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| 1 | Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders: executive summary and 2019 update of clinical management of ischaemic cerebrovascular diseases显示文摘Aim Stroke is the leading cause of disability and death in China.Ischaemic stroke accounts for about 60%-80%of all strokes.It is of considerable significance to carry out multidimensional management of ischaemic cerebrovascular diseases.This evidence-based guideline aims to provide the latest detailed and comprehensive recommendations on the diagnosis,treatment and secondary prevention of ischaemic cerebrovascular diseases.Methods We had performed comprehensive searches of MEDLINE(via PubMed)(before 30 June 2019),and integrated the relevant information into charts and distributed to the writing group.Writing group members discussed and determined the recommendations through teleconference.We used the level of evidence grading algorithm of Chinese Stroke Association to grade each recommendation.The draft was reviewed by the Guideline Writing Committee of Chinese Stroke Association Stroke and finalised.This guideline is fully updated every 3 years.results This evidence-based guideline is based on the treatment,care and prevention of ischaemic cerebrovascular diseases,which emphasises on pathogenesis evaluation,intravenous thrombolysis,endovascular therapy,antiplatelet therapy,prevention and treatment of complications,and risk factor management.Conclusions This updated guideline presents a framework for the management of ischaemic cerebrovascular diseases.Timely first-aid measures,professional care in the acute stage,and proactive secondary prevention will be helpful to patients. | Liping Liu Weiqi Chen Hongyu Zhou Wanying Duan Shujuan Li Xiaochuan Huo Weihai Xu Li'an Huang Huaguang Zheng Jingyi Liu Hui Liu Yufei Wei Jie Xu Yongjun Wang | 2020 | Stroke & Vascular Neurology2020，5，2： | 42 |
| 2 | Overexpressed miR-9 promotes tumor metastasis via targeting E-cadherin in serous ovarian cancer显示文摘MicroRNAs (miRNAs ) 玩在在各种各样的癌症的发展和前进的关键角色。不正常的 miR-9 表示仍然保持模糊,并且卵巢的癌症的变形前进上的一致都没被到达。在这研究,从生物信息学分析的结果证明 E-cadherin mRNA 的 3-UTR 被 miR-9 直接调整。酶记者试金结果证实 miR-9 能直接指向这 3-UTR。在卵巢的癌症织物的 miR-9 和 E-cadherin 表示被 qRT-PCR 确定。移植和侵略被在 SKOV3 和 A2780 愈合弯屈和 Transwell 系统试金检测。qRT-PCR 和西方的污点被执行检测上皮 ? 间充质的联系转变的 mRNA 和蛋白质。Immunofluorescence 技术被用来分析表示和 E-cadherin, N-cadherin,和 vimentin 的 subcellular 本地化。结果证明 miR-9 经常与配对的主要的相比是在变形浆液的卵巢的癌症织物的 upregulated。miR-9 的 Upregulation 能 downregulate E-cadherin 的表示但是 upregulate 间充质的标记(N-cadherin 和 vimentin ) 的表示。miR-9 的 Overexpression 能在卵巢的癌症支持房间移植和侵略,并且这些进程能有效地经由 miR-9 禁止者被禁止。因此,我们的学习证明 miR-9 可以经由指向 E-cadherin 和一条新奇潜在的治疗学的途径控制卵巢的癌症的转移支持卵巢的癌症转移。 | Bo Zhou Hongbin Xu Meng Xia Chaoyang Sun Na Li Ensong Guo Lili Guo Wanying Shan Hao Lu Yifan Wu Yuan Li Degui Yang Danhui Weng Li Meng Junbo Hu Ding Ma Gang Chen Kezhen Li | 2017 | Frontiers of Medicine2017，11，2： | 10 |
| 3 | Room temperature ferromagnetism in ultra-thin van der Waals crystals of 1T-CrTe2显示文摘Although many emerging new phenomena have been unraveled in two dimensional(2D)materials with long-range spin orderings,the usually low critical temperature in van der Waals(vdW)magnetic material has thus far hindered the related practical applications.Here,we show that ferromagnetism can hold above 300 K in a metallic phase of 1T-CrTe2 down to the ultra-thin limit.It thus makes CrTe2 so far the only known exfoliated ultra-thin vdW magnets with intrinsic long-range magnetic ordering above room temperature.An in-plane room-temperature negative anisotropic magnetoresistance(AMR)was obtained in ultra-thin CrTe2 devices,with a sign change in the AMR at lower temperature,with−0.6%and+5%at 300 and 10 K,respectively.Our findings provide insights into magnetism in ultra-thin CrTe2,expanding the vdW crystals toolbox for future room-temperature spintronic applications. | Xingdan Sun Wanying Li Xiao Wang Qi Sui Tongyao Zhang Zhi Wang Long Liu Da Li Shun Feng Siyu Zhong Hanwen Wang Vincent Bouchiat Manuel Nunez Regueiro Nicolas Rougemaille Johann Coraux Anike Purbawati Abdellali Hadj-Azzem Zhenhua Wang Baojuan Dong Xing Wu Teng Yang Guoqiang Yu Bingwu Wang Zheng Han Xiufeng Han Zhidong Zhang | 2020 | Nano Research2020，13，12： | 6 |
| 4 | Development of the National Air Quality Health Index-China,2013−2018显示文摘What is already known about this topic?While the establishment of an air quality health index(AQHI)in some countries yielded positive outcomes in communicating health risks of air pollution,China lagged behind in developing its own AQHI.Several research studies of AQHI were conducted in China,but this scientific research has not yet been applied to standards.What is added by this report?This report introduced the method of calculation of Chinese AQHI to be launched in pilot cities.The index in this report was established on the basis of fully drawing on international experience and considering Chinese characteristics.What are the implications for public health practice?The purpose of this report is to guide unified application of the AQHI throughout China and translate scientific evidence into public services to promote public health.Based on the AQHI construction method in this report,an AQHI real-time computing platform and data transfer interface will be developed.The release of AQHI aims to communicate health risk of air pollution and provide scientific health protective guidance to the general public,accordingly to protect people’s health. | Qinghua Sun Huanhuan Zhu Wanying Shi Yu Zhong Yingjian Zhang Tiantian Li | 2021 | China CDC weekly2021，3，4： | 5 |
| 5 | Polymer coated nanodiamonds as gemcitabine prodrug with enzymatic sensitivity for pancreatic cancer treatment显示文摘The fabrication of Gemcitabine(GEM) prodrug was reported to be an effective method to enhance its pancreatic cancer treatment efficiency. Here, a kind of nanocarbon-based materials, nanodiamond(ND), was selected as the nanocarrier of GEM, owing to its outstanding surface properties and non-cytotoxicity. The polyelectrolytes,polyethyleneimine and polyacrylic acid, were used to self-assemble outside ND surface through electrostatic forces, followed by attachment of polyethylene glycol to address better biocompatibility. GEM was conjugated with an enzyme-sensitive peptide gly-phe-leu-gly to build up the controlled release platform. From characterization results of dynamic laser scattering, zeta potential and transmission electron microscope, the significant improvement of ND stability in physiological condition was proved. Non-cytotoxicity of this functionalized ND carriers and cytotoxicity of the prodrug against Bx PC-3 pancreatic cancer cells were indicated by methylthiazolyl tetrazolium(MTT) assay. In vivo experiments also revealed its superior anticancer effect compared with free GEM treatment. Therefore, the combination of polymer coated NDs with high surface capability and enzymeresponsive intracellular GEM release make it possible to realize higher treatment efficiency on pancreatic tumor therapy. | Wanying Ye Haijie Han Huan Li Qiao Jin Yuzhou Wu Sabyasachi Chakrabortty Tanja Weil Jian Ji | 2020 | Progress in Natural Science:Materials International2020，30，5： | 3 |
| 6 | Inflammation and aging:signaling pathways and intervention therapies显示文摘Aging is characterized by systemic chronic inflammation,which is accompanied by cellular senescence,immunosenescence,organ dysfunction,and age-related diseases.Given the multidimensional complexity of aging,there is an urgent need for a systematic organization of inflammaging through dimensionality reduction. | Xia Li Chentao Li Wanying Zhang Yanan Wang Pengxu Qian He Huang | 2023 | Signal Transduction and Targeted Therapy2023，8，7： | 3 |
| 7 | PM_(2.5) exposure associated with microbiota gut-brain axis:Multi-omics mechanistic implications from the BAPE study显示文摘Recent studies have shown that PM_(2.5) may activate the hypothalamus-pituitary-adrenal(HPA)axis by inducing hormonal changes,potentially explaining the increase in neurological and cardiovascular risks.In addition,an association between PM_(2.5) and gut microbiota and metabolites was established.The above evidence represents crucial parts of the gut-brain axis(GBA).In view of this evidence. | Tiantian Li Jianlong Fang Song Tang Hang Du Liang Zhao Yanwen Wang Fuchang Deng Yuanyuan Liu Yanjun Du Liangliang Cui Wanying Shi Yan Wang Jiaonan Wang Yingjian Zhang Xiaoyan Dong Ying Gao Yu Shen Li Dong Huichan Zhou Qinghua Sun Haoran Dong Xiumiao Peng Yi Zhang Meng Cao Hong Zhi Jingyang Zhou Xiaoming Shi | 2022 | The Innovation2022，3，2： | 2 |
| 8 | Continuous biohydrogen production from liquid swine manure supplemented with glucose using an anaerobic sequencing batch reactor显示文摘 | Xiao Wu Jun Zhu Chunying Dong Curt Miller Yecong Li Liang Wang Wanying Yao | 2009 | International Journal of Hydrogen Energy2009，，16： | 1 |
| 9 | Regulating the nanoscale intimacy of metal and acidic sites in Ru/γ-Al_(2)O_(3)for the selective conversions of lignin-derived phenols to jet fuels显示文摘Catalytic hydrodeoxygenation(HDO)of biomass-derived oxy-compounds to advanced hydrocarbon fuels usually requires bifunctional catalysts containing metals and acidic sites.The appropriate tuning of metal and/or acidic active sites at interfaces of bifunctional catalysts can significantly improve catalyst activity and product selectivity.Here,4-trifuoromethyl salicylic acid(TFMSA),as a hydrothermal stable organic acid,was employed to tailor the bifunctional interface of Ru/γ-Al_(2)O_(3)to enhance the catalytic performance on converting lignin-derived phenols to jet fuel range cycloalkanes.More than 80%phenol was converted into cyclohexane at 230°C for 1 h over Ru/γ-Al_(2)O_(3)modified by TFMSA,which was about three times higher than that over unmodified Ru/γ-Al_(2)O_(3).X-ray diffraction(XRD),Transmission electron microscope(TEM),H2 chemisorption,and energy dispersive X-ray spectroscopy(EDS)elemental mapping results indicated that Ru nanoparticles and TFMSA were well distributed onγ-Al_(2)O_(3),and a nanoscale intimacy between Ru and TFMSA was reached.Meanwhile,Fourier transform infrared spectroscopy after pyridine adsorption(Py-FT-IR)analysis proved that Brønsted acidic sites on the catalytic interfaces of TFMSA modified Ru/γ-Al_(2)O_(3)had been improved.Moreover,the kinetic and density functional theory(DFT)results suggested that the synergistic effects of adjacent Ru nanoparticles and acidic sites were crutial for promoting the rate-limiting conversion step of phenol HDO to cyclohexane. | Shanshuai Chen Weichen Wang Xue Li Puxiang Yan Wanying Han Tian Sheng Tiansheng Deng Wanbin Zhu Hongliang Wang | 2022 | Journal of Energy Chemistry2022，31，3： | 1 |
| 10 | GRIP: A Group Recommender Based on Interactive Preference Model显示文摘recommender 系统的众多的应用程序能提供我们理解用户的一个工具。组 recommender 反映多重用户行为的分析,并且试图向这个组的每个用户提供他们根据用户偏爱包含的事情。当前,大多数存在的组 recommenders 在用户之中忽略相互作用。在组活动期间,然而,交互偏爱将戏剧性地影响 recommenders 的成功。当用户的一些未知偏爱被另外的用户部分在这个组影响时,这个问题变得甚至更挑战性。能使用组活动历史信息和 recommender 的命名掌握(基于交互偏爱的组 Recommender ) 被介绍的一个基于相互作用的方法产生交互偏爱参数的等级以后的反馈机制。评估建议方法的表演,它与在 MovieLens 数据集上的传统的合作过滤相比。结果关于有效性和精确性为多用户显示 GRIP recommender 的优势。 | Bo-Han Li An-Man Zhangi Wei Zheng Shuo Wani Xiao-Lin Qin Xue Li Hai-Lian Yin | 2018 | Journal of Computer Science & Technology2018，33，5： | 1 |
| 11 | Spatial Heterogeneity of Agricultural Science and Technology Parks Technology Diffusion: A Case Study of Yangling ASTP显示文摘Agricultural science and technology parks(ASTPs) represent an important growth pole in China’s agricultural modernization.Clarifying their diffusion laws can optimize the technological diffusion process and improve its efficiency. Our study uses disaggregated spatial information in its model to analyze ASTP technology diffusion in a heterogeneous space. We constructed a comprehensive index system to evaluate the diffusion environmental quality and introduced the heterogeneous diffusion equation to calculate the technological diffusion probability. We applied this framework to a real-world scenario: the apple planting technology diffusion of the Yangling ASTP in the Loess Plateau, China. The results indicated: (1)the technological diffusion environment of the Loess Plateau advantageous apple producing area showed strong spatial heterogeneity caused by climate, topography, and external transportation links.(2) Under the combined effects of distance and spatial heterogeneity, the spatial diffusion pattern of the Yangling ASTP apple technology was expansion diffusion supplemented by hierarchical diffusion and banded diffusion, and (3) ASTP technology diffusion showed a strong distance attenuation effect, and the frictional effect of distance can be decreased by improving the diffusion environmental quality. These laws can promote regional balanced ASTP-driven development. | WANG Zhao LIU Jianhong LI Tongsheng REN Wanying RUI Yang | 2021 | Chinese Geographical Science2021，31，4： | 1 |
| 12 | UHP metamorphism and ex-humation of the Dabie Orogen: evidence from SHRIMP dating ofzircon and monazite from a UHP granitic gneiss cobble from theHefei Basin, China显示文摘 | WanY S Li R W Wilde S A | 2005 | Geochimica et Cosmochimica Acta2005，69，： | 1 |
| 13 | Atorvastatin inhibits pancreatic carcinogenesis and increases survival in LSL‐Kras <sup> G12D </sup> ‐LSL‐Trp53 <sup> R172H </sup> ‐Pdx1‐Cre mice显示文摘 | Jie Liao Yeon T. Chung Allison L. Yang Meng Zhang Haonan Li Wanying Zhang Liang Yan Guang‐Yu Yang | 2013 | Mol Carcinog2013，，9： | 1 |
| 14 | Soluble Epoxide Hydrolase Gene Deficiency or Inhibition Attenuates Chronic Active Inflammatory Bowel Disease in IL-10(?/?) Mice显示文摘 | Wanying Zhang Allison L. Yang Jie Liao Haonan Li Hua Dong Yeon Tae Chung Han Bai Kristina A. Matkowskyj Bruce D. Hammock Guang-Yu Yang | 2012 | Digestive Diseases and Sciences2012，，10： | 1 |
| 15 | The NAD (P) H : Quinone Oxi- doreductase 1 induces cell cycle progression and prolifera- tion of melanoma cells 显示文摘 | Garate M Wani AA Li G | 2010 | Free Radio Biol Med2010，48，12： | 1 |
| 16 | The NAD (P)I-I: Quinone Oxi- doreductase 1 induces cell cycle progression and prolifera- tion of melanoma cells显示文摘 | Garate M Wani AA Li G | 2010 | Free Radic Biol Meal2010，48，12： | 1 |
| 17 | Diffusive shrinkage of a void within a grian of a stressed polycrystal 显示文摘 | WANY Hua LI Zhong-hua | 2003 | J Mech Phys Solids2003，51，： | 1 |
| 18 | Temperature-Modified Acute Effects of Ozone on Human Mortality-Beijing Municipality,Tianjin Municipality,Hebei Province,and Surrounding Areas,China,2013-2018显示文摘Summary What is already known about this topic?Ozone(O_(3))is a weather-driven photochemical ambient pollutant,and its harm to human health may be affected by meteorological factors such as temperature.However,there is conflicting evidence regarding whether temperature can modify the effects of ozone on health. | Chen Chen Jing Liu Wanying Shi Tiantian Li Xiaoming Shi | 2021 | China CDC weekly2021，3，45： | 1 |
| 19 | GmGPDH12,a mitochondrial FAD-GPDH from soybean, increases salt and osmotic stress resistance by modulating redox state and respiration显示文摘In plants,glycerol-3-phosphate dehydrogenase(GPDH)catalyzes the interconversion of glycerol-3-phosphate(G3P)and dihydroxyacetone phosphate(DHAP)coupled to the reduction/oxidation of the nicotinamide adenine dinucleotide(NADH)pool,and plays a central role in glycerolipid metabolism and stress response.Previous studies have focused mainly on the NAD+-dependent GPDH isoforms,neglecting the role of flavin adenine dinucleotide(FAD)-dependent GPDHs.We isolated and characterized three mitochondrialtargeted FAD-GPDHs in soybean,of which one isoform(GmGPDH12)showed a significant transcriptional response to NaCl and mannitol treatments,suggesting the existence of a major FAD-GPDH isoform acting in soybean responses to salt and osmotic stress.An enzyme kinetic assay showed that the purified GmGPDH12 protein possessed the capacity to oxidize G3P to DHAP in the presence of FAD.Overexpression and RNA interference of GmGPDH12 in soybean hairy roots resulted in elevated tolerance and sensitivity to salt and osmotic stress,respectively.G3P contents were significantly lower in GmGPDH12-overexpressing hair roots and higher in knockdown hair roots,indicating that GmGPDH12 was essential for G3P catabolism.A significant perturbation in redox status of NADH,ascorbic acid(ASA)and glutathione(GSH)pools was observed in GmGPDH12-knockdown plants under stress conditions.The impaired redox balance was manifested by higher reactive oxygen species generation and consequent cell damage or death;however,overexpressing plants showed the opposite results for these traits.GmGPDH12 overexpression contributed to maintaining constant respiration rates under salt or osmotic stress by regulating mRNA levels of key mitochondrial respiratory enzymes.This study provides new evidence for the roles of mitochondria-localized GmGPDH12 in conferring resistance to salt or osmotic stress by maintaining cellular redox homeostasis,protecting cells and respiration from oxidative injury. | Ying Zhao Xin Li Zexin Zhang Wenjing Pan Sinan Li Yun Xing Wanying Xin Zhanguo Zhang Zhenbang Hu Chunyan Liu Xiaoxia Wu Zhaoming Qi Dawei Xin Qingshan Chen | 2021 | The Crop Journal2021，9，1： | 1 |
| 20 | Growth Kinetics and Phenol Biodegradation of Psychrotrophic Pseudomonas putida LY1显示文摘 | LI Y LI J WANY C | 2010 | Bioresource Technology2010，101，17： | 1 |
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