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| 1 | Update on the management of gastrointestinal varices显示文摘Cirrhosis of liver is a major problem in the western world. Portal hypertension is a complication of cirrhosis and can lead to a myriad of pathology of which include the development of porto-systemic collaterals. Gastrointestinal varices are dilated submucosal veins, which often develop at sites near the formation of gastroesophageal collateral circulation. The incidence of varices is on the rise due to alcohol and obesity. The most significant complication of portal hypertension is life-threatening bleeding from gastrointestinal varices, which is associated with substantial morbidity and mortality. In addition, this can cause a significant burden on the health care facility. Gastrointestinal varices can happen in esophagus, stomach or ectopic varices. There has been considerable progress made in the understanding of the natural history, pathophysiology and etiology of portal hypertension. Despite the development of endoscopic and medical treatments, early mortality due to variceal bleeding remains high due to significant illness of the patient. Recurrent variceal bleed is common and in some cases, there is refractory variceal bleed. This article aims to provide a comprehensive review of the management of gastrointestinal varices with an emphasis on endoscopic interventions, strategies to handle refractory variceal bleed and newer endoscopic treatment modalities. Early treatment and improved endoscopic techniques can help in improving morbidity and mortality. | Umesha Boregowda Chandraprakash Umapathy Nasir Halim Madhav Desai Arpitha Nanjappa Subramanyeswara Arekapudi Thimmaiah Theethira Helen Wong Marina Roytman Shreyas Saligram | 2019 | World Journal of Gastrointestinal Pharmacology and Therapeutics2019，10，1： | 18 |
| 2 | Endoscopic ultrasound guided gallbladder drainage - is it ready for prime time?显示文摘Management of acute cholecystitis includes initial stabilization and antibiotics. However, the most definitive treatment is cholecystectomy. A small percentage of patients who are not suitable for surgery due to the severity of cholecystitis or comorbidities will require a temporary measure as a bridge to surgery or permanent nonoperative management to decrease the mortality and morbidity. Most of these patients who require conservative management were managed with percutaneous transhepatic cholecystostomy or trans-papillary drainage of gallbladder drainage with cystic duct stenting through endoscopic retrograde cholangiopancreaticography(ERCP). Although, these conservative measures are effective, they can cause significant discomfort to the patients especially if used as a long-term measure. In view of this, there is a need for further minimally invasive procedures, which is safe, effective and comfortable to patients. Endoscopic ultrasound(EUS) guided gallbladder drainage is a novel method of gallbladder drainage first described in 2007^([1]). Over the last decade, EUS guided gallbladder drainage has evolved as an effective alternative to percutaneous cholecystostomy and trans-papillary gallbladder drainage. Our goal is to review available literature regarding the scope of EUS guided gallbladder drainage as a viable alternative to percutaneous cholecystostomy or cystic duct stenting through ERCP among patients who are not suitable for cholecystectomy. | UmeshaBoregowda Chandraprakash Umapathy Arpitha Nanjappa Helen Wong Madhav Desai Marina Roytman Thimmaiah Theethira Shreyas Saligram | 2018 | World Journal of Gastrointestinal Pharmacology and Therapeutics2018，9，6： | 2 |
| 3 | Regression of Inflammation in Atherosclerosis by the LXR Agonist R211945显示文摘 | Esad Vucic Claudia Calcagno Stephen D. Dickson James H.F. Rudd Katsumi Hayashi Jan Bucerius Erin Moshier Jessica S. Mounessa Michelle Roytman Matthew J. Moon James Lin Sarayu Ramachandran Tatsuo Tanimoto Karen Brown Masakatsu Kotsuma Sotirios Tsimikas Edw | 2012 | JACC: Cardiovascular Imaging2012，，8： | 2 |
| 4 | Positive margin during partial nephrectomy: does cancer remain in the renal remnant显示文摘 | Snndaram V Figenshau R S Roytman T M | 2011 | Umlogy2011，77，6： | 1 |
| 5 | Endovascular repair of renal artery anastomotic pseudoaneurysm following living donor kidney transplant 显示文摘 | Patil VV Roytman M Ames S | 2015 | Cardiovasc Intervent Radiol2015，38，6： | 1 |
| 6 | Laparoscopic cryoablation of renal masses: single-center long-term experi- ence显示文摘 | Tanagho YS Roytman TM Bhayani SB | 2012 | Urology2012，80，2： | 1 |
| 7 | Dynamic Color Quantization of Video Sequences显示文摘 | Evgeny Roytman Craig Gotsman | 1995 | IEEE Transactions on Visualization and Computer Graphics1995，1，3： | 1 |
| 8 | Lap aroscopic cryoablation of renal masses: single-center long term experience 显示文摘 | TANAQHO YS ROYTMAN TM BHAYANI SB | 2012 | Urology2012，80，2： | 1 |
| 9 | Application of advanced very high resolution radiometer (AVHRR) based vegetation health indices for estimation of malaria cases 显示文摘 | Rahman A Krakauer N Roytman L | 2010 | Am J Trop Med Hyg2010，82，6： | 1 |
| 10 | Adaptive clustering for hyperspectral sounder data compression显示文摘 | Gladkova I Roytman L Goldberg M | | 0，，5889： | 1 |
| 11 | Application of advanced very high resolution radiometer (AVHRR) -based vegetation health indices for estimation of malaria cases 显示文摘 | Rahman A Krakaner N Roytman L | 2010 | Am J Trop Med Hyg2010，82，6： | 1 |
| 12 | Positive margin during partial nephrectomy : does cancer remain in the renal rem- nant? 显示文摘 | Sundaram V Figenshau RS Roytman TM | 2011 | Urology2011，77，： | 1 |
| 13 | Laparoscopic Cryoablation of Renal Masses: Single-center Long-term Experience显示文摘 | Youssef S. Tanagho Timur M. Roytman Sam B. Bhayani Eric H. Kim Brian M. Benway Michael W. Gardner R. Sherburne Figenshau | 2012 | Urology2012，，2： | 1 |
| 14 | Hepatitis E infection:A review显示文摘Hepatitis E virus(HEV)is a small non-enveloped virus that is transmitted via the fecal-oral route.It is a highly common cause of acute hepatitis,particularly in low to middle income regions of Asia,Africa,and Central America.Most cases are self-limited,and symptomatic patients usually present with acute icteric hepatitis.A subset of patients including pregnant women,older men,those with preexisting liver disease and immunocompromised patients however,may develop severe disease and hepatic failure.Immunocompromised patients are also at risk for chronic infection,and their immunosuppression should be decreased in order to facilitate viral clearance.HEV can also present with a variety of extra-intestinal manifestations including neurological,renal,hematological,and pancreatic derangements.The gold standard of diagnosis is HEV ribonucleic acid detection via nucleic acid amplification testing.Currently,there are no approved treatments for Hepatitis E,though ribavirin is the most commonly used agent to reduce viral load.Studies assessing the safety and efficacy of other antiviral agents for HEV are currently underway.HEV vaccination has been approved in China,and is currently being investigated in other regions as well.This review article aims to discuss the epidemiology,pathogenesis,presentation,diagnosis,complications,and treatment of Hepatitis E infection. | Humzah Iqbal Bilal Fazal Mehmood Aalam Sohal Marina Roytman | 2023 | World Journal of Virology2023，12，5： | 0 |
| 15 | Alcohol-related hepatitis:A review article显示文摘Alcohol-related hepatitis(ARH)is a unique type of alcohol-associated liver disease characterized by acute liver inflammation caused by significant alcohol use.It ranges in severity from mild to severe and carries significant morbidity and mortality.The refinement of scoring systems has enhanced prognostication and guidance of clinical decision-making in the treatment of this complex disease.Although treatment focuses on supportive care,steroids have shown benefit in select circumstances.There has been a recent interest in this disease process,as coronavirus disease 2019 pandemic led to substantial rise in cases.Although much is known regarding the pathogenesis,prognosis remains grim due to limited treatment options.This article summarizes the epidemiology,genetics,pathogenesis,diagnosis and treatment of ARH. | Hunza Chaudhry Aalam Sohal Humzah Iqbal Marina Roytman | 2023 | World Journal of Gastroenterology2023，29，17： | 0 |
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