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| 1 | Regulatory T cells in cancer immunotherapy显示文摘表示 FOXP3 规章的 T (Treg ) 房间,对自我抗原压制异常有免疫力的反应,也压制反肿瘤免疫者反应。进肿瘤纸巾的很多 Treg 房间的渗入经常与差的预后被联系。正在积累 Treg 房间的移动能唤起并且提高反肿瘤免疫者反应的证据。然而, Treg 房间的全身的弄空可以并发地得到有害 autoimmunity。为没有 autoimmunity,唤起有效肿瘤免疫的一策略是明确地严重地指向区分的受动器 Treg 房间而非所有 FOXP3 + T 房间,因为受动器 Treg 房间是在肿瘤纸巾的占优势的房间类型。各种各样的房间表面分子包括象 CCR4 那样的 chemokine 受体,那被受动器 Treg 房间明确地表示能是弄空的候选人由特定的弄空房间的 monoclonal 抗体的受动器 Treg 房间。另外,受动器 Treg 房间的另外的免疫学的特征例如他们 CTLA-4,活跃增长,和 apoptosis 容易的趋势的高表达式,能被利用明确地控制他们的函数。例如, anti-CTLA-4 抗体可以杀死受动器 Treg 房间或稀释他们的镇压活动。这被希望指向的 Treg 房间的联合(例如,由减少 Treg 房间或 attenuating 他们在肿瘤纸巾的镇压活动) 与肿瘤特定的受动器 T 房间的激活(例如,由疫苗的癌症或有免疫力的检查点封锁) 将使当前的癌症免疫疗法更有效。 | Atsushi Tanaka Shimon Sakaguchi | 2017 | Cell Research2017，27，1： | 107 |
| 2 | Transcriptional and epigenetic basis of Treg cell development and function: its genetic anomalies or variations in autoimmune diseases显示文摘Naturally arising regulatory CD4^+T(Treg)cells,which specifically express the transcription factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface,are a T-cell subpopulation specialized for immune suppression,playing a key role in maintaining immunological self-tolerance and homeostasis.FoxP3 is required for Treg function,especially for its suppressive activity.However,FoxP3 expression per se is not necessary for Treg cell lineage commitment in the thymus and insufficient for full Treg-type gene expression in mature Treg cells.It is Treg-specific epigenetic changes such as CpG demethylation and histone modification that can confer a stable and heritable pattern of Treg type gene expression on developing Treg cells in a FoxP3-independent manner.Anomalies in the formation of Treg-specific epigenome,in particular,Treg-specific super-enhancers,which largely include Tregspecific DNA demethylated regions,are indeed able to cause autoimmune diseases in rodents.Furthermore,in humans,single nucleotide polymorphisms in Treg-specific DNA demethylated regions associated with Treg signature genes,such as IL2RA(CD25)and CTLA4,can affect the development and function of naive Treg cells rather than effector T cells.Such genetic variations are therefore causative of polygenic common autoimmune diseases including type 1 diabetes and rheumatoid arthritis via affecting endogenous natural Treg cells.These findings on the transcription factor network with FoxP3 at a key position as well as Tregspecific epigenetic landscape facilitate our understanding of Treg cell development and function,and can be exploited to prepare functionally stable FoxP3-expressing Treg cells from antigen-specific conventional T cells to treat autoimmune diseases. | Naganari Ohkura Shimon Sakaguchi | 2020 | Cell Research2020，30，6： | 29 |
| 3 | Development and Maintenance of Regulatory T cells显示文摘 | Naganari Ohkura Yohko Kitagawa Shimon Sakaguchi | 2013 | Immunity2013，，3： | 4 |
| 4 | Regulatory T Cells and Immune Tolerance显示文摘 | Shimon Sakaguchi Tomoyuki Yamaguchi Takashi Nomura Masahiro Ono | 2008 | Cell2008，，5： | 4 |
| 5 | Naturally Arising CD4+ Regulatory T Cells for Immunologic Self-Tolerance and Negative Control of Immune Responses显示文摘 | Shimon Sakaguchi | 2004 | Annual Review of Immunology2004，，： | 2 |
| 6 | The Presence of Foxp3 Expressing T Cells Within Grafts of Tolerant Human Liver Transplant Recipients显示文摘 | Ying Li Xiangdong Zhao Donghua Cheng Hironori Haga Tatsuaki Tsuruyama Kathryn Wood Shimon Sakaguchi Koichi Tanaka Shinji Uemoto Takaaki Koshiba | 2008 | Transplantation2008，，12： | 2 |
| 7 | Requirement of Protocol Biopsy Before and After Complete Cessation of Immunosuppression After Liver Transplantation显示文摘 | Mami Yoshitomi Takaaki Koshiba Hironori Haga Ying Li Xiangdong Zhao Donghua Cheng Aya Miyagawa Hiromi Sakashita Tatsuaki Tsuruyama Hidenori Ohe Mikiko Ueda Shinya Okamoto Hiroto Egawa Kathryn Wood Shimon Sakaguchi Toshiaki Manabe Koichi Tanaka Shinji Uemo | 2009 | Transplantation2009，，4： | 2 |
| 8 | Human FoxP3 + regulatory T cells in systemic autoimmune diseases显示文摘 | Makoto Miyara Guy Gorochov Michael Ehrenstein Lucile Musset Shimon Sakaguchi Zahir Amoura | 2011 | Autoimmunity Reviews2011，，12： | 2 |
| 9 | Regulatory T cells: roles of T cell receptor for their development and function显示文摘 | Naganari Ohkura Shimon Sakaguchi | 2010 | Seminars in Immunopathology2010，，2： | 1 |
| 10 | CD25 + CD4 + T cells in human cord blood: an immunoregulatory subset with naive phenotype and specific expression of forkhead box p3 (Foxp3) gene显示文摘 | Yasushi Takahata Akihiko Nomura Hidetoshi Takada Shouichi Ohga Kenji Furuno Shunji Hikino Hideki Nakayama Shimon Sakaguchi Toshiro Hara | 2004 | Experimental Hematology2004，，7： | 1 |
| 11 | Foxp3:a critical regulator of the development and function of regulatory T cells显示文摘 | Shohei Hori Shimon Sakaguchi | 2004 | Microbes and Infection2004，6，8： | 1 |
| 12 | Naturally arising Foxp3-expressing CD25+CD4+,regulatory T cells in immunological tolerance to self and non-self显示文摘 | Sakaguchi S Shimon R | 2005 | Nature Immunology2005，6，4： | 1 |
| 13 | Regulatory T cell in immune surveillance and treatment of cancer 显示文摘 | Tomoyuki Yamaguchi Shimon Sakaguchi | 2006 | Seminars in Cancer Biology2006，16，： | 1 |
| 14 | Regulatory T Cells显示文摘 | Shimon Sakaguchi | 2000 | Cell2000，，5： | 1 |
| 15 | Regulatory T Cells显示文摘 | Shimon Sakaguchi | 2000 | Cell2000，，5： | 1 |
| 16 | Regulatory T Cells, Derived from Na?ve CD4+CD25? T Cells by In Vitro Foxp3 Gene Transfer, Can Induce Transplantation Tolerance显示文摘 | Jian-Guo Chai Shao-an Xue David Coe Caroline Addey Istvan Bartok Diane Scott Elizabeth Simpson Hans J. Stauss Shohei Hori Shimon Sakaguchi Julian Dyson | 2005 | Transplantation2005，，10： | 1 |
| 17 | T Cell Receptor Stimulation-Induced Epigenetic Changes and Foxp3 Expression Are Independent and Complementary Events Required for Treg Cell Development显示文摘 | Naganari Ohkura Masahide Hamaguchi Hiromasa Morikawa Kyoko Sugimura Atsushi Tanaka Yoshinaga Ito Motonao Osaki Yoshiaki Tanaka Riu Yamashita Naoko Nakano Jochen Huehn Hans Joerg Fehling Tim Sparwasser Kenta Nakai Shimon Sakaguchi | 2012 | Immunity2012，，5： | 1 |
| 18 | Clinical, immunological, and pathological aspects of operational tolerance after pediatric living-donor liver transplantation显示文摘 | Takaaki Koshiba Ying Li Mami Takemura Yanling Wu Shimon Sakaguchi Nagahiro Minato Kathryn J. Wood Hironori Haga Mikiko Ueda Shinji Uemoto | 2006 | Transplant Immunology2006，，2： | 1 |
| 19 | Natural regulatory T cells: mechanisms of suppression显示文摘 | Makoto Miyara Shimon Sakaguchi | 2007 | Trends in Molecular Medicine2007，，3： | 1 |
| 20 | Development and Maintenance of Regulatory T cells显示文摘 | Naganari Ohkura Yohko Kitagawa Shimon Sakaguchi | 2013 | Immunity2013，，3： | 1 |
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