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| 1 | Elevated plasma levels of selective cytokines in COVID-19 patients reflect viral load and lung injury显示文摘A recent outbreak of pneumonia in Wuhan,China was found to be caused by a 2019 novel coronavirus(2019-nCoV or SARS-CoV-2 or HCoV-19).We previously reported the clinical features of 12 patients with2019-n Co V infections in Shenzhen,China.To further understand the pathogenesis of COVID-19 and find better ways to monitor and treat the disease caused by 2019-n Co V,we measured the levels of 48 cytokines in the blood plasma of those 12 COVID-19 patients.Thirty-eight out of the 48 measured cytokines in the plasma of 2019-n Co V-infected patients were significantly elevated compared to healthy individuals.Seventeen cytokines were linked to 2019-nCoV loads.Fifteen cytokines,namely M-CSF,IL-10,IFN-α2,IL-17,IL-4,IP-10,IL-7,IL-1 ra,G-CSF,IL-12,IFN-γ,IL-1α,IL-2,HGF and PDGF-BB,were strongly associated with the lung-injury Murray score and could be used to predict the disease severity of2019-n Co V infections by calculating the area under the curve of the receiver-operating characteristics.Our results suggest that 2019-nCoV infections trigger extensive changes in a wide array of cytokines,some of which could be potential biomarkers of disease severity of 2019-n Co V infections.These findings will likely improve our understanding of the immunopathologic mechanisms of this emerging disease.Our results also suggest that modulators of cytokine responses may play a therapeutic role in combating the disease once the functions of these elevated cytokines have been characterized. | Yingxia Liu Cong Zhang Fengming Huang Yang Yang Fuxiang Wang Jing Yuan Zheng Zhang Yuhao Qin Xiaoyun Li Dandan Zhao Shunwang Li Shuguang Tan Zhaoqin Wang Jinxiu Li Chenguang Shen Jianming Li Ling Peng Weibo Wu Mengli Cao Li Xing Zhixiang Xu Li Chen Congzhao Zhou William J Liu Lei Liu Chengyu Jiang | 2020 | National Science Review2020，7，6： | 6 |
| 2 | Tool Orientation Optimization and Path Planning for 5-Axis Machining显示文摘Tool path generation is a fundamental problem in 5-axis CNC machining, which consists of tool orientation planning and cutter-contact(CC) point planning. The planning strategy highly depends on the type of tool cutters. For ball-end cutters, the tool orientation and CC point location can be planned separately;while for flat end cutters, the two are highly dependent on each other. This paper generates a smooth tool path of workpiece surfaces for flat end mills from two stages: Computing smooth tool orientations on the surface without gouging and collisions and then designing the CC point path. By solving the tool posture optimization problem the authors achieve both the path smoothness and the machining efficiency. Experimental results are provided to show the effectiveness of the method. | YUAN Chunming MI Zhenpeng JIA Xiaohong LIN Fengming SHEN Liyong | 2021 | Journal of Systems Science & Complexity2021，34，1： | 3 |
| 3 | Complement and HIV-I infection/HIV-associated neurocognitive disorders显示文摘 | Fengming Liu Shen Dai Jennifer Gordon Xuebin Qin | 2014 | Journal of NeuroVirology2014，，2： | 1 |
| 4 | Electronic Parameter Modu late Hyperchaos System Base on Semiconductor Laser 显示文摘 | Bai Fengming Shen Ke | 2000 | SPIE2000，4222，： | 1 |
| 5 | Carbonization fabrication of a piezoresistive sensor with improved sensitivity via Ni decoration of carbonized cotton fibers显示文摘The development of wearable electronics urgently requires the cost-effective and scalable fabrication of high-performance pressure sensors.This work aims to develop a simple carbonization strategy to facilitate sensor sensitivity by decorating discrete nickel nanoparticles on carbonized cotton fibers(CCFs).The increased air gap between the fibers at the unloading state,as well as the enlargement of the deformation distance and the contact area between the conductive materials at the loading state,contribute to a more significant resistance change.Therefore,the sensitivity of the piezoresistive sensor is improved more than 5 times within 1 N by introducing Ni nanoparticles,and it is characterized by a rapid response(~160 ms)and recovery(~100 ms),wide detection range(~20 N/~130 kPa),and good durability(~4000 cycles).The flexible sensor has been successfully demonstrated to monitor human movements,physical stimuli,and pressure distribution.Furthermore,the proposed device can control temperature accurately as a uniform and large-scale heater.This work reveals that the Ni@CCFs-based sensor is prospective in wearable electronics,artificial intelligence,health monitoring,medical diagnosis and treatment. | HE Xiang WANG FengMing LIANG YiYing WU JiaWei LIANG JiongHong SHEN GengZhe LI BaiJun SU DaoJian ZHANG Chi SONG WeiDong HE Xin | 2022 | Science China(Technological Sciences)2022，65，12： | 0 |
| 6 | Research Progress of Modern Children's Outdoor Play Areas and Relevant Legal Framework显示文摘By briefing history and current situation of researches,designs and construction of children’s outdoor play areas in the United States and Japan,and legislative framework of children’s welfare in the United Nations and developed countries,the relationship between sound relationship and Children’s outdoor play areas was elaborated.Suggestions were given for the development of childrens’outdoor spaces in China. | GENG Fengming SHEN Xiaohui | 2013 | Journal of Landscape Research2013，5，Z2： | 0 |
| 7 | Predicting and overcoming resistance to CDK9 inhibitors for cancer therapy显示文摘Abnormally activated CDK9 participates in the super-enhancer mediated transcription of short-lived proteins required for cancer cell survival.Targeting CDK9 has shown potent anti-tumor activity in clinical trials among different cancers.However,the study and knowledge on drug resistance to CDK9 inhibitors are very limited.In this study,we established an AML cell line with acquired resistance to a highly selective CDK9 inhibitor BAY1251152.Through genomic sequencing,we identified in the kinase domain of CDK9 a mutation L156F,which is also a coding SNP in the CDK9 gene.By knocking in L156F into cancer cells using CRISPR/Cas9,we found that single CDK9 L156F could drive the resistance to CDK9 inhibitors,not only ATP competitive inhibitor but also PROTAC degrader.Mechanistically,CDK9 L156F disrupts the binding with inhibitors due to steric hindrance,further,the mutation affects the thermal stability and catalytic activity of CDK9 protein.To overcome the drug resistance mediated by the CDK9-L156F mutation,we discovered a compound,IHMT-CDK9-36 which showed potent inhibition activity both for CDK9 WT and L156F mutant.Together,we report a novel resistance mechanism for CDK9 inhibitors and provide a novel chemical scaffold for the future development of CDK9 inhibitors. | Chen Hu Lijuan Shen Fengming Zou Yun Wu Beilei Wang Aoli Wang Chao Wu Li Wang Jing Liu Wenchao Wang Qingsong Liu | 2023 | Acta Pharmaceutica Sinica B2023，13，9： | 0 |
| 8 | Research Progress on Production of Chlorophyll and Other Products with Silkworm Excrement and Industrial Development over the Past 50 Years显示文摘The development of sericultural industry in the Pearl River Delta has contributed greatly to good ecological environment and economic prosperity of the people’s livelihood.Comprehensive utilization of sericulture resources can turn waste into valuable resources and expand the development approaches of sericultural industry.For example,using abundant silkworm excrement to produce chlorophyll is one of the good practices in comprehensive utilization of sericulture resources,which has leading technologies and good economic benefits.In addition to chlorophyll,the products produced from silkworm excrement can be used as the main raw materials of medicine,food,plant growth regulator and cosmetics.For instances,phytol,the important raw material for synthesis of vitamin E and vitamin K,was extracted from silkworm excrement,enabling China to become an important production base of vitamin E and vitamin K.Triacontanol extracted from silkworm excrement is a new crop growth regulator,which can increase the yield of rice and vegetable.Pectin,dietary fiber and carotenoid extracted from silkworm excrement as well can be used as natural raw material in many fields.China is the biggest manufacturer and supplier of silkworm excrement products in the world,which has a development history of about 50 years and generated high export revenue.It is believed that close combination of academic research and industry development is the only way to promote the industrial development of silkworm excrement resources. | Huang Ziran Ji Pingxiong Feng Guodong Li Guangxue Cao Yongmin Shen Fengming Zhu Xiangrui Luo Quan Pang Guozhang | 2016 | Animal Husbandry and Feed Science2016，8，3： | 0 |
| 9 | A Neural Circuit Controlling Virgin Female Aggression Induced by Mating-related Cues in Drosophila显示文摘Females increase aggression for mating opportunities and for acquiring reproductive resources.Although the close relationship between female aggression and mating status is widely appreciated,whether and how female aggression is regulated by mating-related cues remains poorly understood.Here we report an interesting observation that Drosophila virgin females initiate high-frequency attacks toward mated females.We identify 11-cis-vaccenyl acetate(cVA),a male-derived pheromone transferred to females during mating,which promotes virgin female aggression.We subsequently reveal a cVA-responsive neural circuit consisting of four orders of neurons,including Or67d,DA1,aSP-g,and pC1 neurons,that mediate cVA-induced virgin female aggression.We also determine that aSP-g neurons release acetylcholine(ACh)to excite pC1 neurons via the nicotinic ACh receptor nAChRα7.Together,beyond revealing cVA as a mating-related inducer of virgin female aggression,our results identify a neural circuit linking the chemosensory perception of mating-related cues to aggressive behavior in Drosophila females. | Xiaolu Wan Peng Shen Kai Shi Jing Li Fengming Wu Chuan Zhou | 2023 | Neuroscience Bulletin2023，39，9： | 0 |
| 10 | Highly stable capacitive tactile sensors with tunable sensitivity facilitated by electrostatic interaction of layered double hydroxide,MXene,and Ag NWs显示文摘A capacitive tactile sensor(CTS)has been developed by assembling a double-sided patterned dielectric layer and novel electrodes.The patterned aluminium foil-supported electrode comprises zinc-aluminium layered double hydroxides(Zn AlLDH),MXene,and Ag NWs via electrostatic interaction.This flexible device enables greater structural deformation,thereby enhancing sensitivity to a wide range of pressure.The sensitivity of the CTS can be customized to meet specific requirements by matching the microstructured electrodes with the patterned dielectric layer.An optimized sensor exhibits a sensitivity of 2.752 kPa^(–1)within 30 kPa,a response time of approximately 100 ms,and a wide detection range of 0–300 kPa.The strong physical interaction among the electrode materials ensures a reliable conductive network,ensuring the long-term stability of the sensor,even after 7500 loading and unloading cycles.Furthermore,the fabricated CTS device presents a promising prospect for the integration into wearable electronics,with the ability to effectively respond to both human activities and external physical stimuli. | SHEN GengZhe HUANG WeiQing LI HaiFeng WANG FengMing SU DaoJian LI BaiJun ZHANG BoLun LIANG Ping ZHANG Chi XIN Yue HE Xin | 2023 | Science China(Technological Sciences)2023，66，11： | 0 |
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