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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | A dynamic estimator for tracking the state of a power system显示文摘 | DebsA S Larson R E | 1970 | IEEE Transactions on Power Apparatus arid Systems1970，89，7： | 1 |
| 3 | Diurnal variation of radon and mixing heights along a coast: a case study 显示文摘 | Hsu S A Larson R E Bressan D J | 1980 | Journal of Geophysical Research1980，85，： | 1 |
| 4 | Effect of surfactant layers on the size changes of aerosol particles as a function of relative humidity显示文摘 | ANDREWS E LARSON S M | 1993 | Envi- ronmental Science & Technology1993，27，5： | 1 |
| 5 | Types of human papillomavirus revealed in cervical adenocarcinomas after DNA sequencing显示文摘 | Andersson S Rylander E Larson B | | 0，，01： | 1 |
| 6 | Asymmetric frontal brain activity, cortisol, and behavior associated with fearful temperament in rhesus monkeys显示文摘 | Kalin N H Larson C Shelton S E Davidson R J | 1998 | Behavioral Neuroscience1998，112，2： | 1 |
| 7 | Predicting the effects of tillage and crop residue management on soil erosion显示文摘 | GUPTA S C ONSTAD C A LARSON W E | 1979 | Soil Water Conserv1979，34，： | 1 |
| 8 | Tea tree oil 显示文摘 | LARSON D JACOB S E | 2012 | Dermatitis2012，23，1： | 1 |
| 9 | Impact of high - normal blood pressure on the risk of cardiovascular disease 显示文摘 | Vasari R S Larson M G Leip E P | 2001 | N Engl J Med2001，345，18： | 1 |
| 10 | Deratofibrosarcoma protuberans:a report on 29 patients treated by Mohs micrographic surgery with long-term follow-up and review of the literature显示文摘 | Snow S N Gordon E M Larson P O | 2004 | Cancer2004，101，1： | 1 |
| 11 | The economics of air pollution health risks in Russia: a case study of Volgograd 显示文摘 | Larson B A Avaliani S Golub A Rosen S Shaposhnikov D Strukova E Vincent J R Wolff S K | 1999 | World development1999，27，10： | 1 |
| 12 | The satisfaction with life scale' 显示文摘 | DIENER E EMMONMS R A LARSON R J GRIF- FIN S | 1985 | Journal of Personality Assessment1985，49，： | 1 |
| 13 | A randomized tri- al of high-dose compared with low-dose omegas3 fatty acids in se- vere IgA nephropathy显示文摘 | Donadio J V Jr Larson T S Bergstralh E J | 2001 | J Am Soc Nephrol2001，12，4： | 1 |
| 14 | Applying power systems stabilizers,part 1:General concepts;part 2:Performance objectives and tuning concepts;part 3:Practical consideration显示文摘 | LARSON E V SWANN S A | 1981 | IEEE Transactions on Power Apparatus and Systems1981，100，9： | 1 |
| 15 | Impact of high normal blood pressure on the risk of cardiovascular disease显示文摘 | Vasan R S Larson M G Leip E P | 2001 | N Engl J Med2001，345，18： | 1 |
| 16 | Is gratitude a moral affect 显示文摘 | McCullough M E Kilpatrick S D Emmons R A larson D B | 2001 | Psychological Bulletin2001，127，24： | 1 |
| 17 | Estimating soil water retention characteristics from particle size distribution organic matter percent, and bulk density显示文摘 | GUPTA S C LARSON W E | 1979 | Water Resources Research1979，15，6： | 1 |
| 18 | Should aspirin be continued in patients started on warfarin? 显示文摘 | Larson R J Fisher E S | 2004 | J Gen Intern Med2004，19，8： | 1 |
| 19 | A digital calibration method for synthetic aperture radar systems显示文摘 | LARSON R W JACKSON P L KASISCHKE E S | 1988 | IEEE Trans Geosei Remote Sensing1988，26，： | 1 |
| 20 | Impact of High-Normal blood pressure on the risk of cardiovascular disease显示文摘 | Vasan R S Larson M G Leip E P | 2001 | N Engl J Med2001，345，18： | 1 |
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