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| 1 | 在有煽动性、非煽动性的腹的疼痛显型的孩子的 interleukin-6 和桅杆房间的反的关系显示文摘 AIM: To investigate interleukin-6 (IL-6), mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P in the gastrointestinal mucosa of children with abdominal pain. METHODS: Formalin-fixed paraffin-embedded gas-trointestinal biopsy blocks from patients (n = 48) with non-inflammatory bowel disease (irritable bowel syndrome and functional abdominal pain) and inflammatory bowel disease were sectioned and stained for IL-6, mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P. All children had chronic abdominal pain as part of their presenting symptoms. Biopsy phenotype was confirmed by a pathologist, blinded to patient information. Descriptive statistics, chi-square, and independent sample t tests were used to compare differences between the inflammatory and non-inflammatory groups. RESULTS: The cohort (n = 48), mean age 11.9 years (SD = 2.9), 54.2% females, 90% Caucasian, was comprised of a non-inflammatory (n = 26) and an inflammatory (n = 22) phenotype. There was a significant negative correlation between substance P expression and mast cell count (P = 0.05, r = -0.373). Substance P was found to be expressed more often in female patient biopsies and more intensely in the upper gastrointestinal mucosa as compared to the lower mucosa. There were significantly increased gastrointestinal mucosal immunoreactivity to IL-6 (P = 0.004) in the inflammatory phenotype compared to non-inflammatory. Additionally, we found significantly increased mast cells (P = 0.049) in the mucosa of the non-inflammatory phenotype compared to the inflammatory group. This difference was particularly noted in the lower colon biopsies. CONCLUSION: The findings of this study yield preliminary evidence in identifying biomarkers of undiagnosed abdominal pain in children and may suggest candidate genes for future evaluation. | Wendy A Henderson Ravi Shankar Tara J Taylor Arseima Y Del Valle-Pinero David E Kleiner Kevin H Kim Nader N Youssef | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，6： | 2 |
| 2 | initial clinical experience with RF ablation of lung tumors 显示文摘 | Van Sonnenberg E Shankar S Tuncali KT | 2002 | Radiology2002，，： | 1 |
| 3 | Three dimensional simulation for an open channel flow with a constriction 显示文摘 | SHANKAR N J CHAN E S ZHANG Q Y | 2001 | Journal of Hydraulic Reserach2001，39，2： | 1 |
| 4 | Diagnosis and treatment of intrahepatic biloma complicating radiofrequency ablation of hepatic metastases显示文摘 | Shankar S van Sonnenberg E Silverman SG | 2003 | American Journal of Roentgenology2003，181，2： | 1 |
| 5 | Highlr ordered TiO2 Nanotube Arrays up to 220 jxm in Length:Use in Water Photoelectrolysis and Dye-sensitized Solar Cells显示文摘 | SHANKAR KrMOR G KfPRAKASAM H E | 2007 | Nanotechnology2007，18，06： | 1 |
| 6 | ATM-dependent IGF-1induction regulates secretory clusterin expression after DNA damage and in genetic instability显示文摘 | Goetz E M Shankar B Zou Y | 2011 | Oncogene2011，30，35： | 1 |
| 7 | Highly-ordered TiO2 Nanotube Arrays up to 220 txm in Length:Use in Water Photoelectrolysis and Dye-sensitized Solar Cells 显示文摘 | SHANKAR Karthik MOR Gopal K PRAKASAM1 Haripriya E | 2007 | Nanotechnology2007，18，06： | 1 |
| 8 | Heat-in, duced change in ultrastructure of milk and its effect on gel formation in yoghurt 显示文摘 | DAVIES F L SHANKAR P A BROOKER B E | 1978 | Journal of Dairy Research1978，，45： | 1 |
| 9 | Limited volume resuscitation in penetrating thoracoabdomina trauma显示文摘 | Shankar MN Mattox KL | 1999 | AACN Clin Lssues1999，10，： | 1 |
| 10 | High- ly-Ordered TiO2 Nanotube Arrays up to 220 μm in Length : Use in Water Photoelectrolysis and Dye-Sensitized Solar Cells显示文摘 | SHANKAR K MOR G K PRAKASAM H E | 2007 | Nanotechnology2007，18，6： | 1 |
| 11 | High-fat diet activates pro-inflammatory response in the prostate through association of Stat-3and NF-κB显示文摘 | Shankar E Vykhovanets EV Vykhovanets OV | 2012 | Prostate2012，72，3： | 1 |
| 12 | Bacterial etiology of diabetic foot infections in South India显示文摘 | Shankar E M Mohan V Premalatha G | 2010 | European Journal of Internal Medicine2010，79，34： | 1 |
| 13 | Highly-ordered TiO2 nanotube arrays up to 220 Ima in length use in water photoeleetrolysis and dye-sensitized solar cells 显示文摘 | SHANKAR K MOR G K PRAKASAM H E | 2007 | Nanotechnologty2007，18，06： | 1 |
| 14 | Low Temperature Flow Behavior of B2 Intermetallie Phase in Ti -A1 - Nb System显示文摘 | Shankar H Prasad N E Singh A K | 2006 | Materials Science and Engineering A2006，424，： | 1 |
| 15 | High isolation rate of Staphylococcus aureus from surgical site infections in an Indian hospital显示文摘 | Kownhar H Shankar E M Vignesh R | 2008 | J Antirnicrob Chernother2008，61，3： | 1 |
| 16 | Highly-ordered TiO2 nanotube arrays up to 220 pm in length: use in water photoelec- trolysis and dye-sensitized solar cells 显示文摘 | SHANKAR K MOR G K PRAKASAM H E | 2007 | Nanotechnology2007，18，6： | 1 |
| 17 | Customer value, satisfaction, loyalty, and switching costs: an illustration from a business-to-business service context 显示文摘 | SHUN Y L VENKATESH SHANKAR M KRISHNA E | 2004 | Journal of the Academy of Marketing Science2004，32，2： | 1 |
| 18 | Protein kinase C epsilon confers resistance of MCF-7 cells to TRAIL by Akt- dependent activation of Hdm2 and downregulation of p53 显示文摘 | Shankar E Sivaprasad U Basu A | 2008 | Oncogene2008，27，28： | 1 |
| 19 | 显示文摘 | Shankar K Mor G K Prakasam H E | 2007 | Nanotechnology2007，18，06： | 1 |
| 20 | RNA interference targeting Fas protects mice from fulminant hepatitis显示文摘 | Song E Lee SK Wang I Ince N Ouyang N Min I Chen Shankar P Lieberman J | 2003 | Nat Med2003，9，： | 1 |
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