa Yoshiro Saikawa Masakazu Ueda Masahito Ebina Shingo Yamada Satoru Hashimoto Shinji Fukata Edward Abraham Ikuro Maruyama Masaki Kitajima Akitoshi Ishizaka | 2006 | World Journal of Surgery2006，，9： | 1 |
| 13 | Serum 1,5-anhydroglucitol is low in gastrectomized men显示文摘 | Jun Murai Masafumi Koga Hiroshi Saito Mikio Mukai Soji Kasayama | | Acta Diabetologica0，，2： | 1 |
| 14 | Vascular Endothelial Growth Factor Expression Predicts Outcome and Lymph Node Metastasis in Squamous Cell Carcinoma of the Esophagus 显示文摘 | Chih-Horng Shih Soji Ozawa Nobutoshi Ando | 2000 | Clinical Cancer Research2000，6，： | 1 |
| 15 | Habitual intake of dairy products influences serum 1,5-anhydroglucitol levels independently of plasma glucose显示文摘 | Masafumi Koga Jun Murai Hiroshi Saito Mikio Mukai Soji Kasayama | 2010 | Diabetes Research and Clinical Practice2010，，1： | 1 |
| 16 | Free radical-induced megamitochondria formation and apoptosis显示文摘 | Karbowski M Kurono C Wozniak M Ostrowski M Teranishi M Nishizawa Y Usukura J Soji T Wakabayashi T | 1999 | Free Radic Biol Med1999，26，34： | 1 |
| 17 | Participation of endodermal epithelial cells on the synthesis of plasma LDL and HDL in the chick yolk sac显示文摘 | Kanai M Soji T Sugawara E | 1996 | Microscopy Research and Technology1996，35，4： | 1 |
| 18 | Body mass index negatively regulates glycated albumin through insulin secretion in patients with type 2 diabetes mellitus 显示文摘 | MASAFUMI KOGA TAKUMI HIRATA SOJI KASAYAMA | 2014 | Clinica Chimica Acta2014，438，1： | 1 |
| 19 | The Transition of Plain Bearing Materials显示文摘 | Hiroshi Ito Soji Kamiya Yoshio Kumada | 2003 | Journal of Japanese Society of Tribologists2003，48，3： | 1 |
| 20 | Effects of high light and low temperature during harsh winter on needle photodamage of Abies mariesii growing at the forest limit on Mt. Norikura in Central Japan显示文摘 | Jun-ya Yamazaki Aiko Ohashi Yuko Hashimoto Eriko Negishi Soji Kumagai Takaya Kubo Takehisa Oikawa Emiko Maruta Yasumaro Kamimura | 2003 | Plant Science2003，，1： | 1 |
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