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| 1 | Connecting Calcium-Based Nanomaterials and Cancer:From Diagnosis to Therapy显示文摘As the indispensable second cellular messenger,calcium signaling is involved in the regulation of almost all physiological processes by activating specific target proteins.The importance of calcium ions(Ca^(2+))makes its“Janus nature”strictly regulated by its concentration.Abnormal regulation of calcium signals may cause some diseases;however,artificial regulation of calcium homeostasis in local lesions may also play a therapeutic role.“Calcium overload,”for example,is characterized by excessive enrichment of intracellular Ca^(2+),which irreversibly switches calcium signaling from“positive regulation”to“reverse destruction,”leading to cell death.However,this undesirable death could be defined as“calcicoptosis”to offer a novel approach for cancer treatment.Indeed,Ca^(2+)is involved in various cancer diagnostic and therapeutic events,including calcium overload-induced calcium homeostasis disorder,calcium channels dysregulation,mitochondrial dysfunction,calcium-associated immunoregulation,cell/vascular/tumor calcification,and calcification-mediated CT imaging.In paral-lel,the development of multifunctional calcium-based nanomaterials(e.g.,calcium phosphate,calcium carbonate,calcium peroxide,and hydroxyapatite)is becoming abundantly available.This review will highlight the latest insights of the calcium-based nanomaterials,explain their application,and provide novel perspective.Identifying and characterizing new patterns of calcium-dependent signaling and exploiting the disease element linkage offer additional translational opportunities for cancer theranostics. | Shuang Bai Yulu Lan Shiying Fu Hongwei Cheng Zhixiang Lu Gang Liu | 2022 | Nano-Micro Letters2022，14，9： | 2 |
| 2 | Kinetics of lipid oxidation and off-odor formation in silver carp mince: the effect of lipoxygenase and hemoglobin显示文摘 | FU Xiangjin XU Shiying WANG Zhang | 2009 | Food Research International2009，42，1： | 1 |
| 3 | Kinetics of lipid oxidation and off-odor formation in silver carp mince: the effect of lipoxygenase and hemoglobin显示文摘 | FU Xiangjin XU Shiying WANG Zhang | 2009 | Food Research International2009，42，： | 1 |
| 4 | Effect of microwave heating on the low-salt gel from silver carp ( Hypophthalmichthys molitrix ) surimi显示文摘 | Xiangjin Fu Khizar Hayat Zhonghai Li Qinlu Lin Shiying Xu Shuiping Wang | 2011 | Food Hydrocolloids2011，，2： | 1 |
| 5 | Use of a high thoracic epidural analgesia for treatment of end-stage congestive heart failure secondary to coronary artery disease显示文摘 | Wu Shuang Fu Shiying Liu Fengqi Qu Renhai Wang Lanfeng Li Zhuqin Wang Xu | 2007 | International Journal of Cardiology2007，，2： | 1 |
| 6 | Kinetics of lipid oxidation and off-odor formation in silver carp mince: The effect of lipoxygenase and hemoglobin显示文摘 | Xiangjin Fu Shiying Xu Zhang Wang | 2008 | Food Research International2008，，1： | 1 |
| 7 | Kinetics of lipid oxidation and off-odor formation in silver carp mince: The effect of lipoxygenase and hemoglobin显示文摘 | Xiangjin Fu Shiying Xu Zhang Wang | 2008 | Food Research International2008，，1： | 1 |
| 8 | Kinetics of lipid oxidation and off-odor formation in silver carp mince:the effect of lipoxygenase and hemoglobin显示文摘 | FU Xiangjin XU Shiying WANG Zhang | | 0，，01： | 1 |
| 9 | Kinetics of lipid oxidation and off-odor formation in silver carp mince: the effect of lipoxygenase and hemoglobin显示文摘 | FU Xiangjin XU Shiying WANG Zhang | 2009 | Journal of Food Research International2009，42，： | 1 |
| 10 | Kinetics of lipid oxidation and off-odor formation in silver carp mince: the effect of lipoxygenase and hemoglobin显示文摘 | FU Xiangjin XU Shiying WANG Zhang | 2009 | Food Research International2009，42，： | 1 |
| 11 | Hypertensive epidemiobgy in Heilongjiang province in China显示文摘 | FU Shiying CAO Yamin LI Yaoping | 2002 | Chin Med J(Engl)2002，115，4： | 1 |
| 12 | Role of cyclin-dependent kinase inhibitors in the growth arrest at senescence in human prostate epithelial and uroepithelial cells显示文摘 | Schwarze SR ShiY Fu VX | 2001 | Oncogene2001，20，57： | 1 |
| 13 | Postoperative sequential chemotherapy and radiotherapy for locally advanced gastric cancer显示文摘Objective The aim of the study was to evaluate the role of postoperative sequential chemotherapy and radiotherapy in patients with locally advanced gastric cancer.Methods From January 2003 to December 2010, 146 gastric cancer patients at our institution(Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China) received postoperative sequential chemotherapy and radiotherapy after radical surgery. Radiotherapy was administered as a dose of 4500 cGy in 25 fractions. For patients with positive margins, the dose was raised to 5040 cGy in 28 fractions. Three cycles of m FOLFOX or PF(cisplatin, 5-fluorouracil) chemotherapy regimen were applied before and after radiotherapy. Three-and 5-year survival rates were analyzed; any adverse effects with respect to hematology, hepatic and renal function, or the gastrointestinal tract that occurred during the treatment were evaluated.Results This cohort consisted of non-metastatic patients: 104 men and 42 women with a median age of 51.0 years. The full course of sequential chemotherapy and radiotherapy(4500–5040 cGy) was completed by 129 patients(88.4%). Seventeen regional relapses(9.8%) and 46 distant relapses(23.8%) were recorded. Fifty patients(34.2%) died during follow-up. The 3-and 5-year overall survival rates(OS) were 60% and 54%, and disease-free survival rates(DFS) were 53% and 47%, respectively. There were no significant differences in survival rate with respect to age, sex, histopathology, N stage, site of the tumor, or margin status. Multivariate analysis showed that only the depth of tumor invasion(T stage) was an independent prognostic factor for OS(P = 0.009) and DFS(P = 0.006). The rates of grades 3 and 4 neutropenia and vomiting were 9.6% and 3.4%, respectively, during the treatment.Conclusion Postoperative sequential chemotherapy with an m FOLFOX or PF regimen and radiotherapy were found to be an effective means of treating advanced gastric cancer patients with T3–T4 disease. The adverse effects of this treatment were tolerable. | Qiang Fu Shiying Yu Guoqing Hu Yuan Chen Junbo Hu Lihong Zhang Hong Qiu Xianglin Yuan | 2018 | Oncology and Translational Medicine2018，4，3： | 1 |
| 14 | RING finger 138 deregulation distorts NF-κB signaling and facilities colitis switch to aggressive malignancy显示文摘Prolonged activation of nuclear factor(NF)-кB signaling significantly contributes to the development of colorectal cancer(CRC).New therapeutic opportunities are emerging from targeting this distorted cell signaling transduction.Here,we discovered the critical role of RING finger 138(RNF138)in CRC tumorigenesis through regulating the NF-кB signaling,which is independent of its Ubiquitin-E3 ligase activity involved in DNA damage response.RNF138^(−/−) mice were hyper-susceptible to the switch from colitis to aggressive malignancy,which coincided with sustained aberrant NF-кB signaling in the colonic cells.Furthermore,RNF138 suppresses the activation of NF-кB signaling pathway through preventing the translocation of NIK and IKK-Beta Binding Protein(NIBP)to the cytoplasm,which requires the ubiquitin interaction motif(UIM)domain.More importantly,we uncovered a significant correlation between poor prognosis and the downregulation of RNF138 associated with reinforced NF-кB signaling in clinical settings,raising the possibility of RNF138 dysregulation as an indicator for the therapeutic intervention targeting NF-кB signaling.Using the xenograft models built upon either RNF138-dificient CRC cells or the cells derived from the RNF138-dysregulated CRC patients,we demonstrated that the inhibition of NF-кB signaling effectively hampered tumor growth.Overall,our work defined the pathogenic role of aberrant NF-кB signaling due to RNF138 downregulation in the cascade events from the colitis switch to colonic neoplastic transformation and progression,and also highlights the possibility of targeting the NF-кB signaling in treating specific subtypes of CRC indicated by RNF138-ablation. | Yalan Lu Rong Huang Jianming Ying Xingchen Li Tao Jiao Lei Guo Haitao Zhou Han Wang Amannisa Tuersuntuoheti Jianmei Liu Qichen Chen Yanhong Wang Luying Su Changyuan Guo Fu Xu Ziyi Wang Yan Lu Kai Li Junbo Liang Zhen Huang Xiao Chen Jinjie Yao Hanjie Hu Xiaowen Cheng Yufeng Wan Xinyan Chen Ning Zhang Shiying Miao Jianqiang Cai Linfang Wang Changzheng Liu Wei Song Hong Zhao | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 0 |
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