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| 1 | Helicobacter pylori infection and extragastric disorders in children: A critical update显示文摘Helicobacter pylori(H. pylori) is a highly prevalent, serious and chronic infection that has been associated causally with a diverse spectrum of extragastric disorders including iron deficiency anemia, chronic idiopathic thrombocytopenic purpura, growth retardation, and diabetes mellitus. The inverse relation of H. pylori prevalence and the increase in allergies, as reported from epidemiological studies, has stimulated research for elucidating potential underlying pathophysiological mechanisms. Although H. pylori is most frequently acquired during childhood in both developed and developing countries, clinicians are less familiar with the pediatric literature in the field. A better understanding of the H. pylori disease spectrum in childhood should lead to clearer recommendations about testing for and treating H. pylori infection in children who are more likely to develop clinical sequelae. A further clinical challenge is whether the progressive decrease of H. pylori in thelast decades, abetted by modern clinical practices, may have other health consequences. | Lucia Pacifico John F Osborn Valeria Tromba Sara Romaggioli Stefano Bascetta Claudio Chiesa | 2014 | World Journal of Gastroenterology2014，20，6： | 18 |
| 2 | Nat Med:靶向两分子或有助于彻底治愈白血病显示文摘科学家在癌细胞内发现两个信号蛋白能够让癌细胞抵抗化疗。研究表明阻断这两种蛋白能够增强化疗对人类白血病小鼠模型的治疗效果。相关研究结果发表在国际学术期刊NatureMedicine上。研究人员发现在治疗中阻断c-Fos和Dusp1这两个蛋白能够治愈一些受激酶驱动且抵抗治疗的白血病和实体瘤。 | Meenu Kesarwani, Zachary Kincaid, Ahmed Gomaa, Erika Huber, Sara Rohrabaugh, Zain Siddiqui, Muhammad F Bouso, Kakajan Komurov, James C Mulloy, Jose A Cancelas, H Leighton Grimes Mohammad Azam Tahir Latif Ming Xu H Leighton Grimes Mohammad Azam | 2017 | 现代生物医学进展2017，17，17： | 4 |
| 3 | Annexin A2 as a biomarker for hepatocellular carcinoma in Egyptian patients显示文摘AIM To investigate the clinical utility of serum annexin A2(ANXA2) as a diagnostic marker for early hepatocellular carcinoma(HCC).METHODS This study was performed in HCC Clinic of Ain Shams University Hospitals, Cairo, Egypt and included: Group 1: Fifty patients with early stage HCC(Barcelona Clinic Liver Cancer stage A); Group 2: Twenty five patients with chronic liver disease; and Control Group: Fifteen healthy, age-and sex-matched subjects who were seronegative for viral hepatitis markers. The followinglaboratory investigations were done: Viral hepatitis markers [hepatitis B surface antigen and hepatitis C virus(HCV) antibodies], HCV RNA in HCV antibody-positive patients, serum alpha fetoprotein(AFP), and serum ANXA2 levels.RESULTS In this study, 88% of HCC patients(n = 44) were HCVpositive, while HBV infection represented only 8% of all HCC patients(n = 4); and two patients were negative for both viral markers. A highly significant difference was found between patients with HCC and chronic liver disease as well as controls with regard to serum ANXA2 levels(130, IQR 15-240; 15, IQR 15-17; and 17, IQR 15-30 ng/m L, respectively). The area under the curve of ANXA2 was 0.865; the cut-off value was established to be 18 ng/mL with a diagnostic sensitivity of 74% and a specificity of 88%, while the sensitivity and specificity of AFP at the cut-off value of 200 ng/dL were 20% and 100%, respectively.CONCLUSION Serum ANXA2 may serve as a biomarker for the early detection of HCC. | Mohamed K Shaker Hanzada I Abdel Fattah Ghada S Sabbour Iman F Montasser Sara M Abdelhakam Eman El Hadidy Rehab Yousry Ahmed K El Dorry | 2017 | World Journal of Hepatology2017，9，9： | 4 |
| 4 | Efficacy of HPV-based screening for prevention of invasive cervical cancer: follow-up of four European randomised controlled trials显示文摘 | Guglielmo Ronco Joakim Dillner K Miriam Elfstr?m Sara Tunesi Peter J F Snijders Marc Arbyn Henry Kitchener Nereo Segnan Clare Gilham Paolo Giorgi-Rossi Johannes Berkhof Julian Peto Chris J L M Meijer | 2013 | The Lancet2013，，： | 3 |
| 5 | Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘 | Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H | 2008 | Plant Physiology2008，147，2： | 1 |
| 6 | Effect of different agricultural management systems on chemical fertility in culiivated tepetates of the Mexican transvolcanic belt 显示文摘 | Sara Covaleda Silvia Pajares Juan F Gallardo | 2009 | Agriculture Ecosystems and Environment2009，129，： | 1 |
| 7 | 4 mouse model of vascular injury that induces rapid onset of medial cell apoptosis followed by reproducible neointimal hyperplssia显示文摘 | Sara M Maejima Y Adachi F | 2000 | J Mol Cell Cardiol2000，32，： | 1 |
| 8 | Molecular detection of circu- lating thyroid specic transcripts (TSHR/Tg-mRNAs) in thyroid cancer patients : Their diagnostic significance显示文摘 | SALAW H T SARA H A AMAL F | 2011 | Egypt J Med Human Genet2011，12，1： | 1 |
| 9 | Evaluating water transport through high solid polyurethane coating using the the EIS method 显示文摘 | REZAEI F SHARIF F SARA BI A A | 2010 | JCoatTeehnolRes2010，7，2： | 1 |
| 10 | Characterization of Transcriptional Complexity during Berry Development in Vitis vinifera Using RNA-Seq显示文摘 | Sara Z Alberto F Enrico G | 2010 | Plant Physiology2010，，152： | 1 |
| 11 | Maternal genetic polymorphisms in CYP1A1, GSTM1 and GSTT1 and the risk of hypospadias显示文摘 | Kurahashi N Sara F Kasai S | 2005 | Mol Hum Reprod2005，11，2： | 1 |
| 12 | Worries and concerns experienced by urse specialists during inter-hospital transports of critically ill patients:A critical incident study显示文摘 | Marcus G Sara W Bengt F | 2010 | Intensive and Critical Care Nurs-ing2010，26，1： | 1 |
| 13 | Cortical sources of resting-state alpha rhythms are abnormal in persistent vegetative state patients 显示文摘 | BABILONI C SARA M VECCHIO F | 2009 | Clin Neurophysiol2009，120，4： | 1 |
| 14 | Cortical sources of resting- state alpha rhythm are abnormal in pm sistent vegelative siale pa- tients 显示文摘 | Balfihmi C Sara M Veeehio F el al | 2009 | Clin Neurophysio12009，120，2： | 1 |
| 15 | F|ow Framework for Analyzing the Quality of Educational Games显示文摘 | KRISTIAN K TIMO L SARA D F | 2014 | Entertainment Computing2014，5，4： | 1 |
| 16 | Organic matter addition, N, and residue burning effects on infiltration, biological, and physical properties of an intensively tilled silt-loam soil显示文摘 | Stewart B Wuest Caesar-Ton That T C Sara F Wright | 2005 | Soil & Tillage Research2005，84，： | 1 |
| 17 | Kinetic study of microwave-assisted Wittig reaction of stabilized Ylides with aromatic aldehydes显示文摘 | Monica Q Enzo C | 2001 | Tetrahedron Letters2001，42，39： | 1 |
| 18 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 19 | Role of alpha/beta interferons in the attenuation and immunogenicity of recombi nant bovine respiratory syncytial viruses lacking NS proteins显示文摘 | Jean F V Julie F Sara W | 2003 | Virolology2003，77，15： | 1 |
| 20 | Disorders of consciousness: a tax?onomy to be changed?显示文摘 | Formisano R Pistoia F Sara M | 2011 | Brain lnj2011，25，： | 1 |
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