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| 1 | Synthesis and evaluation of novel analogues of mangiferin as potent antipyretic显示文摘Objective:To screen different analogues of mangiferin pharmacologically for antipyretic activity. Methods:The naturally occurring xanthone glycoside mangiferin was isolated by column chromatography from the elhanolic extract of stem bark of Mangifera indica.Mangiferin was further converted to 5-(N-phenylamino methyleno) mangiferin.5-(N-p-chlorophenylamino methyleno) mangiferin,5-(N-2-methyl phenylamino methyleno) mangiferin.5-(N-p-methoxy phenylamino methyleno) mangiferin.5-(N,N-diphenylamino methyleno) mangiferin,5-(N-α-napthylamino methyleno) mangiferin and 5-(N-4-methyl phenylamino methyleno) mangiferin analogues.The synthesized compounds were further screened for antipyretic activity along with mangiferin at a dose level of 100 and 200 tng/kg.Mangiferin and its analogues were characterized by melting point and R_f value determination and through spectral technique like UV,IR,and NMR spectral analysis.Results:The antipyretic activity of mangiferin as well as all analogues was found to be more significant in at higher dose ie.200 mg/kg which was depicted thmugh a decrease in rectal temperature up to 3 h.Conclusions:The antipyretic activity of mangiferin and its analogues may be attributed to inhibition in synthesis of TNF-αand anti-oxidant activity associated with amelioration of inflammatory actions of cytokines. | Shashi Kant Singh Saurabh K Sinha SK Prasad R Kumar Bhawani S Bithu S Sadish Kumar P Singh | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，11： | 4 |
| 2 | 分娩所致Valsalva视网膜病变治疗方法的探讨(英文)显示文摘目的:讨论孕妇Valsalva视网膜病变保守或手术治疗方法的选择。方法:一健康孕妇在自然阴道分娩时,右眼底发生黄斑前玻璃体后界膜下出血,本文报道其保守治疗的效果。结果:右眼发病3wk时积血收缩,视力为眼前手动,但病程6mo时,积血溶解,视力恢复至6/5。结论:大多数Valsalva视网膜病变能够自愈。对一些难治性病例,采用Nd:YAG激光行内界膜切开具有一定的效果。而早期玻璃体切除术的增殖膜切除,对预防眼底新生血管膜的发生也具有一定的效果。 | Konstantinos I Papageorgiou Rashmi G Mathew AlexanderS Ioannidis Ajay Sinha Petros S Andreou | 2007 | 国际眼科杂志2007，7，3： | 3 |
| 3 | 显示文摘 | Sinha V R Singla A K Wadhawan S | 2004 | International Journal of Pharmaceutics2004，274，12： | 1 |
| 4 | Diffusion tensor MR imaging Of high-grade cerebral gliomas显示文摘 | Sinha S Bastin ME Whittle IR | 2002 | AJNR2002，23，4： | 1 |
| 5 | Well-controlled Biodegradable Nanocomposite Foams:From Microcellular to Nanocellular 显示文摘 | Fujimoto Y Sinha R S Okamoto M | 2003 | Macromolecular Rapid Communications2003，24，7： | 1 |
| 6 | Diffusion tensor MR imaging of high - grade cerebral gliomas 显示文摘 | Sinha S Bastin ME Whittle IR | 2002 | AJNR2002，23，4： | 1 |
| 7 | Slow light propagation in liquid-crystal infiltrated silicon-on-insulator crystal channel waveguides显示文摘 | Rawal S Sinha R K Richard M | 2010 | Lightwave Technology2010，28，17： | 1 |
| 8 | Myeloid-derived suppressor cells: Linking inflammation and cancer 显示文摘 | Ostrand-Rosenberg S Sinha P | 2009 | J Immunol2009，182，8： | 1 |
| 9 | Software system support for knowledge management 显示文摘 | Lindvall M Rus L Sinha S S | 2003 | Journal of Knowledge Management2003，7，5： | 1 |
| 10 | Overexpression,purification and characterization of recombinant salmon calcitonin,a therapeutic protein,in Streptomyces avermitilis显示文摘 | CHAKRABORTY C NANDI S SINHA S | 2004 | Protein Pept Lett2004，11，2： | 1 |
| 11 | Blood pressure controland left ventricular mass in children with chronic kidney disease显示文摘 | Sinha M D Tibby S M Rasmussen P | 2011 | Clin J Am Soc Nephrol2011，6，3： | 1 |
| 12 | Determining the effectiveness of conventional and alternative coagulants through effective characterization schemes显示文摘 | Sinha S Yoon Y Amy G | 2004 | Chemosphere2004，57，： | 1 |
| 13 | Bcl-2 family members : dual regu- lators of apoptosis and autophagy显示文摘 | Levine B Sinha S Kroemer G | 2008 | Autophagy2008，4，5： | 1 |
| 14 | Human soleus muscle architecture at different ankle joint angles from magnetic resonance diffusion tensor imaging显示文摘 | Sinha U Sinha S HodgsonJA | 2011 | J Appl Physiol2011，110，3： | 1 |
| 15 | Popliteal entrapment syndrome显示文摘 | Sinha S Houghton J Holt P J | 2012 | J Vasc Surg2012，55，1： | 1 |
| 16 | In vivo diffusionweighted MRI of the breast:potential for lesion characterization显示文摘 | Sinha S Lucas-Quesada FA Sinha U | | 0，，06： | 1 |
| 17 | Myeloid-derived suppressor cells: linking inflammation and cancer显示文摘 | Ostrand-Rosenberg S Sinha P | 2009 | J Irnmunol2009，182，8： | 1 |
| 18 | 3D laparoscopy: technique and initial experience in 451 cases 显示文摘 | Sinha R Sundaram M Raje S | 2013 | Gynecol Surg2013，10，： | 1 |
| 19 | Myeloid-derived suppressor cells:linking inflammation and cancer显示文摘 | Ostrand-Rosenberg S Sinha P | 2009 | J Immunol2009，182，： | 1 |
| 20 | Intelligent hybrid wavelet models for short-term load forecasting显示文摘 | Pandey A S Singh D Sinha S K | 2010 | IEEE Transactions on Power Systems2010，25，3： | 1 |
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