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| 1 | Laparoscopic vs open approach to resection of hepatocellular carcinoma in patients with known cirrhosis:Systematic review and meta-analysis显示文摘AIM: To review the currently available literature comparing laparoscopic to open resection of hepatocellular carcinoma(HCC) in patients with known liver cirrhosis.METHODS: A literature search of MEDLINE, EMBASE, and Cochrane databases was conducted. The search terms used included(laparoscopic OR laparoscopy) AND(hepatic or liver) AND(surgery or resection) AND 'hepatocellular carcinoma' AND(cirrhosis or cirrhotic). Furthermore, to widen the search, we also used the 'related articles' section. Studies reporting a comparison of outcomes and methods of open vs laparoscopic hepatic resection for HCC in patients with liver cirrhosis were included. Meta-analysis of results was performed using a random effects model to compute relative risk(RR) and for dichotomous variablesand standard mean differences(SMD) for continuous variables.RESULTS: A total of 420 patients from 4 cohort studies were included in final analysis. Patients undergoing laparoscopic procedures had statistically less blood loss compared to the open cohort, SMD of-1.01(95%CI:-1.23-0.79), P < 0.001, with a reduced risk of transfusion, RR = 0.19(95%CI: 0.09-0.38), P < 0.001. A wider clearance at tumour resection margins was achieved following a laparoscopic approach, SMD of 0.34(95%CI: 0.08-0.60), P = 0.011. No significant difference was noted between laparoscopic and open resection operative times, SMD of-0.15(95%CI: 0.35-0.05), P = 0.142. The overall RR of suffering from postoperative morbidity is 0.25 in favour of the open surgery cohort(95%CI: 0.17-0.37), P < 0.001. Patients under-going laparoscopic surgery had significantly shorter length of stays in hospital compared to the open cohort, SMD of-0.53(95%CI:-0.73 to-0.32), P < 0.001.CONCLUSION: This review suggests that laparoscopic resection of hepatocellular carcinoma in patients with cirrhosis is safe and may provide improved patient outcomes when compared to the open technique. | Ahmed Twaij Philip H Pucher Mikael H Sodergren Tamara Gall Ara Darzi Long R Jiao | 2014 | World Journal of Gastroenterology2014，20，25： | 16 |
| 2 | No difference in mortality among ALPPS,two-staged hepatectomy,and portal vein embolization/ligation:A systematic review by updated traditional and network meta-analyses显示文摘Background:There is an ongoing debate on the feasibility,safety,and oncological efficacy of the associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)technique.The aim of this study was to compare ALPPS,two-staged hepatectomy(TSH),and portal vein embolization(PVE)/ligation(PVL)using updated traditional meta-analysis and network meta-analysis(NMA).Data sources:Electronic databases were used in a systematic literature search.Updated traditional metaanalysis and NMA were performed and compared.Mortality and major morbidity were selected as primary outcomes.Results:Nineteen studies including 1200 patients were selected from the pool of 436 studies.Of these patients,315(31%)and 702(69%)underwent ALPPS and portal vein occlusion(PVO),respectively.Ninetyday mortality based on updated traditional meta-analysis,subgroup analysis of the randomized controlled trials(RCTs),and both Bayesian and frequentist NMA did not demonstrate significant differences between the ALPPS cohort and the PVE,PVL,and TSH cohorts.Moreover,analysis of RCTs did not demonstrate significant differences of major morbidity between the ALPPS and PVO cohorts.The ALPPS cohort demonstrated significantly more favorable outcomes in hypertrophy parameters,time to operation,definitive hepatectomy,and R0 margins rates compared with the PVO cohort.In contrast,1-year disease-free survival was significantly higher in the PVO cohort compared to the ALPPS cohort.Conclusions:This study is the first to use updated traditional meta-analysis and both Bayesian and frequentist NMA and demonstrated no significant differences in 90-day mortality between the ALPPS and other hepatic hypertrophy approaches.Furthermore,two high quality RCTs including 147 patients demonstrated no significant differences in major morbidity between the ALPPS and PVO cohorts. | Paschalis Gavriilidis Robert P Sutcliffe Keith J Roberts Madhava Pai Duncan Spalding Nagy Habib Long R Jiao Mikael H Sodergren | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，5： | 6 |
| 3 | Radiofrequency combined with immunomodulation for hepatocellular carcinoma: State of the art and innovations显示文摘Hepatocellular carcinoma(HCC)is the most common primary liver tumor and has been considered a very immunogenic tumor.The treatment with radiofrequency ablation(RFA)has been established as the standard ablative therapy for early HCC,and is currently recognized as the main ablative tool for HCC tumors<5 cm in size;however,progression and local recurrence remain the main disadvantages of this approach.To solve this clinical problem,recent efforts were concentrated on multimodal treatment,combining different strategies,including the combination of RFA and immunotherapy.This article reviewed the combination treatment of RFA with immunotherapy and found that this treatment strategy leads to an increased response of anti-tumor T cells,significantly reduces the risk of recurrence and improves survival rates compared to RFA alone.This review highlighted scientific evidence that supports the current recommendations for pre-clinical studies,and discuss the need for further research on this topic. | Adriano Carneiro da Costa Mikael Sodergren Kumar Jayant Fernando Santa Cruz Duncan Spalding Madhava Pai Nagy Habib | 2020 | World Journal of Gastroenterology2020，26，17： | 5 |
| 4 | Natural orifice translumenal endoscopic surgery: critical appraisal of applications in clinical practice显示文摘 | Mikael H. Sodergren James Clark Thanos Athanasiou Julian Teare Guang-Zhong Yang Ara Darzi | 2009 | Surgical Endoscopy2009，，4： | 4 |
| 5 | 显示文摘 | Sodergren S Hagfeldt A Olsson J | 1994 | Journal of Physical Chemistry1994，98，21： | 1 |
| 6 | Radio-frequeneyassisted Liver Partition with Portal vein ligation (t/ALPP) for liver regeneration显示文摘 | Gall TM Sodergren MH Frampton AF | 2015 | Ann Surg2015，261，2： | 1 |
| 7 | Genetic basis for in vivo daptomycin resistance in enterococci显示文摘 | Arias CA Panesso D McGrath DM Qin X Mojica MF Miller C Diaz L Tran TT Rincon S Barbu EM Reyes J Roh JH Lobos E Sodergren E Pasqualini R Arap W Quinn JP Shamoo Y Murray BE Weinstock GM | | 0，，： | 1 |
| 8 | Radiofrequencyassisted liver partition and portal vein ligation (RALPP) : eompalative series of a modified ALPPS technique tot two-stage liver reseetion 显示文摘 | Sodergren MH Call TM Nagendran M | 2015 | HPB2015，17，1： | 1 |
| 9 | Single-incision Laparoscopic Surgery (SILS) in General Surgery: A Review of Current Practice显示文摘 | Farid Froghi Mikael Hans Sodergren Ara Darzi Paraskevas Paraskeva | 2010 | Surgical Laparoscopy, Endoscopy & Percutaneous Techniques2010，，： | 1 |
| 10 | Single-incision Laparoscopic Surgery(SILS)in general surgery:a review of current practice 显示文摘 | Froghi F Sodergren M H Darzi A | 2010 | Surg Laparosc Endosc Percutan Tech2010，20，4： | 1 |
| 11 | Use of Semi-permeable Membrane Devices to Monitor Pollutants in Water and Assess Their Effects:A Laboratory Test and Field Verification显示文摘 | Sodergren A Sabaliūnas D | 1997 | Environmental Pollution1997，96，2： | 1 |
| 12 | A randomised comparative study evaluating learning curves of novices in a basic singleincision laparoscopic surgery task显示文摘 | Sodergren M McGregor C Fame HA | | 0，，3： | 1 |
| 13 | Evaluating systemie stress response in single port 显示文摘 | Mcgregor CG Sodergren MH Aslanyan A el al | 2011 | J Gastmintest Surg2011，15，4： | 1 |
| 14 | Radio-frequen- cy-assisted liver partition with portal vein liga/ion (RALPP) for liver regeneration显示文摘 | Gall TM Sodergren MH Frampton AE | 2015 | Ann Surg2015，261，2： | 1 |
| 15 | Carcinosar- coma of the biliary tract:two case reports and review of the literature 显示文摘 | Sodergren MH Silva MA Read-Jones SL | 2005 | Eur J Gastroenterol Hepatol2005，17，6： | 1 |
| 16 | Astrovirus MLB2 vire- mia in thrile ehiht显示文摘 | Holtz LR Wylie KM Sodergren E | 2011 | Emerg infect Dis2011，17，11： | 1 |
| 17 | Variations and adaptations of associated liver partition and portal vein ligation for staged hepatectomy (ALPPS) : Many routes to the summit 显示文摘 | Edmondson MJ Sodergren MH Pucher PH | 2016 | Surgery2016，159，4： | 1 |
| 18 | Physical activity, exercise and self-rated health: a population-based study from Sweden显示文摘 | Sodergren M Sundquist J Johansson SE | 2008 | BMC Public Health2008，8，1： | 1 |
| 19 | The influence of lithium on the aging of a 7000 series alloys显示文摘 | Sodergren A Lloyd D J | 1988 | Acta Metall1988，36，8： | 1 |
| 20 | Theoretical models for the action spectrum and the cunnt-voltage characteristics of microporous semiconductor films in photoelectrochemical cells显示文摘 | Sodergren S Hagfeldt A Olsson J | 1994 | Journal of Physi- cal Chemisity1994，98，21： | 1 |
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