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| 1 | Molecular and cellular bases of chronic myeloid leukemia显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative disease characterized by the overproduction of granulocytes,which leads to high white blood cell counts and splenomegaly in patients.Based on clinical symptoms and laboratory findings,CML is classified into three clinical phases,often starting with a chronic phase,progressing to an accelerated phase and ultimately ending in a terminal phase called blast crisis.Blast crisis phase of CML is clinically similar to an acute leukemia;in particular,B-cell acute lymphoblastic leukemia(B-ALL)is a severe form of acute leukemia in blast crisis,and there is no effective therapy for it yet.CML is induced by the BCR-ABL oncogene,whose gene product is a BCR-ABL tyrosine kinase.Currently,inhibition of BCR-ABL kinase activity by its kinase inhibitor such as imatinib mesylate(Gleevec)is a major therapeutic strategy for CML.However,the inability of BCR-ABL kinase inhibitors to completely kill leukemia stem cells(LSCs)indicates that these kinase inhibitors are unlikely to cure CML.In addition,drug resistance due to the development of BCRABL mutations occurs before and during treatment of CML with kinase inhibitors.A critical issue to resolve this problem is to fully understand the biology of LSCs,and to identify key genes that play significant roles in survival and self-renewal of LSCs.In this review,we will focus on LSCs in CML by summarizing and discussing available experimental results,including the original studies from our own laboratory. | Yaoyu Chen Cong Peng Dongguang Li Shaoguang Li | 2010 | Protein & Cell2010，1，2： | 10 |
| 2 | A hypersonic lift mechanism with decoupled lift and drag surfaces显示文摘In the present study, we propose a novel lift mechanism for which the lifting surface produces only lift. This is achieved by mounting a two-dimensional shock-shock interaction generator below the lifting surface. The shock-shock interaction theory in conjunction with a three dimensional correction and checked with computational fluid dynamics (CFD) is used to analyze the lift and drag forces as function of the geometrical parameters and inflow Mach number. Through this study, though limited to only inviscid flow, we conclude that it is possible to obtain a high lift to drag ratio by suitably arranging the shock interaction generator. | XU YiZhe XU ZhiQi LI ShaoGuang LI Juan BAI ChenYuan WU ZiNiu | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，5： | 6 |
| 3 | Development of Dense Corundum-mullite Bricks for Blast Furnace Ceramic Pad显示文摘Dense corundum-mullite brick for blast furnace ceramic pad was prepared using white fused corundum and tabular corundum as aggregates,andalusite fine powder,sillimanite fine powder,zircon sand powder and Guangxi soil as the matrix,and phosphate as the binder,introducing different amounts ofα-alumina micropowder,tabular corundum fine powder and fused corundum powder.The properties of the prepared brick were studied.The results show that,the brick with 10 mass%of tabular corundum fine powder fired at 1560℃for 3 h in a tunnel kiln has the bulk density of 3.08 g·cm^(-3),the apparent porosity of 13.2%,the cold compressive strength of 178 MPa,the molten iron corrosion rate of 0.6%,the slag corrosion rate of 6.4%,the alkali resistance strength decreasing rate of 7.5%,and the thermal shock resistance of 32 cycles,which is both dense and of good thermal shock resistance.The slag resistance simulation test was performed,which proved that the prepared corundum-mullite brick is better than those currently supplied in the market. | GUO Xiaowei XIN Guiyan LEI Qizhen XIONG Naling SUN Feng LI Shaoguang SUN Gaoyang LI Bing | 2021 | China's Refractories2021，30，4： | 3 |
| 4 | Therapeutic Effect of Human Umbilical Cord Multipotent Mesenchymal Stromal Cells in a Rat Model of Stroke显示文摘 | Wenbin Liao Jiang Xie Jian Zhong Yongjun Liu Lei Du Bin Zhou Jie Xu Pengxia Liu Shaoguang Yang Jiming Wang Zhibo Han Zhong Chao Han | 2009 | Transplantation2009，，3： | 2 |
| 5 | Parallel implementation of w-projection wide-field imaging显示文摘w-Projection is a wide-field imaging technique that is widely used in radio synthesis arrays. Processing the wide-field big data generated by the future Square Kilometre Array(SKA) will require significant updates to current methods to significantly reduce the time consumed on data processing. Data loading and gridding are found to be two major time-consuming tasks in w-projection. In this paper, we investigate two parallel methods of accelerating w-projection processing on multiple nodes: the hybrid Message Passing Interface(MPI) and Open Multi-Processing(OpenMP) method based on multicore Central Processing Units(CPUs) and the hybrid MPI and Compute Unified Device Architecture(CUDA)method based on Graphics Processing Units(GPUs). Both methods are successfully employed and operated in various computational environments, confirming their robustness. The experimental results show that the total runtime of both MPI + OpenMP and MPI + CUDA methods is significantly shorter than that of single-thread processing. MPI + CUDA generally shows faster performance when running on multiple nodes than MPI + OpenMP, especially on large numbers of nodes. The single-precision GPU-based processing yields faster computation than the double-precision processing; while the single-and doubleprecision CPU-based processing shows consistent computational performance. The gridding time remarkably increases when the support size of the convolution kernel is larger than 8 and the image size is larger than 2,048 pixels. The present research offers useful guidance for developing SKA imaging pipelines. | Baoqiang Lao Tao An Ang Yu Wenhui Zhang Junyi Wang Quan Guo Shaoguang Guo Xiaocong Wu | 2019 | Science Bulletin2019，64，9： | 2 |
| 6 | Laparoscopic versus open surgery for colon cancer: A meta-analysis of 5-year follow-up outcomes显示文摘 | Baoshan Di Yan Li Kongping Wei Xiaojuan Xiao Jie Shi Yan Zhang Xiaoqin Yang Peng Gao Ke Zhang Yuan Yuan Dongzhi Zhang Xiaodong Wei Shaoguang Liu Jianping Wang Xuebing Wang Yingmei Zhang Hui Cai | 2013 | Surgical Oncology2013，，： | 2 |
| 7 | Systemic Infusion of FLK1+ Mesenchymal Stem Cells Ameliorate Carbon Tetrachloride-Induced Liver Fibrosis in Mice显示文摘 | Baijun Fang Mingxia Shi Lianming Liao Shaoguang Yang Yuhao Liu Robert Chunhua Zhao | 2004 | Transplantation2004，，1： | 2 |
| 8 | Preparation and magnetic property of Fe nanowire array显示文摘 | Yang Shaoguang Zhu Hao Yu Dongliang | 2000 | J Magn Magn Mater2000，222，： | 1 |
| 9 | Preparation and adsorption property of chitosan beads bearing β-cyclodextrin cross-linked by 1,6-hexamethylene diisocyanate 显示文摘 | Zha Fei Li Shaoguang Chang Yue | 2008 | Carbohydrate Polymers2008，72，3： | 1 |
| 10 | Fabrication and magnetic properties of Co67 Ni33 alloy nanowirc array显示文摘 | Zhu Hao Yang Shaoguang Ni Gang | 2001 | Scripta mater2001，44，： | 1 |
| 11 | 显示文摘 | Yang Shaoguang Zhu Hao Yu Dongliang | 2000 | Journal of Magnetism and Magnetic Materials2000，222，： | 1 |
| 12 | Bacteroides fragilis enterotoxin induces c-Myc expression and cellular proliferation显示文摘 | Shaoguang Wu Patrice J. Morin Djik Maouyo Cynthia L. Sears | 2003 | Gastroenterology2003，，2： | 1 |
| 13 | One- pot synthesis of substituted pyridines via the vilsmeier-haack reaction of acyclic ketene-S, S-acetals 显示文摘 | Shaoguang Sun Yingchun Liu Qun Liu | 2004 | Synlett2004，，： | 1 |
| 14 | Status and progress of China SKA Regional Centre prototype显示文摘The Square Kilometre Array(SKA)project consists of delivering two largest radio telescope arrays being built by the SKA Observatory(SKAO),which is an intergovernmental organization bringing together nations from around the world with China being one of the major member countries.The computing resources needed to process,distribute,curate and use the vast amount of data that will be generated by the SKA telescopes are too large for the SKAO to manage on its own.To address this challenge,the SKAO is working with the international community to create a shared,distributed data,computing and networking capability called the SKA Regional Centre Alliance.In this model,the SKAO will be supported by a global network of SKA Regional Centres(SRCs)distributed around the world in its member countries to build an end-to-end science data system that will provide astronomers with high-quality science products.SRCs undertake deep processing,scientific analysis,and long-term storage of the SKA data,as well as user support.China has been actively participating in and promoting the construction of SRCs.This paper introduces the international cooperation and ongoing prototyping of the global SRC network,the basis for the construction of the China SRC and describes in detail the progress of the China SRC prototype.The paper also presents examples of scientific applications of SKA precursor and pathfinder telescopes performed using resources from the China SRC prototype.Finally,the future prospects of the China SRC are presented. | Tao An Xiaocong Wu Baoqiang Lao Shaoguang Guo Zhijun Xu Weijia Lv Yingkang Zhang Zhongli Zhang | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，12： | 1 |
| 15 | A novel process from cobalt nanowire to Co3O4 nanotube显示文摘 | Li Tao Yang Shaoguang Huang Lisheng | 2004 | Nanotechnology2004，15，： | 1 |
| 16 | A simple and effective system for foreign gene expression in plants via root absorption of agrobacterial suspension显示文摘 | Liping Yang Hongwei Wang Jingying Liu Liang Li Yajun Fan Xiufeng Wang Yehua Song Shaoguang Sun Lei Wang Xiaojuan Zhu Xingzhi Wang | 2008 | Journal of Biotechnology2008，，3： | 1 |
| 17 | Global smoothing for the periodic Benjamin equation in low-regularity spaces显示文摘This paper is intended as an attempt to set up the global smoothing for the periodic Benjamin equation.It is shown that for Hs(T) initial data with s >-1/2 and for any s < s1< min{s+1,3s+1},the diference of the evolution with the linear evolution is in Hs1(T) for all times,with at most polynomial growing Hs1 norm.Unlike Korteweg-de Vries(KdV) equation,there are less symmetries of the Benjamin system,especially for the resonant function.The new ingredient is that we need to deal with some new difculties that are caused by the lack of symmetries. | SHI ShaoGuang LI JunFeng | 2013 | Science China Mathematics2013，56，10： | 1 |
| 18 | Fabrication and Magnetic Properties of Co67Ni33 Alloy Nanowire Array显示文摘 | Hao Zhu Shaoguang Yang Guang Ni | 2001 | Scripta Mater2001，44，： | 1 |
| 19 | Synthesis and crosslinking of hydroxyl-functionalized sulfonated poly(ether ether ketone) copolymer as candidates for proton exchange membranes显示文摘 | Shaoguang Feng Yuming Shang Yaowu Wang Guoshun Liu Xiaofeng Xie Wenqi Dong Jingming Xu V.K. Mathur | 2010 | Journal of Membrane Science2010，，1： | 1 |
| 20 | Study on magnetic property of Fe14Ni86 alloy nanowire array显示文摘 | Zhu Hao Yang Shaoguang Ni Gang | 2001 | Journal of Magnetism and Magnetic Materials2001，234，： | 1 |
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