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| 1 | Clostridium difficile infections in China显示文摘Clostridium difficile (C. difficile) infection has become one of the major hospital-associated infections in West-ern countries in the last two decades. However, there is limited information on the status of C. difficile infection inChinese healthcare settings. Given the large and increasing elderly population and the well-recognized problem ofover-prescribing of broad spectrum antibiotics in China, it is critical to understand the epidemiology and potentialrisk factors that may contribute to C. difficile infection in China. A literature review of available published studies,including those in Chinese language-based journals, was conducted. A review of the currently available literaturesuggested the presence of C. difficile infections in China, but also suggested that these infections were not particu-larly endemic. This finding should lead to better designed and greatly expanded studies to provide a more reliableepidemiologically-based conclusion on the actual status of C. difficile infection in China, including the identifica-tion of any associated risk factors. Such information is ultimately valuable to develop appropriate strategies to pre-vent C. difficile infection and the vast negative impact of such infections in China and other developing countries. | Ke Jin a,b,c,Shixia Wang c,d,Zuhu Huang a,b,c,Shan Lu b,c,daDepartment of Infectious Diseases,bJiangsu Province Key Laboratory in Infectious Diseases,cChina-US Vaccine ResearchCenter,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China d Department of Medicine,University of Massachusetts Medical School,Worcester,MA 01655,USA. | 2010 | The Journal of Biomedical Research2010，24，6： | 14 |
| 2 | Artemisinin derivatives inhibit epithelial ovarian cancer cells via autophagy-mediated cell cycle arrest显示文摘Epithelial ovarian cancer (EOC)is the most fatal gynecologic malignancy due to its late diagnosis and lack of curative therapy.The antimalaria compound artemisinin and its derivatives,such as artesunate (ART)and dihydroartemisinin (DHA),have proven to be potent anticancer drugs and act through various anticancer mechanisms.To identify novel targets of artemisinin derivatives in EOC cells,we investigated the effects of ART and DHA on SKOV3 and primary EOC cell growth via CCK-8 assay.Both ART and DHA inhibited EOC cell growth.A cell cycle distribution analysis showed that ART and DHA caused G2/M cell cycle arrest.Moreover,ART and DHA induced autophagy in EOC cells,whereas autophagy inhibitors reversed the cell growth inhibition and cell cycle arrest induced by ART and DHA.Western blot analysis showed that ART and DHA also suppressed the cell cycle-related NF-κB-signaling pathway in EOC cells.These data suggest that artemisinin derivatives induce autophagy,block the cell cycle,and inhibit cell growth in EOC cells.Our research provides new targets for artemisinin derivatives for EOC treatment. | Boning Li Shixia Bu Junyan Sun Ying Guo Dongmei Lai | 2018 | Acta Biochimica et Biophysica Sinica2018，50，12： | 11 |
| 3 | A Geometric Understanding of Deep Learning显示文摘This work introduces an optimal transportation(OT)view of generative adversarial networks(GANs).Natural datasets have intrinsic patterns,which can be summarized as the manifold distribution principle:the distribution of a class of data is close to a low-dimensional manifold.GANs mainly accomplish two tasks:manifold learning and probability distribution transformation.The latter can be carried out using the classical OT method.From the OT perspective,the generator computes the OT map,while the discriminator computes the Wasserstein distance between the generated data distribution and the real data distribution;both can be reduced to a convex geometric optimization process.Furthermore,OT theory discovers the intrinsic collaborative-instead of competitive-relation between the generator and the discriminator,and the fundamental reason for mode collapse.We also propose a novel generative model,which uses an autoencoder(AE)for manifold learning and OT map for probability distribution transformation.This AE–OT model improves the theoretical rigor and transparency,as well as the computational stability and efficiency;in particular,it eliminates the mode collapse.The experimental results validate our hypothesis,and demonstrate the advantages of our proposed model. | Na Lei Dongsheng An Yang Guo Kehua Su Shixia Liu Zhongxuan Luo Shing-Tung Yau Xianfeng Gu | 2020 | Engineering2020，6，3： | 10 |
| 4 | Towards better analysis of machine learning models:A visual analytics perspective显示文摘Interactive model analysis,the process of understanding,diagnosing,and refining a machine learning model with the help of interactive visualization,is very important for users to efficiently solve real-world artificial intelligence and data mining problems.Dramatic advances in big data analytics have led to a wide variety of interactive model analysis tasks.In this paper,we present a comprehensive analysis and interpretation of this rapidly developing area.Specifically,we classify the relevant work into three categories:understanding,diagnosis,and refinement.Each category is exemplified by recent influential work.Possible future research opportunities are also explored and discussed. | Shixia Liu Xiting Wang Mengchen Liu Jun Zhu | 2017 | Visual Informatics2017，1，1： | 9 |
| 5 | A survey of visual analytics techniques for machine learning显示文摘Visual analytics for machine learning has recently evolved as one of the most exciting areas in the field of visualization.To better identify which research topics are promising and to learn how to apply relevant techniques in visual analytics,we systematically review259 papers published in the last ten years together with representative works before 2010.We build a taxonomy,which includes three first-level categories:techniques before model building,techniques during modeling building,and techniques after model building.Each category is further characterized by representative analysis tasks,and each task is exemplified by a set of recent influential works.We also discuss and highlight research challenges and promising potential future research opportunities useful for visual analytics researchers. | Jun Yuan Changjian Chen Weikai Yang Mengchen Liu Jiazhi Xia Shixia Liu | 2021 | Computational Visual Media2021，7，1： | 6 |
| 6 | Structure,rheology and electrospinning of zein and poly(ethylene oxide) in aqueous ethanol solutions显示文摘Electrospun fiber mats (EFM) integrated proteins and biocompatible polymers have been widely used as tissue scaffold, wound dressing and food packaging. The morphology of EFM has strong correlation with the structure and rheology of the solutions. We studied the structure and rheology of polyethylene oxide (PEO) and zein in 80% ethanol aqueous solutions and the resulted EFM. In solutions, zein with rod-like conformation tends to aggregate and form oligomer, the number of proteins in the oligomer spans from 2.5 to 55.2, while PEO always behaves like Gaussian chain in good solvent. Zein preferred to distribute along PEO chains in their mixed solutions, and the structures decomposed from small angle X-ray scattering have consistent relaxation spatial-temporal characteristics with rheological behaviors.Further, the aging of zein solutions enhanced shear thinning and resulted thicker fibers in EFM, which are attributed to the rod-like growth of zein aggregates. Aggregates in viscous media with long enough relaxation time are probably crucial for the formation of continuous electrospun fibers or ribbons. This study provides a clear correlation of the structure, rheology of solutions with the morphologies of EFM made up of proteins and polymers. | Ce Shi Shixia Xi Yingchun Han Hao Zhang Jingsheng Liu Yunqi Li | 2019 | Chinese Chemical Letters2019，30，2： | 5 |
| 7 | Steering data quality with visual analytics:The complexity challenge显示文摘Data quality management,especially data cleansing,has been extensively studied for many years in the areas of data management and visual analytics.In the paper,we first review and explore the relevant work from the research areas of data management,visual analytics and human-computer interaction.Then for different types of data such as multimedia data,textual data,trajectory data,and graph data,we summarize the common methods for improving data quality by leveraging data cleansing techniques at different analysis stages.Based on a thorough analysis,we propose a general visual analytics framework for interactively cleansing data.Finally,the challenges and opportunities are analyzed and discussed in the context of data and humans. | Shixia Liu Gennady Andrienko Yingcai Wu Nan Cao Liu Jiang Conglei Shi Yu-Shuen Wang Seokhee Hong | 2018 | Visual Informatics2018，2，4： | 5 |
| 8 | The position of tree shrews in the mammalian tree:Comparing multi-gene analyses with phylogenomic results leaves monophyly of Euarchonta doubtful显示文摘The well-accepted Euarchonta grandorder is a pruned version of Archonta nested within the Euarchontoglires(or Supraprimates)clade.At present,it includes tree shrews(Scandentia),flying lemurs(Dermoptera)and primates(Primates).Here,a phylogenomic dataset containing 1912 exons from 22 representative mammals was compiled to investigate the phylogenetic relationships within this group.Phylogenetic analyses and hypothesis testing suggested that tree shrews can be classified as a sister group to Primates or to Glires or even as a basal clade within Euarchontoglires.Further analyses of both modified and original previously published datasets found that the phylogenetic position of tree shrews is unstable.We also found that two of three exonic indels reported as synapomorphies of Euarchonta in a previous study do not unambiguously support the monophyly of such a clade.Therefore,the monophyly of both Euarchonta and Sundatheria(Dermoptera+Scandentia)are suspect.Molecular dating and divergence rate analyses suggested that the ancestor of Euarchontoglires experienced a rapid divergence,which may cause the unresolved position of tree shrews even using the whole genomic data. | Xuming ZHOU Fengming SUN Shixia XU Guang YANG Ming LI | 2015 | Integrative Zoology2015，10，2： | 2 |
| 9 | Estimation of leaf color variances of Cotinus coggygria based on geographic and environmental variables显示文摘Capturing leaf color variances over space is important for diagnosing plant nutrient and health status,estimating water availability as well as improving ornamental and tourism values of plants.In this study,leaf color variances of the Eurasian smoke tree,Cotinus coggygria were estimated based on geographic and climate variables in a shrub community using generalized elastic net(GELnet)and support vector machine(SVM)algorithms.Results reveal that leaf color varied over space,and the variances were the result of geography due to its effect on solar radiation,temperature,illumination and moisture of the shrub environment,whereas the influence of climate were not obvious.The SVM and GELnet algorithm models were similar estimating leaf color indices based on geographic variables,and demonstrates that both techniques have the potential to estimate leaf color variances of C.coggygria in a shrubbery with a complex geographical environment in the absence of human activity. | Xing Tan Jiaojiao Wu Yun Liu Shixia Huang Lan Gao Wen Zhang | 2021 | Journal of Forestry Research2021，32，2： | 2 |
| 10 | Identification and characterization of the cellular subclones that contribute to the pathogenesis of mantle cell lymphoma显示文摘Mantle cell lymphoma(MCL)is a B-cell malignancy with poor clinical outcome and undefined pathogenesis.Development of clinically relevant cellular models for MCL research is an urgent need.Our preliminary observations lead the development of two novel hypotheses that we tested in this study:1.multicellular spheroid might be a unique growth mode of earlystage cells in MCL;2.MCL might be a polyclonal tumor.We made the following original observations that have not been reported:First,we have provided a new experiment method for enriching MCL early-stage cells and characterized the spheroid mode of growth as a unique feature of early-stage MCL cells in cell line as well as in clinical samples.Second,we have established a clinically relevant cellular model of MCL,the JeKo-1-spheroid cell line,that was highly enriched in early-stage sub-clones.JeKo-1-spheroid cells and the spheroid growing cells enriched from MCL patients exhibited comparably enhanced tumorigenic abilities and similar biological features.Third,Immunophenotypic analysis has revealed that MCL may be derived from precursor-B(pre-B),immature-B and mature-B cells,not only the mature-B cells as WHO classified in 2016.Fourth,MCL may be a polyclonal disease composed of CD19e/IgMe,CD19 e/IgMt,CD19t/IgMt three sub-clones,of which the CD19e/IgMt sub-clone might be the dominant sub-clone with the strongest tumorigenic ability.Fifth,CD19t/IgMe that differentiates MCL and normal B cells may represent a new marker for MCL early detection,minor residual disease monitoring after therapies and prognosis. | Junling Tang Li Zhang Tiejun Zhou Zhiwei Sun Liangsheng Kong Li Jing Hongyun Xing Hongyan Wu Yongli Liu Shixia Zhou Jingyuan Li Mei Chen Fang Xu Jirui Tang Tao Ma Min Hu Dan Liu Jing Guo Xiaofeng Zhu Yan Chen Ting Ye Jianyu Wang Xiaoming Li H.Rosie Xing | 2019 | Genes & Diseases2019，6，4： | 2 |
| 11 | Low-dose cisplatin-induced CXCR4 expression promotes proliferation of ovarian cancer stem-like cells显示文摘Chemoresistance 堵住上皮的卵巢的癌症的有效治疗,它所有妇产科的癌症是最致命的。癌症干细胞被相信是至少为 chemoresistance 的发展部分负责。在这研究,癌症的丰富和增长上的 cisplatin (CDP ) 的效果像茎的房间(CSLC ) 被调查,并且行动的内在的机制被阐明。一在里面 vitro 没有锚的系统被采用从 SKOV3 人的上皮的卵巢的癌症房间线充实 CSLC。我们的结果证明有 CDP 的低集中的治疗导致了更好充实的 CSLC,与更高的 proliferative 活动。CDP 的低剂量被发现导致 chemokine (C-X-C 主题) 的表示受体 4 (CXCR4 ) ,它为卵巢的癌症治疗是在癌症干细胞以及一个有希望的治疗学的目标的一个重要 stemness 标记。结果也证明 overexpressed CXCR4 产生了 chemoresistance。把结果基于这些,在低集中, CDP 本身贡献药抵抗的发展,这可以被结束。这发现提供新奇卓见进位于 chemoresistance 下面的机制并且为上皮的卵巢的癌症治疗有重要治疗学的含意。 | Yifei Chen Shuying Wang Shixia Bu Minhua Xu Dongmei Lai | 2016 | Acta Biochimica et Biophysica Sinica2016，48，3： | 2 |
| 12 | Extracellular Ca2+stimulates the activation of mitogen-activated protein kinase and cell growth in human fibroblast显示文摘 | Shixia H Veronica M Justin M | | 0，，： | 1 |
| 13 | Whisper:Tracing the Spctiotemporal Process of InformationDiffusion in Real Time显示文摘 | Nan Cao Yu-Ru Lin Xiaohua Sun David Lazer Shixia Liu Huamin Qu | | 0，，12： | 1 |
| 14 | TextFlow:Towards Beiter Understanding of Evolving Topics in Text显示文摘 | Weiwei Cui Shixia Liu Li Tan Conglei Shi Yangqiu Song Zekai Gao Huamin Qu Xin Tong | | 0，，12： | 1 |
| 15 | First-trimester maternal serum levels of s FLT1,PGF and ADMA predict preeclampsia显示文摘 | Bian Z Shixia C Duan T | 2015 | PLo S One2015，10，01： | 1 |
| 16 | Reconstruction of curved solids from engineering drawings显示文摘 | Liu Shixia Hu Shimin Chen Yujian Sun Jiaguang | | 0，，14： | 1 |
| 17 | OpinionSeer: Interactive visualization of hotel customer feedback 显示文摘 | Wu Yingeai Wei Furu Liu Shixia | 2010 | IEEE Trans on Visualization and Computer Graphics2010，16，6： | 1 |
| 18 | First-Trimester Maternal Serum Levels of sFLT1, PTF and ADMA Predict Preeclampsia 显示文摘 | Bian Z Shixia C Duan T | 2015 | PLoS One2015，10，01： | 1 |
| 19 | A DNA vaccine producing Lcr V antigen in oligomers is effective in protecting mice from lethal mueosal challenge of plague 显示文摘 | Shixia W Destin H Fangjun L | 2004 | Vaccine2004，22，： | 1 |
| 20 | The study of inhibin A, activin A, Placental growth factor and uterine artery Doppler pulsatility index to predict pre-eclampsia显示文摘 | Yu J Shixia C Z Wu Y | 2011 | Ultrasound Obstet Gynecol2011，37，5： | 1 |
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