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| 1 | Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer显示文摘渗入肿瘤的 Tregs 的起源,肿瘤免疫力的抑制的批评调停人,是不清楚的。这里,,我们证明在人的乳癌的渗入肿瘤的天真的 CD4 + T 房间和 Tregs 有重叠 TCR 全部剧目几乎别与传播 Tregs 重叠,建议 intratumoral Tregs 主要在 situ 而非从招募的 Tregs 从天真的 T 房间发展。而且,许多天真的 CD4 + T 房间和 Tregs 密切被相关,两个显示的穷人为乳癌病人的预后。天真的 CD4 + T 房间与许多生产 CCL18 巨噬细胞成比例遵守肿瘤片。而且,采纳地转移的人的天真的 CD4 + T 房间以一种 CCL18 依赖的方式渗入人的乳癌 orthotopic 异种皮移植。在在人性化的鼠标的人的乳癌异种皮移植,由将 PITPNM3 的表达式击倒堵住天真的 CD4 + T 房间的招募进肿瘤, CCL18 受体,显著地减少 intratumoral Tregs 并且禁止肿瘤前进。这些调查结果建议那个乳房渗入肿瘤的 Tregs 从在 situ 区分进 Tregs 的传播天真的 CD4 + T 房间的趋化性产生。由防碍 CCL18 的 PITPNM3 识别禁止天真的 CD4 + T 房间招募进肿瘤可以是为 anticancer 免疫疗法的吸引人的策略。 | Shicheng Su Jianyou Liao Jiang Liu Di Huang Chonghua He Fei Chen LinBing Yang Wei Wu Jianing Chen Ling Lin Yunjie Zeng Nengtai Ouyang Xiuying Cui Herui Yao Fengxi Su Jian-dong Huang Judy Lieberman Qiang Liu Erwei Song | 2017 | Cell Research2017，27，4： | 19 |
| 2 | ERK1/2 mediates lung adenocarcinoma cell proliferation and autophagy induced by apelin-13显示文摘这研究的目的是在房间增长和肺腺癌的 autophagy 调查 apelin 的角色。在肺腺癌的 APJ 的在表示上被 immunohistochemistry 检测,当在肺癌症病人的血浆 apelin 水平被连接酶的 immunosorbent 试金测量时。我们的调查结果表明 apelin-13 显著地增加了 ERK1/2 的 phosphorylation, cyclin D1 的表示,联系微导管的蛋白质 1 轻链 3A/B (LC3A/B ) ,和 beclin1,并且证实 apelin-13 支持了 A549 房间增长并且经由 ERK1/2 发信号导致了 A549 房间 autophagy。而且,人的肺腺癌房间线 A549 的表面和光滑、光滑的 apelin-13 原因房间表面上有毛孔是在原子力量下面观察了显微镜学。这些结果建议 ERK1/2 发信号小径调停 apelin-13-induced 肺腺癌房间增长和 autophagy。在我们的试验性的条件下面,与 3-methyladenine 联系的 autophagy 不涉及房间增长。 | Li Yang Tao Su Deguan Lv FengXie Wei Liu Jiangang Cao Irshad Ali Sheikh Xuping Qin Lanfang Li Linxi Chen | 2014 | Acta Biochimica et Biophysica Sinica2014，46，2： | 15 |
| 3 | Comparison of breast-conserving surgery and mastectomy in early breast cancer using observational data revisited:a propensity score-matched analysis显示文摘Recent observational studies showed that breast-conserving surgery(BCS) resulted in superior survival compared to mastectomy in breast cancer patients. This study compared the clinical outcomes of BCS and mastectomy using propensity score(PS)matching analysis, which had advantages over conventional methods in reducing bias. Nonmetastatic breast cancer patients who underwent BCS and mastectomy were matched 1:1 based on their PS. We used the Kaplan-Meier method and Cox-regression model to estimate the treatment effects. A total of 2,866 patients with a median follow-up time of 67 months were included in the original study population. Although the mastectomy cohort(N=1,219) had more advanced disease compared to the BCS cohort(N=1,647), LRFS was similar between the two groups(93.8% vs. 92.4%, P>0.05). BCS(vs. mastectomy) was associated with improved DFS(73.8% vs. 58.7%, P<0.01) and CSS(91% vs. 78.2%, P<0.01) in the original population. In the PS-matched population(N=1,668), clinicopathological features were equally distributed between the two cohorts. BCS(vs. mastectomy) was not associated with improved DFS(70.7% vs. 66.9%, P>0.05) or CSS(87.5% vs. 84.9%, P>0.05). We found that PS methods reduce bias when estimating treatment effects using observational data. BCS and mastectomy show equivalent outcomes in nonmetastatic breast cancer patients. | Kai Chen Zihao Pan Liling Zhu Tingting Hu Min Peng Weijuan Jia Fengxi Su Shunrong Li Erwei Song | 2018 | Science China(Life Sciences)2018，61，12： | 12 |
| 4 | Introduction of a multicenter online database for non-metastatic breast cancer in China显示文摘Dear Editor,Breast cancer is now the most frequently diagnosed cancer and is the fifth leading cause of cancer-related death in Chinese women. Therefore, the burden of breast cancer in China is gradually increasing. According to figures released by the Chinese Cancer Center in 2018, the number of newly diagnostic breast cancer is about 278,900 cases, accounting for 16.51%of all women who were diagnosed with the first primary malignant tumors;and 66,000 cases of breast cancer died in 2014 (Chen et al., 2016). | Yaping Yang Jieqiong Liu Min Peng Fengxi Su Xiaoming Xie Zhenzhen Liu Jundong Wu Wei Wei Dongxian Zhou Weiwen Li Ailing Zhang Guosen Su Weixiong Yang Jishang Chen Dekui Ma Yongguang Cai Kai Chen Liling Zhu Qiang Liu Erwei Song | 2020 | Science China(Life Sciences)2020，63，9： | 4 |
| 5 | In pursuit of a flawless aphrodite:paving the way to scarless oncoplastic breast surgery显示文摘Introduction Breast cancer is the most commonly diagnosed malig-nancy in women worldwide[1,2]and in the twentieth century,mastectomy was the primary surgical treatment for breast cancer patients.Advances in breast-conserving surgery(BCS)propelled a change in treatment rational from“maximum tolerable”to“minimum effective”ther-apy.Oncoplastic breast surgery aims to restore the shape of the breast and has been widely adopted since the past decade.Although the cosmetic outcome has been sig-nificantly improved,the scar remaining on the surgeried breast skin is still a major pitfall that urges urgent consid-eration.In this editorial,we review a series of techniques that can be incorporated in oncoplastic breast surgery to minimize scarring,signifying the beginning of an era for scarless oncoplastic surgery. | Liling Zhu Shunrong Li Luyuan Tan Xiaolan Zhang Jiannan Wu Fengxi Su Kai Chen Erwei Song | 2019 | Cancer Communications2019，39，1： | 4 |
| 6 | A Positive Feedback Loop between Mesenchymal-like Cancer Cells and Macrophages Is Essential to Breast Cancer Metastasis显示文摘 | Shicheng Su Qiang Liu Jingqi Chen Jianing Chen Fei Chen Chonghua He Di Huang Wei Wu Ling Lin Wei Huang Jin Zhang Xiuying Cui Fang Zheng Haiyan Li Herui Yao Fengxi Su Erwei Song | 2014 | Cancer Cell2014，，5： | 3 |
| 7 | 比较B超定位和常规体表定位法静脉输液港植入术在乳腺癌患者中的应用(英文)显示文摘Objective:The aim of this study was to compare the anatomic-landmark and ultrasound-guided techniques in the placement of an internal jugular vein port in patients with advanced breast cancer.Methods:Between March 2010 and October 2010,60 patients with advanced breast cancer underwent central venous port placement for the delivery of chemotherapy,preferably through the internal jugular vein.Patients were randomly assigned to either the anatomic-landmark or the ultrasound-guided group.Failure on first attempt,number of attempts until successful catheterization,time to successful placement,the accordance of the two placement approaches,and the demographics of each patient were recorded.Results: The consistency of the direction of two lines drawn using the anatomic-landmark and ultrasound-guided techniques or of the diameter of the internal jugular vein as determined by the two approaches was 85%(51/60).The rate of successful placement at first attempt was higher in the ultrasound group than in the anatomic-landmark group(P<0.05).A greater number of attempts and longer time to successful port placement were needed in the latter(P<0.05).Conclusion:The findings of this study indicate that,in the placement of an internal jugular vein port,the ultrasound(US)-guided technique has several advantages over the anatomic-landmark technique. | Nanyan Rao Jiannan Wu Shunrong Li Liang Jin Weijuan Jia Heran Deng Fengxi Su | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，12： | 2 |
| 8 | Let-7 regulates self renewal and tumorigenicity of breast cancer cells 显示文摘 | Fengyan Yu Herui Yao Pengcheng Zhu Xiaoqin Zhang Qiuhui Pan Chang Gong Yijun Huang Xiaoqu Hu Fengxi Su Judy Lieberman and Erwei Song | 2007 | Cell 20072007，，： | 1 |
| 9 | CCL18 from Tumor-Associated Macrophages Promotes Breast Cancer Metastasis via PITPNM3显示文摘 | Jingqi Chen Yandan Yao Chang Gong Fengyan Yu Shicheng Su Jianing Chen Bodu Liu Hui Deng Fengsong Wang Ling Lin Herui Yao Fengxi Su Karen S. Anderson Qiang Liu Mark E. Ewen Xuebiao Yao Erwei Song | 2011 | Cancer Cell2011，，4： | 1 |
| 10 | let-7 Regulates Self Renewal and Tumorigenicity of Breast Cancer Cells显示文摘 | Fengyan Yu Herui Yao Pengcheng Zhu Xiaoqin Zhang Qiuhui Pan Chang Gong Yijun Huang Xiaoqu Hu Fengxi Su Judy Lieberman Erwei Song | 2007 | Cell2007，，6： | 1 |
| 11 | let-7 Regulates Self Renewal and Tumorigenicity of Breast Cancer Cells显示文摘 | Fengyan Yu Herui Yao Pengcheng Zhu Xiaoqin Zhang Qiuhui Pan Chang Gong Yijun Huang Xiaoqu Hu Fengxi Su Judy Lieberman Erwei Song | 2007 | Cell2007，，6： | 1 |
| 12 | 免疫节点抑制剂逆转巨噬细胞抗体依赖细胞吞噬效应介导的免疫抑制显示文摘文章简介抗体依赖细胞毒效应(ADCC)和抗体依赖细胞吞噬效应(ADCP)对于肿瘤治疗性单抗药物疗效的发挥至关重要。本研究发现,巨噬细胞在发生ADCP后可抑制NK细胞的ADCC作用和T细胞介导的肿瘤杀伤作用从而降低单抗治疗效果。 | Shicheng Su Jinghua Zhao Yue Xing Xiaoqian Zhang Jiang Liu Qian Ouyang Jianing Chen Fengxi Su 刘强 宋尔卫 | 2019 | 科学新闻2019，0，2： | 0 |
| 13 | 细胞浆中与NF-KB相互作用的长非编码RNA NKILA通过调控IkB磷酸化抑制乳腺癌转移显示文摘细胞出版社《癌细胞》杂志创刊于2002年,其旨在出版具有高影响力的癌症研究论文。《癌细胞》每年出版12期,每期正式出版前会选择部分文章提前在线出版。该杂志2015年公布的影响因子为23.523。 | Bodu Liu Lijuan Sun Qiang Liu Chang Gong Yandan Yao Xiaobin Lv Ling Lin Herui Yao Fengxi Su Dangsheng Li Musheng Zeng 宋尔卫 | 2016 | 科学新闻2016，0，1： | 0 |
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