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| 1 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 2 | Tumor suppressor ASXL1 is essential for the activation of INK4B expression in response to oncogene activity and anti-proliferative signals显示文摘ASXL1 变化经常在 hematological 肿瘤被发现,并且 Asxl1 的损失在老鼠支持 myeloid 转变。这里我们在 vivo 在在 Histone H2A (H2AK119ub1 ) 上的 mono-ubiquitylated 离氨酸 119 的 deubiquitylation 为 ASXL1-BAP1 建筑群支持一个角色的现在的数据。Polycomb 组蛋白质在正常开发期间控制 INK4B-ARF-INK4A 地点的表达式,部分地通过催化 H2AK119 的 mono-ubiquitylation。自从地点的激活, INK4B-ARF-INK4A 玩一设有自动保险装置机制免于 tumorigenesis,我们调查了 ASXL1 依赖的 H2A deubiquitylation 是否在它的激活起一个作用。有趣地,我们发现 ASXL1 明确地为 p15 响应 oncogenic 发信号和外来的 anti-proliferative 的 INK4B 发信号。因为我们发现 ASXL1 和 BAP1 两个都在 INK4B 地点被充实,我们的结果建议 INK4B 地点的激活要求 H2AK119ub1 的 ASXL1/BAP1-mediated deubiquitylation。一致地,我们 ASXL1 变化与被联系的结果表演降低 p15 INK4B 和在主要骨头髓房间的造血的祖先的一个 proliferative 优点,和在多重房间线的 ASXL1 的那弄空导致抵抗到生长禁止的信号。一起拿,这研究连接 INK4B 表示的调停 ASXL1 的 H2A deubiquitylation 和 transcriptional 激活到它的肿瘤 suppressor 函数。 | Xudong Wu Ida Holst Bekker-Jensen Jesper Christensen Kasper Dindler Rasmussen Simone Sidoli Yan Qi Yu Kong Xi Wang Yajuan Cui Zhijian Xiao Guogang Xu Kristine Williams Juri Rappsilber Casper Kaae Sonderby Ole Winther Ole N Jensens Kristian Helin | 2015 | Cell Research2015，25，11： | 3 |
| 3 | ACCF 2012 Expert Consensus Document on Practical Clinical Considerations in the Interpretation of Troponin Elevations显示文摘 | L. Kristin Newby Robert L. Jesse Joseph D. Babb Robert H. Christenson Thomas M. De Fer George A. Diamond Francis M. Fesmire Stephen A. Geraci Bernard J. Gersh Greg C. Larsen Sanjay Kaul Charles R. McKay George J. Philippides William S. Weintraub | 2012 | Journal of the American College of Cardiology2012，，23： | 2 |
| 4 | Long-term Anastomotic Complications After Pancreaticoduodenectomy for Benign Diseases显示文摘 | Kaye M. Reid-Lombardo Antonio Ramos-De la Medina Kristine Thomsen William S. Harmsen Michael B. Farnell | 2007 | Journal of Gastrointestinal Surgery2007，，12： | 1 |
| 5 | The effect of sevoflurane and propoful on cerebral neurotransmitter concentrations during cerebrai ischemia in rat 显示文摘 | Kristin E Christian W William EH | 2003 | Anesth Analg2003，97，： | 1 |
| 6 | Long term ecological research and information management显示文摘 | William K. Michener John Porter Mark Servilla Kristin Vanderbilt | 2010 | Ecological Informatics2010，，1： | 1 |
| 7 | The effect of sevoflurane and propofol on cerebral neurotransmitter concentrations during cerebral ischemia in rats 显示文摘 | Kristin E Christian W William EH | 2003 | Anesth Analg2003，97，： | 1 |
| 8 | Prevention of Child Behavior Problems Through Universal Implementation of a Group Behavioral Family Intervention显示文摘 | Stephen R. Zubrick Kristine A. Ward Sven R. Silburn David Lawrence Anwen A. Williams Eve Blair Deborah Robertson Matthew R. Sanders | 2005 | Prevention Science2005，，4： | 1 |
| 9 | Mitochondrial Polymorphisms Significantly Reduce the Risk of Parkinson Disease显示文摘 | Joelle M. van der Walt Kristin K. Nicodemus Eden R. Martin William K. Scott Martha A. Nance Ray L. Watts Jean P. Hubble Jonathan L. Haines William C. Koller Kelly Lyons Rajesh Pahwa Matthew B. Stern Amy Colcher Bradley C. Hiner Joseph Jankovic William G. | 2003 | The American Journal of Human Genetics2003，，4： | 1 |
| 10 | Effect of Cardiac Resynchronization Therapy on Left Ventricular Size and Function in Chronic Heart Failure显示文摘 | Martin G. St John Sutton Ted Plappert William T. Abraham Andrew L. Smith David B. DeLurgio Angel R. Leon Evan Loh Dusan Z. Kocovic Westby G. Fisher Myrvin Ellestad John Messenger Kristin Kruger Kathryn E. Hilpisch Michael R.S. Hill | 2003 | Circulation: Journal of the American Heart Association2003，，： | 1 |
| 11 | Induction of specific antitumor immunity in the mouse with the electrofusion product of tumor cells and dendritic cells显示文摘 | Kristin LV Carrie | 2003 | Mol Ther2003，7，4： | 1 |
| 12 | Outcome of sustained virological responders with histologically advanced chronic hepatitis C显示文摘 | Timothy R. Morgan Marc G. Ghany Hae‐Young Kim Kristin K. Snow Mitchell L. Shiffman Jennifer L. De Santo William M. Lee Adrian M. Di Bisceglie Herbert L. Bonkovsky Jules L. Dienstag Chihiro Morishima Karen L. Lindsay Anna S. F. Lok | 2010 | Hepatology2010，，3： | 1 |
| 13 | The effect of sevoflu- rane and propofol on cerebral neurotransmitter concen trations dur- ing cerebrain ischemia in rat 显示文摘 | Kristin E Christian W William EH | 2003 | Anesth Analg2003，97，6： | 1 |
| 14 | Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo 显示文摘 | Jesse J Smith Renee Deehan Kenney David J Gagne Brian P Frushour William Ladd Heidi L Galonek Kristine Israelian Jeffrey Song Giedre Razvadauskaite Amy V Lynch David P Carney Robin J Johnson Siva Lavu Andre Iffland Peter J Elliott Philip D Lambert Keith O Elliston Michael R Jirousek Jill C Milne and Olivier Boss | 2009 | BMC Systems Biology2009，284，27： | 1 |
| 15 | Use of antidepressants near delivery and risk of postpartum hemorrhage:cohort study of low income women in the United States显示文摘 | Palmsten Kristin Hem6ndez- Dlaz Sonia Huybrechts Krista F Williams Paige L Michels Karir B Achtyes Eric D Mogun Helen Setoguchi Soko | 2013 | BMJ (Clinical research ed)2013，8，24： | 1 |
| 16 | The nemertine toxin anabaseine and its derivative DMXB-A (GTS-21) : Chemical and pharmaco- logical properties显示文摘 | WILLIAM K FERENC S KRISTIN W | 2006 | Mar Drugs2006，4，3： | 1 |
| 17 | Social Ostracism by Co-workers:Does Rejection Lead to Loafing or Compensation显示文摘 | Kipling Williams Kristin Sommer | | 0，，07： | 1 |
| 18 | Mesenchymal stem cell interaction with ultra-smooth nanostructured diamond for wear-resistant orthopaedic implants显示文摘 | William C. Clem Shafiul Chowdhury Shane A. Catledge Jeffrey J. Weimer Faheem M. Shaikh Kristin M. Hennessy Valery V. Konovalov Michael R. Hill Alfred Waterfeld Susan L. Bellis Yogesh K. Vohra | 2008 | Biomaterials2008，，： | 1 |
| 19 | Design and control of conventional and reactive distillation processes for the production of butyl acetate显示文摘 | William L Luyben Kristin M | 2004 | Ind Eng Chem Res2004，43，25： | 1 |
| 20 | LcrV Plague Vaccine with Altered Immunomodulatory Properties 显示文摘 | Katie AO William D Kristin LD | 2005 | Infect Immun2005，73，8： | 1 |
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