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| 1 | Hepatoid adenocarcinoma of the colon in a patient with inflammatory bowel disease显示文摘A case is presented of a 36-year-old male with primary sclerosing cholangitis-associated inflammatory bowel disease(PSC-IBD) and two synchronous stage 1 adenocarcinomata of the colon,who was initially treated with a subtotal colectomy with ileostomy.One year later,the patient presented with extensive intra-abdominal lymphadenopathy and peritoneal carcinomatosis,as well as a markedly elevated serum level of alpha-fetoprotein(AFP).Fine needle aspiration biopsy of a porta hepatis lymph node revealed a metastatic hepatoid adenocarcinoma.Subsequent review of the previous colectomy specimen showed that one of the previously identified adenocarcinomata had features suggestive of a hepatoid colonic adenocarcinoma.The patient was subsequently treated with a cytotoxic regimen of FOLFOX(oxaliplatin,leucovorin,5-fluorouracil) and bevacizumab,with stable results being achieved after six months.This case presents the first known report of PSC-IBD associated with synchronous typical and hepatoid adenocarcinomata of the colon and highlights the importance of considering hepatoid adenocarcinoma as a differential diagnosis in patients with an increasing serum AFP level. | Yuanyuan Chen David F Schaeffer Eric M Yoshida | 2014 | World Journal of Gastroenterology2014，20，35： | 6 |
| 2 | 土壤中有机肥源抗生素抗性基因环境归趋与风险管理研究进展显示文摘抗生素抗性基因——一类新型污染物,已对人类健康和环境安全构成威胁,如何有效应对日益严峻的耐药性危机已成为一项全球性挑战。有机肥源抗生素抗性基因是土壤抗生素抗性基因的主要来源,而土壤参与并主导不同环境单元中抗生素抗性基因演化的多元交互作用,因此,有必要厘清有机肥源抗生素抗性基因在土壤和其他环境介质中的命运、归趋与风险。本文综述了近年来有机肥源抗生素抗性基因在土壤中的分布特征、环境归趋、人体暴露风险以及风险管理方面的研究进展,并提出建议与展望,以期为有效减轻抗生素抗性基因在环境中的危害,遏制抗生素抗性基因的增殖与传播提供理论依据与决策参考。 | 王芳 豆庆圆 付玉豪 梅芝 相雷雷 刘雨 蒋新 SCHAEFFER Andreas 朱永官 TIEDJE James M | 2022 | 农业环境科学学报2022，41，12： | 4 |
| 3 | ACC/AHA guidelines for the management of patients with unstable angina and non–st-segment elevation myocardial infarction显示文摘 | Eugene Braunwald Elliott M Antman John W Beasley Robert M Califf Melvin D Cheitlin Judith S Hochman Robert H Jones Dean Kereiakes Joel Kupersmith Thomas N Levin Carl J Pepine John W Schaeffer Earl E Smith David E Steward Pierre Theroux Raymond J Gibbons J | 2000 | Journal of the American College of Cardiology2000，，3： | 4 |
| 4 | Relationships between soybean components and tofu texture显示文摘 | SCHAEFFER M J LOVE J | 1992 | Food Qual1992，15，： | 1 |
| 5 | Relationships between soy- bean components and tofu texture 显示文摘 | SCHAEFFER M J LOVE J | 1992 | J of Food Quali- ty1992，15，： | 1 |
| 6 | Functional magnetic resonance imaging of real and shamacupuncture 显示文摘 | PARRISH TB SCHAEFFER A CATANESE M | 2005 | IEEE Eng Med BioMag2005，24，2： | 1 |
| 7 | Potential for reduction of CO2 emissions and a low-carbon scenario for the Brazilian industrial sector显示文摘 | Henriques J M FDantas F Schaeffer R | | 0，，04： | 1 |
| 8 | Establishment and characterization of bovine mammary myoepithelial cell line 显示文摘 | Zavizion B van Duffelen M Schaeffer W | 1996 | In Vitro Cell Dev Biol-Anim1996，32，： | 1 |
| 9 | PGC-1a coactivates PDK4 gene phan nuclear receptor ERRα: a expression via the or for tran scriptional control of muscle glucose metabolism 显示文摘 | WENDE A R HUSS J M SCHAEFFER P J | 2005 | Mol Cell Biol2005，25，10： | 1 |
| 10 | Lipopolysaccharide-based enzyme-linked immunosorbent assay for experimental use in detection of antibodies to Lawsonia intracellularis in pigs 显示文摘 | Kroll J J Eichmeyer M A Schaeffer M L | 2005 | Clinical and Diagnostic Laboratory Immunology2005，12，6： | 1 |
| 11 | Isotope Effecton Hand Capture by Electron Impact on Hydrogen, Deuterium and Tritium显示文摘 | Schaeffer O A Hastinge J M | 1950 | J Chem Phyc1950，18，： | 1 |
| 12 | Modifiable and nonmodifiable factors associated with osteoporosis in postmenopausal women:results from the Third National Health and Nutrition Examination Survey, 1988-1994显示文摘 | Snelling AM Crespo C J Schaeffer M | 2001 | J Womens Health Gend Based Med2001，10，1： | 1 |
| 13 | Mitogen-activated protein kinases:specific messages from ubiquitous messengers显示文摘 | Schaeffer H J Weber M J | | 0，，： | 1 |
| 14 | Relationships between soybean components and tofu texture显示文摘 | SCHAEFFER M J LOVE J | 1992 | J of Food Quality1992，15，： | 1 |
| 15 | Binding of OTULIN to the PUB domain of HOIP controls NF - KB signaling显示文摘 | Schaeffer V Akutsu M Olma MH | 2014 | Mol Cell2014，54，3： | 1 |
| 16 | Renal medullary carcinoma: molecular, pathological and clini- cal evidence for treatment with topoisomerase-inhihiting therapy显示文摘 | Schaeffer E M Guzzo T J Furge K A | 2010 | BJU Int2010，106，1： | 1 |
| 17 | The treatment of supracondylar humeral fractures with elastic stable in- tramedullary nailing (ESIN)in children显示文摘 | Lacher M Schaeffer K Boehm R | 2011 | J Pediatr Or- thop2011，31，1： | 1 |
| 18 | Transpiration of cottonwood/willow forest estimated from sap flux 显示文摘 | Sean M Schaeffer David G Williams David C Goodrich | 2000 | Agricultural and Forest Meteorology2000，105，： | 1 |
| 19 | A novel series of benzo- hopanes widespread in sediments 显示文摘 | Schaeffer P Adrna P Trendel J M et ai | 1995 | Organic Geochemistry1995，23，1： | 1 |
| 20 | 17 Beta-estra- diol-induced antidepressant-like effect in the forced swim test is ab- sent in estrogen receptor-beta knockout (BERKO) mice显示文摘 | ROCHA B A FLEISCHER R SCHAEFFER J M | 2005 | Psycho- pharmacology ( Berl )2005，179，3： | 1 |
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