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| 1 | Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression显示文摘Recently,increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease(AD)progression,yet the role of gut microbiota in AD pathogenesis remains obscure.Herein,we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression.Using AD mouse models,we discovered that,during AD progression,the alteration of gut microbiota composition leads to the peripheral accumulation of phenylalanine and isoleucine,which stimulates the differentiation and proliferation of pro-inflammatory T helper 1(Thl)cells.The brain-infiltrated peripheral Th1 immune cells are associated with the Ml microglia aaivation,contributing to AD-associated neuroinflammation.Importantly,the elevation of phenylalanine and isoleucine concentrations and the increase of Th1 cell frequency in the blood were also observed in two small independent cohorts of patients with mild cognitive impairment(MCI)due to AD.Furthermore,GV-971,a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China,suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation,harnesses neuroinflammation and reverses the cognition impairment.Together,our findings highlight the role of gut dysbiosis-promoted neuroinflammation in AD progression and suggest a novel strategy for AD therapy by remodelling the gut microbiota. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2019 | Cell Research2019，29，10： | 192 |
| 2 | Towards 6G wireless communication networks:vision,enabling technologies,and new paradigm shifts显示文摘The fifth generation(5G)wireless communication networks are being deployed worldwide from 2020 and more capabilities are in the process of being standardized,such as mass connectivity,ultra-reliability,and guaranteed low latency.However,5G will not meet all requirements of the future in 2030 and beyond,and sixth generation(6G)wireless communication networks are expected to provide global coverage,enhanced spectral/energy/cost efficiency,better intelligence level and security,etc.To meet these requirements,6G networks will rely on new enabling technologies,i.e.,air interface and transmission technologies and novel network architecture,such as waveform design,multiple access,channel coding schemes,multi-antenna technologies,network slicing,cell-free architecture,and cloud/fog/edge computing.Our vision on 6G is that it will have four new paradigm shifts.First,to satisfy the requirement of global coverage,6G will not be limited to terrestrial communication networks,which will need to be complemented with non-terrestrial networks such as satellite and unmanned aerial vehicle(UAV)communication networks,thus achieving a space-airground-sea integrated communication network.Second,all spectra will be fully explored to further increase data rates and connection density,including the sub-6GHz,millimeter wave(mmWave),terahertz(THz),and optical frequency bands.Third,facing the big datasets generated by the use of extremely heterogeneous networks,diverse communication scenarios,large numbers of antennas,wide bandwidths,and new service requirements,6G networks will enable a new range of smart applications with the aid of artificial intelligence(AI)and big data technologies.Fourth,network security will have to be strengthened when developing 6G networks.This article provides a comprehensive survey of recent advances and future trends in these four aspects.Clearly,6G with additional technical requirements beyond those of 5G will enable faster and further communications to the extent that the boundary between physical and cyber worlds disappears. | Xiaohu YOU Cheng-Xiang WANG Jie HUANG Xiqi GAO Zaichen ZHANG Mao WANG Yongming HUANG Chuan ZHANG Yanxiang JIANG Jiaheng WANG Min ZHU Bin SHENG Dongming WANG Zhiwen PAN Pengcheng ZHU Yang YANG Zening LIU Ping ZHANG Xiaofeng TAO Shaoqian LI Zhi CHEN Xinying MA Chih-Lin I Shuangfeng HAN Ke LI Chengkang PAN Zhimin ZHENG Lajos HANZO Xuemin(Sherman)SHEN Yingjie Jay GUO Zhiguo DING Harald HAAS Wen TONG Peiying ZHU Ganghua YANG Jun WANG Erik GLARSSON Hien Quoc NGO Wei HONG Haiming WANG Debin HOU Jixin CHEN Zhe CHEN Zhangcheng HAO Geoffrey Ye LI Rahim TAFAZOLLI Yue GAO HVincent POOR Gerhard P.FETTWEIS Ying-Chang LIANG | 2021 | Science China(Information Sciences)2021，64，1： | 122 |
| 3 | Effects of AT1 receptor antagonist,Iosartan,on rat hepatic fibrosis induced by CCl_4显示文摘AIM To investigate effect of losartan,an AT1receptor antagonist,on hepatic fibrosis induced byCCl;and to determine whether or not AT1receptors are expressed on hepatic stellate cells,METHODS AND RESULTS Fifty male Sprague-Dawley rats,weighing(180±20)g,wererandomized into five groups(control group,modelgroup,and three losartan treated groups),inwhich all rats were given the subcutaneousinjection of 40% CCl4(every 3 days for 6 weeks)except for rats of control group.Rats of losartan-treated groups were treated with losartan(20 mg/kg,10 mg/kg,5 mg/kg,daily gavage),After 6weeks liver tissue and serum samples of all ratswere examined.Serum hyaluronic acid(HA),procollagen typeⅢ(PCⅢ)were detected byradioimmunoassays,van Giesion collagen stainingwas used to evaluate the extracellular matrix of ratswith liver fibrosis.The expression of AT1receptors,transforming growth factor-beta(TGF-β),and alpha-smooth muscle actin(a-SMA)inliver tissue were determined byimmunohistochemical techniques.Compared withmodel group,serum ALT and AST of losartan-treated groups were significantly reduced(t=4.20,P<0.01 and t=4.57,P<0.01).Serum HAand PCⅢalso had significant differences(t=3.53,P<0.01 and t=2.20,P<0.05).Thedegree of fibrosis was improved by losartan and correlated with the expressions of AT1 receptors,TGF-β,and α-SMA in liver tissue.CONCLUSION AT1 receptor antagonist,losartan,could limit the progression of the hepatic fibrosisinduced by CCl4.The mechanism may be related tothe decrease in the expression of AT1 receptorsand TGF-β,ameliorating the injury of hepatocytes;activation of local renin-angiotensin system mightrelate to hepatic fibrosis;and during progressionof fibrosis,activated hepatic stellate cells mightexpress AT1 receptors. | Hong Shan Wei Ding Guo Li Han Ming Lu Yu Tao Zhan Zhi Rong Wang Xin Huang Jing Zhang Ji Lin Cheng Qin Fang Xu Department of Gastroenterology,Xinhua Hospital,Shanghai Second Medical University,Shanghai 200092,China | 2000 | World Journal of Gastroenterology2000，6，4： | 42 |
| 4 | Sevoflurane postconditioning reduces myocardial reperfusion injury in rat isolated hearts via activation of PI3K/Akt signaling and modulation of Bcl-2 family proteins显示文摘Sevoflurane postconditioning reduces myocardial infarct size.The objective of this study was to examine the role of the phosphatidylinositol-3-kinase(PI3K)/Akt pathway in anesthetic postconditioning and to determine whether PI3K/Akt signaling modulates the expression of pro-and antiapoptotic proteins in sevoflurane postconditioning.Isolated and perfused rat hearts were prepared first,and then randomly assigned to the following groups:Sham-operation(Sham),ischemia/reperfusion(Con),sevoflurane postconditioning(SPC),Sham plus 100 nmol/L wortmannin(Sham+Wort),Con+Wort,SPC+Wort,and Con+dimethylsulphoxide(DMSO).Sevoflurane postconditioning was induced by administration of sevoflurane(2.5%,v/v) for 10 min from the onset of reperfusion.Left ventricular developed pressure(LVDP),left ventricular end-diastolic pressure(LVEDP),maximum increase in rate of LVDP(+dP/dt),maximum decrease in rate of LVDP(?dP/dt),heart rate(HR),and coronary flow(CF) were measured at baseline,R30 min(30 min of reperfusion),R60 min,R90 min,and R120 min.Creatine kinase(CK) and lactate dehydrogenase(LDH) were measured after 5 min and 10 min reperfusion.Infarct size was determined by triphenyltetrazolium chloride staining at the end of reperfusion.Total Akt and phosphorylated Akt(phospho-Akt),Bax,Bcl-2,Bad,and phospho-Bad were determined by Western blot analysis.Analysis of variance(ANOVA) and Student-Newman-Keuls' test were used to investigate the significance of differences between groups.The LVDP,±dP/dt,and CF were higher and LVEDP was lower in the SPC group than in the Con group at all points of reperfusion(P<0.05).The SPC group had significantly reduced CK and LDH release and decreased infarct size compared with the Con group [(22.9±8)% vs.(42.4±9.4)%,respectively;P<0.05].The SPC group also had increased the expression of phospho-Akt,Bcl-2,and phospho-Bad,and decreased the expression of Bax.Wortmannin abolished the cardioprotection of sevoflurane postconditioning.Sevoflurane postconditioning may protect the isolated rat heart.Activation of PI3K and modulation of the expression of pro-and antiapoptotic proteins may play an important role in sevoflurane-induced myocardial protection. | Li-na YU Jing YU Feng-jiang ZHANG Mei-juan YANG Ting-ting DING Jun-kuan WANG Wei HE Tao FANG Gang CHEN Min YAN | 2010 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2010，11，9： | 36 |
| 5 | Multispherical interactions and their effects on the Tibetan Plateau's earth system: a review of the recent researches显示文摘The Tibetan Plateau(TP) is a regional Earth system showing very strong interactions among its lithosphere, hydrosphere, cryosphere, biosphere, atmosphere, and anthrosphere. hese interactions manifest TP's impact on surrounding regions and relect TP's response to the global change. Quantifying the multispherical interactions is critically important to understand the TP environment. Our recent years researches including the ongoing program entitled ‘Tibetan Multi-Spheres Interactions and heir Resource-Environment Signiicance(TIMI)', the completed program entitled. ‘Paleo-Altitudes of Tibetan Plateau and Environment(PATE)', as well as the other relating projects have focused on multidisciplinary research approaches and emphasized on three major pathways: Eurasia-Indian plates collision on deep-Earth dynamics, uplit impact on Earth's mantle–crust dynamics, and contemporary interface on land surface and atmospheric dynamics. Our researches have taken in situ measurement as priority and developed several platforms of data acquisition and analysis, including the platforms of water-phase transformations, and ecosystem observations. Our ield investigations have been conducted to obtain data about stratum, paleontology, paleoenvironment, genetic diferentiation of animals and plants. We have developed conceptual and mathematical models for crust uplit formation, paleoclimate, glacial melt,water–air interface lux, vegetation climate, and soil erosion. We have also assessed the anthropogenic impacts on environment. Our researches have achieved new and reliable redating of the mantle–crust interaction and initial formation of the TP, found the interaction between tectonics and uplit of the TP and resultant paleoaltitude acting as a spreading source; discovered the interaction between the westerlies and Indian monsoon acting as a control chain that dominates the TP's contemporary environment. he scientiic results can play fundamental roles in supporting the TP's resource exploration and societal sustainable development. | Tandong Yao Fuyuan Wu Lin Ding Jimin Sun Liping Zhu Shilong Piao Tao Deng Xijun Ni Hongbo Zheng Hua Ouyang | 2015 | National Science Review2015，2，4： | 35 |
| 6 | Paleoaltimetry reconstructions of the Tibetan Plateau:progress and contradictions显示文摘Over the last two decades, many quantitative paleoaltimetry reconstructions of the Tibetan Plateau have been published, but they are still preliminary and controversial, although several approaches have been combined paleontology and geochemistry, including vertebrate, plant, and pollen fossils as well as oxygen,carbon, and hydrogen isotopes. he Tibetan Plateau is the youngest and highest plateau on Earth, and its paleoaltimetry reconstructions are crucial to interpret its geodynamic evolution and to understand the climatic changes in Asia. Uplit histories of the Tibetan Plateau based on diferent proxies difer considerably, and two viewpoints are pointedly opposing on the paleoaltimetry estimations of the Tibetan Plateau. One viewpoint is that the Tibetan Plateau did not strongly uplit to reach its modern elevation until the Late Miocene, but another one, mainly based on stable isotopes, argues that the Tibetan Plateau formed early during the Indo-Asian collision and reached its modern elevation in the Paleogene or by the Middle Miocene. With either a geochemical or paleontological approach, the present is used as the key to the past.However, there are great diiculties because modern processes of isotopic fractionation and species for creature distribution are not easily precisely determined. In addition, the climatic and environmental backgrounds of past geological times have massive diferences from the present, and associated adjustments are inluenced by many human factors. In the future work, the applications of multidisciplinary comprehensive methods and cross-checks of their results will be productive, and we look forward to achieving more reliable estimates for paleoelevations of the Tibetan Plateau. | Tao Deng Lin Ding | 2015 | National Science Review2015，2，4： | 29 |
| 7 | The regulatory role of AT 1 receptor on activated HSCs in hepat,c fibrogenesis,effects of RAS inhibitors on hepatic fibrosis induced by CCl_4显示文摘AIM To assess the effect of ACE inhibitor andAng Ⅱ type Ⅰ(AT1)receptor antagonist inpreventing hepatic fibrosis caused by CCl4administration in rats;to investigate whether ornot there are expression of AT 1 receptors onhepatic stellate cells;and to observe the effectof Ang Ⅱ on proliferation and ECM synthesis ofcultured HSCs.METHODS Studies were conducted in maleSprague-Dawley rats.Except for thehepatofibrotic model group and the controlgroup,in three treated groups,either enalapril(5 mg/kg),or Iosartan(10 mg/kg),or enalapril+Iosartan were given to the fibrotic rats bydaily gavage,and saline vehicle was given tomodel and normal control rats.After 6 weeks,liver fibrosis was assessed directly by hepaticmorphometric analysis,which has beenconsidered the gold standard for thequantification of fibrosis.The expressions of AT1 receptors and(α-mooth muscle actin,α-SMA)in liver tissue or isolated hepatic stellate cells(HSCs)were detected by immunohistochemicaltechniques.The effect of Ang Ⅱ on HSCproliferation was determined by MTT method.Effect of Ang Ⅱ on collagen synthesis of HSCswas determined by 3H-proline incorporation.RESULTS Contrasted to the fibrosis in rats ofthe model group,groups of rats treated with either enalapril or Iosartan,or a combination oftwo drugs showed a limited expansion of theinterstitium(4.23±3.70 vs 11.22±4.79,P<0.05),but no difference was observedamong three treated groups(5.38±3.43,4.96±2.96,4.23±2.70,P>0.05).Expression of AT 1receptors was found in fibrotic interstitium offibrotic rats,whereas in normal control rats theywere limited to vasculature only to a very slightdegree.AT 1 receptors were also expressed onactivated HSCs in the culture.At concentrationsfrom 10-9to 10-5mol/L,Ang Ⅱ stimulated HSCproliferation in culture in a dose-dependentmanner.Increasing Ang Ⅱ concentrationsproduced corresponding increases in 3H-prolineincorporation.Differences among groups were significant.CONCLUSION Angiotensin-converting enzyme inhibitors and AT I blocker may slow the progression of hepatic fibrosis; activated HSCs express AT 1 receptors, and Ang Ⅱ can stimulate the proliferation and collagen synthesis of HSCs in a dose-dependent manner; and activation of RAS may be related to hepatic fibrogenesis induced by CCI4. | Hong Shan Wei Han Ming Lu Ding Guo Li Yu Tao Zhan Zhi Rong Wang Xin Huang Ji Lin Cheng Qin Fang Xu Department of Gastroenterology,Xinhua Hospital,Shanghai Second Medical University,Shanghai 200092,China | 2000 | World Journal of Gastroenterology2000，6，6： | 27 |
| 8 | Tillage and straw mulching impacts on grain yield and water use efficiency of spring maize in Northern Huang–Huai–Hai Valley显示文摘A two-year field experiment(2012–2013) was conducted to investigate the effects of two tillage methods and five maize straw mulching patterns on the yield, water consumption,and water use efficiency(WUE) of spring maize(Zea mays L.) in the northern Huang–Huai–Hai valley of China. Compared to rotary tillage, subsoil tillage resulted in decreases in water consumption by 6.3–7.8% and increases in maize yield by 644.5–673.9 kg ha-1, soil water content by 2.9–3.0%, and WUE by 12.7–15.2%. Chopped straw mulching led to higher yield,soil water content, and WUE as well as lower water consumption than prostrate whole straw mulching. Mulching with 50% chopped straw had the largest positive effects on maize yield, soil water content, and WUE among the five mulching treatments. Tillage had greater influence on maize yield than straw mulching, whereas straw mulching had greater influence on soil water content, water consumption, and WUE than tillage. These results suggest that 50% chopped straw mulching with subsoil tillage is beneficial in spring maize production aiming at high yield and high WUE in the Huang–Huai–Hai valley. | Zhiqiang Tao Congfeng Li Jingjing Li Zaisong Ding Jie Xu Xuefang Sun Peilu Zhou Ming Zhao | 2015 | The Crop Journal2015，3，5： | 26 |
| 9 | The effect of an electric field on the thermomechanical damage of nodular defects in dielectric multilayer coatings irradiated by nanosecond laser pulses显示文摘Thermomechanical damage of nodules in dielectric multilayer coatings that are irradiated by nanosecond laser pulses has been interpreted with respect to mechanical properties and electric-field enhancement.However,the effect of electric-field enhancement in nodular damage,especially the influence of electric-field distributions,has never been directly demonstrated through experimental results,which prevents the achievement of a clear understanding of the damage process of nodular defects.Here,a systematic and comparative study was designed to reveal how electric-field distributions affect the damage behavior of nodules.To obtain reliable results,two series of artificial nodules with different geometries and film absorption characteristics were prepared from monodisperse silica microspheres.After establishing simplified geometrical models of the nodules,the electric-field enhancement was simulated using a three-dimensional finite-difference time-domain code.Then,the damage morphologies of the artificial nodules were directly compared with the simulated electric-field intensity profiles.For both series of nodules,the damage morphologies reproduced our simulated electric-field intensity distributions very well.These results indicated that the electric-field distribution was actually a bridge that connected the nodular mechanical properties to the final thermomechanical damage.Understanding of the damage mechanism of nodules was deepened by obtaining data on the influence of electric-field distributions on the damage behavior of nodules. | Xinbin Cheng Jinlong Zhang Tao Ding Zeyong Wei Hongqiang Li Zhanshan Wang | 2013 | Light(Science & Applications)2013，2，1： | 20 |
| 10 | Environmental variability study on the measured responses of Runyang Cablestayed Bridge using wavelet packet analysis显示文摘The structural damage alarming method based on wavelet packet energy spectrum (WPES) for long-span cable-stayed bridges is presented through combination of ambient vibration test and wavelet packet analysis. The environmental variability in the measured WPES and damage alarming indices ERVD of the Runyang Cable-stayed Bridge are discussed in detail using the wavelet packet analysis of the measured acceleration responses of the bridge under daily environmental conditions. The analysis results reveal that the actual environmental conditions including traffic loadings, environmental temperature and typhoon loadings have remarkable correlations with the measured WPES. The changes of environmental temperature have a long-term trend influence on the WPES, while the influences of traffic and typhoon loadings on the measured WPES of the bridge present instantaneous changes because of the nonstationary properties of the loadings. The analysis results of the measured responses further reveal that the damage alarming indices ERVD can sensitively reflect the influences of environmental temperature and typhoon loadings on the dynamic properties of Runyang Cable-stayed Bridge. Therefore, the proposed structural damage alarming indices ERVD under ambient vibrations are suitable for real-time damage alarming for long-span cable-stayed bridges. | DING YouLiang LI AiQun LIU Tao | 2008 | Science China(Technological Sciences)2008，51，5： | 20 |
| 11 | Changes of meibomian glands in patients with type 2diabetes mellitus显示文摘AIM: To investigate the morphological changes of meibomian glands in patients with type 2 diabetes mellitus(DM).·METHODS: Of 118 eyes(118 patients) with type 2 DM(DM group) and 100 eyes of 100 control subjects(control group) were enrolled. After completing an ocular surface disease index(OSDI) questionnaire, the non-invasive tear film break-up time(NI-BUT) and the structure of the meibomian glands(MGs, meibography) were assessed by the Keratograph 5M system. Partial or complete loss of MG was scored for each eyelid from grade 0(no loss) to grade 3(lost area was >2/3 of the total MG area), which were also examined by laser scanning confocal microscopy(LSCM). The primary outcomes were meibomian gland acinar unit density(MGAUD),meibomian gland acinar longest diameter(MGALD) and meibomian gland acinar shortest diameter(MGASD).·RESULTS: Compared with control group, the OSDI was significantly higher in DM group(Z =-5.916; P <0.001),while the NI-BUT was significantly lower(Z =-7.765; P <0.001). Keratograph showed that there were more MGs dropout in DM group than that in control group. The meiboscore was significantly higher in DM group compared with control group(Z =-3.937; P <0.001).LSCM revealed that there were cytological alterations of MGs in DM group compared with control group, which included enlargement of MG acinar units and decreased in density of MG acinar units. Specifically, there were lower MGAUD, larger MGALD and MGASD in DM group than control group(Z =-10.120,-9.4442,-7.771; P <0.001).· CONCLUSION: Compared with the normal control participants, the patients with type 2 DM had more unstable tear films and severe symptoms of dry eye.Using Keratograph 5M system and LSCM, we found that the patients with type 2 DM had more significant morphological and cytological changes and dysfunction in MGs. | Tao Yu Wei-Yun Shi Ai-Ping Song Yang Gao Guang-FuDang Gang Ding | 2016 | International Journal of Ophthalmology(English edition)2016，9，12： | 19 |
| 12 | Comparison of Undernutrition Prevalence of Children under 5 Years in China between 2002 and 2013显示文摘Objective To describe the undernutrition status of children under 5-year in China, and study the trend between 2002 and 2013. Methods The study was based on two national surveys. Undernutrition was determined against WHO's 2006 growth standards. The prevalence in 2013 and 2002 was weighted by China sixth National Population Census(2010). The relationship between undernutrition and gender/age groups/different areas use weighted logistic regression. Results The results indicated the overall prevalence of stunting, underweight, and wasting of Chinese children under 5-year was 8.1%, 2.4%, and 1.9% in 2013, respectively. The prevalence of stunting was higher for children aged 12-47 month, while underweight was higher for children aged 48-59 month. The prevalence of undernutrition was higher in rural areas than in urban areas, especially in poor rural areas. There was a decline of stunting, underweight, and wasting between 2002 and 2013 among the children, with greater reduction in rural areas than in urban areas. Conclusion The prevalence of undernutrition of children under 5-year remains high in rural areas especially in poor rural areas in China. It is urgent to take action to control undernutrition in the vulnerable areas and subgroups. | YU Dong Mei ZHAO Li Yun YANG Zhen Yu CHANG Su Ying YU Wen Tao FANG Hong Yun WANG Xun YU Dan GUO Qi Ya XU Xiao Li FANG Yue Hui ZHAO Wen Hua YANG Xiao Guang DING Gang Qiang LIANG Xiao Feng | 2016 | Biomedical and Environmental Sciences2016，29，3： | 18 |
| 13 | Mobile-robotic machining for large complex components:A review study显示文摘Even though the robotic machining has achieved great success in machining of small components, it lacks the competence to machine large complex components, such as wind turbine blade, train carriage, and aircraft wing. In order to cope with this issue,the mobile machining robot system, which consists of a robot arm integrated with a mobile platform, is proposed to achieve the large workspace and high dexterity, and thus has the potential to machine the large complex components. However, due to the limitation of motion accuracy and structural stiffness, the current mobile-robots are hard to satisfy the high precision requirement of machining tasks. In this paper, some historical mobile-robotic machining systems are reviewed firstly, followed by some key techniques related to structure optimization, dynamics of the machining process, localization, and control techniques, which are fundamental for the structural stiffness and motion accuracy of mobile-robots. Finally, the prospect of mobile-robotic machining and the open questions are addressed. | TAO Bo ZHAO XingWei DING Han | 2019 | Science China(Technological Sciences)2019，62，8： | 17 |
| 14 | A Dual-mode Nonlinear Model Predictive Control with the Enlarged Terminal Constraint Sets显示文摘Aiming at a class of nonlinear systems with multiple equilibrium points, we present a dual-mode model predictive control algorithm with extended terminal constraint set combined with control invariant set and gain schedule. Local LQR control laws and the corresponding maximum control invariant sets can be designed for finite equilibrium points. It is guaranteed that control invariant sets are overlapped each other. The union of the control invariant sets is treated as the terminal constraint set of predictive control. The feasibility and stability of the novel dual-mode model predictive control are investigated with both variable and fixed horizon. Because of the introduction of extended terminal constrained set, the feasibility of optimization can be guaranteed with short prediction horizon. In this way, the size of the optimization problem is reduced so it is computationally efficient. Finally, a simulation example illustrating the algorithm is presented. | ZOU Tao LI Shao-Yuao DING Bao-Cang | 2006 | 自动化学报2006，32，1： | 16 |
| 15 | Effects of continuously regenerating diesel particulate filters on regulated emissions and number-size distribution of particles emitted from a diesel engine显示文摘The effects of continuously regenerating diesel particulate filter (CRDPF) systems on regulated gaseous emissions, and number-size distribution and mass of particles emanated from a diesel engine have been investigated in this study. Two CRDPF units (CRDPF-1 and CRDPF-2) with different specifications were separately retrofitted to the engine running with European steady-state cycle (ESC). An electrical low pressure impactor (ELPI) was used for particle number-size distribution measurement and mass estimation. The conversion/reduction rate (R CR ) of hydrocarbons (HC) and carbon monoxide (CO) across CRDPF-1 was 83% and 96.3%, respectively. Similarly, the R CR of HC and CO and across CRDPF-2 was 91.8% and 99.1%, respectively. The number concentration of particles and their concentration peaks; nuclei mode, accumulation mode and total particles; and particle mass were highly reduced with the CRDPF units. The nuclei mode particles at downstream of CRDPF-1 and CRDPF-2 decreased by 99.9% to 100% and 97.8% to 99.8% respectively; and the particle mass reduced by 73% to 92.2% and 35.3% to 72.4%, respectively, depending on the engine conditions. In addition, nuclei mode particles increased with the increasing of engine speed due to the heterogeneous nucleation initiated by the higher exhaust temperature, while accumulation mode particles were higher at higher loads due to the decrease in the air-to-fuel ratio (A/F) at higher loads. | Zhihua Liu Asad Naeem Shah Yunshan Ge Yan Ding, Jianwei Tan Lei Jiang Linxiao Yu Wei Zhao Chu Wang Tao Zeng | 2011 | Journal of Environmental Sciences2011，23，5： | 15 |
| 16 | Liver transplant recipients with portal vein thrombosis:a single center retrospective study显示文摘BACKGROUND:Portal vein thrombosis(PVT)used to be a contraindication for liver transplantation(LT).This obstacle has been delt with following the improvement of LT-related techniques and therapeutic approaches to thrombosis. But the effect of PVT on LT outcomes is still controversial. We reviewed retrospectively the outcome of LT patients with PVT as well as risk factors and surgical management according to PVT grades. METHODS:A total of 465 adult LTs were performed from December 2002 through December 2006.Operative findings and the result of preoperative ultrasonography and imaging were reviewed for PVT grading(Yerdel grading).Comparison of risk factors,variables associated with perioperative period and prognosis between recipients with and without PVT is based on the grades. RESULTS:In the 465 LTs,42 were operatively confirmed to have PVT(9.0%)(19 recipients with grade 1,14 with grade 2,7 with grade 3,and 2 with grade 4).Increased age and treatment of portal hypertension were associated with PVT.Grade 1 or 2 PVT was treated by direct anastomosis or single thrombectomy.In grade 3 PVT patients,the donor PV was directly anastomosed to the dilated branch of the recipient portal venous system or to the distal open superior mesenteric vein through an interposition vein graft if needed.Grade 4 PVT was managed by our modified cavoportal hemitransposition technique.The comparison between PVT patients and controls showed no significant difference in operative duration and blood transfusion(P>0.05).The flow rate of the PV was lower in the PVT patients(48.881±12.788 cm/s)than in the controls(57.172±21.715 cm/s,P<0.05).The PVT patients had such postoperative complications as renal failure and PV rethrombosis(P<0.05).The 1-year survival rates in PVT and non-PVT patients were 78.6%and 76.4%respectively (P>0.05);the 3-year survival rates were 58.8%and 56.4% respectively(P>0.05). CONCLUSIONS:PVT is not contraindicated for LT if it is graded.PVT recipients may have post-transplantation complications like renal failure and PV rethrombosis,and operative difficulty and patient survival are similar to those in recipients without PVT.Development of therapeutic approaches and accumulation of experience in dealing with PVT further improve the outcomes of LT in PVT recipients. | Tao, Yi-Feng Teng, Fei Wang, Zheng-Xin Guo, Wen-Yuan Shi, Xiao-Min Wang, Gui-Hua Ding, Guo-Shan Fu, Zhi-Ren | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，1： | 14 |
| 17 | Baicalein attenuates cardiac hypertrophy in mice via suppressing oxidative stress and activating autophagy in cardiomyocytes显示文摘Baicalein is a natural flavonoid extracted from the root of Scutellaria baicalensis that exhibits a variety of pharmacological activities.In this study,we investigated the molecular mechanisms underlying the protective effect of baicalein against cardiac hypertrophy in vivo and in vitro.Cardiac hypertrophy was induced in mice by injection of isoproterenol(ISO,30 mg·kg^(−1)·d^(−1))for 15 days.The mice received caudal vein injection of baicalein(25 mg/kg)on 3rd,6th,9th,12th,and 15th days.We showed that baicalein administration significantly attenuated ISO-induced cardiac hypertrophy and restored cardiac function.The protective effect of baicalein against cardiac hypertrophy was also observed in neonatal rat cardiomyocytes treated with ISO(10μM).In cardiomyocytes,ISO treatment markedly increased reactive oxygen species(ROS)and inhibited autophagy,which were greatly alleviated by pretreatment with baicalein(30μM).We found that baicalein pretreatment increased the expression of catalase and the mitophagy receptor FUN14 domain containing 1(FUNDC1)to clear ROS and promote autophagy,thus attenuated ISO-induced cardiac hypertrophy.Furthermore,we revealed that baicalein bound to the transcription factor FOXO3a directly,promoting its transcription activity,and transactivated catalase and FUNDC1.In summary,our data provide new evidence for baicalein and FOXO3a in the regulation of ISO-induced cardiac hypertrophy.Baicalein has great potential for the treatment of cardiac hypertrophy. | Bing-yan Liu Ling Li Gao-li Liu Wei Ding Wen-guang Chang Tao Xu Xiao-yu Ji Xian-xin Zheng Jing Zhang Jian-xun Wang | 2021 | Acta Pharmacologica Sinica2021，42，5： | 13 |
| 18 | Chinese Hα Solar Explorer(CHASE)——a complementary space mission to the ASO-S显示文摘The Chinese HαSolar Explorer(CHASE)is designed to test a newly developed satellite platform and conduct solar observations.The scientific payload of the satellite is an Hαimaging spectrograph(HIS),which can,for the first time,acquire full-disk spectroscopic solar observations in the Hαwaveband.This paper briefly introduces CHASE/HIS including its scientific objectives,technical parameters,scientific application system,etc.The CHASE mission is scheduled to launch in 2021.It will complement the observations by on-orbit solar spacecraft(such as SDO,IRIS,STEREO and PSP),as well as future solar missions of the Solar Orbiter and Advanced Space-based Solar Observatory(ASO-S). | Chuan Li Cheng Fang Zhen Li Ming-De Ding Peng-Fei Chen Zhe Chen Liang-Kui Lin Chang-Zheng Chen Chang-Ya Chen Hong-Jiang Tao Wei You Qi Hao Yu Dai Xin Cheng Yang Guo Jie Hong Min-Jie An Wei-Qiang Cheng Jian-Xin Chen Wei Wang Wei Zhang | 2019 | Research in Astronomy and Astrophysics2019，19，11： | 12 |
| 19 | Expression changes of activin A in the development of hepatic fibrosis显示文摘AIM To examine the expression of activin A, amember of the transforming growth factor (TGF-β) superfamily, recently has been reported to beoverexpressed in liver cirrhosis, in the course ofcarbon tetrachloride-induced rat hepaticfibrosis.METHODS Hepatic fibrosis was induced in ratsby subcutaneous injections of 40% carbontetrachloride oily solution for a period of 1 to 7weeks. At the end of 1, 2, 3, 4, 5, 6 and 7 weeksafter carbon tetrachloride injections, the ratswere killed in group (6- 10 rats each time) forstudy. The activin A messenger RNA expressionand its protein localization were assessed bysemi-quantitative reverse transcriptionpolymerase chain reaction ( RT-PCR ) andimmunohistochemistry.RESULTS The normal rat liver expressedactivin A mRNA and protein, and its expressionwas transiently decreased and becameundetectable after carbon tetrachlorideinjections for 2 or 3 weeks and then increasedgradually. After injection of carbon tetrachloridefor 6 and 7 weeks, activin A mRNA and proteinexpressions were significantly enchanced in ratliver. Compared with that of the normal ratliver. Activin A mRNA expression levels in ratsreceiving carbon tetrachloride injections for 6and 7 weeks were 1.6 and 2.2 times that of thosein normal rat liver respectively (0.456±0.094 vs0.286± 0.0670, P<0.01; 0.620± 0.134 vs 0.286±± 0.0670, P<0.01). Immunohistochemistryshowed that activin A expressed in hepatocytesof normal liver, and its expression wasdecreased in rats receiving carbon tetrachloridefor 2 or 3 weeks. Compared with normal liver,activin A expression distribution mode changedin fibrotic liver, being increased significantly inhepatocytes around fibrotic areas.CONCLUSION Activin A expression wasincreased in latestage of hepatic fibrosis, andthis may be involved in hepatic fibrosisformation in this period. | Xin Huang1 Ding Guo Li1 Zhi Rong Wang1 Hong Shan Wei1 Ji Lin Cheng1 Yu Tao Zhan1 Xin Zhou1 Qin Fang Xu1 Xin Li2 Han Ming Lu1 1Xinhua Hospital, Shanghai Second Medical University, Shanghai 200092, China2Ninth Hospital. Shanghai Second Medical University, Shanghai 200011. China | 2001 | World Journal of Gastroenterology2001，7，1： | 12 |
| 20 | Resistant mutants induced by adefovir dipivoxil in hepatitis B virus isolates显示文摘AIM:To investigate the loci of adefovir dipivoxil(ADV)-induced resistance in hepatitis B virus(HBV)isolates and optimize the management of ADV-treated patients.METHODS:Between June 2008 and August 2010,a cross-sectional control study was conducted comprising 79 patients with chronic HBV infection-related liver disease who had been administered ADV monotherapy.Patients underwent liver imaging.Serum DNA extracts were analyzed for HBV DNA levels,genotypes,and serology markers,and deep sequencing of the HBV P gene was performed.RESULTS:ADV-resistant patients were found either with a single mutated locus,or with coexisting mutated loci.The most prevalent mutations were rt A181T,rt V214A,and rt N236T.Twenty-six patients had more than two mutated loci.The mutants were distributed among the patients without any significant affinity for gender,age,end-stage of liver disease,complications of non-alcoholic fatty liver disease,or HBV DNA levels.Patients with the rt A181T mutant were primarily infected with genotype C and e-antigen negative HBV,while patients with the rt N236T mutant were primarily infected by genotype B HBV(χ2=6.004,7.159;P=0.023,0.007).The duration of treatment with ADV was shorter in the single mutant group compared with the multi-mutant group(t=2.426,P=0.018).CONCLUSION:Drug-resistant HBV mutants are complex and diverse.Patients should receive the standard and first-line antiviral treatment,strictly comply with medication dosage,and avoid short-term withdrawal. | Su-Wen Jiang Li-Peng Yao Ai-Rong Hu Yao-Ren Hu Shi-Xiang Chen Tao Xiong Guo-Sheng Gao Xiao-Yue Liang Shi-Xiong Ding Peng-Jian Weng | 2014 | World Journal of Gastroenterology2014，20，45： | 12 |
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