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| 1 | Comparisons of cropland area from multiple datasets over the past 300 years in the traditional cultivated region of China显示文摘陆地使用 / 盖住变化是在气候和生态的模拟的一个重要参数。尽管他们广泛地在社区,半自动地面防空系统数据集和 HYDE 数据集被使用了,二代表性的全球历史的陆地使用数据集,很少在地区性的规模关于他们的精确性被估计。这里,我们为中国(TCRC ) 的传统的栽培区域执行了一些评价在上持续 300 年,由把 SAGE2010 和 HYDE (v3.1 ) 与中国历史的农田数据集(CHCD ) 作比较。比较在三空间规模被执行:由 60 km 格子房间的全部学习区域,省的区域和 60 km。结果证明(1 ) 从 SAGE2010 的农田区域从 CHCD 是多于那的大部分;而且,以在 1950 以后的从 1700 ~ 1950 和 0.34% 的 0.51% 的率的生长从 CHCD 与那也不一致。(2 ) HYDE 数据集(v3.1 ) 在全部学习区域上比半自动地面防空系统数据集接近了 CHCD 数据集。然而,大偏爱能被 60 km 格子房间规模在省的规模和 60 km 检测。有比70%大的偏爱的格子房间的百分比(<-70%或>70%)并且90%(<-90%或>90%)当那些有的偏爱为仅仅5%6%从10%~10%并且从30%~30%报道 时,分别地说明了全部的格子房间的56%63%和40%45%并且17%全部的格子房间分别地。(3 ) 用本地历史的档案,有高精确性的历史的数据集将是改进气候和生态的模拟的精确性的一个珍贵方法重建。 | HE Fanneng LI Shicheng ZHANG Xuezhen GE Quansheng DAI Junhu | 2013 | Journal of Geographical Sciences2013，23，6： | 21 |
| 2 | A Road Extraction Method for Remote Sensing Image Based on Encoder-Decoder Network显示文摘According to the characteristics of the road features,an Encoder-Decoder deep semantic segmentation network is designed for the road extraction of remote sensing images.Firstly,as the features of the road target are rich in local details and simple in semantic features,an Encoder-Decoder network with shallow layers and high resolution is designed to improve the ability to represent detail information.Secondly,as the road area is a small proportion in remote sensing images,the cross-entropy loss function is improved,which solves the imbalance between positive and negative samples in the training process.Experiments on large road extraction datasets show that the proposed method gets the recall rate 83.9%,precision 82.5%and F1-score 82.9%,which can extract the road targets in remote sensing images completely and accurately.The Encoder-Decoder network designed in this paper performs well in the road extraction task and needs less artificial participation,so it has a good application prospect. | Hao HE Shuyang WANG Shicheng WANG Dongfang YANG Xing LIU | 2020 | Journal of Geodesy and Geoinformation Science2020，3，2： | 20 |
| 3 | Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer显示文摘渗入肿瘤的 Tregs 的起源,肿瘤免疫力的抑制的批评调停人,是不清楚的。这里,,我们证明在人的乳癌的渗入肿瘤的天真的 CD4 + T 房间和 Tregs 有重叠 TCR 全部剧目几乎别与传播 Tregs 重叠,建议 intratumoral Tregs 主要在 situ 而非从招募的 Tregs 从天真的 T 房间发展。而且,许多天真的 CD4 + T 房间和 Tregs 密切被相关,两个显示的穷人为乳癌病人的预后。天真的 CD4 + T 房间与许多生产 CCL18 巨噬细胞成比例遵守肿瘤片。而且,采纳地转移的人的天真的 CD4 + T 房间以一种 CCL18 依赖的方式渗入人的乳癌 orthotopic 异种皮移植。在在人性化的鼠标的人的乳癌异种皮移植,由将 PITPNM3 的表达式击倒堵住天真的 CD4 + T 房间的招募进肿瘤, CCL18 受体,显著地减少 intratumoral Tregs 并且禁止肿瘤前进。这些调查结果建议那个乳房渗入肿瘤的 Tregs 从在 situ 区分进 Tregs 的传播天真的 CD4 + T 房间的趋化性产生。由防碍 CCL18 的 PITPNM3 识别禁止天真的 CD4 + T 房间招募进肿瘤可以是为 anticancer 免疫疗法的吸引人的策略。 | Shicheng Su Jianyou Liao Jiang Liu Di Huang Chonghua He Fei Chen LinBing Yang Wei Wu Jianing Chen Ling Lin Yunjie Zeng Nengtai Ouyang Xiuying Cui Herui Yao Fengxi Su Jian-dong Huang Judy Lieberman Qiang Liu Erwei Song | 2017 | Cell Research2017，27，4： | 19 |
| 4 | Evaluating the accuracy of Chinese pasture data in global historical land use datasets显示文摘Global historical land use datasets are widely used in global environmental change studies; however, uncertainties in the included pasture data have not been evaluated. In this study, using trend, relative difference ratio(RDR), and spatial comparisons, we evaluated the accuracy of China pasture data in the HYDE(versions 3.1 and 3.2), SAGE, and PJ datasets using historical document-based reconstructions, including the land use datasets for China covering 1935–1997(hereafter Ge-dataset)and Northeast China covering the 1700 s–2000(hereafter Ye-dataset), and the satellite-based China's Land-Use/cover Datasets(CLUDs) for 1980–2015. Four important results were obtained.(1) China pasture area in the HYDE, SAGE, and PJ datasets and grassland area in the Ge-dataset, Ye-dataset, and CLUDs show both disparate trends and large differences in absolute values.(2)Spatially, 50.9%, 52.8%, and 63.0% pasture/grassland grids in 2000 had RDRs greater than 60% between HYDE3.1, HYDE3.2,and SAGE datasets, and CLUDs, respectively. The percentage of grids with RDRs less than 20% were 24.9%, 26.7%, and 16.0%,respectively.(3) Based on HYDE3.2, the spatial distribution of pasture in Northeast China over the last 300 year has expanded,which is in contrast to the results from the Ye-dataset, which shows the spatial distribution of grassland shrinking because of human reclamation activities.(4) The large contrasts between the global datasets and Chinese native datasets are due to differences in pasture/grassland definitions, land use practices, and spatial reconstruction methods. | Fanneng HE Shicheng LI Fan YANG Meijiao LI | 2018 | Science China Earth Sciences2018，61，11： | 7 |
| 5 | Reconstruction of cropland area and spatial distribution in the mid-Northern Song Dynasty (AD1004-1085)显示文摘为了理解历史的导致人的土地,盖住变化和它的气候的效果,与明确的空间信息创造历史的陆地使用数据集是必要的。用税农田区域和从历史的文件编的家庭的数字,我们在每陆(在北歌王朝的一个省级的政治区域) 以内估计了真实农田区域和人口在中间 -- 北歌王朝(AD1004-1085 ) 。评价通过分析税,人口和农业开发的当代的政策被完成。然后,我们把政治基于区域的农田区域变换成地理上明确的格子在由 60 km 的 60 km 的房间尺寸的基于房间的部分农田。变换作为独立变量用地志的斜坡,高度和人口密度基于每个格子房间的精明的耕作适用性。作为结果,在在 1070 年代的北歌领土以内的农田的全部的区域被估计是大约 7.2 亿亩(中国区域单位, 1 亩 = 666.7 m2 ) ,哪个 40.1% 和 59.9% 分别地发生在北方和南方。人口被估计是大约 8720 万,哪个 38.7% 和 61.3% 分别地在北方和南方,并且人均的农田区域是大约 8.2 亩。国家吝啬的开垦比率(即到全部的土地的农田区域的比率区域;RRA 此后为短) 是一回 16.6% 。平凡区域例如诺思中国平原,中间和长江的更低的活动范围, Guanzhong 平原,包围东廷·莱克和波伊昂·莱克和四川盆的平原,有更高的 RRA,主要是超过 40% ;当时多山、多山的区域例如 Nanling 山的南方,西南区域(排除 Chengdu 平原) ,黄土高原和东南沿海的区域,有更低的 RRA,是不到 20% 。而且, RRA 与地志的斜坡和高度变化了。在低高度(250 m ) 的区域,中间的高度(250100 m ) 和高高度(10003500 m ) ,有 4.43 亿, 2.15 亿并且 6400 万亩农田分别地并且他们的地区性的吝啬的 RRA 分别地是 27.5% , 12.6% 和 7.2% 。在扁平的斜坡,轻轻的斜坡,中等斜坡和陡峭的斜坡的区域,有 1.16 亿, 4.56 亿, 1.44 亿并且 200 万亩农田分别地并且他们的地区性的吝啬的 RRA 分别地是 34.6% , 20.7% , 8.5% 和 2.3% 。 | HE Fanneng LI Shicheng ZHANG Xuezhen | 2012 | Journal of Geographical Sciences2012，22，2： | 7 |
| 6 | Cancer metabolism and tumor microenvironment:fostering each other?显示文摘The changes associated with malignancy are not only in cancer cells but also in environment in which cancer cells live.Metabolic reprogramming supports tumor cells’high demand of biogenesis for their rapid proliferation,and helps tumor cells to survive under certain genetic or environmental stresses.Emerging evidence suggests that metabolic alteration is ultimately and tightly associated with genetic changes,in particular the dysregulation of key oncogenic and tumor suppressive signaling pathways.Cancer cells activate HIF signaling even in the presence of oxygen and in the absence of growth factor stimulation.This cancer metabolic phenotype,described firstly by German physiologist Otto Warburg,ensures enhanced glycolytic metabolism for the biosynthesis of macromolecules.The conception of metabolite signaling,i.e.,metabolites are regulators of cell signaling,provides novel insights into how reactive oxygen species(ROS)and other metabolites deregulation may regulate redox homeostasis,epigenetics,and proliferation of cancer cells.Moreover,the unveiling of noncanonical functions of metabolic enzymes,such as the moonlighting functions of phosphoglycerate kinase 1(PGK1),reassures the importance of metabolism in cancer development.The metabolic,microRNAs,and ncRNAs alterations in cancer cells can be sorted and delivered either to intercellular matrix or to cancer adjacent cells to shape cancer microenvironment via media such as exosome.Among them,cancer microenvironmental cells are immune cells which exert profound effects on cancer cells.Understanding of all these processes is a prerequisite for the development of a more effective strategy to contain cancers. | Yiyuan Yuan Huimin Li Wang Pu Leilei Chen Dong Guo Hongfei Jiang Bo He Siyuan Qin Kui Wang Na Li Jingwei Feng Jing Wen Shipeng Cheng Yaguang Zhang Weiwei Yang Dan Ye Zhimin Lu Canhua Huang Jun Mei Hua-Feng Zhang Ping Gao Peng Jiang Shicheng Su Bing Sun Shi-Min Zhao | 2022 | Science China(Life Sciences)2022，65，2： | 5 |
| 7 | Comparison of changes in land use and land cover in China and the USA over the past 300 years显示文摘在在在长时间规模上的不同国家之间的陆地使用和陆地盖子的变化的比较研究在处于不同状况理解这些变化的过程和驱动力是有用的。我们在过去的 300 年比较了并且分析在瓷器大陆和有共同边界的美国之间的农田,森林和草地的时间、空间的特征。我们发现在过去的 300 年,农田的区域在中国并且在 USA 显示出一个全面增加趋势。在中国,农田的区域增加了大约 79.46 ? 慷浲湩 ? 湡 ? 湩牣慥楳杮挠楬慭整攠瑸敲敭攠敶瑮 ? 潷汵? 污整 ? 桴 ? 慭湧瑩摵 ? 湡 ? 灳瑡潩整灭牯污瀠瑡整湲 ? 景朠潬慢 ? 整牲獥牴慩?偎 | HE Fanneng LI Meijiao LI Shicheng XIAO Ran | 2015 | Journal of Geographical Sciences2015，25，9： | 3 |
| 8 | A Positive Feedback Loop between Mesenchymal-like Cancer Cells and Macrophages Is Essential to Breast Cancer Metastasis显示文摘 | Shicheng Su Qiang Liu Jingqi Chen Jianing Chen Fei Chen Chonghua He Di Huang Wei Wu Ling Lin Wei Huang Jin Zhang Xiuying Cui Fang Zheng Haiyan Li Herui Yao Fengxi Su Erwei Song | 2014 | Cancer Cell2014，，5： | 3 |
| 9 | Overexpression of PITPNM3 promotes hepatocellular carcinoma cell metastasis显示文摘A previous study indicated that C–C chemokine(C–C motif)ligand 18(CCL18)is capable of inducing tumor cell invasion and metastasis by interacting with receptor membrane-associated phosphatidylinositol transfer protein 3(PITPNM3)in breast cancer cells.The present study aims to investigate the correlation between the PITPNM3 expression and metastasis in hepatocellular carcinoma(HCC).Real-time quantitative polymerase chain reaction and Western blot were performed to detect the expression pattern of PITPNM3 in patient samples and HCC cell lines.Wound-healing and transwell chamber assays were performed to assess the migration and invasiveness of HCC cells,and the activation of the signaling protein downstream of PITPNM3 was also detected by Western blot and immunofluorescence.The results revealed that PITPNM3 was upregulated in HCC tissue compared to matched normal liver tissue.Silencing the expression of PITPNM3 by specific siRNAs markedly attenuated the invasive and metastatic abilities of HCC cells,whereas the upregulation of PITPNM3 significantly increased HCC cell mobility.Furthermore,inhibiting the expression of PITPNM3 suppressed the activation of Pyk2,FAK,and Src,while overexpression of PITPNM3enhanced the phosphorylation of FAK and Src in HCC cells.Besides,suppression of Pyk2 can also impair the clustering of integrin.These results imply that PITPNM3 is a vital determinant of HCC migration and invasion. | Chonghua He Shicheng Su Fei Chen Di Huang Fang Zheng Wei Huang Jianing Chen Xiuying Cui Qiang Liu Erwei Song Herui Yao Yujie Liu | 2014 | Chinese Science Bulletin2014，59，12： | 3 |
| 10 | An approach to spatially explicit reconstruction of historical forest in Northeast China显示文摘历史的陆地封面数据集的空间地明确的重建在学习陆地使用和陆地封面变化(LUCC ) 的气候、生态的效果起一个重要作用。用潜在的自然植被(PNV ) 和基于卫星的陆地使用数据,我们当人的骚乱不在时决定了森林盖子的可能的最大的分发程度。随后,地形学和气候因素被选择为耕作估计土地的适用性。最后,一个历史的森林区域分配模型为耕作根据土地的适用性被设计。作为案例研究,我们使用了历史的森林区域分配模型重建在有一个 10-km 决定的东北中国的为 1780 和 1940 的森林盖子。验证模型,我们为 2000 把基于卫星的森林盖子数据与我们的重建作比较。绝对偏爱的一个样品 t 测试证明二尾巴的意义是 0.12,比重要水平大 0.05,建议模型有强壮的能力捕获森林的空间分发。另外,我们在东北中国为 1780 在县规模计算了我们的重建的相对差别。差别其亲戚从 30% ~ 30%的县的数字是 99,为 74.44% 所有县的财务。这些调查结果证明省的森林区域能用模型被转变成森林盖子地图很好。 | LI Shicheng HE Fanneng ZHANG Xuezhen | 2014 | Journal of Geographical Sciences2014，24，6： | 2 |
| 11 | Wood waste biochar promoted anaerobic digestion of food waste:focusing on the characteristics of biochar and microbial community analysis显示文摘Anaerobic digestion(AD)has been considered as a promising technique for food waste(FW)recycling.However,the accumulation of volatile fatty acids(VFAs)restricts the stability of anaerobic reactors.The present study investigated the use of biochar produced at different conditions(750℃-30 min,750℃-60 min,750℃-120 min,550℃-60 min,650℃-60 min,850℃-60 min,950℃-60 min)for enhancing the AD of FW.Batch experiments showed that all the biochar increased the methane production rates and biochar obtained at 750℃-60 min resulted in the highest enhance-ment by 21.5%.It was further showed surface oxygen-containing functional groups and graphitization degree of biochar were the critical factors for improving methane production.Microbial analysis showed that biochar addi-tion formed different microbial communities,and Methanosaeta,Romboutsia,and norank_f_Anaerolineaceae were enriched,which might be correlated with direct interspecies electron transfer(DIET).This research showed biochar could enhance the AD of FW and also revealed the main characteristics of biochar relating with the enhancement of AD. | Chao Zhang Rui Yang Meichen Sun Shicheng Zhang Mingjing He Daniel C.W.Tsang Gang Luo | 2022 | Biochar2022，4，1： | 2 |
| 12 | Essential role of Msx1 in regulating anterior-posterior patterning of the secondary palate in mice显示文摘Development of the secondary palate displays molecular heterogeneity along the anterior-posterior axis;however, the underlying molecular mechanism remains largely unknown. MSX1 is an anteriorly expressed transcription repressor required for palate development. Here, we investigate the role of Msx1 in regional patterning of the secondary palate. The Wnt1-Cre-mediated expression of Msx1(Rosa Msx1^(Wnt1-Cre))throughout the palatal mesenchyme leads to cleft palate in mice, associated with aberrant cell proliferation and cell death. Osteogenic patterning of the hard palate in Rosa Msx1^(Wnt1-Cre)mice is severely impaired, as revealed by a marked reduction in palatine bone formation and decreased expression of the osteogenic regulator Sp7. Overexpression and knockout of Msx1 in mice show that the transcription repressor promotes the expression of the anterior palate-specific Alx1 but represses the expression of the medialposterior palate genes Barx1, Meox2, and Tbx22. Furthermore, Tbx22 constitutes a direct Msx1 target gene in the secondary palate, suggesting that Msx1 can directly repress the expression of medial-posterior specific genes. Finally, we determine that Sp7 is downstream of Tbx22 in palatal mesenchymal cells,suggesting that a Msx1/Tbx22/Sp7 axis participates in the regulation of palate development. Our findings unveil a novel role for Msx1 in regulating the anterior-posterior growth and patterning of the secondary palate. | Shicheng Zhu Hanjing Song Liangjun Zhong Suman Huo Yukun Fang Wanxin Zhao Xueqin Yang Zhong-Min Dai Rui He Mengsheng Qiu Zunyi Zhang Xiao-Jing Zhu | 2022 | Journal of Genetics and Genomics2022，49，1： | 2 |
| 13 | Fertilizer recommendation for maize in China based on yield response and agronomic efficiency显示文摘 | Xinpeng Xu Ping He Mirasol F. Pampolino Adrian M. Johnston Shaojun Qiu Shicheng Zhao Limin Chuan Wei Zhou | 2014 | Field Crops Research2014，，： | 1 |
| 14 | Polyetheretherketone/nano-fluorohydroxyapatite composite with antimicrobial activity and osseointegration properties显示文摘 | Lixin Wang Shu He Xiaomian Wu Shanshan Liang Zhonglin Mu Jie Wei Feng Deng Yi Deng Shicheng Wei | 2014 | Biomaterials2014，，25： | 1 |
| 15 | Nutrient requirements for maize in China based on QUEFTS analysis显示文摘 | Xinpeng Xu Ping He Mirasol F. Pampolino Limin Chuan Adrian M. Johnston Shaojun Qiu Shicheng Zhao Wei Zhou | 2013 | Field Crops Research2013，，： | 1 |
| 16 | Estimating nutrient uptake requirements for wheat in China显示文摘 | Limin Chuan Ping He Jiyun Jin Shutian Li Cynthia Grant Xinpeng Xu Shaojun Qiu Shicheng Zhao Wei Zhou | 2013 | Field Crops Research2013，，： | 1 |
| 17 | Long-term effects of potassium fertilization and straw return on soil potassium levels and crop yields in north-central China显示文摘 | Zhao Shicheng He Ping Qiu Shaojun | 2014 | Field Crops Research2014，169，： | 1 |
| 18 | Evaluating the reliability of global historical land use scenarios for forest data in China显示文摘Global historical land use scenarios are widely used to simulate the climatic and ecological effects of changes in land cover;however,reliability evaluation of these scenarios for data on China’s forests is missing.By using a historical document-derived Chinese forest dataset(CHFD)for the years 1700–2000,we evaluated the reliability of data on forests in China over three global scenarios-SAGE(Center for Sustainability and the Global Environment),PJ(Pongratz Julia),and KK10(Kaplan and Krumhardt 2010)-through trend-related,quantitative,and spatial comparisons.The results show the following:(1)Although the area occupied by forests in China in the SAGE,PJ,KK10,and CHFD datasets decreased over the past 300 years,there were large differences between global scenarios and CHFD.The area occupied by forests in China in the SAGE scenario for 1700–1990 was 20%–40%more than that according to CHFD,and that occupied by forests in the KK10 from 1700 to 1850 was 32%–46%greater than that in CHFD.The difference between the PJ and CHFD was lower than 20%for most years.(2)Large differences were detected at the provincial and grid cell scales,where the PJ scenario was closer to CHFD in terms of total forested area.Provinces with large differences in terms of trend and quantity were 84%and 92%of all provinces,respectively.Grid cells with relative differences greater than 70%accounted for 60%–80%of all grids.(3)These global historical land use scenarios do not accurately reveal the spatiotemporal pattern of Chinese forests due to differences in the data sources,methods of reconstruction,and spatial scales. | YANG Fan HE Fanneng LI Meijiao LI Shicheng | 2020 | Journal of Geographical Sciences2020，30，7： | 1 |
| 19 | Genome analysis and epidemiological investigation of goose circovirus detected in eastern China显示文摘 | Xuping Yu Chun Zhu Xintian Zheng Shicheng He Xiaoning Liu | 2007 | Virus Genes2007，，3： | 1 |
| 20 | Nutrient requirements for maize in China based on QUEFTS analysis显示文摘 | Xinpeng Xu Ping He Mirasol F. Pampolino Limin Chuan Adrian M. Johnston Shaojun Qiu Shicheng Zhao Wei Zhou | 2013 | Field Crops Research2013，，： | 1 |
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