|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Surface modification of small intestine submucosa in tissue engineering显示文摘With the development of tissue engineering,the required biomaterials need to have the ability to promote cell adhesion and proliferation in vitro and in vivo.Especially,surface modification of the scaffold material has a great influence on biocompatibility and functionality of materials.The small intestine submucosa(SIS)is an extracellular matrix isolated from the submucosal layer of porcine jejunum,which has good tissue mechanical properties and regenerative activity,and is suitable for cell adhesion,proliferation and differentiation.In recent years,SIS is widely used in different areas of tissue reconstruction,such as blood vessels,bone,cartilage,bladder and ureter,etc.This paper discusses the main methods for surface modification of SIS to improve and optimize the performance of SIS bioscaffolds,including functional group bonding,protein adsorption,mineral coating,topography and formatting modification and drug combination.In addition,the reasonable combination of these methods also offers great improvement on SIS surface modification.This article makes a shallow review of the surface modification of SIS and its application in tissue engineering. | Pan Zhao Xiang Li Qin Fang Fanglin Wang Qiang Ao Xiaohong Wang Xiaohong Tian Hao Tong Shuling Bai Jun Fan | 2020 | Regenerative Biomaterials2020，7，4： | 9 |
| 2 | Autologous transplantation of adipose-derived mesenchymal stem cellsameliorates streptozotocin-induced diabetic nephropathy in rats by inhibitingoxidative stress, pro-inflammatory cytokines and the p38 MAPK signaling pathway显示文摘 | Yan Fang Xiaohong Tian Shuling Bai Jun Fan Weijian Hou Hao Tong Dehua Li | 2012 | International Journal of Molecular Medicine2012，，1： | 1 |
| 3 | Autologous transplantation of adipose-derived mesenchymal stem cellsameliorates streptozotocin-induced diabetic nephropathy in rats by inhibitingoxidative stress, pro-inflammatory cytokines and the p38 MAPK signaling pathway显示文摘 | Yan Fang Xiaohong Tian Shuling Bai Jun Fan Weijian Hou Hao Tong Dehua Li | 2012 | International Journal of Molecular Medicine2012，，1： | 1 |
| 4 | Metagenomics analysis identifies oral Streptococcus as potential biomarkers for nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma(NPC)is a malignancy originating from the nasopharyngeal epithelial cells.Although some studies have identified potential biomarkers for early diagnosis of NPC based on metabolomics data(Chen et al.,2023;Zhou et al.,2023)and Epstein-Barr virus subtypes(Xu et al.,2019),their effectiveness and applicability need further investigation,particularly when consideringthe roles of oral microbiota. | Yanmin Liu Chengtao Wang Lixiang Xie Shuling Du Li Ding Ying Cui Runzhi Chen Jingxiang Zhang Wan Wang Xi Liu Yan Wang Shiyan Chen Tian Tan Qiaochu Zhao Limei Yin Chunwei Li Yong Chen Tao Ding | 2024 | Journal of Genetics and Genomics2024，51，3： | 0 |
| 5 | Effect of growth hormone-releasing peptide on cardiac cholinergic nerve fiber density distribution in a rat model of heart failure显示文摘BACKGROUND:Changes in the cardiac autonomic nerve are considered to be important factors in the mechanisms of heart failure.It is possible to reduce or slow down nerve degeneration and necrosis,provided that patients take effective neuroprotectants during the early stages of heart failure.Moreover,it is possible to relieve the pathological process and reduce the risk of death. OBJECTIVE:To study the effect of growth hormone releasing peptide(GHRP) on cardiac cholinergic nerve fiber density distribution in a rat model of heart failure,and verify whether GHRP can ameliorate denervation. DESIGN,TIME AND SETTING:A randomized controlled study was performed at the Key Laboratory of Anatomy,Harbin Medical University,between June and October 2009. MATERIALS:Fifty adult,healthy,female,Wistar rats,weighing(200±20) g,were randomly divided into GHRP(n = 30),model(n = 10),and sham operation(n = 10) groups.GHRP-2 was made in Shanghai,China(batch No.z071212-03). METHODS:Acute myocardial infarction was established by ligating the left anterior descending coronary artery in the GHRP and model groups.Five weeks later,myocardial function was detected using color ultrasound electrocardiograph.Ejection fraction<60%was considered to be a successful marker of chronic heart failure models.However,the left anterior descending coronary artery was not ligated in the sham operation group.The GHRP group was injected with 100μg/kg GHRP-2,and the other two groups were injected with the same volume of physiological saline,once per day. MAIN OUTCOME MEASURES:After 4 weeks,pathological changes in cardiac cholinergic nerve fibers were detected under optic microscopy following hematoxylin/eosin staining.In addition, density distribution was measured using a multi-function color pathological image system. RESULTS:In the sham operation group,myocardial cells were regular,uniformly stained,and no inflammatory cells were present.In the model group,myocardial cells were unevenly stained, exhibited nuclear atrophy,degeneration,dissolution,or disappearance.In the GHRP group, myocardial damage was less than in the model group;cardiac muscle fibers exhibited slight degeneration.The myocardium in the sham operation group was serried,spreading the cholinergic innervations along the cardiac fiber.In the model group,there was a decreased number of cholinergic nerve fibers decreased,which also became shorter and smaller,compared with the sham operation group(P<0.01).In the GHRP group,cholinergic positive nerve fibers were significantly increased compared with the model group(P<0.01),but still less than the sham surgery group(P<0.05). CONCLUSION:GHRP delayed denervation and reduced nerve reconstitution following heart failure in rats. | Guozhong Tian Xiuqin Ni Yong Zhao Jia Feng Yanjun Li Zhenya Zhong Shuling Bai | 2009 | Neural Regeneration Research2009，4，4： | 0 |
| 6 | Uncertainty Quantification of Store-Separation Simulation Due to Ejector Modeling using a Monte Carlo Approach with Kriging Model显示文摘Precise calculation of the trajectory of store separation is critical in assess-ing whether the store can be released safely.Store ejection is the initial stage of the releasing process and any uncertainty introduced at this stage will propagate through the whole trajectory.In this work,the impact of the uncertainties in ejector modeling on the simulation of a generic store separation is investigated by using a Monte-Carlo-based approach.To reduce the extremely large computation cost resulted from the direct use CFD in Monte Carlo simulation,the CFD solutions are represented by a time-dependent Kriging model,which is constructed at each time step by using the samples from the URANS simulations.The stochastic outputs,including the distri-bution of probability density function,expected value and 95%confidence interval of store separation trajectory,are obtained by the Monte Carlo simulations.The sensitiv-ity analysis is also carried out by using the Monte-Carlo-based method to determine the most significant variables in ejector modeling,which affect the output uncertainty.Our results show that ejector modeling is one of the main uncertainty sources of store separation simulation and the approximation in ejector modeling can cause a signifi-cant deviation,especially in the angular displacement. | Shuling Tian Rongjie Li Jiawei Fu Zihan Jiao Jiangtao Chen | 2022 | Advances in Applied Mathematics and Mechanics2022，14，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员