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| 1 | Risk factors for bleeding after endoscopic submucosal dissection of colorectal neoplasms显示文摘AIM:To investigate the risk factors for delayed bleeding following endoscopic submucosal dissection(ESD)treatment for colorectal neoplasms.METHODS:We retrospectively reviewed the medical records of 317 consecutive patients with 325 lesions who underwent ESD for superficial colorectal neoplasms at our hospital from January 2009 to June2013.Delayed post-ESD bleeding was defined as bleeding that resulted in overt hematochezia 6 h to 30d after ESD and the observation of bleeding spots as confirmed by repeat colonoscopy or a required blood transfusion.We analyzed the relationship between risk factors for delayed bleeding following ESD and the following factors using univariate and multivariate analyses:age,gender,presence of comorbidities,use of antithrombotic drugs,use of intravenous heparin,resected specimen size,lesion size,lesion location,lesion morphology,lesion histology,the device used,procedure time,and the presence of significant bleeding during ESD.RESULTS:Delayed post-ESD bleeding was found in14 lesions from 14 patients(4.3%of all specimens,4.4%patients).Patients with episodes of delayed postESD bleeding had a mean hemoglobin decrease of2.35 g/dL.All episodes were treated successfully using endoscopic hemostatic clips.Emergency surgery was not required in any of the cases.Blood transfusion was needed in 1 patient(0.3%).Univariate analysis revealed that lesions located in the cecum(P=0.012)and the presence of significant bleeding during ESD(P=0.024)were significantly associated with delayed post-ESD bleeding.The risk of delayed bleeding was higher for larger lesion sizes,but this trend was not statistically significant.Multivariate analysis revealed that lesions located in the cecum(OR=7.26,95%CI:1.99-26.55,P=0.003)and the presence of significant bleeding during ESD(OR=16.41,95%CI:2.60-103.68,P=0.003)were independent risk factors for delayed post-ESD bleeding.CONCLUSION:Location in the cecum and significant bleeding during ESD predispose patients to delayed post-procedural bleeding.Therefore,careful and additional management is recommended for these patients. | Sho Suzuki Akiko Chino Teruhito Kishihara Naoyuki Uragami Yoshiro Tamegai Takanori Suganuma Junko Fujisaki Masaaki Matsuura Takao Itoi Takuji Gotoda Masahiro Igarashi Fuminori Moriyasu | 2014 | World Journal of Gastroenterology2014，20，7： | 21 |
| 2 | Chromoendoscopy of gastric adenoma using an acetic acid indigocarmine mixture显示文摘AIM:To investigate the usefulness of chromoendoscopy,using an acetic acid indigocarmine mixture(AIM),for gastric adenoma diagnosed by forceps biopsy.METHODS:A total of 54 lesions in 45 patients diagnosed as gastric adenoma by forceps biopsy were prospectively enrolled in this study and treated by endoscopic submucosal dissection(ESD)between January 2011 and January 2012.AIM-chromoendoscopy(AIMCE)was performed followed by ESD.AIM solution was sprinkled and images were recorded every 30 s for 3min.Clinical characteristics such as tumor size(<2cm,≥2 cm),surface color in white light endoscopy(WLE)(whitish,normochromic or reddish),macroscopic appearance(flat or elevated,depressed),and reddish change in AIM-CE were selected as valuables.RESULTS:En bloc resection was achieved in all 54 cases,with curative resection of fifty two lesions(96.3%).Twenty three lesions(42.6%)were diagnosed as welldifferentiated adenocarcinoma and the remaining 31lesions(57.4%)were gastric adenoma.All adenocarcinoma lesions were well-differentiated tubular adenocarcinomas and were restricted within the mucosal layer.The sensitivity of reddish color change in AIM-CE is significantly higher than that in WLE(vs tumor size≥2 cm,P=0.016,vs normochromic or reddish surface color,P=0.046,vs depressed macroscopic type,P=0.0030).On the other hand,no significant differences were found in the specificity and accuracy.In univariate analysis,normochromic or reddish surface color in WLE(OR=3.7,95%CI:1.2-12,P=0.022)and reddish change in AIM-CE(OR=14,95%CI:3.8-70,P<0.001)were significantly related to diagnosis of early gastric cancer(EGC).In multivariate analysis,only reddish change in AIM-CE(OR=11,95%CI:2.3-66,P=0.0022)was a significant factor associated with diagnosis of EGC.CONCLUSION:AIM-CE may have potential for screening EGC in patients initially diagnosed as gastric adenoma by forceps biopsy. | Yoshiyasu Kono Ryuta Takenaka Yoshiro Kawahara Hiroyuki Okada Keisuke Hori Seiji Kawano Yasushi Yamasaki Koji Takemoto Takayoshi Miyake Shigeatsu Fujiki Kazuhide Yamamoto | 2014 | World Journal of Gastroenterology2014，20，17： | 12 |
| 3 | Endoscopic features and prognoses of mantle cell lymphoma with gastrointestinal involvement显示文摘AIM: To evaluate the endoscopic manifestations and prognoses of gastrointestinal (GI) mantle cell lymphoma (MCL). METHODS: A database search at the Department of Pathology of Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences revealed 57 MCL patients with GI involvement. Clinical records were available for 35 of the 57 patients from 21 institutions, and those 35 patients were enrolled in this study. We summarized the gross types of endoscopic features, event-free survival (EFS), and overall survival (OS) of those patients.RESULTS: Of the 35 patients, GI involvement in the esophagus, stomach, and duodenum was found in 2 (5.7%), 26 (74.3%), and 12 (34.3%) patients, respectively. Twenty-one of the 35 patients underwent colonoscopy; among them, GI involvement in the ileum, cecum, colon, and rectum was found in 10 (47.6%), 3 (14.3%), 12 (57.1%), and 10 (47.6%), respectively. Various lesions, such as superficial, protruded, fold thickening, or ulcerative, were found in the stomach, whereas multiple lymphomatous polyposis (MLP) was dominant from the duodenum to the rectum. Twelve patients were treated with a hyper-CVAD/MA regimen, and they had better OS (3-year rate, 88.3% vs 46.4%, P < 0.01) and better EFS (3-year rate, 66.7% vs 33.8%, P < 0.05) than the remaining 23 patients who were not treated with this regimen. CONCLUSION: MLP was a representative form of intestinal involvement, whereas a variety of lesions were found in the stomach. The hyper-CVAD/MA regimen may improve survival in these patients. | Masaya Iwamuro Hiroyuki Okada Yoshiro Kawahara Katsuji Shinagawa Toshiaki Morito Tadashi Yoshino Kazuhide Yamamoto | 2010 | World Journal of Gastroenterology2010，16，37： | 9 |
| 4 | Tolerability of magnifying narrow band imaging endoscopy for esophageal cancer screening显示文摘AIM:To compare the tolerability of magnifying narrow band imaging endoscopy for esophageal cancer screening with that of lugol chromoendoscopy.METHODS:We prospectively enrolled and analyzed 51 patients who were at high risk for esophageal cancer.All patients were divided into two groups:a magnifying narrow band imaging group,and a lugol chromoendoscopy group,for comparison of adverse symptoms.Esophageal cancer screening was performed on withdrawal of the endoscope.The primary endpoint was a score on a visual analogue scale for heartburn after the examination.The secondary endpoints were scale scores for retrosternal pain and dyspnea after the examinations,change in vital signs,total procedure time,and esophageal observation time.RESULTS:The scores for heartburn and retrosternal pain in the magnifying narrow band imaging group were significantly better than those in the lugol chromoendoscopy group(P =0.004,0.024,respectively,ANOVA for repeated measures).The increase in heart rate after the procedure was significantly greater in the lugol chromoendoscopy group.There was no significant difference between the two groups with respect to othervital sign.The total procedure time and esophageal observation time in the magnifying narrow band imaging group were significantly shorter than those in the lugol chromoendoscopy group(450 ± 116 vs 565 ± 174,P =0.004,44 ± 26 vs 151 ± 72,P < 0.001,respectively).CONCLUSION:Magnifying narrow band imaging endoscopy reduced the adverse symptoms compared with lugol chromoendoscopy.Narrow band imaging endoscopy is useful and suitable for esophageal cancer screening periodically. | Yasushi Yamasaki Ryuta Takenaka Keisuke Hori Koji Takemoto Seiji Kawano Yoshiro Kawahara Hiroyuki Okada Shigeatsu Fujiki Kazuhide Yamamoto | 2015 | World Journal of Gastroenterology2015，21，9： | 5 |
| 5 | Magnifying Narrowband Imaging Is More Accurate Than Conventional White-Light Imaging in Diagnosis of Gastric Mucosal Cancer显示文摘 | Yasumasa Ezoe Manabu Muto Noriya Uedo Hisashi Doyama Kenshi Yao Ichiro Oda Kazuhiro Kaneko Yoshiro Kawahara Chizu Yokoi Yasushi Sugiura Hideki Ishikawa Yoji Takeuchi Yoshibumi Kaneko Yutaka Saito | 2011 | Gastroenterology2011，，6： | 4 |
| 6 | Percoll fractionation of adult mouse spermatogonia improvesgerm cell transplantation显示文摘Aim: To isolate and transplant germ cells from adult mouse testes for transplantation. Methods: In order to distinguish transplanted cells from endogenous cells of recipients, donor transgenic mice expressing green fluorescent protein (GFP) were used. Germ cells were collected from the donors at 10-12 weeks of age and spermatogonia were concentrated by percoll fractionation and transplanted into recipient seminiferous tubules that had been previously treated with busulfan at 5 weeks of age to remove the endogenous spermatogenic cells. Results: Twenty weeks after the transplantation, a wide spread GFP signal was observed in the recipient seminiferous tubules. The presence of spermatogenesis and spermatozoa was confirmed in sections of 12 out of 14 testes transplanted (86%).However, when germ cells were transplanted without concentration the success rate was zero (0/9). Conclusion:Germ cells from adult mouse testes can be successfully transplanted into recipient seminiferous tubules if the cell population is rich in spermatogonia and the percoll fractionation is useful in obtaining such a cell population. | Kyu-Bom Koh Masatoshi Komiyama Yoshiro Toyama Tetsuya Adachi Chisato Mori | 2004 | Asian Journal of Andrology2004，6，2： | 3 |
| 7 | 三氧化二砷对慢性粒细胞白血病细胞系的作用(英文)显示文摘本研究探讨三氧化二砷 (As2 O3)对两种慢性粒细胞白血病 (CML)细胞系有无作用及作用机制。实验选用了两种不同的CML细胞系KU81 2和MEG 0 1及两种其它白血病细胞系U937和PL2 1 ,加入不同浓度的As2 O3(0 .2 ,2和 1 0 μmol/L) ,在不同时间计数活细胞数 ,观察细胞形态 ,并以TUNEL法和DNA凝胶电泳检测细胞有无凋亡的发生 ;同时检测 0 .2 μmol/LAs2 O3作用时细胞表面CD34 ,CD1 3 ,CD33 ,CD1 9,CD1 1b ,CD1 4和CD7的变化 ,并通过RT PCR检测细胞bcr abl水平及caspase 3的变化。研究结果发现 ,不同浓度的As2 O3对 4种细胞系的作用不同 ,1 0 μmol/L时 4种细胞系均会发生细胞凋亡 ,2 μmol/L时则仅CML细胞系KU81 2和MEG 0 1会产生凋亡 ,0 .2μmol/L时 4种细胞系均不发生凋亡。在培养 2 4小时后 ,4种细胞系表面的CD34 ,CD1 3 ,CD33 ,CD1 9,CD1 1b ,CD1 4和CD7等均无明显改变。RT PCR检测bcr abl的水平发现在 2种CML细胞系中无明显改变 ,其caspase 3的活性较对照细胞均有所增加。结论 :As2 O3在较高浓度下可诱导 4种白血病细胞系产生凋亡 ,在 2 μmol/L仅可诱导CML来源的两种细胞系产生凋亡 ,CML细胞系对As2 O3较其它两种细胞系敏感 ,其作用机制与caspase | 景红梅 Shimizu Yukihiro 克晓燕 Kashii Yoshiro Watanabe Akiharu | 2002 | 中国实验血液学杂志2002，10，5： | 3 |
| 8 | Significance of K-ras mutation and CEA level in pancreatic juice in the diagnosis of pancreatic cancer显示文摘 | Noriaki Futakawa Wataru Kimura Seiichi Yamagata Bin Zhao Han Ilsoo Tomomi Inoue Naohiro Sata Yoneei Kawaguchi Yoshiro Kubota Tetsuichiro Muto | 2000 | Journal of Hepato - Biliary - Pancreatic Surgery2000，，1： | 2 |
| 9 | Minimally invasive surgery for gastric cancer — toward a confluence of two major streams: a review显示文摘 | Yuko Kitagawa Seigo Kitano Tetsuro Kubota Koichiro Kumai Yoshihide Otani Yoshiro Saikawa Masashi Yoshida Masaki Kitajima | 2005 | Gastric Cancer2005，，2： | 2 |
| 10 | Risk Factors for Metachronous Gastric Cancer in the Remnant Stomach After Early Cancer Surgery显示文摘 | Isao Nozaki Junichirou Nasu Yoshiro Kubo Minoru Tanada Rieko Nishimura Akira Kurita | 2010 | World Journal of Surgery2010，，7： | 2 |
| 11 | Carcinoma of the gallbladder and anomalous arrangement of the pancreaticobiliary ductal system: Cell kinetic studies of gallbladder epithelial cells显示文摘 | Yang Yang Hideki Fujii Yoshiro Matsumoto Koichi Suzuki Akira Kawaoi Koichi Suda | 1997 | Journal of Gastroenterology1997，，6： | 2 |
| 12 | Endoscopic resection of large colorectal polyps using a clipping method显示文摘 | Dr. Yoshiro Iida M.D. Shoji Miura M.D. Yoshinori Munemoto M.D. Yoshio Kasahara M.D. Yasuyuki Asada M.D. Daishu Toya M.D. Masakiyo Fujisawa M.D | 1994 | Diseases of the Colon & Rectum1994，，2： | 2 |
| 13 | A Novel Approach to the Prevention of Postoperative Delirium in the Elderly After Gastrointestinal Surgery显示文摘 | Ken-ichiro Aizawa Toshio Kanai Yoshiro Saikawa Tsukasa Takabayashi Yukio Kawano Naoto Miyazawa Tetsuya Yamamoto | 2002 | Surgery Today2002，，4： | 2 |
| 14 | The prognostic significance of lymph node metastasis and intrapancreatic perineural invasion in pancreatic cancer after curative resection显示文摘 | Hideo Ozaki Takehisa Hiraoka Ryuji Mizumoto Seiki Matsuno Yoshiro Matsumoto Toshimichi Nakayama Tsukasa Tsunoda Takashi Suzuki Morito Monden Yoichi Saitoh Hidemi Yamauchi Yoshiro Ogata | 1999 | Surgery Today1999，，1： | 2 |
| 15 | Aggressive surgery for pancreatic duct cell cancer: Feasibility, validity, limitations显示文摘 | Shin Takahashi M.D. Yoshiro Ogata M.D. Hiroshi Miyazaki M.D. Dai Maeda M.D. Shinji Murai M.D. Koichi Yamataka M.D. Toshiharu Tsuzuki M.D | 1995 | World Journal of Surgery1995，，4： | 2 |
| 16 | Synchronous rectal and esophageal cancer treated with chemotherapy followed by two-stage resection显示文摘We report a case of 61-year-old male who had synchronous advanced rectal cancer involving the urinary bladder massively associated with multiple liver metastases, and esophageal cancer successfully treated by neoadjuvant chemotherapy followed by two-stage resection. Although complete resection of each of the lesions was considered possible by performing anterior pelvic exenteration, liver resection, and esophagectomy, it might be impossible for the patient to endure the stress of all of these operative procedures at once. Therefore, we planned to perform staged treatment with prioritizing consideration. First, we instituted chemotherapy with the FOLFOX(oxaliplatin + fluorouracil + leucovorin) plus cetuximab regimen, which could adequately control both rectal and esophageal cancer. After 6 cycles of chemotherapy, high anterior resection combined with cystoprostatectomy and lateral segmentectomy plus partial hepatectomy was performed followed by staged esophagectomy with three-field lymph node dissection. It was possible to use oxaliplatin and cetuximab safely as neoadjuvant therapy not only for advanced rectal cancer but for esophageal cancer, and it was effective. | Setsuo Utsunomiya Keisuke Uehara Takuya Kurimoto Ken Hirose Masahide Fukaya Yu Takahashi Yoshiro Taguchi Keita Itatsu Masato Nagino | 2013 | World Journal of Clinical Cases2013，1，2： | 2 |
| 17 | Advantages of totally laparoscopic distal gastrectomy over laparoscopically assisted distal gastrectomy for gastric cancer显示文摘 | Osamu Ikeda Yoshihisa Sakaguchi Yoshiro Aoki Norifumi Harimoto Jyunya Taomoto Takaaki Masuda Takefumi Ohga Eisuke Adachi Yasushi Toh Takeshi Okamura Hideo Baba | 2009 | Surgical Endoscopy2009，，10： | 2 |
| 18 | Endoscopic submucosal dissection for cancers of the remnant stomach after distal gastrectomy显示文摘 | Ryuta Takenaka Yoshiro Kawahara Hiroyuki Okada Takao Tsuzuki Satoru Yagi Jun Kato Nobuya Ohara Tadashi Yoshino Atsushi Imagawa Shigeatsu Fujiki Rie Takata Masahiro Nakagawa Motowo Mizuno Tomoki Inaba Tatsuya Toyokawa Kohsaku Sakaguchi | 2008 | Gastrointestinal Endoscopy2008，，2： | 2 |
| 19 | Diagnosis and Treatment of a Gastric Hamartomatous Inverted Polyp: Report of a Case显示文摘 | Masahiko Aoki Masashi Yoshida Yoshiro Saikawa Yoshihide Otani Tetsuro Kubota Koichiro Kumai Go Wakabayashi Tai Omori Makio Mukai Masaki Kitajima | 2004 | Surgery Today2004，，6： | 2 |
| 20 | An encoder-less ultrasonic stepping motor using openloop control system显示文摘 | Chiharu Kusakabe Yoshiro Tomikawa Takehiro Takano | 1992 | Japanese Journal of Applied Physics1992，31，1： | 1 |
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