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| 1 | Synthesis and evaluation of novel analogues of mangiferin as potent antipyretic显示文摘Objective:To screen different analogues of mangiferin pharmacologically for antipyretic activity. Methods:The naturally occurring xanthone glycoside mangiferin was isolated by column chromatography from the elhanolic extract of stem bark of Mangifera indica.Mangiferin was further converted to 5-(N-phenylamino methyleno) mangiferin.5-(N-p-chlorophenylamino methyleno) mangiferin,5-(N-2-methyl phenylamino methyleno) mangiferin.5-(N-p-methoxy phenylamino methyleno) mangiferin.5-(N,N-diphenylamino methyleno) mangiferin,5-(N-α-napthylamino methyleno) mangiferin and 5-(N-4-methyl phenylamino methyleno) mangiferin analogues.The synthesized compounds were further screened for antipyretic activity along with mangiferin at a dose level of 100 and 200 tng/kg.Mangiferin and its analogues were characterized by melting point and R_f value determination and through spectral technique like UV,IR,and NMR spectral analysis.Results:The antipyretic activity of mangiferin as well as all analogues was found to be more significant in at higher dose ie.200 mg/kg which was depicted thmugh a decrease in rectal temperature up to 3 h.Conclusions:The antipyretic activity of mangiferin and its analogues may be attributed to inhibition in synthesis of TNF-αand anti-oxidant activity associated with amelioration of inflammatory actions of cytokines. | Shashi Kant Singh Saurabh K Sinha SK Prasad R Kumar Bhawani S Bithu S Sadish Kumar P Singh | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，11： | 4 |
| 2 | Artificial intelligence applications in inflammatory bowel disease:Emerging technologies and future directions显示文摘Inflammatory bowel disease(IBD)is a complex and multifaceted disorder of the gastrointestinal tract that is increasing in incidence worldwide and associated with significant morbidity.The rapid accumulation of large datasets from electronic health records,high-definition multi-omics(including genomics,proteomics,transcriptomics,and metagenomics),and imaging modalities(endoscopy and endomicroscopy)have provided powerful tools to unravel novel mechanistic insights and help address unmet clinical needs in IBD.Although the application of artificial intelligence(AI)methods has facilitated the analysis,integration,and interpretation of large datasets in IBD,significant heterogeneity in AI methods,datasets,and clinical outcomes and the need for unbiased prospective validations studies are current barriers to incorporation of AI into clinical practice.The purpose of this review is to summarize the most recent advances in the application of AI and machine learning technologies in the diagnosis and risk prediction,assessment of disease severity,and prediction of clinical outcomes in patients with IBD. | John Gubatan Steven Levitte Akshar Patel Tatiana Balabanis Mike T Wei Sidhartha R Sinha | 2021 | World Journal of Gastroenterology2021，27，17： | 2 |
| 3 | 显示文摘 | Sinha V R Singla A K Wadhawan S | 2004 | International Journal of Pharmaceutics2004，274，12： | 1 |
| 4 | Lead-induced cell death in testes of young rats 显示文摘 | Adhikari N Sinha N Narayan R | 2001 | J Appl Toxicol2001，21，4： | 1 |
| 5 | Well-controlled Biodegradable Nanocomposite Foams:From Microcellular to Nanocellular 显示文摘 | Fujimoto Y Sinha R S Okamoto M | 2003 | Macromolecular Rapid Communications2003，24，7： | 1 |
| 6 | Slow light propagation in liquid-crystal infiltrated silicon-on-insulator crystal channel waveguides显示文摘 | Rawal S Sinha R K Richard M | 2010 | Lightwave Technology2010，28，17： | 1 |
| 7 | 显示文摘 | Morris D E Chandrachood M R Sinha A P B | 1991 | Physica C1991，175，： | 1 |
| 8 | Characterization of M-type barium hexagonal ferrite-based wide band microwave absorber显示文摘 | Meshram M R Agrawal N K Sinha B | 2004 | J Magn Magn Mater2004，，271： | 1 |
| 9 | Comparison of left ventricular lead placement via the coronary venous approach versus lateral thoracotomy in patients receiving cardiac resynchronization therapy 显示文摘 | Koos R Sinha AM Markus K | 2004 | Am J Cardiol2004，94，： | 1 |
| 10 | 3D laparoscopy: technique and initial experience in 451 cases 显示文摘 | Sinha R Sundaram M Raje S | 2013 | Gynecol Surg2013，10，： | 1 |
| 11 | Toxicological effects ofMalachite green 显示文摘 | SRIVASTAVA S SINHA R ROY D | 2004 | Aquatic Toxicology2004，66，3： | 1 |
| 12 | Pontine tuberculoma presenting with horizontal gaze palsy显示文摘 | Saxena R Menon V Sinha A | 2006 | J Neuroophthalmol2006，26，4： | 1 |
| 13 | A Contact Stress Model for Multifingered Grasps of Rough Objects显示文摘 | Sinha P R Abel J M | 1992 | IEEE Transaction on Roboties and Automation1992，8，1： | 1 |
| 14 | Meat intake and cooking techniques: associations with pancreatic cancer显示文摘 | SINHA R KULLDORFF M | 2002 | Mutat Res2002，，： | 1 |
| 15 | CEDAR:A Core-extraction Distributed Ad Hoc Routing Algorithm显示文摘 | Sinha P Bharghavan V | 1997 | IEEE Journal on Selected Areas in Communications1997，17，8： | 1 |
| 16 | Urinary mutagenesis and fried red meat intake: Influence of cooking temperature, phenotype, and genotype of metabolizing enzymes in a con- trolled feeding study 显示文摘 | Peters U Sinha R Bell D A | 2004 | Environmental and Molecular Mu- tagenesis2004，43，1： | 1 |
| 17 | CQC and SRSS method for non-classically damped structures 显示文摘 | Sinha R Igusa T | 1990 | Earthq Engrg and Struc Dyn1990，24，4： | 1 |
| 18 | An insecticidal amide from Piper falconeri 显示文摘 | Parmar V S Sinha R Shakil N A | 1993 | Indian J Chem1993，32，3： | 1 |
| 19 | Polysaccharides in colon-specific drug delivery显示文摘 | Sinha VR Kumria R | 2001 | Int J Pharm2001，224，12： | 1 |
| 20 | Composable models for simulation-based design显示文摘 | PAREDIS C J J DIAZ-CALDERON A SINHA R | 2001 | Engineering with Computers2001，17，2： | 1 |
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