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| 1 | Estimation of Turbulent Fluxes Using the Flux-Variance Method over an Alpine Meadow Surface in the Eastern Tibetan Plateau显示文摘流动变化类似关系和数量的垂直转移在表面的不同类型上展出不同,导致在估计用流动变化方法的狂暴的流动的数量之中的相对运输效率的不同 parameterization 途径。我们调查了在雨季期间在中间的水文学条件下面在夏天在东方西藏的高原在一块开、同类、扁平的草地上使用 eddycovariance 大小的这些问题。处于不稳定的条件,温度,水蒸汽,和 CO2 跟随了流动变化类似关系,但是没出现在精确一样的方法由于不同角色(活跃或被动) 这些数量。温度,水蒸汽和 CO2 的类似常数被发现分别地是 1.12, 1.19 和 1.17。热交通比水蒸汽和 CO2 更有效。基于估计的理智的热流动,到水蒸汽和 CO2 的热的相对运输效率的五个 parameterization 方法被检验估计潜伏的热和 CO2 流动。流动变化类似关系的本地决心的策略为潜伏的热和 CO2 流动的评价被推荐。这条途径对代表平均相对运输效率更好,并且对技术上更容易适用,与另外的更复杂的相比。 | WANG Shaoying ZHANG Yu LU Shihua LIU Heping SHANG Lunyu | 2013 | Advances in Atmospheric Sciences2013，30，2： | 11 |
| 2 | Lithospheric structure and faulting characteristics of the Helan Mountains and Yinchuan Basin: Results of deep seismic reflection profiling显示文摘The Helan Mountains and Yinchuan Basin(HM-YB) are located at the northern end of the North-South tectonic belt,and form an intraplate tectonic deformation zone in the western margin of the North China Craton(NCC).The HM-YB has a complicated history of formation and evolution,and is tectonically active at the present day.It has played a dominant role in the complex geological structure and modern earthquake activities of the region.A 135-km-long deep seismic reflection profile across the HM-YB was acquired in early 2014,which provides detailed information of the lithospheric structure and faulting characteristics from near-surface to various depths in the region.The results show that the Moho gradually deepens from east to west in the depth range of 40-48 km along the profile.Significant differences are present in the crustal structure of different tectonic units,including in the distribution of seismic velocities,depths of intra-crustal discontinuities and undulation pattern of the Moho.The deep seismic reflection profile further reveals distinct structural characteristics on the opposite sides of the Helan Mountains.To the east,The Yellow River fault,the eastern piedmont fault of the Helan Mountains,as well as multiple buried faults within the Yinchuan Basin are all normal faults and still active since the Quaternary.These faults have controlled the Cenozoic sedimentation of the basin,and display a 'negative-flower' structure in the profile.To the west,the Bayanhaote fault and the western piedmont fault of the Helan Mountains are east-dipping thrust faults,which caused folding,thrusting,and structural deformation in the Mesozoic stratum of the Helan Mountains uplift zone.A deep-penetrating fault is identified in the western side of the Yinchuan Basin.It has a steep inclination cutting through the middle-lower crust and the Moho,and may be connected to the two groups of faults in the upper crust.This set of deep and shallow fault system consists of both strike-slip,thrust,and normal faults formed over different eras,and provides the key tectonic conditions for the basin-mountains coupling,crustal deformation and crust-mantle interactions in the region.The other important phenomenon revealed from the results of deep seismic reflection profiling is the presence of a strong upper mantle reflection(UMR) at a depth of 82-92 km beneath the HM-YB,indicating the existence of a rapid velocity variation or a velocity discontinuity in that depth range.This is possibly a sign of vertical structural inhomogeneity in the upper mantle of the region.The seismic results presented here provide new clues and observational bases for further study of the deep structure,structural differences among various blocks and the tectonic relationship between deep and shallow processes in the western NCC. | LIU BaoJin FENG ShaoYing JI JiFa WANG ShuaiJun ZHANG JianShi YUAN HongKe YANG GuoJun | 2017 | Science China Earth Sciences2017，60，3： | 11 |
| 3 | Geometry,kinematics and evolution of the Tongbai orogenic belt显示文摘The Tongbai orogenic belt (TOB) is composed of six tectonic units. From south to north these units are: Tongbai gneiss rise (TGR); Hongyihe-Luozhuang eclogite belt (HLE); Ma- opo-Hujiazhai igneous rock belt (MHI); Zhoujiawan flysch belt (ZFB); Yangzhuang greenschist belt (YGB); and Dongjiazhuang marble belt (DMB).The geometry and kinematic images of the TOB in- clude: the antiformal structures caused by a later uplift process, the top-to-north ductile shear struc- ture that related to a process that the ultrahigh pressure rocks are brought to surface, the top-to-south ductile shear thrust and the sinistrial shear structures related to a south-north direction compression, and the east-west direction fold structures in the upper crust. In the view of the multistage subduc- tion-collision orogenic belt, according to the characters of petrology and its distribution, geometry, kinematics and structural chronology in these tectonic units, tectonic evolution of the TOB can be divided into four stages: oceanic crust subduction during 400―300 Ma, continental collision during 270―250 Ma, continental deep subduction and uplift during 250―205 Ma and doming deformation during 200―185 Ma. | HUANG Shaoying XU Bei WANG Changqiu ZHAN Sheng DENG Rongjing | 2006 | Science China Earth Sciences2006，49，8： | 9 |
| 4 | Digitized Outcrop Geomodeling of Ramp Shoals and its Reservoirs: as an Example of Lower Triassic Feixianguan Formation of Eastern Sichuan Basin显示文摘Numerous hydrocarbon accumulations are found in ramp crest shoals worldwide and therefore this depositional setting has a high potential of being the hydrocarbon reservoir.In this paper,we combined digital outcrop geology and traditional geological mapping to build an outcrop-based geocellular model of the ramp-crest shoal complex of the Lower Triassic Feixianguan Formation in the Eastern Sichuan Basin.The outcrop model serves as an analogue for the subsurface reservoir of the Feixianguan Formation and illustrates the complexity of the lithofacies types,stratigraphic architecture,and reservoir heterogeneities at a scale below conventional subsurface data resolution.The studied ramp-crest shoal complex consists of thirteen types of lithofacies that can be grouped into three facies-groups corresponding to subtidal intraclastic shoal,sub-to inter-tidal oolitic shoal,and tidal flat depositional environments respectively.The stratigraphic architecture of the shoal complex shows mostly a strong progradation of the high energy facies associated with an overall decrease of accommodation space associated with relative sea level still stand.Two reservoir facies associations have been recognized.The first one consists of supratidal dolomudstone and upper intertidal partially dolomitized oolitic packstone with anhydrite or nodules.These facies were deposited above the high energy oolitic grainstones and occurs as thin-bedded and laterally continuous layers,characterized by high porosity and low permeability.The second reservoir facies association is composed of intertidal crystalline dolomite and subtidal intraclastic bindstone that occurs stratigraphically below the oolitic grainstones.These deposits consist of massive laterally discontinuously beds,and are characterized by high porosity and high permeability.Both types of reservoir facies tend to be stacked vertically and migrated laterally with the progradation of the shoal complex.The construction of the outcrop-based 3D geological model provide a description and quantification of the facies distribution within a robust stratigraphic framework and the style and amount of reservoir heterogeneities associated with a ramp-crest shoal complex reservoir such as the one found in Lower Triassic Feixianguan Formation and Cambrian Longwangmiao Formation in Sichuan Basin or other ramp-crest reservoir worldwide. | QIAO Zhanfeng SHEN Anjiang ZHENG Jianfeng Xavier JANSON CHANG Shaoying WANG Xiaofang CHEN Yana LIAO Yisha | 2017 | Acta Geologica Sinica(English Edition)2017，91，4： | 8 |
| 5 | Magnesium Acetate Used as an Effective Catalyst for Synthesizing Aliphatic Polycarbonates via Melt Transesterification Process显示文摘 | WANG Ziqing YANG Xiangui LIU Shaoying ZHANG Hua WANG Gongying | 2016 | Chemical Research in Chinese Universities2016，32，3： | 7 |
| 6 | Physical design of target station and neutron instruments for China Spallation Neutron Source显示文摘The China Spallation Neutron Source(CSNS)is the first accelerator-based multidiscipline user facility to produce pulsed neutrons by tungsten target under collision of a pulsed proton beam with a beam power of 100 kW at a repetition rate of 25 Hz.In this paper,we focus on the physical design of CSNS target station and neutron instruments.Under optimized design,the flat tungsten target and the compact target-moderator-reflector coupling enhance effective cold and thermal neutron output from moderators.Three wing-type moderators supply four different characteristics of neutrons to 19 beamlines primarily for neutron scattering applications.Layout of neutron instruments are conceptually planned for total 20 beamlines,the configuration and specification have been determined for three day-one neutron instruments.All designs are optimized for the Phase I of 100 kW with a upgradable capacity to 500 kW. | WANG FangWei LIANG TianJiao YIN Wen YU QuanZhi HE LunHua TAO JuZhou ZHU Tao JIA XueJun ZHANG ShaoYing | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，12： | 7 |
| 7 | Elemental sulfur in northern South China Sea sediments and its significance显示文摘Elemental sulfur(ES) is one of the intermediates in the inorganic sulfur cycle and thus plays a key role in the fractionation of stable sulfur isotopes in different reservoirs and the marine environment. In this study, solid ES is discovered in sediments near the Jiulong Methane Reef in the northern South China Sea by scanning electron microscopy and Raman spectroscopy. Combining the morphology and distribution of ES, pyrite concentrations, and sulfur isotopes, we conclude that:(1) solid ES coexists with pyrite microcrystals and sulfide(oxyhydr)oxides as well as clay minerals, and they are mainly distributed on the surface of mineral aggregates;(2) ES mainly occurs within and near the sulfate-methane transition zone(SMTZ) despite little morphological diversity;(3) ES formation might be related to hydrogen sulfide oxidation and is therefore linked with fluctuations in the SMTZ. Within the SMTZ, hydrogen sulfide is produced and pyrite precipitates because of enhanced anaerobic oxidation of methane coupled with dissimilatory sulfate reduction. This enhances the efficiency of the inorganic sulfur cycle and provides favorable conditions for ES formation. The discovery of solid ES in sediments near the Jiulong Methane Reef suggests an important relationship with SMTZ fluctuations that could have implications for the evolution of methane hydrate in the South China Sea. | LIN Qi WANG JiaSheng FU ShaoYing LU HongFeng BU QingTao LIN RongXiao SUN Fei | 2015 | Science China Earth Sciences2015，58，12： | 6 |
| 8 | Parameter estimation of chirp signal under low SNR显示文摘Aiming at solving the problem of great difficulty and low accuracy existing in parameter estimation of chirp signal under low signal-to-noise ratio(SNR) condition, an algorithm of accurate parameter estimation of chirp signal is proposed. First, the algorithm extracts ridge frequency of chirp signal based on Short Time Fourier Transform. Second, the protruding glitch frequencies are eliminated through median filter with proper size and the smoothing frequencies are obtained corresponding to the time. Third, the frequency time frequencymodulated(FM) line is fitted coarsely by the least-square linear fitting method, and some frequency points are removed, which are far away from the FM line. Repeat the process several times until the sample correlation coefficient of the fitted line is in high degree when the optimum chirp line is fitted out, so chirp rate and initial frequency are obtained. Simulation shows that the correct rate of parameter estimation is very high. When SNR is not less than –17 d B, the correct rate is 100%, and when the SNR is –18 d B, the correct rate is still capable of up to 99%. This algorithm has a lower SNR threshold of about –17 d B. When the SNR is greater than threshold,parameter estimation accuracy is close to Cramer Rao low bound(CRLB), higher than parameter estimation based on the phase field method. Measured data experiments show that the algorithm can reasonably fit the chirp line of measured chirp signal, which better characterizes the FM features of chirp signal. | WANG JinZhen SU ShaoYing CHEN ZengPing | 2015 | Science China(Information Sciences)2015，58，2： | 5 |
| 9 | Enhanced Electrocatalytic Activity of Dual Template Based Pt/Cu-zeolite A/Graphene for Methanol Electrooxidation显示文摘新奇 Pt/Cu-zeolite A/graphene 基于 electrocatalyst 被化学减小方法成功地为甲醇 electrooxidation 作好准备。石墨氧化物和 Cu functionalized 沸石 A 被 NaBH 4 同时减少准备被用来扔磅 nanoparticles 的 Cu 沸石 A/graphene 支持。同样准备的 Pt/Cu-zeolite A/graphene composites 的 nanostructure 和作文被 X 光检查衍射计描绘, X 光检查荧光, Fourier 变换红外线的分光计和扫描电子显微镜学。Pt/Cu-zeolite A/graphene 的 electrocatalytic 性质修改了电极因为甲醇氧化被周期的 voltammetry 和 chronoamperometry 在 0.10 mol/L H 2 那么 4+ 0.50 mol/L CH 3 哦答案。与磅 / 沸石 A/graphene 电极和 Pt/graphene 电极相比,基于的电极展出了的 Pt/Cu-zeolite A/graphene 显然为甲醇 electrooxidation 提高了电流和更高的 electrocatalytic 活动。增加的 electrocatalytic 活动被归因于存在沸石 A 和减少的 graphene 氧化物基于双模板,它显著地增加了有效电极表面并且便于 analytes 的散开进 electroactive 催化剂。 | Shuai Wang Ping He Mingqian He Faqin Dong Huanhuan Liu Hong Lei Xiaojuan Zhang Shaoying He | 2018 | Chinese Journal of Chemistry2018，36，1： | 5 |
| 10 | Energy Optimization of the Fin/Rudder Roll Stabilization System Based on the Multi-objective Genetic Algorithm (MOGA)显示文摘精力优化是为在最后十年的轮船转动减小系统的关键问题之一。根据轮船运动的非线性的特征,自由的四度鳍 / 赤睛鱼转动稳定的非线性的模型能被建立。这份报纸分析克服抵抗和 yaw 引起的精力消费,它作为新性能索引被加到鳍 / 赤睛鱼转动稳定系统。以便达到转动减小,轮船路线保留和精力优化的目的,自我调节的 PID 控制器基于多客观的基因算法(MOGA ) ,方法被用来优化性能索引。另外,随机的重量系数被采用造一个多客观的基因算法优化模型。客观功能被改进以便客观功能能被规范化为经常的水平。模拟结果证明控制方法基于 MOGA,与传统的控制方法相比,不是仅仅改进效率卷稳定并且偏航控制精确,而且优化系统的精力。建议方法论能以不同的海状态得到更好的表演。 | Lijun Yu Shaoying Liu Fanming Liu Hui Wang | 2015 | Journal of Marine Science and Application2015，14，2： | 3 |
| 11 | Synthesis of Poly(isosorbide carbonate) via Melt Polycondensation Catalyzed by a KF/MgO Catalyst显示文摘MgO loaded with KF was prepared by using tlie impregnation method and was employed as the catalyst for tlie direct traiisesterification of diphenyl carbonate(DPC) witli isosorbide to synthesize high-molecular-weight poly(isosorbide carbonate)(PIC). The relationship between physical-chemical properties and catalytic performance for KF/MgO in this melt process was investigated by various characterization techniques. The basic site amount and strength were found to be responsible for this transesterification process, and the medium and strong basic sites tended to promote the polycondensation reaction. 20-KF/Mg0-500 exhibited the best catalytic performance, giving PIC with Mw of 84200 and glass transition temperature(rg) of 173℃ under optimal conditions. Additionally, 20-KF/MgO-500 was found to catalyze the transerification of DPC with isosorbide and other diols to syntliesize the corresponding poly(aliphatic diol-co-isosorbide carbonate)s(PAICs). This excellent activity can be ascribed to the presence of an abundance of basic sites and their specific basic strength on the surface of KF/MgO. | SHEN Xiaolong LIU Shaoying WANG Qingyin ZHANG Hua WANG Gongying | 2019 | Chemical Research in Chinese Universities2019，35，4： | 3 |
| 12 | Synthesis and Properties of Poly(butylene carbonate-co-spirocyclic carbonate)显示文摘Poly(butylene carbonateXPBC) has significantly promising applications as a degradable material in the field of polymers, while its poor thermal performance and low crystallization rate are its main defects. To overcome these shortcomings, a series of poly(butylene carbonate-co-spirocyclic carbonateXPBSC) copolymers were synthesized from diphenyl carbonate, 1,4-butanediol and spiroglycol via two-step polycondensation reactions, using magnesium oxide as a catalyst. Differential scanning calorimetry(DSC) results indicated that the glass transition temperature(Tg) values of PBSC copolymers were enhanced from -19℃ to 56℃ with rising the spiroacetal moiety content. Thermogravimetric analysis(TGA) results showed that the resulting PBSCs have a higher thermal stability than that of poly(butylene carbonate). Wide angle X-ray diflraction(WXRD) patterns were characterized to investigate the crystallization behaviour of PBSCs. Tensile testing demonstrated that copolymerization of spiroacetal moieties into PBC chains imparted PBSC with favourable mechanical performance. Typically, PBSC 30 had a tensile modulus of (1735±430) MPa, a tensile strength of (42±5) MPa and an elongation of 504%±36%. | ZHU Changliang LIU Shaoying WANG Qingyin ZHANG Hua | 2019 | Chemical Research in Chinese Universities2019，35，4： | 3 |
| 13 | Therapeutic window of Qingkailing injection for focal cerebral ischemia/reperfusion injury显示文摘The time window in which a drug is effective varies between drugs. The present study investigated the therapeutic window of Qingkailing injection for focal cerebral ischemia/reperfusion in mice. Animals underwent middle cerebral artery occlusion and were injected with Qingkailing (1.5, 3, 6 mL/kg). Infarct volume and neurological function were assessed after 24 hours of ischemia. In addition, to establish the therapeutic time window, mice were injected with 3 mL/kg Qingkailing at 0, 1, 3, 4, 6, 9 and 12 hours after occlusion. Results revealed that Qingkailing injection significantly reduced infarct volume and improved neurological function in model mice after cerebral infarction for up to 9 hours, demonstrating that the therapeutic window of Qingkailing injection can extend to 9 hours for cerebral ischemia/reperfusion in mice. | Fafeng Cheng Wenting Song Xianggen Zhong Yi Lu Shaoying Guo Dong Wang Weipeng Zhao Qingguo Wang | 2011 | Neural Regeneration Research2011，6，21： | 3 |
| 14 | Derivation and characterization of human embryonic stem cell lines from poor quality embryos显示文摘Poor quality embryos discarded from in vitro fertilization (IVF) laboratories are good sources for deriving human embryonic stem cell (hESC) lines. In this study, 166 poor quality embryos donated from IVF centers on day 3 were cultured in a blastocyst medium for 2 days, and 32 early blastocysts were further cultured in a blastocyst optimum culture medium for additional 2 days so that the inner cell masses (ICMs) could be identified and isolated easily. The ICMs of 17 blastocysts were isolated by a mechanical method, while those of the other 15 blastocysts were isolated by immunosurgery. All isolated ICMs were inoculated onto a feeder layer for subcultivation. The rates of ICM at- tachment, primary ICM colony formation and the efficiency of hESC derivation were similar between the ICMs isolated by the two methods (P>0.05). As a result, four new hESC lines were established. Three cell lines had normal karyotypes and one had an unbalanced Robertsonian translocation. All cell lines showed normal hESC characteristics and had the differentiation ability. In conclusion, we established a stable and effective method for hESC isolation and culture, and it was confirmed that the mechanical isolation was an effective method to isolate ICMs from poor embryos. These results further indicate that hESC lines can be derived from poor quality embryos discarded by IVF laboratories. | Weiqiang Liu, Yifei Yin, Xiaolin Long, Yumei Luo, Yonghua Jiang, Wenhong Zhang, Hongzi Du, Shaoying Li, Yuhong Zheng, Qing Li, Xinjie Chen, Baoping Liao, Guohong Xiao, Weihua Wang, Xiaofang Sun Guangzhou Key Laboratory of Reproductive and Genetics Institute of Gynecology and Obstetrics, The Third Affiliated Hospital of Guangzhou Medical College, Guangzhou 510150, China | 2009 | Journal of Genetics and Genomics2009，36，4： | 3 |
| 15 | Radiation balance and the response of albedo to environmental factors above two alpine ecosystems in the eastern Tibetan Plateau显示文摘Understanding the energy balance on the Tibetan Plateau is important for better prediction of global climate change. To characterize the energy balance on the Plateau, we examined the radiation balance and the response of albedo to environmental factors above an alpine meadow and an alpine wetland surfaces in the eastern Tibetan Plateau, using 2014 data. Although our two sites belong to the same climatic background, and are close geographically, the annual incident solar radiation at the alpine meadow site(6,447 MJ/(m2·a)) was about 1.1 times that at the alpine wetland site(6,012 MJ/(m2·a)),due to differences in the cloudiness between our two sites. The alpine meadow and the alpine wetland emitted about 38%and 42%, respectively, of annual incident solar radiation back into atmosphere in the form of net longwave radiation; and they reflected about 22% and 18%, respectively, of the annual incident solar radiation back into atmosphere in the form of shortwave radiation. The annual net radiation was 2,648 and 2,544 MJ/(m2·a) for the alpine meadow site and the alpine wetland site, respectively, accounting for only about 40% of the annual incident solar radiation, significantly lower than the global mean. At 30-min scales, surface albedo exponentially decreases with the increase of the solar elevation angle; and it linearly decreases with the increase of soil-water content for our two sites. But those relationships are significantly influenced by cloudiness and are site-specific. | ShaoYing Wang Yu Zhang ShiHua Lyu LunYu Shang YouQi Su HanHui Zhu | 2017 | Research in Cold and Arid Regions2017，9，2： | 2 |
| 16 | Collective properties of neon isotopes investigated by projected shell model显示文摘Collective phenomenon in neon isotopes is an interesting topic.However,even the ground-state deformations cannot be well described by theories.Recently,QJ Zhi and ZZ Ren[Phys Lett B 638:166(2006)]have suggested an improved Nilsson potential,which can give a suitable description of ground-state properties in magnesium isotopes.In order to test the description of neon isotopes located around the‘‘island of inversion’’,we have used this potential to provide the deformed basis for the projectedshell-model calculations.The low-lying spectra and transition properties of neon isotopes can be reproduced reasonably.The gyromagnetic factors of neon isotopes have also been investigated.The structures of excited states along the yrast line are studied in the language of band diagrams. | Guoxiang Dong Xiaobao Wang Furong Xu Shaoying Yu | 2014 | Chinese Science Bulletin2014，59，29： | 2 |
| 17 | An improvement of soil temperature simulations on the Tibetan Plateau显示文摘The simulation of soil temperature on the Tibetan Plateau(TP) plays a dominant role in the performance of both global climate and numerical weather forecast models. To improve the simulation of soil temperature on the TP, the Johansen soil thermal conductivity parameterization scheme was introduced into Community Land Model 3.5(CLM3.5) and Regional Climatic Model 4(Reg CM4). The improved CLM3.5 and Reg CM4-CLM were utilized to conduct offline and regional simulation experiments on the TP. Comparison of the new and old schemes revealed that CLM3.5 provides high thermal conductivity parameters of mineral soil solid on the TP. The Johansen scheme is more practical for the TP than the soil thermal conductivity parameterization in CLM3.5. The simulation of soil temperature and liquid water content was improved in offline experiment. The improved parameterization scheme can also reduce the simulation error of soil temperature in winter throughout the entire TP. | SiQiong Luo BoLi Chen ShiHua Lyu XueWei Fang JingYuan Wang XianHong Meng LunYu Shang ShaoYing Wang Di Ma | 2018 | Research in Cold and Arid Regions2018，10，1： | 2 |
| 18 | SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors显示文摘Muta nt isocitrate dehydrog en ase 1(mlDH1)drives tumorigenesis via produci ng on cometabolite R-2-hydroxyglutarate(R-2-HG)across various tumor types.However,mlDHl in hibitors appear only effective in hematological tumors.The therapeutic ben efit in solid tumors remains elusive,likely due to the complex tumor microenvironment.In this study,we discover that R-2-HG produced by IDH1-mutant tumor cells is preferentially imported into vascular endothelial cells and remodels mitochondrial respiration to promote tumor angiogenesis,conferring a therapeutic vulnerability in IDH1-mutant solid tumors.Mechanistically,SLC1 Alz a Na'-depe ndent glutamate tran sporter that is prefere ntially expressed in en dothelial cells,facilitates the in flux of R-2-HG from the tumor microenvironment into the endothelial cells as well as the intracellular trafficking of R-2-HG from cytoplasm to mitochondria.R-2-HG hijacks SLC1A1 to promote mitochondrial Na^(+)/Ca^(2+)exchange,which activates the mitochondrial respiratory chain and fuels vascular en dothelial cell migratio n in tumor an giogenesis.SLC1A1 deficiency in mice abolishes mlDHl-promoted tumor an giogenesis as well as the therapeutic benefit of mlDHl in hibitor in solid tumors.Moreover,we report that HH2301,a newly discovered mlDHl inhibitor,shows promising efficacy in treating IDH1-mutant cholangiocarcinoma in preclinical models.Together,we identify a new role of SLC1A1 as a gatekeeper of R-2-HG-mediated crosstalk between IDH1-mutant tumor cells and vascular en dothelial cells,and dem on strate the therapeutic potential of mlDHl in hibitors in treating IDH1-muta nt solid tumors via disrupting R-2-HG-promoted tumor angiogenesis. | Xiaomin Wang Ziqi Chen Jun Xu Shuai Tang Nan An Lei Jiang Yixiang Zhang Shaoying Zhang Qingli Zhang Yanyan Shen Shijie Chen Xiaojing Lan Ting Wang Linhui Zhai Siyuwei Cao Siqi Guo Yingluo Liu Aiwei Bi Yuehong Chen Xiameng Gai Yichen Duan Ying Zheng Yixian Fu Yize Li Liang Yuan Linjiang Tong Kun Mo Mingcheng Wang Shu-Hai Lin Minjia Tan Cheng Luo Yi Chen Jia Liu Qiansen Zhang Leping Li Min Huang | 2022 | Cell Research2022，32，7： | 2 |
| 19 | Measure Synchronization of High-cycle Islets in Couple Hamiltonian Sys- tems 显示文摘 | CHEN Shaoying WANG Guangrui CHEN Shigang | 2004 | Chin Phys Leu2004，21，11： | 1 |
| 20 | Comprehensive Multi-Level Exploration of Buried Active Faults:an Example of the Yinchuan Buried Active Fault显示文摘The paper introduces the steps and methods of multi-approach,multi-level exploration of buried faults in thick Quaternary sediment regions by taking the test exploration of the Yinchuan active fault as example.Based on the comprehensive analyses of previous data,we choose the Xinqushao Village of Xingqing District of Yinchuan City as the test site for the comprehensive exploration.Firstly,we adopted shallow seismic investigation with group intervals of 10m,5m and 1m to gradually trace layer by layer the master fault of the Yinchuan buried fault from a deep depth to a shallow depth where drilling could be used.Then,with composite geological profile drilling,we determined the precise location and dip angle of the fault.The drilling show the buried depth of the upper offset point is 8.3m.Finally,large-scale trenching revealed that the actual buried depth of the upper offset point of the fault is 1.5m from the ground surface and there are paleoearthquake events of 5 stages.Combined with the preliminary result of corresponding sample age,we conclude the Yinchuan buried fault is a mid to late Holocene active fault. | Chai Chizhang Meng Guangkui Du Peng Wang Yin Liu Baojin Shen Weihua LeiQiyun Liao Yuhua Zhao Chengbin Feng Shaoying Zhang Xuehui Xie Xiaofeng | 2007 | Earthquake Research in China2007，21，3： | 1 |
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