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| 1 | Development of the personalized criteria for microscopic review following four different series of hematology analyzer in a Chinese large scale hospital显示文摘 | CUI Wei WU Wei WANG Xin WANG Geng HAO Ying-ying CHEN Yu LUO Dan SHOU Wei-ling ZHANG Shuo XIANG Xue-fang SI Yong-zhen CHEN Qian CAI Hao LI Tan SHEN Han SHANG Kun ZHANG Yong-qiang | 2010 | Chinese Medical Journal2010，，22： | 10 |
| 2 | The effects and regulatory mechanism of RIP3 on RGC-5 necroptosis following elevated hydrostatic pressure显示文摘Necroptosis 是在各种各样的疾病被含有的调整房间死亡的一种类型。交往受体的蛋白质 3 (RIP3 ) , RIP 家庭的一个成员,是 necroptotic 小径的一个重要调停人。在由 caspase-8 的 Asp328 的 RIP3 的劈开废除 RIP3 的 kinase 活动,它为 necroptosis 是批评的。而且, RIP3 是显著地 upregulated 在尖锐高 intra 眼睛的压力和氧葡萄糖剥夺的早阶段期间。在这研究, RIP3 的效果在提高的静水力学的压力(EHP ) 期间被调查, caspase-8 通过调整了 RIP3 劈开的可能的机制被探索。流动 cytometry 分析表明导致 EHP 的坏死的网膜的中心房间 5 的数字(RGC-5 ) 房间被减少在以后 RIP3 击倒。而且,在正常 RGC-5 房间的 malondialdehyde (MDA ) 层次和肝糖 phosphorylase (PYGL ) 活动比在在 EHP 以后的 RIP3 击倒的房间的那些高得多。导致 EHP 的 RGC-5 坏死显著地与 butylated hydroxyanisole (BHA ) 在处理以后被减少,反应的氧种类(ROS ) scavenger。MDA 层次和 PYGL 活动比在有在 EHP 以后的 caspase-8 抑制的房间的那些在正常 RGC-5 房间是更低的。西方的污点分析证明 RIP3 劈开产品是在有 caspase-8 抑制的房间的 upregulated。另外,流动 cytometry 分析表明导致 EHP 的坏死的 RGC-5 房间的数字在 caspase-8 抑制以后被增加。我们的结果建议 RGC-5 necroptosis 追随者 EHP 被 RIP3 通过 PYGL 活动和随后的 ROS 累积的正式就职调停。因此, caspase-8 可以经由 RIP3 劈开参予 RGC-5 necroptosis 的规定。 | Lei Shang Wei Ding Na Li Lvshuang Liao Dan Chen Jufang Huang Kun Xiong | 2017 | Acta Biochimica et Biophysica Sinica2017，49，2： | 9 |
| 3 | An area-based position and attitude estimation for unmanned aerial vehicle navigation显示文摘The paper aims to challenge non-GPS navigation problems by using visual sensors and geo-referenced images. An area-based method is proposed to estimate full navigation parameters(FNPs), including attitude, altitude and horizontal position, for unmanned aerial vehicle(UAV) navigation. Our method is composed of three main modules: geometric transfer function, local normalized sobel energy image(LNSEI) based objective function and simplex-simulated annealing(SSA) based optimization algorithm. The adoption of relatively rich scene information and LNSEI, makes it possible to yield a solution robustly even in the presence of very noisy cases, such as multi-modal and/or multi-temporal images that differ in the type of visual sensor, season, illumination, weather, and so on, and also to handle the sparsely textured regions where features are barely detected or matched. Simulation experiments using many synthetic images clearly support noise resistance and estimation accuracy, and experimental results using 2367 real images show the maximum estimation error of 5.16(meter) for horizontal position, 9.72(meter) for altitude and 0.82(degree) for attitude. | LIU XiaoChun WANG Hou FU Dan YU QiFeng GUO PengYu LEI ZhiHui SHANG Yang | 2015 | Science China(Technological Sciences)2015，58，5： | 7 |
| 4 | Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia显示文摘好攻击的 NK 房间白血病(ANKL ) 是在从亚洲的人之中是更流行的 NK 房间瘤的一种稀罕形式并且中央并且南美洲。病人们通常在天以内死到月,甚至在收到迅速的治疗学的管理以后。这里,我们由集成整个染色体执行了 ANKL 的第一全面研究, transcriptome 并且定序指向,象功能的试金一样的 cytokine 数组。在 JAK-STAT 小径的变化在 48% 被识别(14/29 ) ANKL 病人,当细胞外的 STAT3 激发器 IL10 被 56 褶层的一般水准提高时(P < 0.0001 ) 在检查的所有病人的血浆。另外的经常变异的基因包括的 TP53 (34%) , TET2 (28%) , CREBBP (21%) 和 MLL2 (21%) 。耐心的 NK 白血病房间在多重新陈代谢的小径显示出 STAT3 phosphorylation, MYC 表示和 transcriptional 活动的突出的激活。机能上地, STAT3 激活和 MYC 表示为 ANKL 房间的增长和幸存是批评的。发信号的 STAT 调整了发信号的 MYC 抄写节目,和两 STAT, MYC 抄写被要求维持核苷酸合成和 glycolysis 的激活。一起, JAK-STAT 小径在 ANKL 为 genomic 改变和 IL10 刺激代表一个主要目标。这最新发现的 JAK/STAT-MYC-biosynthesis 轴可以在对待白血病的这种子类型为新奇治疗学的策略的发展提供机会。 | Liang Huang Dan Liu Na Wang Shaoping Ling Yuting Tang Jun Wu Lingtong Hao Hui Luo Xuelian Hu Lingshuang Sheng Lijun Zhu Di Wang Yi Luo Zhen Shang Min Xiao Xia Mao Kuangguo Zhou Lihua Cao Lili Dong Xinchang Zheng Pinpin Sui Jianlin He Shanlan Mo Jin Yan Qilin Ao Lugui Qiu Hongsheng Zhou Qifa Liu Hongyu Zhang Jianyong Li Jie Jin Li Fu Weili Zhao Jieping Chen Xin Du Guoliang Qing Hudan Liu Xin Liu Gang Huang Ding Ma Jianfeng Zhou Qian-fei Wang | 2018 | Cell Research2018，28，2： | 5 |
| 5 | Mixed lineage kinase domain-like protein induces RGC-5 necroptosis following elevated hydrostatic pressure显示文摘 | Lvshuang Liao Lei Shang Na Li Shuchao Wang Mi Wang Yanxia Huang Dan Chen Jufang Huang Kun Xiong | 2017 | Acta Biochimica et Biophysica Sinica2017，49，10： | 5 |
| 6 | Short-term environmental enrichment exposure induces proliferation and maturation of doublecortin-positive cells in the prefrontal cortex显示文摘Previous studies have demonstrated that doublecortin-positive immature neurons exist predominantly in the superficial layer of the cerebral cortex of adult mammals such as guinea pigs, and these neurons exhibit very weak properties of self-proliferation during adulthood under physiological conditions. To verify whether environmental enrichment has an impact on the proliferation and maturation of these immature neurons in the prefrontal cortex of adult guinea pigs, healthy adult guinea pigs were subjected to short-term environmental enrichment. Animals were allowed to play with various cognitive and physical stimulating objects over a period of 2 weeks, twice per day, for 60 minutes each. Immunofluorescence staining results indicated that the number of doublecortin-positive cells in layer II of the prefrontal cortex was significantly increased after short-term environmental enrichment exposure. In addition, these doublecortin-positive cells co-expressed 5-bromo-2-deoxyuridine(a marker of cell proliferation), c-Fos(a marker of cell viability) and NeuN(a marker of mature neurons). Experimental findings showed that short-term environmental enrichment can induce proliferation, activation and maturation of doublecortin-positive cells in layer II of the prefrontal cortex of adult guinea pigs. | Chunling Fan Mengqi Zhang Lei Shang Ngobe Akume Cynthia Zhi Li Zhenyu Yang Dan Chen Jufang Huang Kun Xiong | 2014 | Neural Regeneration Research2014，9，3： | 4 |
| 7 | Small-scale spatial analysis of intermediate and definitive hosts of Angiostrongylus cantonensis显示文摘Background:Angiostrongyliasis is a food-borne parasitic zoonosis.Human infection is caused by infection with the third-stage larvae of Angiostrongylus cantonensis.The life cycle of A.cantonensis involves rodents as definitive hosts and molluscs as intermediate hosts.This study aims to investigate on the infection status and characteristics of spatial distribution of these hosts,which are key components in the strategy for the prevention and control of angiostrongyliasis.Methods:Three villages from Nanao Island,Guangdong Province,China,were chosen as study area by stratified random sampling.The density and natural infection of Pomacea canaliculata and various rat species were surveyed every three months from December 2015 to September 2016,with spatial correlations of the positive P.canaliculata and the infection rates analysed by ArcGIS,scan statistics,ordinary least squares(OLS)and geographically weighted regression(GWR)models.Results:A total of 2192 P.canaliculata specimens were collected from the field,of which 1190 were randomly chosen to be examined for third-stage larvae of A.cantonensis.Seventy-two Angiostrongylus-infected snails were found,which represents a larval infection rate of 6.1%(72/1190).In total,110 rats including 85 Rattus norvegicus,10 R.flavipectus,one R.losea and 14 Suncus murinus were captured,and 32 individuals were positive(for adult worms),representing an infection rate of 29.1%of the definitive hosts(32/110).Worms were only found in R.norvegicus and R.flavipectus,representing a prevalence of 36.5%(31/85)and 10%(1/10),respectively in these species,but none in R.losea and S.murinus,despite testing as many as 32 of the latter species.Statistically,spatial correlation and spatial clusters in the spatial distribution of positive P.canaliculata and positive rats existed.Most of the spatial variability of the host infection rates came from spatial autocorrelation.Nine spatial clusters with respect to positive P.canaliculata were identified,but only two correlated to infection rates.The results show that corrected Akaike information criterion,R2,R2 adjusted andσ2 in the GWR model were superior to those in the OLS model.Conclusions:P.canaliculata and rats were widely distributed in Nanao Island and positive infection has also been found in the hosts,demonstrating that there was a risk of angiostrongyliasis in this region of China.The distribution of positive P.canaliculata and rats exhibited spatial correlation,and the GWR model had advantage over the OLS model in the spatial analysis of hosts of A.cantonensis. | Qiu-An Hu Yi Zhang Yun-Hai Guo Shan Lv Shang Xia He-Xiang Liu Yuan Fang Qin Liu Dan Zhu Qi-Ming Zhang Chun-Li Yang Guang-Yi Lin | 2018 | Infectious Diseases of Poverty2018，7，1： | 4 |
| 8 | Dielectric,magnetic and microwave absorbing properties of polyaniline-Co0.7Cr0.1Zn0.2Fe2O4 composites显示文摘The spinel cobalt chromium zinc ferrites(Co_(0.7)Cr_(0.1)Zn_(0.2)Fe_2O_4) and the polyaniline(PANI)-(Co_(0.7)Cr_(0.1)Zn_(0.2)Fe_2O_4 composites were prepared by polyacrylamide gel and an in situ polymerization method,respectively.The structure of the synthesized material was characterized by X-ray diffraction(XRD) and Fourier transform infrared spectrometer(FTIR),which shows that the spinel Co_(0.7)Cr_(0.1)Zn_(0.2)Fe_2O_4 ferrites and the PANICo_(0.7)Cr_(0.1)Zn_(0.2)Fe_2O_4 composites are obtained.As a small amount of Co^(2+) in the octahedron ferrite is replaced by Cr^(3+),the lattice constant of Co_(0.8)Zn_(0.2)Fe_2O_4 ferrites reduces from0.8409 to 0.8377 nm.The magnetic properties of the two materials were investigated by vibrating sample magnetometer(VSM).The VSM results confirm that the saturation magnetization(M_s),remanent magnetization(M_r) and coercive force(H_c) of the PANI-Co_(0.7)Cr_(0.1)Zn_(0.2)Fe_2O_4composites are 8.80 mA·m^2·g^(-1),3.14 mA·m^2·g^(-1) and37.22 kA·m^(-1),respectively,which are smaller than those of the Co_(0.7)Cr_(0.1)Zn_(0.2)Fe_2O_4 ferrites.The microwave absorbing capability of the two materials was studied by waveguide method.In the frequency range of 5-20 GHz,two reflection loss maximum values of the PANI-Co_(0.7)Cr_(0.1)Zn_(0.2)Fe_2O_4composites appear at 14.1 and 17.9 GHz with-13.17 and-15.36 dB,respectively,which are obviously higher than those of the Co_(0.7)Cr_(0.1)Zn_(0.2)Fe_2O_4 ferrites. | Rui-Ting Ma Huai-Yu Shang Xiao Wang Dan Jiang | 2017 | Rare Metals2017，36，2： | 4 |
| 9 | Synthesis, characterization and tribological evaluation of novel1,4-diazabicyclo[2.2.2]octane based dicationic ionic liquids as efficient antiwear lubricant additives显示文摘Ionic liquids have developed and been applied in lubricant field since 2001. Nevertheless, it is little known about novel dicationic ionic liquids for tribology applications in the past several years. In this paper, a sequence of novel dicationic ionic liquids based on 1,4-diazabicyclo[2.2.2]octane cations(DABCO) and different anions have been designed and identified. The structures of ILs were confirmed by Fourier transform infrared(FTIR) spectra, multinuclear(~1H,^(13)C,^(11)B,^(31)P and ^(19)F) magnetic resonance and mass spectrometry. The effects of anion type on thermal properties, wettability, kinematic viscosity and tribological properties were studied. It is found that all of these dicationic ionic liquids as additives exhibit excellent anti-wear and friction-reducing properties in PEG synthetic base oil under boundary lubrication conditions for steel-to-steel contact, which offers great potential for the highly efficient lubricant additives. Simultaneously, novel 1,4-diazabicyclo[2.2.2]octane cation offers an exceptional chance for the research and development of dicationic ionic liquids in various applications. | ZHAO LiNa CAI Tao ZHANG YunXiao YE MengTing SHANG WangJi LIU Dan TONG DingYi LIU ShengGao | 2019 | Science China(Technological Sciences)2019，62，2： | 3 |
| 10 | Gut microbiota mediates the absorption of FLZ,a new drug for Parkinson’s disease treatment显示文摘The gut microbiota plays an important role in regulating the pharmacokinetics and pharmacodynamics of many drugs.FLZ,a novel squamosamide derivative,has been shown to have neuroprotective effects on experimental Parkinson’s disease(PD)models.FLZ is under phase I clinical trial now,while the underlying mechanisms contributing to the absorption of FLZ are still not fully elucidated.Due to the main metabolite of FLZ was abundant in feces but rare in urine and bile of mice,we focused on the gut microbiota to address how FLZ was metabolized and absorbed.In vitro studies revealed that FLZ could be exclusively metabolized to its major metabolite M1 by the lanosterol 14 alpha-demethylase(CYP51)in the gut microbiota,but was almost not metabolized by any other metabolism-related organs,such as liver,kidney,and small intestine.M1 was quickly absorbed into the blood and then remethylated to FLZ by catechol O-methyltransferase(COMT).Notably,dysbacteriosis reduced the therapeutic efficacy of FLZ on the PD mouse model by inhibiting its absorption.The results show that the gut microbiota mediate the absorption of FLZ through a FLZ-M1-FLZ circulation.Our research elucidates the vital role of the gut microbiota in the absorption of FLZ and provides a theoretical basis for clinical pharmacokinetic studies and clinical application of FLZ in the treatment of PD. | Junmei Shang Shurong Ma Caixia Zang Xiuqi Bao Yan Wang Dan Zhang | 2021 | Acta Pharmaceutica Sinica B2021，11，5： | 3 |
| 11 | Crustal Stress Evolution over the Past 700 Years in North China and Earthquake Occurrence显示文摘Fault interaction and earthquake occurrence have attracted much attention in seismological community during recent years. Many studies have shown that the rupture of one fault could encourage or discourage earthquake nucleation on a neighboring fault, depending on the relative geometry of the two faults and the earthquake rupture mechanisms. In this paper, we simulate the evolutionary process of cumulative Coulomb failure stress change (CCFSC) in North China since 1303, manifested by secular tectonic stress loading and occurrence of large earthquakes. Secular tectonic stress loading is averaged from crustal strain rates derived from GPS. Fault rupture parameters of historical earthquakes are estimated as follows: the earthquake rupture length and the amount of slip are derived based on their statistical relationships with the earthquake intensity distribution and magnitude, calibrated using parameters of instrumentally measured contemporary earthquakes. The earthquake rake angle is derived based on geologically determined fault orientational parameters and seismically estimated orientation of regional tectonic stresses. Assuming a layered visco-elastic medium, we calculate stress evolution resulting from secular tectonic loading and coseismic and postseismic deformation. On the eve of each large earthquake, the accumulated stress field is projected to the fault surface of that earthquake and the CCFSC is evaluated to assess the triggering effect of CCFSC. Forty-nine earthquakes with M≥6.5 have occurred in North China since 1303. Statistics shows that 39 out of the 48 subsequent events were triggered by positive CCFSC, yielding a triggering rate of 81.3%. If we use the accumulative stress field to evaluate the CCFSC for the M≥5.0 earthquakes that occurred in North China since 1303, we find that 75.5% of those events were triggered. The triggering rate for the M≥5.0 earthquakes after the 1976 Ninghe earthquake is up to 82.1%. The triggering rates can be higher if corrections are made for some aftershocks which were wrongly identified as occurring in stress shadow zones because of errors in parameter estimates of historical earthquakes. Our study shows a very high correlation between positive CCFSC and earthquake occurrences. Relatively high CCFSC in North China at present is concentrated around the Bohai Sea, the west segment of the Northern Qinling fault, the western end of the Zhangjiakou-Bohai Sea seismic zone, and the Taiyuan basin, Shanxi graben, suggesting relatively higher earthquake potential in these areas. | Wan Yongge Shen Zhengkang Shang Dan Li Tieming Zeng Yuehua | 2006 | Earthquake Research in China2006，20，3： | 3 |
| 12 | The correlation between rat retinal nerve fiber layer thickness around optic disc by using optical coherence tomography and histological measurements显示文摘AIM:To explore the correlation between the retinal nerve fiber layer(RNFL) thickness by using optical coherence tomography(OCT) and by histological measurements in normal adult rats and optic nerve transected rats.·METHODS:The RNFL thickness of 36 rats was scanned in a circle 3.46mm far from the optic disc by OCT.The two experimental groups were the normal group(n =20 rats) and the optic nerve transected group(n =16 rats).The latter group included 4 groups(n =4 /group)surviving for 1 day,3,5 and 7 days.Then the RNFL thickness of the same retina area was also measured by NF-200 immunohistochemical staining method.Linear regression was used to analyze the correlation between the data obtained from these two methods.·RESULTS:The RNFL thickness of normal right eyes around optic disc by OCT was 72.35 ±5.71μm and that ofthe left eyes was 72.65 ±5.88μm(P =0.074).The RNFL thickness of the corresponding histological section by immunohistochemistry was 37.54 ±4.05μm(right eyes)and 37.38 ±4.23μm(left eyes)(P =0.059).There was a good correlation between the RNFL thickness measured by OCT and that measured by histology(R2=0.8131).After optic nerve transection,the trend of the RNFL thickness was thinner with the prolonged survival time.The correlation of the thickness detected by the above two methods was approximately(R2=0.8265).Value of the RNFL thickness in rats around optic disc measured by OCT was obviously higher than that measured by common histological measurement in normal adult rats and optic nerve transected rats.·CONCLUSION:The RNFL thickness measured by OCT has a strong correlation with that measured by histological method.Through OCT scanning,we found that the thickness of RNFL gradually becomes thinner in a time-dependent manner. | Ju-Fang Huang Hui-Min Yu Lei Shang Ruo-Fei Ma Ngobe Akume Cynthia Yan-Qun Cao Jia Luo Le-Ping Zeng Dan Chen Kun Xiong | 2013 | International Journal of Ophthalmology(English edition)2013，6，4： | 2 |
| 13 | Role of unc5b in retinal neovascularization in mice with oxygen-induced retinopathy显示文摘·AIM:To explore the role of unc5b in retinal neovascularization in murine oxygen-induced retinopathy (OIR).·METHODS:On postnatal 7(P7),C57BL/6J mice were exposed to 75%?à2% oxygen for 5 days.On postnatal 12(P12),the mice were brought back to the room air (21% oxygen) to induce retinal neovascularization.Western blot analysis was performed to examine the temporal expression of unc5b in murine retinas.Double staining for unc5b and isolectin B4 were employed to determine the location of unc5b in murine retinas.The effect of unc5b on retinal neovascularization was evaluated by intravitreal injection of unc5b-FC in mice with OIR.Retinal neovascularization was measured by counting neovascular cell nuclei above the internal limiting membrane and by angiography of flat-mounted retinas perfused with fluorescein dextran.·RESULTS:Compared to age-matched normal mice,the expression of unc5b was significantly increased in retinas of OIR mice on P17 and P21.Unc5b was apparently expressed in retinal vessels of OIR while being negative in normal retinal vessels.Retinal neovascularization in eyes injected with unc5b-FC was significantly reduced.·CONCLUSION:Unc5b-FC can effectively inhibit retinal neovascularization induced by OIR.It may serve as a powerful and novel therapy for ischemia-induced retinal disease.· | Dan Liu, Lei Shang | 2011 | International Journal of Ophthalmology(English edition)2011，4，2： | 2 |
| 14 | Highly ordered mesoporous carbons-based glucose/O 2 biofuel cell显示文摘 | Ming Zhou Liu Deng Dan Wen Li Shang Lihua Jin Shaojun Dong | 2009 | Biosensors and Bioelectronics2009，，9： | 1 |
| 15 | Laser Doppler vibrometer for real-time speech-signal acquirement显示文摘 | Shang Jianhua He Yan Liu Dan | 2009 | Chinese Optical Letters2009，7，8： | 1 |
| 16 | Silver nanoparticles capped with 8-hydroxyquinoline-5-sulfonate for the determination of trace aluminum in water samples and for intracellular fluorescence imaging显示文摘 | SHANG YAN GAO DAN WU FANGYING | 2013 | Microchim Acta2013，，180： | 1 |
| 17 | Characterization and biodegradability of amphoteric superabsorbent polymers 显示文摘 | Wang Dan Song Zhanqian Shang Shibin | 2007 | Journal of Applied Polymer Science2007，107，： | 1 |
| 18 | Organic–inorganic hybrid material for the cells immobilization: Long-term viability mechanism and application in BOD sensors显示文摘 | Ling Liu Li Shang Shaojun Guo Dan Li Changyu Liu Li Qi Shaojun Dong | 2009 | Biosensors and Bioelectronics2009，，2： | 1 |
| 19 | 求解箱式约束全局优化问题的新的填充函数显示文摘In this paper, auxiliary function method for global optimization with box constraints is considered. First, a new non-parameter filled function which has the same local minimizers of the objective function is proposed. By the character that having same local minimizers, and these minimizers are all better than the current minimizer of the objective function, it does not need to minimize the objective function except for thefirst iteration in the filled function method. It changes the frame of conventional filled function methods that objective function and filled function are minimized alternately,and can effectively reduce the iterations of the algorithm and accelerate the speed of global optimization. And then the theoretical properties of the filled function are discussed and the corresponding algorithm is established. Finally, numerical experiments are made and comparisons on several test problems are shown which exhibit the feasibility and effectiveness of the algorithm. | QU De-qiang WU Dan SHANG You-lin | 2020 | Chinese Quarterly Journal of Mathematics2020，35，4： | 1 |
| 20 | Highly efficient fiber-shaped organic solar cells toward wearable flexible electronics显示文摘Fiber-shaped solar cells(FSCs)show great potential to act as the power source in the wearable electronics field.Due to the unique advantages of the fiber-shaped organic solar cells(FOSCs),such as all-solid-state,ease of fabrication,and environmental friendliness,FOSCs are the strongest candidate among all types of FSCs for wearable electronics.However,the development of FOSCs is seriously lagging behind other types of FSCs.In this work,we demonstrate the efficient FOSCs with non-fullereneacceptors(NFAs)-based light-harvesting materials.The FOSCs present efficiencies exceeding 9%under AM 1.5 G irradiation conditions.The performance influence factors including hole/electron transport layers,active layer,counter electrodes,solvents,and especially,the environmental humidity is systematically studied.The FOSCs not only can easily drive the electrical devices but also can be woven into the textile to charge the smartwatch.The study exhibits the great potential to apply the FOSCs as the power supply source in the wearable electronic field. | Dan Lv Qianqing Jiang Yuanyuan Shang Dianyi Liu | 2022 | npj Flexible Electronics2022，6，1： | 1 |
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