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| 1 | Pathogenic mechanisms of pancreatitis显示文摘Pancreatitis is inflammation of pancreas and caused by a number of factors including pancreatic duct obstruction, alcoholism, and mutation in the cationic trypsinogen gene. Pancreatitis is represented as acute pancreatitis with acute inflammatory responses and; chronic pan-creatitis characterized by marked stroma formation with a high number of infiltrating granulocytes(such as neutrophils, eosinophils), monocytes, macrophages and pancreatic stellate cells(PSCs). These inflammatory cells are known to play a central role in initiating and promoting inflammation including pancreatic fibrosis, i.e., a major risk factor for pancreatic cancer. A number of inflammatory cytokines are known to involve in pro-moting pancreatic pathogenesis that lead pancreatic fibrosis. Pancreatic fibrosis is a dynamic phenomenon that requires an intricate network of several autocrine and paracrine signaling pathways. In this review, we have provided the details of various cytokines and molecular mechanistic pathways(i.e., Transforming growth factor-β/SMAD, mitogen--activated protein kinases, Rho kinase, Janus kinase/signal transducers and activators, and phosphatidylinositol 3 kinase) that have a critical role in the activation of PSCs to promote chronic pancreatitis and trigger the phenomenon of pancreatic fibrogenesis. In this review of literature, we discuss the involvement of several pro-inflammatory and anti-inflammatory cytokines, such as in interleukin(IL)-1, IL-1β, IL-6, IL--8 IL-10, IL-18, IL--33 and tumor necrosis factor-α, in the pathogenesis of disease. Our review also highlights the significance of several experimental animal models that have an important role in dissecting the mechanistic pathways operating in the development of chronic pancreatitis, including pancreatic fibrosis. Additionally, we provided several intermediary molecules that are involved in major signaling pathways that might provide target molecules for future therapeutic treatment strategies for pancreatic pathogenesis. | Murli Manohar Alok Kumar Verma Sathisha Upparahalli Venkateshaiah Nathan L Sanders Anil Mishra | 2017 | World Journal of Gastrointestinal Pharmacology and Therapeutics2017，8，1： | 21 |
| 2 | Proteomic profiling of high glucose primed monocytes identifies cyclophilin A as a potential secretory marker of inflammation in type 2 diabetes显示文摘 | Ramachandran S Venugopal A Sathisha K | 2012 | Proteomics2012，12，18： | 1 |
| 3 | 18-kDa protein as a marker to detect WSSV infection in shrimps显示文摘 | Sathisha S Selvakkumara C Sahul Hameed A S | 2004 | Aquaculture2004，238，： | 1 |
| 4 | Structural elucidation of possible lutein oxidation products mediated through peroxyl radical inducer 2, 2' Azobis (2methylpropionamidine) dihydrochloride , antioxidant and cytotoxic influence of oxidized lutein in HeLa cells显示文摘 | Lakshminarayana R Aruna G Sathisha UV | 2013 | Chern boil interact2013，203，44： | 1 |
| 5 | Proteomic profi- ling of high glucose primed monocytes identifies cyclophilin A as a po- tential secretory marker of inflammation in type 2 diabetes 显示文摘 | Ramachandran S Venugopal A Sathisha K | 2012 | Pro- teomics2012，12，18： | 1 |
| 6 | Pro- teomic profiling of high glucose primed monocytes identi- fies cyclophilin A as a potential secretory marker of in- flammation in type 2 diabetes 显示文摘 | Ramachandran S Venugopal A Sathisha K | 2012 | Proteomics2012，12，18： | 1 |
| 7 | Proteomic profiling of high glucose primed monocytes identifies cyclophilin A as a potential secretory marker of inflammation in type 2 diabetes 显示文摘 | Ramachandran S Venugopal A Sathisha K | 2012 | Proteomics2012，12，18： | 1 |
| 8 | Selective determination of dopamine in presence of ascorbic acid and uric acid at hydroxy double salt/surfac- tant film modified carbon paste electrode显示文摘 | Sathisha T V Kumara Swamy Chandrashekar B N | 2012 | Journal of Electroanalytical Chemistry2012，674，： | 1 |
| 9 | Effect of Acid Ensiling on the Stability of Visceral Waste Proteases of Indian Major Carp Labeo rohita显示文摘 | N. Bhaskar A. D. Sathisha N. M. Sachindra P. Z. Sakhare N. S. Mahendrakar | 2007 | Journal of Aquatic Food Product Technology2007，，1： | 1 |
| 10 | Cytoprotective and antioxidant activity of free, conjugated and insoluble-bound phenolic acids from swallow root (Decalepis hamiltonii) 显示文摘 | Harish Nayaka M A Sathisha U V Dharmesh S M | 2010 | Food Chemistry2010，119，4： | 1 |
| 11 | Structural elucidation of possible lutein oxidation products mediated through peroxyl radical inducer 2,2'-Azobis(2-methylpropionamidine)dihydrochloride:antioxidant and cytotoxic influence of oxidized lutein in He La cells显示文摘 | Lakshminarayana R Aruna G Sathisha UV | 2013 | Chem Biol Interact2013，203，2： | 1 |
| 12 | Synthesis and xanthine oxidase inhibitory activity of 7-methyl-2-( phenoxymethyl ) -5H- thiadiazolo E 3,2-a ] pyrimidin-5-one derivatives 显示文摘 | SATHISHA K R KHANUM S A CHANDRA J N | 2011 | Bioorg Med Chem2011，19，1： | 1 |
| 13 | A variant peptide of buffalo colostrum betalactoglobulin inhibits angiotensin I-converting enzyme activity显示文摘 | ROHIT A C SATHISHA K APARNA H S | 2012 | European Journal of Medicinal Chemistry2012，53，： | 1 |
| 14 | Inhibition of galectin-3 mediated cellular interactions by pectic polysaccharides from dietary sources显示文摘 | Sathisha U Jayaram S Harish Nayaka M Dharmesh S | | 0，，08： | 1 |
| 15 | Synthesis and Xanthine Oxidase Inhibitory Activity of 7-Methyl-2- (phenoxymethyl) -5 H- Thiadiazolo Pyrimidin-5-One Derivatives 显示文摘 | Sathisha K R Khanum S A Chandra J N N S | 2011 | Bioorg Med Chem2011，19，1： | 1 |
| 16 | Inhibition of galectin-3 mediated cellular interactions by pectic polysaccharides from dietary sources显示文摘 | SATHISHA U V JAYARAM S NAYAKA M A H | 2007 | Glycoconjugate Journal2007，24，8： | 1 |
| 17 | Protein extract of kenaf seed exhibits anticoagulant,antiplatelet and antioxidant activities显示文摘Objective:To explore the anticoagulant,antiplatelet and antioxidant activities of protein extract of kenaf seed(PEKS).Methods:Sodium dodecyl sulphate polyacrylamide gel electrophoresis and reverse-phase high-performance liquid chromatography techniques were employed for protein characterization.Antioxidant activity of PEKS was assessed using 1,1-diphenyl-2-picrylhydrazyl(DPPH)assay.The protective effect of PEKS on sodium nitrite(NaNO2)induced oxidative stress was evaluated using the in vitro red blood cell model,while the effect of PEKS on diclofenacinduced oxidative stress was examined in vivo in rats.Platelet-rich plasma and platelet-poor plasma were used for anticoagulant and antiplatelet activities of PEKS.Results:PEKS revealed similar protein bands on SDS-PAGE under reduced and non-reduced conditions.Several acidic proteins were present in native PAGE.PEKS showed antioxidant properties by scavenging DPPH with an IC50 of 24.58μg.PEKS exhibited a protective effect on NaNO2 induced oxidative stress in red blood cells by restoring the activity of stress markers.In addition,PEKS alleviated diclofenac-induced tissue damage of the liver,kidney,and small intestine.PEKS showed an anticoagulant effect in both in vivo and in vitro experiments by enhancing normal clotting time.PEKS did not affect prothrombin time but increase activated partial thromboplastin time.Furthermore,PEKS inhibited adenosine diphosphate and epinephrine-induced platelet aggregation.Conclusions:PEKS protects tissues from oxidative stress and exhibits antithrombotic activity. | Sujatha M.Hanumegowda Chandramma Srinivasa Ashwini Shivaiah Manjula M.Venkatappa Ramesha Hanumanthappa Rajesh Rangappa Ramesh K.Laxmaiah Sathisha J.Gonchigar Devaraja Sannaningaiah | 2022 | Asian Pacific Journal of Tropical Biomedicine2022，12，2： | 0 |
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