|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hyperglycemia is a significant prognostic factor of hepatocellular carcinoma after curative therapy显示文摘AIM:To evaluate whether metabolic factors are related to distant recurrence of hepatocellular carcinoma(HCC) and survival after curative treatment.METHODS:This retrospective study included 344 patients whose HCC was treated curatively by radiofrequency ablation(RFA) therapy.The mean age was 67.6 years and the mean observation period was 4.04 years.The etiological background of liver disease was hepatitis B virus infection in 30,hepatitis C virus infection in 278,excessive alcohol drinking in 9,and other in 27 patients.The Child-Pugh classification grade was A(n = 307) or B(n = 37).The number of HCC nodules was one in 260,two in 61,and three in 23 patients.For surveillance of HCC recurrence after curative therapy with RFA,patients were radiologically evaluated every 3 mo.Factors associated with distant recurrence of HCC or survival were studied.RESULTS:Inadequate maintenance of blood glucose in diabetic patients was associated with higher incidence of distant recurrence.The 1-,2-,and 3-year recurrence rates were significantly higher in diabetic patients with inadequate maintenance of blood glucose compared with the others:50.6% vs 26.8%,83.5% vs 54.4%,and 93.8% vs 73.0%,respectively(P = 0.0001).Inadequate maintenance of blood glucose was an independent predictor of distant recurrence [adjusted relative risk 1.97(95%CI,1.33-2.91),(P = 0.0007)] after adjustment for other risk factors,such as number of HCC nodules [2.03(95%CI,1.51-2.73),P < 0.0001] and initial level of serum alpha fetoprotein(AFP) [1.43(95%CI,1.04-1.97),P = 0.028].Obesity was not an independent predictor of recurrence.The incidence of distant recurrence did not differ between diabetic patients with adequate maintenance of blood glucose and non-diabetic patients.Among 232 patients who had HCC recurrence,138 had a second recurrence.The 1-,2-,and 3-year rates of second recurrence were significantly higher in diabetic patients with inadequate maintenance of blood glucose than in the others:9.0% vs 5.9%,53.1% vs 24.3%,and 69.6% vs 42.3%,respectively(P = 0.0021).Inadequate maintenance of blood glucose in diabetic patients [1.99(95%CI,1.23-3.22),P = 0.0049] and presence of multiple HCC nodules [1.53(95%CI,1.06-2.22),P = 0.024] were again significantly associated with second HCC recurrence.Inadequate maintenance of blood glucose in diabetic patients was also a significant predictor of poor survival [2.77(95%CI,1.38-5.57),P = 0.0046] independent of excessive alcohol drinking [6.34(95%CI,1.35-29.7),P = 0.019],initial level of serum AFP [3.40(95%CI,1.88-6.18),P < 0.0001] and Child-Pugh classification grade B [2.24(95%CI,1.12-4.46),P = 0.022].Comparing diabetic patients with inadequate maintenance of blood glucose vs the others,the 1-,2-,and 3-year survival rates were significantly lower in diabetic patients with inadequate maintenance of blood glucose:92% vs 99%,85% vs 96%,and 70% vs 92%,respectively(P = 0.0003).CONCLUSION:Inadequate maintenance of blood glucose in diabetic patients is a significant risk factor for recurrence of HCC and for poor survival after curative RFA therapy. | Takanori Hosokawa Masayuki Kurosaki Kaoru Tsuchiya Shuya Matsuda Masaru Muraoka Yuichiro Suzuki Nobuharu Tamaki Yutaka Yasui Toru Nakata Takashi Nishimura Shoko Suzuki Ken Ueda Hiroyuki Nakanishi Jun Itakura Yuka Takahashi Namiki Izumi | 2013 | World Journal of Gastroenterology2013，19，2： | 12 |
| 2 | Altered mucosal DNA methylation in parallel with highly active Helicobacter pylori -related gastritis显示文摘 | Takeichi Yoshida Jun Kato Takao Maekita Satoshi Yamashita Shotaro Enomoto Takayuki Ando Tohru Niwa Hisanobu Deguchi Kazuki Ueda Izumi Inoue Mikitaka Iguchi Hideyuki Tamai Toshikazu Ushijima Masao Ichinose | 2013 | Gastric Cancer2013，，4： | 3 |
| 3 | Clinicopathologic Analysis of Combined Hepatocellular-Cholangiocarcinoma According to the Latest WHO Classification显示文摘 | Jun Akiba Osamu Nakashima Satoshi Hattori Ken Tanikawa Miki Takenaka Masamich Nakayama Reiichiro Kondo Yoriko Nomura Keiko Koura Kousuke Ueda Sakiko Sanada Yoshiki Naito Rin Yamaguchi Hirohisa Yano | 2013 | The American Journal of Surgical Pathology2013，，4： | 3 |
| 4 | Decrease in alpha-fetoprotein levels predicts reduced incidence of hepatocellular carcinoma in patients with hepatitis C virus infection receiving interferon therapy: a single center study显示文摘 | Yukio Osaki Yoshihide Ueda Hiroyuki Marusawa Jun Nakajima Toru Kimura Ryuichi Kita Hiroki Nishikawa Sumio Saito Shinichiro Henmi Azusa Sakamoto Yuji Eso Tsutomu Chiba | 2012 | Journal of Gastroenterology2012，，4： | 3 |
| 5 | Greater Incidence of Delirium during Recovery from Sevoflurane Anesthesia in Preschool Boys显示文摘 | Jun Aono Wasa Ueda Kikyo Mamiya Eri Takimoto Masanobu Manabe | 1997 | Anesthesiology1997，，： | 2 |
| 6 | Multicenter phase II study of weekly paclitaxel plus S-1 combination chemotherapy in patients with advanced gastric cancer显示文摘 | Yuji Ueda Hisakazu Yamagishi Daisuke Ichikawa Kazuma Okamoto Eigo Otsuji Jun Morii Kinya Koizumi Naoki Kakihara Masataka Shimotsuma Tetsuro Yamashita Fumihiro Taniguchi Hideki Aragane Hiroshi Nishi Yoshiki Itokawa Satoshi Morita Junichi Sakamoto | 2010 | Gastric Cancer2010，，3： | 2 |
| 7 | A study of the changes in the cause of peptic ulcer bleeding显示文摘AIM: To clarify the frequency of and changes in the cause of peptic ulcer bleeding. METHODS: This study retrospectively evaluated the out- and inpatients who underwent endoscopy between 2002 to 2008. The subjects were patients presenting with peptic ulcer bleeding. The details of these patients were obtained from their endoscopic reports and medical records. RESULTS: The rates of Helicobacter pylori (H. pylori ) infection were significantly low (P = 0.039), while the proportion of nonsteroidal antiinflammatory drugs (NSAIDs) users and vascular disease significantly increased over the period studied (P = 0.034 and P = 0.04, respectively). However, there was no significant difference in the proportion of low-dose aspirin users (P = 0.832).CONCLUSION: It's found that the primary cause of peptic ulcer bleeding changed from H. pylori infection to use of NSAIDs over the 7-year period of study. It seems that the number of low-dose aspirin users has increased with the increase in the proportion of vascular disease. It is necessary to take measures to prevent peptic ulcer bleeding among NSAIDs and low dose aspirin users. | Haruka Fujinami Takahiko Kudo Ayumu Hosokawsa Kouhei Ogawa Takako Miyazaki Jun Nishikawa Shinya Kajiura Takayuki Ando Akira Ueda Toshiro Sugiyama | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，7： | 2 |
| 8 | A case of chronic pancreatitis in which endoscopic ultrasonography was effective in the diagnosis of a pseudoaneurysm显示文摘Endoscopic ultrasonography (EUS) was performed on a patient being treated for chronic pancreatitis because a submucosal tumor was observed in the stomach during gastrointestinal endoscopy. As internal pulsa- tile blood flow on Doppler was present, the diagnosis of an aneurysm was made. The pseudoaneurysm of the left gastric artery was embolized with histoacryl and lipiodol and the splenic artery was embolized with coils at the location of the pseudoaneurysm to prevent hemorrhage. Follow up EUS confirmed the cessation of blood flow from the pseudoaneurysm. Clinicians encountering a gastric submucosal tumor-like protrusion in a patient with chronic pancreatitis should use EUS to investigate the possibility of a pseudoaneurysm, which must be treated as quickly as possible once identified. | Kazuhiro Fukatsu Kazuki Ueda Hiroki Maeda Yasunobu Yamashita Masahiro Itonaga Yoshiyuki Mori Kosaku Moribata Naoki Shingaki Hisanobu Deguchi Shotaro Enomoto Izumi Inoue Takao Maekita Mikitaka Iguchi Hideyuki Tamai Jun Kato Masao Ichinose | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，7： | 2 |
| 9 | A field survey of agarwood in Indonesia显示文摘 | Subehan Ueda Jun Ya Fujino H | 2005 | Journal of Traditional Medicines2005，22，4： | 1 |
| 10 | DNA microarray analysis of stage progression mechanism in myelodysplastic syndrome显示文摘 | Ueda Masuzu Ota Jun Yamashita Yoshihiro | 2003 | Br J Haematol2003，123，2： | 1 |
| 11 | Elevated risk of recurrent colorectal neoplasia with Helicobacter pylori?associatedchronic atrophic gastritis: A follow?up study of patients with endoscopicallyresected colorectal neoplasia显示文摘 | Izumi Inoue Jun Kato Noriko Yoshimura Yoshimasa Maeda Kosaku Moribata Naoki Shingaki Hisanobu Deguchi Shotaro Enomoto Takao Maekita Kazuki Ueda Mikitaka Iguchi Hideyuki Tamai Mitsuhiro Fujishiro Nobutake Yamamichi Tatsuya Takeshita Masao Ichinose | 2013 | Molecular and Clinical Oncology2013，，1： | 1 |
| 12 | Ig SF11 regulates osteoclast differentiation through association with the scaffold protein PSD-95显示文摘Osteoclasts are multinucleated, giant cells derived from myeloid progenitors. While receptor activator of NF-κB ligand(RANKL)stimulation is the primary driver of osteoclast differentiation, additional signaling further contributes to osteoclast maturation.Here, we demonstrate that immunoglobulin superfamily member 11(Ig SF11), whose expression increases during osteoclast differentiation, regulates osteoclast differentiation through interaction with postsynaptic density protein 95(PSD-95), a scaffold protein with multiple protein interaction domains. Ig SF11 deficiency in vivo results in impaired osteoclast differentiation and bone resorption but no observed defect in bone formation. Consequently, Ig SF11-deficient mice exhibit increased bone mass.Using in vitro osteoclast culture systems, we show that Ig SF11 functions through homophilic interactions. Additionally, we demonstrate that impaired osteoclast differentiation in Ig SF11-deficient cells is rescued by full-length Ig SF11 and that the Ig SF11-PSD-95 interaction requires the 75 C-terminal amino acids of Ig SF11. Our findings reveal a critical role for Ig SF11 during osteoclast differentiation and suggest a role for Ig SF11 in a receptor-and signal transduction molecule-containing protein complex. | Hyunsoo Kim Noriko Takegahara Matthew CWalsh Sarah AMiddleton Jiyeon Yu Jumpei Shirakawa Jun Ueda Yoshitaka Fujihara Masahito Ikawa Masaru Ishii Junhyong Kim Yongwon Choi | 2020 | Bone Research2020，8，1： | 1 |
| 13 | Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium that depends on microbial commensa-Lisms 显示文摘 | KENJI Ueda ATSUSHI Yamashita JUN Ishikawa | 2004 | Nucleic Acids Research2004，32，16： | 1 |
| 14 | α‐fetoprotein levels after interferon therapy and risk of hepatocarcinogenesis in chronic hepatitis C显示文摘 | Yasuhiro Asahina Kaoru Tsuchiya Takashi Nishimura Masaru Muraoka Yuichiro Suzuki Nobuharu Tamaki Yutaka Yasui Takanori Hosokawa Ken Ueda Hiroyuki Nakanishi Jun Itakura Yuka Takahashi Masayuki Kurosaki Nobuyuki Enomoto Mina Nakagawa Sei Kakinuma Mamoru Wat | 2013 | Hepatology2013，，4： | 1 |
| 15 | Corrigendum to “Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor” [Biochem. Biophys. Res. Commun. 326 (2005) 744–751]显示文摘 | Takatoshi Soga Takahide Ohishi Tetsuo Matsui Tetsu Saito Mitsuyuki Matsumoto Jun Takasaki Shun-ichiro Matsumoto Masazumi Kamohara Hideki Hiyama Shigeru Yoshida Kazuhiro Momose Yoshitaka Ueda Hitoshi Matsushime Masato Kobori Kiyoshi Furuichi | 2005 | Biochemical and Biophysical Research Communications2005，，1： | 1 |
| 16 | Clinicopathologic Analysis of Combined Hepatocellular-Cholangiocarcinoma According to the Latest WHO Classification显示文摘 | Jun Akiba Osamu Nakashima Satoshi Hattori Ken Tanikawa Miki Takenaka Masamich Nakayama Reiichiro Kondo Yoriko Nomura Keiko Koura Kousuke Ueda Sakiko Sanada Yoshiki Naito Rin Yamaguchi Hirohisa Yano | 2013 | The American Journal of Surgical Pathology2013，，4： | 1 |
| 17 | Dyeing natural fibres in supercritical carbon dioxide using a nonionic surfactant reverse micellar system 显示文摘 | SAWADA K TAKAGI T JUN J H UEDA M LEWIS D M | 2002 | Coloration Technology2002，118，5： | 1 |
| 18 | All-ceramic passively Q-switched Yb:YAG/Cr^4+ :YAG microchip laser显示文摘 | Jun Dong Akira Shirakawa Ken-ichi Ueda | 2006 | Electronics Letters2006，42，20： | 1 |
| 19 | Dyeing of natural fibres from perfluoro-polyether reverse micelles in supercritical carbon dioxide显示文摘 | SAWADA K JUN J H UEDA M | 2003 | Coloration Technology2003，119，6： | 1 |
| 20 | Fas-mediated apoptosis in adriamycin-induced cardiomyopathy in rats in vivo study显示文摘 | Tsuneyuki Nakamura Yoshimi chi Ueda Yang Jun | 2000 | Circulation2000，102，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员