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| 1 | Potentially probiotic bacteria induce efficient maturation but differential cytokine production in human monocyte-derived dendritic cells显示文摘AIM: To analyze the ability of nine different potentially probiotic bacteria to induce maturation and cytokine production in human monocyte-derived dendritic cells (moDCs). METHODS: Cytokine production and maturation of moDCs in response to bacterial stimulation was analyzed with enzyme-linked immunosorbent assay (ELISA) and flow cytometric analysis (FACS), respectively. The kinetics of mRNA expression of cytokine genes was determined by Northern blotting. The involvement of different signaling pathways in cytokine gene expression was studied using specific pharmacological signaling inhibitors. RESULTS: All studied bacteria induced the maturation of moDCs in a dose-dependent manner. More detailed analysis with S. thermophilus THS, B. breve Bb99, and L. lactis subsp. cremoris ARH74 indicated that these bacteria induced the expression of moDC maturationmarkers HLA class Ⅱ and CD86 as efficiently as pathogenic bacteria. However, these bacteria differed in their ability to induce moDC cytokine gene expression. S. thermophilus induced the expression of pro-inflammatory (TNF-α, IL-12, IL-6, and CCL20) and Th1 type (IL-12 and IFN-γ) cytokines, while B. breve and L. lactis were also potent inducers of anti- inflammatory IL-10. Mitogen-activated protein kinase (MAPK) p38, phosphatidylinositol 3 (PI3) kinase, and nuclear factor-kappa B (NF-κB) signaling pathways were shown to be involved in bacteria-induced cytokine production. CONCLUSION: Our results indicate that potentially probiotic bacteria are able to induce moDC maturation, but their ability to induce cytokine gene expression varies significantly from one bacterial strain to another. | Sinikka Latvala Taija E Pietil Ville Veckman Riina A Kekkonen Soile Tynkkynen Riitta Korpela Ilkka Julkunen | 2008 | World Journal of Gastroenterology2008，14，36： | 8 |
| 2 | Probiotic intervention has strain-specific anti-inflammatory effects in healthy adults显示文摘AIM: To evaluate the effects of three potentially anti- inflammatory probiotic bacteria from three different genera on immune variables in healthy adults in a clinical setting based on previous in vitro characterization of cytokine responses. METHODS: A total of 62 volunteers participated in this randomized, double-blind and placebo-controlled parallel group intervention study. The volunteers were randomized to receive a milk-based drink containing either Lactobacillus rhamnosus GG (LGG), Bifidobacterium animalis ssp. lactis Bb12 (Bb12), or Propionibacterium freudenreichii ssp. shermanii JS (PJS) or a placebo drink for 3 wk. Venous blood and saliva samples were taken at baseline and on d 1, 7 and 21. Fecal samples were collected at baseline and at the end of intervention. RESULTS: The serum hsCRP expressed as the median AUC0-21 (minus baseline) was 0.018 mg/L in the placebo group, -0.240 mg/L in the LGG group, 0.090 mg/L in the Bb12 group and -0.085 mg/L in the PJS group (P = 0.014). In vitro production of TNF-α from in vitro cultured peripheral blood mononuclear cells (PBMC) was significantly lower in subjects receiving LGG vs placebo. IL-2 production from PBMC in the Bb12 group was significantly lower compared with the other groups. CONCLUSION: In conclusion, probiotic bacteria have strain-specific anti-inflammatory effects in healthy adults. | Riina A Kekkonen Netta Lummela Heli Karjalainen Sinikka Latvala Soile Tynkkynen Salme Jrvenp Hannu Kautiainen Ilkka Julkunen Heikki Vapaatalo Riitta Korpela | 2008 | World Journal of Gastroenterology2008，14，13： | 6 |
| 3 | Elevated pro-inflammatory and lipotoxic mucosal lipids characterise irritable bowel syndrome显示文摘AIM:To investigate the pathophysiology of irritable bowel syndrome(IBS)by comparing the global mucosal metabolic profiles of IBS patients with those of healthy controls.METHODS:Fifteen IBS patients fulfilling the Rome Ⅱcriteria,and nine healthy volunteers were included in the study.A combined lipidomics(UPLC/MS)and metabolomics(GC×GC-TOF)approach was used to achieve global metabolic profiles of mucosal biopsies from the ascending colon.RESULTS:Overall,lipid levels were elevated in patients with IBS.The most significant upregulation was seen for pro-inflammatory lysophosphatidylcholines.Other lipid groups that were significantly upregulated in IBS patients were lipotoxic ceramides,glycosphingolipids,and di-and triacylglycerols.Among the metabolites,the cyclic ester 2(3H)-furanone was almost 14-fold upregulated in IBS patients compared to healthy subjects(P=0.03).CONCLUSION:IBS mucosa is characterised by a distinct pro-inflammatory and lipotoxic metabolic profile.Especially,there was an increase in several lipid species such as lysophospholipids and ceramides. | Kajsa Kajander Eveliina Myllyluoma Sinikka Kyrnpalo Martin Rasmussen Pentti Sipponen Ismo Mattila Tuulikki Seppnen-Laakso Heikki Vapaatalo Matej Orei Riitta Korpela | 2009 | World Journal of Gastroenterology2009，15，48： | 5 |
| 4 | Effects of inten- sive therapy using gait trainer or floor walking exercises early after stroke显示文摘 | Sinikka H Airaksinen O Huuskonen P | 2009 | Rehabil Med2009，41，： | 1 |
| 5 | Annotated catalogue of Chinese Hepaticae and Anthocerotae 显示文摘 | SINIKKA P | 1990 | Hattori Bot Lab1990，68，： | 1 |
| 6 | Tedizolid- phosphate for the management of acute bacterial skin and skin structure infections: safety summary 显示文摘 | WILLIAN O SINIKKA G PURUI M | 2014 | Clin Infect Dis2014，58，1： | 1 |
| 7 | Pretreatment transvaginal ultrasound examination predicts ovarian responsiveness to gonadotrophins in in-vitro fertilization显示文摘 | Candido T Sinikka Nuojua H Hannu M | 1997 | Hum Reprod1997，12，2： | 1 |
| 8 | Health-related qual- ity of life during adjuvant radiotherapy in bast eancer显示文摘 | Luutonen Sinikka Sintonen Harri Stormi Teija | 2014 | Qual Life Res2014，23，4： | 1 |
| 9 | Immunob- lot analysis of bacterial polysaccharides: application to the type-specific polysaccharides of streptococcus suis and streptococcus agalactige显示文摘 | KATRINA T JUKKA H SINIKKA P | 1995 | Journal of Immunolog- ical Methos1995，187，： | 1 |
| 10 | 显示文摘 | Sinikka M Ilkka S | 1990 | N Engl J Med1990，322，： | 1 |
| 11 | Androgen receptors in laryngeal carcinoma显示文摘 | Tuohimaa P T Sinikka K Heinijok J | 1981 | Acta Otolaryngol1981，91，： | 1 |
| 12 | Pretreatment transvaginal ultrasound examination predicts ovarian responsiveness to gonadotrophins in in-vitro fertilization显示文摘 | Candido Tomas Sinikka Nuojua-Huttumen Hannu Martikuinen | 1997 | Hum Reprod1997，12，2： | 1 |
| 13 | Intrauterine insemination treatment in subfertility:an analysis of factors affecting outcome显示文摘 | Candido T Risto B | 1999 | Human Reprod1999，14，4： | 1 |
| 14 | Lagging Effects of the Use of Activity‐Based Costing on the Financial Performance of Small Firms*显示文摘 | Sinikka J?nk?l? Hanna Silvola | 2012 | Journal of Small Business Management2012，，3： | 1 |
| 15 | Health -related quality of life during adjuvant radiotherapy in breast cancer 显示文摘 | Luutonen Sinikka Sintonen Harri Stormi Teija | 2014 | QualLifeRes2014，23，4： | 1 |
| 16 | Intrauteine insemination treatment in subfertility: an analysis of factors affecting outcome 显示文摘 | Sinikka Nuojua - Huttunen Candido Tomas Risto Bloigu | 1999 | Hum Reprod1999，14，3： | 1 |
| 17 | Intrauterine insemination treatment in subfertility :an analysis of factors affecting outcome 显示文摘 | Sinikka Nuojua - Huttunen Candido Tomas Risto Bloigu | 1999 | Hum Reprod1999，14，3： | 1 |
| 18 | Characteristics of Recurrent Ventricular Fibrillation Associated With Inferolateral Early Repolarization显示文摘 | Michel Ha?ssaguerre Frederic Sacher Akihiko Nogami Nohiriro Komiya Anne Bernard Vincent Probst Sinikka Yli-Mayry Pascal Defaye Yoshifusa Aizawa Robert Frank Roberto Mantovan Riccardo Cappato Christian Wolpert Antoine Leenhardt Luc de Roy Hein Heidbuchel I | 2009 | Journal of the American College of Cardiology2009，，7： | 1 |
| 19 | The meaning of craft: Craft makers' descriptions of craft as an occupation显示文摘 | Sinikka P觟ll覿nen | 2013 | Scand J Occup Ther2013，20，3： | 1 |
| 20 | Immunoblot analysis of bacterial polysaccharides: application to the type-specific polysaccharides of Streptococcus suis and Streptococcus agalactige 显示文摘 | Katrina Tikkanen Jukka Hayrinen Sinikka Pelkonen | 1995 | Journal of Immunological Methos1995，187，： | 1 |
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