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| 1 | Reproducibility of thrombus volume quantification in multicenter computed tomography pulmonary angiography studies显示文摘AIM To evaluate reproducibility of pulmonary embolism(PE) clot volume quantification using computed tomography pulmonary angiogram(CTPA) in a multicenter setting.METHODS This study was performed using anonymized data in conformance with HIPAA and IRB Regulations(March 2015-November 2016). Anonymized CTPA data was acquired from 23 scanners from 18 imaging centers using each site's standard PE protocol. Two independent analysts measured PE volumes using a semi-automated region-growing algorithm on an FDA-approved image analysis platform. Total thrombus volume(TTV) was calculated per patient as the primary endpoint. Secondary endpoints were individual thrombus volume(ITV), Qanadli score and modified Qanadli score per patient. Inter-and intra-observer reproducibility were assessed using intra-class correlation coefficient(ICC) and BlandAltman analysis. RESULTS Analyst 1 found 72 emboli in the 23 patients with a mean number of emboli of 3.13 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.0041-47.34 cm3(mean +/-SD, 5.93 +/-10.15 cm3). On the second read, analyst 1 found the same number and distribution of emboli with a range of volumes for read 2 from 0.0041 – 45.52 cm3(mean +/-SD, 5.42 +/-9.53 cm3). Analyst 2 found 73 emboli in the 23 patients with a mean number of emboli of 3.17 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.00459-46.29 cm3(mean +/-SD, 5.91 +/-10.06 cm3). Inter-and intraobserver variability measurements indicated excellent reproducibility of the semi-automated method for quantifying PE volume burden. ICC for all endpoints was greater than 0.95 for inter-and intra-observer analysis. Bland-Altman analysis indicated no significant biases.CONCLUSION Semi-automated region growing algorithm for quantifying PE is reproducible using data from multiple scanners and is a suitable method for image analysis in multicenter clinical trials. | Audrey E Kaufman Alison N Pruzan Ching Hsu Sarayu Ramachandran Adam Jacobi Indravadan Patel Lee Schwocho Michele F Mercuri Zahi A Fayad Venkatesh Mani | 2018 | World Journal of Radiology2018，10，10： | 3 |
| 2 | Effect of varying computed tomography acquisition and reconstruction parameters on semi-automated clot volume quantification显示文摘AIM To examine effects of computed tomography(CT)image acquisition/reconstruction parameters on clot volume quantification in vitro for research method validation purposes.METHODS This study was performed in conformance with HIPAA and IRB Regulations(March 2015-November 2016).A ten blood clot phantom was designed and scanned on a dual-energy CT scanner(SOMATOM Force,Siemens Healthcare Gm BH,Erlangen,Germany)with varying pitch,iterative reconstruction,energy level and slicethickness.A range of clot and tube sizes were used in an attempt to replicate in vivo emboli found within central and segmental branches of the pulmonary arteries in patients with pulmonary emboli.Clot volume was the measured parameter and was analyzed by a single image analyst using a semi-automated region growing algorithm implemented in the FDA-approved Siemens syngo.via image analysis platform.Mixed model analysis was performed on the data.RESULTS On the acquisition side,the continuous factor of energy showed no statistically significant effect on absolute clot volume quantification(P=0.9898).On the other hand,when considering the fixed factor of pitch,there were statistically significant differences in clot volume quantification(P<0.0001).On the reconstruction side,with the continuous factor of reconstruction slice thickness no statistically significant effect on absolute clot volume quantification was demonstrated(P=0.4500).Also on the reconstruction side,with the fixed factor of using iterative reconstructions there was also no statistically significant effect on absolute clot volume quantification(P=0.3011).In addition,there was excellent R^2 correlation between the scale-measured mass of the clots both with respect to the CT measured volumes and with respect to volumes measure by the water displacement method.CONCLUSION Aside from varying pitch,changing CT acquisition parameters and using iterative reconstructions had no significant impact on clot volume quantification with a semi-automated region growing algorithm. | Audrey E Kaufman Alison N Pruzan Ching Hsu Sarayu Ramachandran Adam Jacobi Zahi A Fayad Venkatesh Mani | 2018 | World Journal of Radiology2018，10，3： | 3 |
| 3 | Regression of Inflammation in Atherosclerosis by the LXR Agonist R211945显示文摘 | Esad Vucic Claudia Calcagno Stephen D. Dickson James H.F. Rudd Katsumi Hayashi Jan Bucerius Erin Moshier Jessica S. Mounessa Michelle Roytman Matthew J. Moon James Lin Sarayu Ramachandran Tatsuo Tanimoto Karen Brown Masakatsu Kotsuma Sotirios Tsimikas Edw | 2012 | JACC: Cardiovascular Imaging2012，，8： | 2 |
| 4 | Review of radiographic findings in COVID-19显示文摘The purpose of this study is to review the published literature for the range ofradiographic findings present in patients suffering from coronavirus disease 2019infection. This novel corona virus is currently the cause of a worldwide pandemic.Pulmonary symptoms and signs dominate the clinical picture and radiologists arecalled upon to evaluate chest radiographs (CXR) and computed tomography (CT)images to assess for infiltrates and to define their extent, distribution andprogression. Multiple studies attempt to characterize the disease course bylooking at the timing of imaging relative to the onset of symptoms. In general,plain CXR show bilateral disease with a tendency toward the lung periphery andhave an appearance most consistent with viral pneumonia. Chest CT images aremost notable for showing bilateral and peripheral ground glass and consolidatedopacities and are marked by an absence of concomitant pulmonary nodules,cavitation, adenopathy and pleural effusions. Published literature mentioningorgan systems aside from pulmonary manifestations are relatively less common,yet present and are addressed in this review. Similarly, publications focusing onimaging modalities aside from CXR and chest CT are sparse in this evolving crisisand are likewise addressed in this review. The role of imaging is examined as it iscurrently being debated in the medical community, which is not at all surprisingconsidering the highly infectious nature of Severe Acute Respiratory Syndromecoronavirus 2. | Audrey E Kaufman Sonum Naidu Sarayu Ramachandran Dalia S Kaufman Zahi A Fayad Venkatesh Mani | 2020 | World Journal of Radiology2020，12，8： | 2 |
| 5 | Aerobic Biodegradation Pathway for Remazol Orange by Pseudomonas aeruginosa 显示文摘 | Sarayu K Sandhya S | 2010 | Applied Biochemistry and Biotechnology2010，160，： | 1 |
| 6 | Current technologies for biological treatment of textile wastewater:a review 显示文摘 | Sarayu K Sandhya S | 2012 | Applied Biochemistry and Bio-technology2012，167，3： | 1 |
| 7 | Response surfacemethodology for optimization of medium for decolorization of textile dyeDirect Black 22 by a novel bacterial consortium显示文摘 | Sarayu Mohana Shalini Shrivastava Jyoti Divecha | 2008 | Bioresource Tech-nology2008，99，： | 1 |
| 8 | Response surface methodology for optimization of medium for decolorization of textile dye direct black 22 by a novel bacterial consortium 显示文摘 | Sarayu M Shalini S Jyoti D | 2007 | Bioresource Technology2007，99，： | 1 |
| 9 | Assess- ment of degradation of eight commercial reactive azo dyes indi- vidually and in mixture in aqueous solution by ozonation显示文摘 | SARAYU K SWAMINATHAN K SANDHYA S | 2007 | Dyes and Pigments2007，75，2： | 1 |
| 10 | Aerobic biodegradation pathway for remazol orange by Pseudomonas aeruginosa显示文摘 | Sarayu K Sandhya S | | 0，，04： | 1 |
| 11 | Response surface methodology for optimization of medium for deeolorization of textile dye direct black 22 by a novel bacterial consortium 显示文摘 | Sarayu M Shalini S Jyoti D | 2007 | Bioresource Technology2007，99，3： | 1 |
| 12 | Determination of kinetic constants of hybrid textile wastewater treatment system 显示文摘 | Sandhya S Sarayu K Swaminathan K | 2008 | Bioresource Technology2008，99，13： | 1 |
| 13 | Current technologies for biological treatment of textile wastewater-a review显示文摘 | Sarayu K Sandhya S | 2012 | Applied Biochemistry and Biotechnol- ogy2012，167，64： | 1 |
| 14 | Current technologies for biological treatment of textile wastewater: a review显示文摘 | Sarayu K Sandhya S | 2012 | Applied Biochemistry and Biotechnology2012，167，3： | 1 |
| 15 | Assessment of degradation of eight commercial reactive azo dyes individually and in mixture in aqueous solution by ozonation 显示文摘 | Sarayu K Swaminathan K Sandhya S | 2007 | Dyes and Pigments2007，75，2： | 1 |
| 16 | Current technologies for biological treatment of textile wastewater-a review显示文摘 | SARAYU K SANDHYA S | 2012 | Applied Biochemistry and Biotechnology2012，167，3： | 1 |
| 17 | Response surface methodology for optimization of medium for decolorization of textile dye Direct Black 22 by a novel bacterial consortium显示文摘 | Sarayu M Shalini S Jyoti D | 2008 | Bioresource Technology2008，99，3： | 1 |
| 18 | Solid state fermentation of Achras zapota lignocellulose by Phanerochaete chrysosporium 显示文摘 | A Ganesh Kumar G Sekaran Sarayu Krishnamoorthy | 2006 | Bioresource Technology2006，97，： | 1 |
| 19 | Aerobic biodegradation pathway for Remazol Orange by Pseudomonas aeruginosa显示文摘 | Sarayu K Sandhya S | 2010 | Applied Biochemistry and Biotechnology2010，160，4： | 1 |
| 20 | Response surface methodology for optimization of medium for decolorization of textile dye Direct Black 22 by a novel bacterial consortium 显示文摘 | Sarayu M Shalini S Jyoti D | 2008 | Bioresource Technology2008，99，3： | 1 |
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