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| 1 | Tumor suppressor ASXL1 is essential for the activation of INK4B expression in response to oncogene activity and anti-proliferative signals显示文摘ASXL1 变化经常在 hematological 肿瘤被发现,并且 Asxl1 的损失在老鼠支持 myeloid 转变。这里我们在 vivo 在在 Histone H2A (H2AK119ub1 ) 上的 mono-ubiquitylated 离氨酸 119 的 deubiquitylation 为 ASXL1-BAP1 建筑群支持一个角色的现在的数据。Polycomb 组蛋白质在正常开发期间控制 INK4B-ARF-INK4A 地点的表达式,部分地通过催化 H2AK119 的 mono-ubiquitylation。自从地点的激活, INK4B-ARF-INK4A 玩一设有自动保险装置机制免于 tumorigenesis,我们调查了 ASXL1 依赖的 H2A deubiquitylation 是否在它的激活起一个作用。有趣地,我们发现 ASXL1 明确地为 p15 响应 oncogenic 发信号和外来的 anti-proliferative 的 INK4B 发信号。因为我们发现 ASXL1 和 BAP1 两个都在 INK4B 地点被充实,我们的结果建议 INK4B 地点的激活要求 H2AK119ub1 的 ASXL1/BAP1-mediated deubiquitylation。一致地,我们 ASXL1 变化与被联系的结果表演降低 p15 INK4B 和在主要骨头髓房间的造血的祖先的一个 proliferative 优点,和在多重房间线的 ASXL1 的那弄空导致抵抗到生长禁止的信号。一起拿,这研究连接 INK4B 表示的调停 ASXL1 的 H2A deubiquitylation 和 transcriptional 激活到它的肿瘤 suppressor 函数。 | Xudong Wu Ida Holst Bekker-Jensen Jesper Christensen Kasper Dindler Rasmussen Simone Sidoli Yan Qi Yu Kong Xi Wang Yajuan Cui Zhijian Xiao Guogang Xu Kristine Williams Juri Rappsilber Casper Kaae Sonderby Ole Winther Ole N Jensens Kristian Helin | 2015 | Cell Research2015，25，11： | 3 |
| 2 | The possibility of in situ heavy metal decontamination of polluted soils using crops of metal - accu-mulating crops 显示文摘 | Baker A J M McGrath S P Sidoli C M D | 1994 | Resources Conservation and Recycling1994，11，： | 1 |
| 3 | The possibility of in situ heavy metal decontamination of polluted soils using crops of metal-accumulating plants显示文摘 | Baker A J M McGrath S P Sidoli C M D | 1994 | Resources Conservation and Recyling1994，11，： | 1 |
| 4 | Organization of the human transferrin gene:Direct evidence that it originated by gene duplication显示文摘 | Park I Schaeffer E Sidoli A | 1985 | Proc Natl Acad Sci USA1985，82，： | 1 |
| 5 | The possibility of in situ heavy metal decontamination of polluted soils using crops of metal-accumulating plants显示文摘 | BAKER A J M MCGRATH S P SIDOLI C M D | 1994 | Resources Conservation and Recycling1994，11，： | 1 |
| 6 | The possibility ofinsituh eavymetal decontamination of pollutedsoilsusin gcrops Ofmetal-accumulating plants显示文摘 | BakerA J M McGrath S P Sidoli C M D | 1994 | Resources Conserwtionand Recycling1994，11，： | 1 |
| 7 | The possibility ofinsitu heavy metal decontamination of polluted soils using crops of metal accumulating plats 显示文摘 | Baker A J M McGrath S P Sidoli CMD | 1994 | Resources Conservation and Recycling1994，11，： | 1 |
| 8 | An in vitro evaluation of a carbon fiber based post and core system显示文摘 | Sidoli GE King DA Setchell DJ | 1997 | J Prosthet Dent1997，78，1： | 1 |
| 9 | Genetic reassort- ment between avian and human influenza A viruses in Italian pigs显示文摘 | Castrucci MR Donatelli I Sidoli L | 1993 | Virology1993，193，1： | 1 |
| 10 | Genetic re-assortment between avian and human influenza A vi-ruses in Italian pigs显示文摘 | Donatelli I Sidoli L | 1993 | Virology1993，193，： | 1 |
| 11 | The possibility ofin situ heavy metal decontamination of polluted soils using metalac cumulating plants显示文摘 | BAKER A J M MCGRATH S P SIDOLI C M D | 1994 | Rea Conserv Rec1994，11，： | 1 |
| 12 | The possibility of in situ heavy metal decontamination of polluted soils using crops of metal accumulating plants显示文摘 | Baker AJ McGrath S P Sidoli CMD | 1994 | Rcsour Conscr Reeyel1994，11，： | 1 |
| 13 | The possibility of in situ heavy metal decontamination of polluted soils using crops of metal-accumulating plants 显示文摘 | Baker A J M McGrath S P Sidoli C M D | 1994 | Resource Conservation and Recycling1994，11，14： | 1 |
| 14 | An in vitro evaluation of a carbon fiber- based post and core system 显示文摘 | Sidoli GE King PA Setchell DJ | 1997 | J Prosthet Dent1997，78，1： | 1 |
| 15 | Organization of the human tmnsferrin gene: direct evidence that it originated by gene duplication显示文摘 | PARK I SCHAEFFER E SIDOLI A | 1985 | Proc Nail Acad Sci USA1985，82，： | 1 |
| 16 | The possibility of insitu heavy metal decontamination of polluted-soils using crops of metal-accumulating plants, Resourse 显示文摘 | Barker A JM Mc Grath S P Sidoli C M D etal | 1994 | Conservatlon and Recycling1994，，11： | 1 |
| 17 | The possibility of in situ heavy metal decontamination of polluted soils using crops of metal-accumulating plants 显示文摘 | Baker A J M McGrath S P Sidoli C M D | 1994 | Resource Conservation and Recycling1994，11，1： | 1 |
| 18 | The possibility of in situ heavy metal decontamination of polluted soils using crops of metal-accumulating plants 显示文摘 | Baker A J M McGrath S P Sidoli C M D | 1994 | Resources Conservation and Recycling1994，11，： | 1 |
| 19 | Genetic reassort- ment between avian and human influenza A viruses in Ital- ian pigs显示文摘 | Castrucci M R Donatelli I Sidoli L | 1993 | Virology1993，193，1： | 1 |
| 20 | The possibil of in situ heavy metal decontamination of polluted soils using crops of metal- accumulating plants 显示文摘 | Mc Grmh S P Sidoli C M D | 1994 | Resources Conservation and Recycling1994，11，： | 1 |
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