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| 1 | Enhanced recovery after surgery:Current research insights and future direction显示文摘Since the concept of enhanced recovery after surgery(ERAS)was introduced in the late 1990 s the idea of implementing specific interventions throughout the perioperative period to improve patient recovery has been proven to be beneficial. Minimally invasive surgery is an integral component to ERAS and has dramatically improved post-operative outcomes. ERAS can be applicable to all surgical specialties with the core generic principles used together with added specialty specific interventions to allow for a comprehensive protocol,leading to improved clinical outcomes. Diffusion of ERAS into mainstream practice has been hindered due to minimal evidence to support individual facets and lack of method for monitoring and encouraging compliance. No single outcome measure fully captures recovery after surgery,rather multiple measures are necessary at each stage. More recently the pre-operative period has been the target of a number of strategies to improve clinical outcomes,described as prehabilitation. Innovation of technology in the surgical setting is also providing opportunities to overcome the challenges within ERAS,e.g.,the use of wearable activity monitors to record information and provide feedback and motivation to patients peri-operatively. Both modernising ERAS and providing evidence for key strategies across specialties will ultimately lead to better,more reliable patient outcomes. | Aliza Abeles Richard Mark Kwasnicki Ara Darzi | 2017 | World Journal of Gastrointestinal Surgery2017，9，2： | 46 |
| 2 | Laparoscopic vs open approach to resection of hepatocellular carcinoma in patients with known cirrhosis:Systematic review and meta-analysis显示文摘AIM: To review the currently available literature comparing laparoscopic to open resection of hepatocellular carcinoma(HCC) in patients with known liver cirrhosis.METHODS: A literature search of MEDLINE, EMBASE, and Cochrane databases was conducted. The search terms used included(laparoscopic OR laparoscopy) AND(hepatic or liver) AND(surgery or resection) AND 'hepatocellular carcinoma' AND(cirrhosis or cirrhotic). Furthermore, to widen the search, we also used the 'related articles' section. Studies reporting a comparison of outcomes and methods of open vs laparoscopic hepatic resection for HCC in patients with liver cirrhosis were included. Meta-analysis of results was performed using a random effects model to compute relative risk(RR) and for dichotomous variablesand standard mean differences(SMD) for continuous variables.RESULTS: A total of 420 patients from 4 cohort studies were included in final analysis. Patients undergoing laparoscopic procedures had statistically less blood loss compared to the open cohort, SMD of-1.01(95%CI:-1.23-0.79), P < 0.001, with a reduced risk of transfusion, RR = 0.19(95%CI: 0.09-0.38), P < 0.001. A wider clearance at tumour resection margins was achieved following a laparoscopic approach, SMD of 0.34(95%CI: 0.08-0.60), P = 0.011. No significant difference was noted between laparoscopic and open resection operative times, SMD of-0.15(95%CI: 0.35-0.05), P = 0.142. The overall RR of suffering from postoperative morbidity is 0.25 in favour of the open surgery cohort(95%CI: 0.17-0.37), P < 0.001. Patients under-going laparoscopic surgery had significantly shorter length of stays in hospital compared to the open cohort, SMD of-0.53(95%CI:-0.73 to-0.32), P < 0.001.CONCLUSION: This review suggests that laparoscopic resection of hepatocellular carcinoma in patients with cirrhosis is safe and may provide improved patient outcomes when compared to the open technique. | Ahmed Twaij Philip H Pucher Mikael H Sodergren Tamara Gall Ara Darzi Long R Jiao | 2014 | World Journal of Gastroenterology2014，20，25： | 16 |
| 3 | Natural orifice translumenal endoscopic surgery: critical appraisal of applications in clinical practice显示文摘 | Mikael H. Sodergren James Clark Thanos Athanasiou Julian Teare Guang-Zhong Yang Ara Darzi | 2009 | Surgical Endoscopy2009，，4： | 4 |
| 4 | The role of total mesorectal excision in the management of rectal cancer显示文摘 | Ridgway PF Darzi AW | | 0，，： | 3 |
| 5 | The Risk of Cancer in Patients with Crohn’s Disease显示文摘 | Alexander C. Roon M.R.C.S. George Reese M.R.C.S. Julian Teare F.R.C.P. Vasilis Constantinides M.B.B.S. Ara W. Darzi F.Med.Sci. Paris P. Tekkis M.D. F.R.C.S | 2007 | Diseases of the Colon & Rectum2007，，6： | 3 |
| 6 | Laparoscopic Versus Open Surgery for Rectal Cancer: A Meta-Analysis显示文摘 | Omer Aziz Vasilis Constantinides Paris P. Tekkis Thanos Athanasiou Sanjay Purkayastha Paraskevas Paraskeva Ara W. Darzi Alexander G. Heriot | 2006 | Annals of Surgical Oncology2006，，3： | 3 |
| 7 | The role of epithelial mesenchymal transition and resistance to neoadjuvant therapy in locally advanced rectal cancer显示文摘 | A. Bhangu G. Wood G. Brown A. Darzi P. Tekkis R. Goldin | 2014 | Colorectal Dis2014，，4： | 2 |
| 8 | Laparoscopic versus open hepatic resections for benign and malignant neoplasms—a meta-analysis显示文摘 | Constantinos Simillis Vasilis A. Constantinides Paris P. Tekkis Ara Darzi Richard Lovegrove Long Jiao Anthony Antoniou | 2007 | Surgery2007，，2： | 2 |
| 9 | Experience with laparoscopic color-ectal surgery for malignant disease显示文摘 | Guillon P J Darzi A Monson J R | 1993 | Surg Oncol1993，2，511： | 1 |
| 10 | Laparoscopic sigmoid colectomy: total laporascopic approach显示文摘 | Darzi A Super P Guillou PJ | 1994 | Dis Colon Rectum1994，37，： | 1 |
| 11 | Hand-assisted laparoscopic surgery with the Hand Port system:initial experience with 68 patients显示文摘 | Litwin DEM Darzi A Jakimowicz J | 2000 | JAnn Surg2000，231，： | 1 |
| 12 | Hand-assisted laparoscopic surgery (HALS) with the handPort system: initial experience with 68 patients显示文摘 | Litwin DE Darzi A Jakimowicz J | 2000 | Ann Surg2000，231，5： | 1 |
| 13 | Hand-assisted laparoscopic surgery(HALS) with the handport system 显示文摘 | Liw in D Darzi A Jakinowicz J | 2000 | Ann Surg2000，231，5： | 1 |
| 14 | Evaluation of various methods of treating keloids and hypertrophic scars:a 10-years follow-up study显示文摘 | Darzi MA Chowdri NA Kaul SK | 1992 | Br J Plast Surg1992，45，5： | 1 |
| 15 | Laparoscopic resection for colorectal cancer: evidence to date显示文摘 | Aziz O Darzi AW | 2008 | Surg Oncol Clin N Am2008，17，3： | 1 |
| 16 | Technologies for global health显示文摘 | Howitt P Darzi A Yang Guangzhong | 2012 | Lancet2012，380，9840： | 1 |
| 17 | Hand--assisted laparoscopic colorectal surgery显示文摘 | Darzi A | 2000 | Surg Endosc2000，14，11： | 1 |
| 18 | Laparoscopic versus open hepatic resections for benign and malignant neoplasms—a meta-analysis显示文摘 | Constantinos Simillis Vasilis A. Constantinides Paris P. Tekkis Ara Darzi Richard Lovegrove Long Jiao Anthony Antoniou | 2007 | Surgery2007，，2： | 1 |
| 19 | Surgical ward round quality and impact on variable patient outcomes显示文摘 | Pucher PH Aggarwal R Darzi | 2014 | Ann Surg2014，259，2： | 1 |
| 20 | Lattice Boltzmann simulation of nanofluidin lid-driven cavity显示文摘 | Nemati H Farhadi M Sedighi K Fattahi E Darzi A A R | 2010 | International Communications in Heat and Mass Transfer2010，37，10： | 1 |
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