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| 1 | 高级别胶质瘤放、化疗耐药性可能与microRNAs相关(英文)显示文摘High-grade gliomas(HGGs) are malignant primary brain tumors of glial cell origin.Despite optimal course of treatment,including maximal surgical resection followed by adjuvant chemo-and/or radiotherapy,the prognosis still remains poor.The main reason is the commonly occurring chemo-and radioresistance of these tumors.In recent years,several signaling pathways,especially PI3K/AKT and ATM/CHK2/p53,have been linked to the resistance of gliomas.Moreover,additional studies have shown that these pathways are significantly regulated by microRNAs(miRNAs),short endogenous RNA molecules that modulate gene expression and control many biological processes including apoptosis,proliferation,cell cycle,invasivity,and angiogenesis.MiRNAs are not only highly deregulated in gliomas,their expression signatures have also been shown to predict prognosis and therapy response.Therefore,they present promising biomarkers and therapeutic targets that might overcome the resistance to treatment and improve prognosis of glioma patients.In this review,we summarize the current knowledge of the functional role of miRNAs in gliomas resistance to chemo-and radiotherapy. | Besse A Sana J Fadrus P Slaby O | 2013 | 中华神经外科疾病研究杂志2013，12，2： | 3 |
| 2 | Feldspar crystallization under magma-mixing conditions shown by cathodoluminescence and geochemical modelling-a case study from the Karkonosze pluton (SW Poland)显示文摘 | Slaby E Gotze J | 2004 | Mineralogical Magazine2004，68，4： | 1 |
| 3 | Expression of miRNA-106h in conventional renal cell carcinoma is a potential marker for prediction of early metastasis after nephrectomy 显示文摘 | Slaby O Jancovicova J Lakomy R | 2010 | J Exp Clin Cancer Res2010，29，： | 1 |
| 4 | MicroRNA involvement inglioblastoma pathogenesis显示文摘 | Novakova J Slaby O Vyzula R | 2009 | Biochem Biophys Res Commun2009，386，1： | 1 |
| 5 | MicroRNAs in eolorec- tal cancer:translation of molecular biology into clinical appli- cation 显示文摘 | Slaby O Svoboda M Michalek J | 2009 | Mol Cancer2009，8，： | 1 |
| 6 | MicroRNAs in colorectal cancer: translation of molecular biology into clinical application显示文摘 | Slaby O Svoboda M Michalek J | 2009 | Mol Cancer2009，8，： | 1 |
| 7 | Expression of miR- NA-106b in conventional renal cell carcinoma is a potential mark- er for predictionof early metastasis after nephrectomy显示文摘 | Slaby O Jancovicova J Lakomy R | 2010 | J Exp Clin Cancer Res2010，7，： | 1 |
| 8 | Expression of miRNA-106b in conventional renal cell carcinoma is a potential marker for prediction of early metastasis after nephrectomy显示文摘 | Slaby O Jancovicova J Lakomy R | 2010 | J Exp Clin Cancer Res2010，29，： | 1 |
| 9 | MicroRNA involvement in glioblaatoma pathogenesis显示文摘 | Novakova J Slaby O Vyzula R | | 0，，01： | 1 |
| 10 | MicroRNA profiling of activated and tolerogenic human dendriticcells显示文摘 | Stumpfova Z Hezova R Meli AC Slaby O Michalek J | 2014 | Mediat Inflamm2014，2014，25： | 1 |
| 11 | Comparison of various substrate technologies under steady state and transient conditions显示文摘 | Larson S E Slaby J | 2004 | Integr Electron Syst Sector2004，2，： | 1 |
| 12 | Expression of miRNA-106bin conventional renal cell carcinoma is a potential marker forprediction of early metastasis after nephrectomy 显示文摘 | Slaby 0 Jancovicova J Lakomy R | 2010 | Exp Clin CancerRes2010，29，： | 1 |
| 13 | MicroRNA involvement in glioblastoma pathogenesis 显示文摘 | Novakova J Slaby O Vyzula R | 2009 | Biochemical and Biophysical Research Communications2009，386，： | 1 |
| 14 | MicroR-NA involvement in glioblastoma pathogenesis 显示文摘 | NOVAKOVA J SLABY O VYZULA R | 2009 | Bio- chemical and biophysical research communications2009，386，1： | 1 |
| 15 | Expression of miRNA-106b in conventional renal cell carcinoma is a potential marker for predic- tion of early metastasis after nephrectomy 显示文摘 | Slaby O Jancovicova J Lakomy R | 2010 | Journal of Experi- mental & Clinical Cancer Research: CR2010，29，： | 1 |
| 16 | MicroRNAs in colorectal cancer:translation of molecular biology into clinical application显示文摘 | Slaby O Svoboda M Michalek J | 2009 | Mol Cancer2009，8，： | 1 |
| 17 | Genetic pol- ymorphisms and microRNAs:new direction in molecular epidemiology of solid cancer显示文摘 | Slaby O Bienertova-Vasku J Svoboda M Vyzula R | 2012 | J Cell Mol Med2012，16，1： | 1 |
| 18 | MicroRNAs in colorectal cancer: translation of molecular biology into clinical application 显示文摘 | Slaby O Svoboda M Michalek J | 2009 | Molecular cancer2009，8，： | 1 |
| 19 | Expression of miRNA-106b in conventional renal cell carcinoma is a potential marker for prediction of early metastasis after nephrectomy显示文摘 | SLABY O JANCOVICOVA J LAKOMY R | 2010 | J Exp Clin Canc Res2010，29，： | 1 |
| 20 | MicroRNA involvement in glioblastoma pathogenesis显示文摘 | Novakova J Slaby O Vyzula R | 2009 | Biochem Biophys Res Commun2009，386，1： | 1 |
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