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| 1 | Repurposing vitamin D for treatment of human malignancies via targeting tumor microenvironment显示文摘Tumor cells along with a small proportion of cancer stem cells exist in a stromal microenvironment consisting of vasculature, cancer-associated fibroblasts, immune cells and extracellular components.Recent epidemiological and clinical studies strongly support that vitamin D supplementation is associated with reduced cancer risk and favorable prognosis. Experimental results suggest that vitamin D not only suppresses cancer cells, but also regulates tumor microenvironment to facilitate tumor repression. In this review, we have outlined the current knowledge on epidemiological studies and clinical trials of vitamin D. Notably, wesummarized and discussed the anticancer action of vitamin D in cancer cells, cancer stem cells and stroma cells in tumor microenvironment, providing a better understanding of the role of vitamin D in cancer. We presently re-propose vitamin D to be a novel and economical anticancer agent. | Xu Wu Wei Hu Lan Lu Yueshui Zhao Yejiang Zhou Zhangang Xiao Lin Zhang Hanyu Zhang Xiaobing Li Wanping Li Shengpeng Wang Chi Hin Cho Jing Shen Mingxing Li | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 20 |
| 2 | Task space control of free-floating space robots using constrained adaptive RBF-NTSM显示文摘Trajectory tracking control of space robots in task space is of great importance to space missions,which require on-orbit manipulations.This paper focuses on position and attitude tracking control of a free-floating space robot in task space.Since neither the nonlinear terms and parametric uncertainties of the dynamic model,nor the external disturbances are known,an adaptive radial basis function network based nonsingular terminal sliding mode(RBF-NTSM)control method is presented.The proposed algorithm combines the nonlinear sliding manifold with the radial basis function to improve control performance.Moreover,in order to account for actuator physical constraints,a constrained adaptive RBF-NTSM,which employs a RBF network to compensate for the limited input is developed.The adaptive updating laws acquired by Lyapunov approach guarantee the global stability of the control system and suppress chattering problems.Two examples are provided using a six-link free-floating space robot.Simulation results clearly demonstrate that the proposed constrained adaptive RBF-NTSM control method performs high precision task based on incomplete dynamic model of the space robots.In addition,the control errors converge faster and the chattering is eliminated comparing to traditional sliding mode control. | GUO ShengPeng LI DongXu MENG YunHe FAN CaiZhi | 2014 | Science China(Technological Sciences)2014，57，4： | 11 |
| 3 | Metals in water and surface sediments from Henan reaches of the Yellow River,China显示文摘The concentrations of Cd,Cr,Cu,Ni,Pb and Zn were determined in the water and surface sediments from the Henan reaches of the Yellow River.Twenty-three sampling sites along the Yellow River and its tributaries were selected.Generally,metal concentrations were found to decrease in sequences of Zn>Cu>Pb>Cr>Ni>Cd in water and Zn>Cr>Pb>Ni>Cu>Cd in sediments.High levels of metal concentration were determined at a few stations of the river and its tributaries,such as Yiluo River,Si River and Qin River.The pollution of the Yellow River by Cd,Cr,Cu,Ni,Pb and Zn can be regarded as much higher compared to the background values,US EPA criteria(1999) and China water quality criteria(2002) .For sediments,metal lev-els except Pb did not significantly exceed the average shale levels and backgrounds in several countries including China.Data analysis manifests that positive correlations were found between Cu,Ni and Zn in water,and Pb,Ni,Zn and Cr in sediments. The Pearson correlation coefficient analysis and Cluster analysis were provided to assess the possible contamination sources. The results indicate a general appearance of serious pollution along the banks of the Yellow River.The wastewaters discharged by the mine plants,smelter plants,power plants,battery plants,tannery plants,etc.,and sewage inputs from the cities along the river banks may be the sources of metals. | Feng, JingLan Wang, GuoLiang Sun, JianHui Sun, ShengPeng Liu, XiangFu | 2010 | Science China Chemistry2010，53，5： | 5 |
| 4 | Numerical study of hydrofoil surface jet flow on cavitation suppression显示文摘Cavitation caused vibration and noise of hydraulic machinery. To some extent,cavitation made fatigue damage in advance. Many scholars found that the re-entrant jets were the reasons of the shedding of cavities. To suppress cavitation,based on the idea of blocking the re-entrant jets,a special surface flow structure of 2D hydrofoil was proposed. The through-hole was made in the proper position of the hydrofoil. The incoming flow can outflow from this jet-hole automatically depending on the pressure difference between pressure side and suction side. Re-entrant jet growth can be weakened by optimizing the jet-hole geometry. Based on the standard k-ε turbulence model and Schnerr & Sauer cavitation model,under different cavitation numbers( σ) and jet-angles( β) for NACA0066( 2D) hydrofoil with 8° angles of attack,cavitation field numerical analysis was carried out. The results show that 2D hydrofoil cavitation flow had a strong unsteadiness. Making a jet-hole at the junction between the re-entrant jet and cavity can effectively minimize cloud cavitation. For a certain cavitation condition,optimal jet-angles( β) can be obtained to control cavitation growth. For the same β,the effects of cavitation suppression were changed with different cavitation numbers( σ). Consequently,suitable jet-angle and jet-position could extend the stable operating range of the hydrofoil. | WANG Wei LU Shengpeng XU Ruiduo YI Qi WANG Yayun WANG Xiaofang | 2017 | 排灌机械工程学报2017，35，10： | 5 |
| 5 | Macroporous Ni foam-supported Co_3O_4 nanobrush and nanomace hybrid arrays for high-efficiency CO oxidation显示文摘Herein, we reported the synthesis of well-defined Co_3O_4 nanoarrays(NAs) supported on a monolithic three-dimensional macroporous nickel(Ni) foam substrate for use in highefficiency CO oxidation. The monolithic Co_3O_4 NAs catalysts were obtained through a generic hydrothermal synthesis route with subsequent calcination. By controlling the reaction time,solvent polarity and deposition agent, these Co_3O_4 NAs catalysts exhibited various novel morphologies(single or hybrid arrays), whose physicochemical properties were further characterized by using several analytical techniques. Based on the catalytic and characterization analyses, it was found that the Co_3O_4 NAs-6 catalyst with nanobrush and nanomace arrays displayed enhanced catalytic activity for CO oxidation, achieving an efficient 100% CO oxidation conversion at a gas hourly space velocity(GHSV) 10,000 hr^(-1) and 150°C with longterm stability. Compared with the other Co_3O_4 NAs catalysts, it had the highest abundance of surface-adsorbed oxygen species, excellent low-temperature reducibility and was rich in surface-active sites(Co^(3+)/Co^(2+)= 1.26). | Shengpeng Mo Hui He Quanming Ren Shuangde Li Weixia Zhang Mingli Fu Limin Chen Junliang Wu Yunfa Chen Daiqi Ye | 2019 | Journal of Environmental Sciences2019，31，1： | 4 |
| 6 | Joints of continuous carbon fiber reinforced lithium aluminosilicate glass ceramics matrix composites to Ti60 alloy brazed using Ti-Zr-Ni-Cu active alloy显示文摘Continuous carbon fiber reinforced lithium aluminosilicate glass ceramics matrix composites(C_f/LAS composites) are joined to Ti60 alloy vacuum brazed using Ti-Zr-Ni-Cu brazing alloy. The effects of the brazing temperature on the interfacial microstructure and mechanical properties of brazed joints are investigated in details. The interfacial microstructure varies apparently with an increase of the brazing temperature. The thicknesses of the banded Ti solid solution(Ti(s, s)) and the reactive layer between Cf/LAS composites and the interlayer grow gradually. The mechanical properties of brazed joints increase firstly and then decrease with an increasing temperature. In addition, a joint that is brazed at 980 °C for 10 min shows the highest shear strength of$38.13 MPa. At the same time, the fracture paths of brazed joints also change as the temperature increases. When the brazing temperature is 950 °C, the fracture position is in the TiC + ZrC +Ti_2O + ZrSi_2+ Ti_5Si_3 layer on the composite side. When the brazing temperature is 980 °C, the fracture position is on the side of the braze seam(Ti, Zr)2(Ni, Cu), Ti_2O + ZrSi_2+ Ti_5Si_3 layer,and carbon fiber in the composite material. When the brazing temperature is 990 °C, the fracture position is in the Ti_2O + ZrSi_2+ Ti_5Si_3 layer on the composite side and the carbon fiber in the composite material. | Shengpeng HU Dongdong FENG Long XIA Ke WANG Renwei LIU Zhentao XIA Hongwei NIU Xiaoguo SONG | 2019 | Chinese Journal of Aeronautics2019，32，3： | 4 |
| 7 | Adaptability research of hydrofoil surface water injection on cavitation suppression显示文摘To study the effectiveness of hydrofoil surface water injection on cavitation suppression,the unsteady cavitation flow field around the NACA0066 hydrofoil at attack angle of 6°was simulated by the modified RNG k-εturbulence model combined with the full-cavitation model.The structure of cavitation flow field and the hydrodynamic performance of hydrofoil were analyzed at the cavitation number of 0.85,0.70,0.55,respectively.The results show that barriered by the jet,the momentum of the reentrant jet was reduced;The development of cavitation and the strength of cavity shedding were weakened to some extent.Cavitation suppression effect was very obvious in the cavitation conditions with the cavitation number of 0.7 and above when the injection position was at 37% chord length from the hydrofoil leading edge and the jet-flow ratio kept 0.3.Time-averaged lift and drag coefficient were reduced,and the lift-drag ratio increased in water injection conditions. | WANG Wei YI Qi WANG Yayun LU Shengpeng WANG Xiaofang | 2017 | 排灌机械工程学报2017，35，6： | 4 |
| 8 | Rabdosia serra alleviates dextran sulfate sodium salt-induced colitis in mice through anti-inflammation,regulating Th17/Treg balance,maintaining intestinal barrier integrity,and modulating gut microbiota显示文摘Rabdosia serra(R.serra),an important component of Chinese herbal tea,has traditionally been used to treat hepatitis,jaundice,cholecystitis,and colitis.However,the chemical composition of R.serra and its effect against colitis remain unclear.In this study,the chemical composition of the water extract of R.serra was analyzed using ultra performance liquid chromatography coupled with a hybrid linear ion trap quadrupole-orbitrap mass spectrometer(UPLC-LTQ-Orbitrap-MS).A total of 46 compounds,comprising ent-kaurane diterpenoids,flavonoids,phenolic acids,and steroids,were identified in the water extract of R.serra,and the extract could significantly alleviate dextran sulfate sodium salt-induced colitis by improving colon length,upregulating anti-inflammatory factors,downregulating proinflammatory factors,and restoring the balance of T helper 17/T regulatory cells.R.serra also preserved intestinal barrier function by increasing the level of tight junction proteins(zonula occludens 1 and occludin)in mouse colonic tissue.In addition,R.serra modulated the gut microbiota composition by increasing bacterial richness and diversity,increasing the abundance of beneficial bacteria(Muribaculaceae,Bacteroides,Lactobacillus,and Prevotellaceae_UCG-001),and decreasing the abundance of pathogenic bacteria(Turicibacter,Eubacterium_fissicatena_group,and Eubacterium_xylanophilum_group).Gut microbiota depletion by antibiotics further confirmed that R.serra alleviated colitis in a microbiota-dependent manner.Overall,our findings provide chemical and biological evidence for the potential application of R.serra in the management of colitis. | Hongyi Li Yi Wang Shumin Shao Hui Yu Deqin Wang Chuyuan Li Qin Yuan Wen Liu Jiliang Cao Xiaojuan Wang Haibiao Guo Xu Wu Shengpeng Wang | 2022 | Journal of Pharmaceutical Analysis2022，12，6： | 4 |
| 9 | Determination of time-and size-dependent fine particle emission with varied oil heating in an experimental kitchen显示文摘Particulate matter(PM) from cooking has caused seriously indoor air pollutant and aroused risk to human health.It is urged to get deep knowledge of their spatial-temporal distribution of source emission characteristics,especially ultrafine particles(UFP < 100 nm) and accumulation mode particles(AMP 100-555 nm).Four commercial cooking oils are auto dipped water to simulate cooking fume under heating to 255℃ to investigate PM emission and decay features between 0.03 and 10 μm size dimension by electrical low pressure impactor(ELPI) without ventilation.Rapeseed and sunflower produced high PM_(2.5) around5.1 mg/m^3,in comparison with those of soybean and corn(5.87 and 4.55 mg/m^3,respectively)at peak emission time between 340 and 450 sec since heating oil,but with the same level of particle numbers 6-9 × 10~5/cm^3.Mean values of PM_(1.0)/PM_(2.5) and PM_(2.5)/PM_(10) at peak emission time are around 0.51-0.55 and 0.23-0.29.After 15 min naturally deposition,decay rates of PM_(1.0),PM_(2.5) and PM_(10) are 13.3%-29.8%,20.1%-33.9%and 41.2%-54.7%,which manifest that PM_(1.0) is quite hard to decay than larger particles,PM_(2.5) and PM_(1.0).The majority of the particle emission locates at 43 nm with the largest decay rate at 75%,and shifts to a larger size between137 and 555 nm after 15 min decay.The decay rates of the particles are sensitive to the oil type. | Shuangde Li Jiajia Gao Yiqing He Liuxu Cao Ang Li Shengpeng Mo Yunfa Chen Yaqun Cao | 2017 | Journal of Environmental Sciences2017，29，1： | 3 |
| 10 | A method for computing unsupported roof distance in roadway advancement and its in-situ application显示文摘A reasonable unsupported roof distance(URD) when advancing underground coal mine roadways can contribute greatly to safe and rapid roadway development.A mechanical model of the roof,using the relationship between the roof stress distribution and URD,obtained by the difference method,and roof stability according to the in-situ roof stress and rock mass strength was developed.We subsequently designed a proper range of URD,developed a testing method of URD with the function of mining protection,evaluated roof stability through analyzing the test data and then determined a reasonable URD.Considering the factors of the geological conditions,the immediate roof stability and the efficiency of the labor arrangement system,the URD of the advancing roadway of 9802 working face in Zhangshuanglou coal mine was determined to be 6 m using the proposed method.The results show that,when a 2 m length of roadway was reinforced by temporary support and high pre-stressed bolt support after the roadway advancement of 6 m per cycle,the speed and the security of the roadway development can be achieved and the advance rate can reach more than 400 m per month. | Chen Yong Bai Jianbiao Yan Shuai Hao Shengpeng Dao Viet Doan | 2016 | International Journal of Mining Science and Technology2016，26，4： | 2 |
| 11 | Molecular dynamics simulation of nanoscale contact and sliding processes for probes with different tip radius of curvature显示文摘Three-dimensional molecular dynamics(MD)simulations were carried out to study the contact and sliding processes between diamond points with different tip radius of curvature and surfaces of single crystal copper.The material deformation,abrasion mechanism,lattice defects,the force of contact process,and the sliding friction process were investigated.The simulation results show that the contact force,dislocations,and stacking fault defects,increase during the contact process with increasing contact depth or tip radius of curvature.The dislocations emit along the 10'1and'10'1direction and then a glide band is formed.It was also found that a greater tip radius of curvature results in a larger groove and more material deformation.The normal force and friction increase with increasing tip radius of curvature,but the coefficient of friction decreases.The stacking faults spread along the sliding direction and increase with increasing tip radius of curvature.In addition,the number of upheaval atoms increases as the radius of tip curvature or sliding distance increases. | Xiaojing Yang Shengpeng Zhan | 2014 | Chinese Science Bulletin2014，59，13： | 2 |
| 12 | Construction of Cu-Ce interface for boosting toluene oxidation:Study of Cu-Ce interaction and intermediates identified by in situ DRIFTS显示文摘A facile hydrothermal method was applied to gain stably and highly efficient CuO-CeO_(2)(denoted as Cu1Ce2)catalyst for toluene oxidation.The changes of surface and inter properties on Cu1Ce2 were investigated comparing with pure CeO_(2)and pure CuO.The formation of Cu-Ce interface promotes the electron transfer between Cu and Ce through Cu^(2+)+Ce^(3+)↔Cu^(+)+Ce^(4+)and leads to high redox properties and mobility of oxygen species.Thus,the Cu1Ce2 catalyst makes up the shortcoming of CeO_(2)and CuO and achieved high catalytic performance with T_(50)=234°C and T_(99)=250°C(the temperature at which 50%and 90%C_(7)H_(8)conversion is obtained,respectively)for toluene oxidation.Different reaction steps and intermediates for toluene oxidation over Cu1Ce2,CeO_(2)and CuO were detected by in situ DRIFTS,the fast benzyl species conversion and preferential transformation of benzoates into carbonates through C=C breaking over Cu1Ce2 should accelerate the reaction. | Jiahui Lu Jinping Zhong Quanming Ren Jiaqi Li Linghe Song Shengpeng Mo Mingyuan Zhang Peirong Chen Mingli Fu Daiqi Ye | 2021 | Chinese Chemical Letters2021，32，11： | 2 |
| 13 | Solar-Driven Producing of Value-Added Chemicals with Organic Semiconductor-Bacteria Biohybrid System显示文摘Photosynthetic biohybrid systems exhibit promising performance in biosynthesis;however,these systems can only produce a single metabolite and cannot further transform carbon sources into highly valuable chemical production.Herein,a photosynthetic biohybrid system integrating biological and chemical cascade synthesis was developed for solar-driven conversion of glucose to value-added chemicals.A new ternary cooperative biohybrid system,namely bacterial factory,was constructed by self-assembling of enzyme-modified light-harvesting donor-acceptor conjugated polymer nanoparticles(D-A CPNs)and genetically engineered Escherichia coli(E.coli).The D-A CPNs coating on E.coli could effectively generate electrons under light irradiation,which were transferred into E.coli to promote the 37%increment of threonine production by increasing the ratio of nicotinamide adenine dinucleotide phosphate(NADPH).Subsequently,the metabolized threonine was catalyzed by threonine deaminase covalently linking with D-A CPNs to obtain 2-oxobutyrate,which is an important precursor of drugs and chemicals.The 2-oxobutyrate yield under light irradiation is increased by 58%in comparison to that in dark.This work provides a new organic semiconductor-microorganism photosynthetic biohybrid system for biological and chemical cascade synthesis of highly valuable chemicals by taking advantage of renewable carbon sources and solar energy. | Wen Yu Haotian Bai Yue Zeng Hao Zhao Shengpeng Xia Yiming Huang Fengting Lv Shu Wang | 2022 | Research2022，，3： | 2 |
| 14 | A polyphenol-assisted IL-10 mRNA delivery system for ulcerative colitis显示文摘With the development of synthesis technology, modified messenger RNA(mRNA) has emerged as a novel category of therapeutic agents for a broad of diseases. However, effective intracellular delivery of mRNA remains challenging, especially for its sensitivity to enzymatic degradation. Here, we propose a polyphenol-assisted handy delivery strategy for efficient in vivo delivery of IL-10 mRNA.IL-10 mRNA binds to polyphenol ellagic acid through supramolecular binding to yield a negatively charged core, followed by complexing with linear polyetherimide and coating with bilirubin-modified hyaluronic acid to obtain a layer-by-layer nanostructure. The nanostructure specifically up-regulated the level of IL-10, effectively inhibited the expression of inflammatory factors, promoted mucosal repair, protected colonic epithelial cells against apoptosis, and exerted potent therapeutic efficacy in dextran sulfate sodium salt-induced acute and chronic murine models of colitis. The designed delivery system without systemic toxicity has the potential to facilitate the development of a promising platform for mRNA delivery in ulcerative colitis treatment. | Zhejie Chen Wei Hao Caifang Gao Yangyang Zhou Chen Zhang Jinming Zhang Ruibing Wang Yitao Wang Shengpeng Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，8： | 2 |
| 15 | Photocatalytic degradation of Orange G on nitrogen-doped TiO 2 catalysts under visible light and sunlight irradiation显示文摘 | Jianhui Sun Liping Qiao Shengpeng Sun Guoliang Wang | 2007 | Journal of Hazardous Materials2007，，1： | 1 |
| 16 | Substation remote video security monitoring显示文摘 | XU Shengpeng JIANG Li GONG Jianxue | 2008 | Power System Communication2008，29，8： | 1 |
| 17 | An inves- tigation on distortion of PLA thin-plate part in the FDM process 显示文摘 | XINHUA L SHENGPENG L ZHOU L | 2015 | Int J Adv Manuf Technol2015，79，： | 1 |
| 18 | Statistical Analysis and Prediction of the Concentration of Harmful Algae in Bohai Bay显示文摘 | WANG Hongli FENG Jianfeng LI Shengpeng | 2005 | Transactions of Tianjin University2005，，： | 1 |
| 19 | Anti-Lung-Cancer Activity and Liposome-Based Delivery Systems of β -Elemene显示文摘 | Meiwan Chen Jinming Zhang Siqin Yu Shengpeng Wang Zaijun Zhang Jianqiang Chen Jian Xiao Yitao Wang Yoshiyuki Kimura | 2012 | Evidence-Based Complementary and Alternative Medicine2012，，： | 1 |
| 20 | Vasorelaxant effect of isopropyl 3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate,a novel metabolite from Salvia miltiorrhiza,on isolated rat mesenteric artery显示文摘 | Wang Shengpeng Zang Weijin Kong Shanshan | 2008 | Eur J Pharmacol2008，579，13： | 1 |
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