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| 1 | TIMI Frame Count: A Quantitative Method of Assessing Coronary Artery Flow显示文摘 | C. Michael Gibson Christopher P. Cannon William L. Daley Jr Dodge Barbara Alexander Susan J. Marble Carolyn H. McCabe Lori Raymond Terry Fortin W. Kenneth Poole Eugene Braunwald | 1996 | Circulation1996，，5： | 6 |
| 2 | ACC/AHA guidelines for the management of patients with unstable angina and non–st-segment elevation myocardial infarction显示文摘 | Eugene Braunwald Elliott M Antman John W Beasley Robert M Califf Melvin D Cheitlin Judith S Hochman Robert H Jones Dean Kereiakes Joel Kupersmith Thomas N Levin Carl J Pepine John W Schaeffer Earl E Smith David E Steward Pierre Theroux Raymond J Gibbons J | 2000 | Journal of the American College of Cardiology2000，，3： | 4 |
| 3 | Intensive versus moderate lipid lowering with statins after acute coronary syndromes显示文摘 | Cannon CP Braunwald E McCabe CH | | New England Journal of Medicine0，，： | 3 |
| 4 | Reduction in Recurrent Cardiovascular Events With Intensive Lipid-Lowering Statin Therapy Compared With Moderate Lipid-Lowering Statin Therapy After Acute Coronary Syndromes显示文摘 | Sabina A. Murphy Christopher P. Cannon Stephen D. Wiviott Carolyn H. McCabe Eugene Braunwald | 2009 | Journal of the American College of Cardiology2009，，25： | 3 |
| 5 | 接受纤溶治疗的ST段抬高心肌梗死患者在经皮冠状动脉介入治疗前服用氯吡格雷的效果:PCI-CLARITY研究显示文摘背景:关于经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)前氯吡格雷预治疗的益处目前仍有争议,并且其使用亦未获得普遍认可。
目的:于新近发生ST段抬高心肌梗死(ST—segment elevation myocardial infarction,STEMI)的患者中确定PCI前氯吡格雷预治疗预防严重不良心血管事件的效果是否优于PCI时开始采用氯吡格雷治疗。
设计、地点及参试者:CLARITY(PCI—Clopidogrel as Adjunctive Reperfusion Therapy)研究是一项于1863例患者中进行的前瞻性计划分析。这些患者均于CLARITY—TIMI(Thrombolysis in Myocardial Infarction)28试验中在血管造影后实施了PCI。CLARITY—TIMI28是一项在接受纤溶治疗的患者中进行的有关氯吡格雷效果的随机、双盲、安慰剂对照试验。患者于2003年2月至2004年10月入选自23个国家的319家医院。
干预:患者服用阿斯匹林并于纤溶治疗时开始随机接受氯吡格雷(300mg负荷剂量,以后75mg,每日1次)或安慰剂,直至冠状动脉造影前为止。造影在开始研究药物后2~8天进行。接受冠脉支架的患者建议于诊断性血管造影后给予开标氯吡格雷(包括负荷剂量)。
主要观测指标:一级终点为PCI至随机分组后30天心血管死亡、MI复发或脑卒中的复合发生率。二级终点包括在PCI之前发生的MI或脑卒中以及前述随机分组后30天相关终点。
结果:氯吡格雷预治疗可显著降低PCI后心血管死亡、MI或脑卒中的发生率(34[3.6%]比58[6.2%];校正优势比[odds ratio,OR],0.54[95%CI,0.35—0.85];P=0.008)。氯吡格雷预治疗还可降低PCI前MI或脑卒中的发生率(37[4.0%]比58[6.2%];OR,0.62[95%CI,0.40~0.95];P=0.03)。总体上,氯吡格雷预治疗可导致随机分组后30天心血管死亡、MI或脑卒中显著下降(70[7.5%]比112[12.0%];校正OR,0.59[95%CI,0.43~0.81];P=0.001;所需治疗例数=23)。TIMI严重或轻微出血的发生率未显著增加((18[20%]比17[1.9%];P〉0.99)。
结论:氯吡格雷预治疗可显著降低PCI前后心血管死亡或缺血并发症,而严重或轻微出血无显著增加。这些数据为STEMI患者早期使用氯吡格雷以及接受PCI的患者常规采用氯吡格雷预治疗方案提供了进一步的支持。 | Marc S. Sabatine Christopher P.Cannon C. Michael Gibson Jose L Lopez-Sendon Gilles Montalescot Pierre Theroux Basil S. Lewis Sabina A. Murphy Carolyn H. McCabe Eugene Braunwald 李呈亿(译) | 2006 | 美国医学会杂志(中文版)2006，25，4： | 2 |
| 6 | Impact of Triglyceride Levels Beyond Low-Density Lipoprotein Cholesterol After Acute Coronary Syndrome in the PROVE IT-TIMI 22 Trial显示文摘 | Michael Miller Christopher P. Cannon Sabina A. Murphy Jie Qin Kausik K. Ray Eugene Braunwald | 2008 | Journal of the American College of Cardiology2008，，7： | 2 |
| 7 | TIMI Risk Score for ST-Elevation Myocardial Infarction: A Convenient, Bedside, Clinical Score for Risk Assessment at Presentation: An Intravenous nPA for Treatment of Infarcting Myocardium Early II Trial Substudy显示文摘 | David A. Morrow Elliott M. Antman Andrew Charlesworth Richard Cairns Sabina A. Murphy James A. de Lemos Robert P. Giugliano Carolyn H. McCabe Eugene Braunwald | 2000 | Circulation: Journal of the American Heart Association2000，，17： | 2 |
| 8 | Design of the Pravastatin or Atorvastatin Evaluation and Infection Therapy (PROVE IT)—TIMI 22 trial显示文摘 | Christopher P. Cannon Carolyn H. McCabe Rene Belder Jeanne Breen Eugene Braunwald | 2002 | The American Journal of Cardiology2002，，7： | 2 |
| 9 | ACC/ AHA guidelines for the management of patients ,with unstable angina and non - ST segment elevation myocardial infarction 显示文摘 | Braunwald E Antman EM Beasley JW | 2000 | J Am Coll Cardiol2000，36，3： | 1 |
| 10 | Unstable angina :A classification显示文摘 | Braunwald E | 1989 | Circulation1989，80，： | 1 |
| 11 | ACC/AHAGuidelines for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction:a report of american college of caridogy/american heart association task force on practice guidelines(Committe on the management of patients with unstable angina)显示文摘 | Braunwald E Antman EM Beasley JW | 2000 | J Am Coll Cardiol2000，36，3： | 1 |
| 12 | Congestive heart failure 显示文摘 | Braunwald E Bristow MR | 2000 | Circulation2000，102，： | 1 |
| 13 | Application of current guidelines to the management of unstable angina and non-ST-elevation myocardial infarction显示文摘 | Braunwald E | 2003 | Circulation2003，108，161： | 1 |
| 14 | Sphygmomanometrically determined pulse pressure is a powerful independent predictor of recurrent events after myocardial infarction in patients with impaired left ventricular function显示文摘 | Mitchell GF Moye LA Braunwald BE | 1997 | Circulation1997，96，11： | 1 |
| 15 | ACC/AHA guidelines for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on the Management of Patients with Unstable Angina)显示文摘 | Braunwald E Antman E M Beasley J W | 2000 | J Am Coil Cardiol2000，36，3： | 1 |
| 16 | Shattuck Lecture: Cardiovascular medicine at the tern of the millennium: Triumphs, concerns, and opportunities 显示文摘 | Braunwald E | 1997 | N Engl J Mcd1997，337，： | 1 |
| 17 | Vorapaxar in the secondary prevention of atherothrombotic events显示文摘 | MORROW DA BRAUNWALD E BONACA MP | 2012 | N Engl J Med2012，366，15： | 1 |
| 18 | Bariatric surgery:a systematic review and meta-analysis显示文摘 | Buchwald H Avidor Y Braunwald E | 2004 | JAMA2004，292，14： | 1 |
| 19 | Ventricularremodeling after myocar- dial infarction: experimental observations and clinical impli- cations显示文摘 | Pfeffer MA Braunwald E | 1990 | Circulation1990，81，： | 1 |
| 20 | Prasugrel versus clopidogrel in patients with acute coronary syndromes显示文摘 | Wiviott SD Braunwald E McCabe CH | 2007 | N Engl J Med2007，357，20： | 1 |
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