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| 1 | New fecal test for non-invasive Helicobacter pylori detection:A diagnostic accuracy study显示文摘AIM To assess the diagnostic accuracy of a new fecal test for detecting Helicobacter pylori(H. pylori), using ^(13)Curea breath test as the reference standard, and explore bacterial antibiotic resistance. METHODS We conducted a prospective two-center diagnostic test accuracy study. We enrolled consecutive people≥ 18 years without previous diagnosis of H. pylori infection, referred for dyspepsia between February and October 2017. At enrollment, all participants underwent 13 C-urea breath test. Participants aged over 50 years were scheduled to undergo upper endoscopy with histology. Participants collected stool samples 1-3 d after enrollment for a new fecal investigation(THD fecal test). The detection of bacterial 23 S rRNA subunit gene indicated H. pylori infection. We also used the index diagnostic test to examine mutations conferring resistance to clarithromycin and levofloxacin. Independent investigators analyzed index test and reference test standard results blinded to the other test findings. We estimated sensitivity, specificity, positive(PPV) and negative(NPV) predictive value, diagnostic accuracy, positive and negative likelihood ratio(LR), together with 95% confidence intervals(CI).RESULTS We enrolled 294 consecutive participants(age: Median 37.0 years, IQR: 29.0-46.0 years; men: 39.8%). Ninetyfive(32.3%) participants had a positive ^(13)C-urea breath test. Twenty-three(7.8%) participants underwent upper endoscopy with histology, with a full concordance between ^(13)C-urea breath test and histology in detecting H. pylori infection. Four(1.4%) out of the 294 participants withdrew from the study after the enrollment visit and did not undergo THD fecal testing. In the 290 participants who completed the study, the THD fecal test sensitivity was 90.2%(CI: 84.2%-96.3%), specificity 98.5%(CI:96.8%-100%), PPV 96.5%(CI: 92.6%-100%), NPV 95.6%(CI: 92.8%-98.4%), accuracy 95.9%(CI: 93.6%-98.2%), positive LR 59.5(CI: 19.3-183.4), negative LR 0.10(CI: 0.05-0.18). Out of 83 infected participants identified with the THD fecal test, 34(41.0%) had bacterial genotypic changes consistent with antibiotic-resistant H. pylori infection. Of these, 27(32.5%) had bacterial strains resistant to clarithromycin, 3(3.6%) to levofloxacin, and 4(4.8%) to both antibiotics. CONCLUSION The THD fecal test has high performance for the non-invasive diagnosis of H. pylori infection while additionally enabling the assessment of bacterial antibiotic resistances. | Andrea Iannone Floriana Giorgio Francesco Russo Giuseppe Riezzo Bruna Girardi Maria Pricci Suetonia C Palmer Michele Barone Mariabeatrice Principi Giovanni FM Strippoli Alfredo Di Leo Enzo Ierardi | 2018 | World Journal of Gastroenterology2018，24，27： | 5 |
| 2 | 查看详情显示文摘 | Saladino M L Caponetti E Martino D C Enzo S Ibba G | | 0，，2： | 1 |
| 3 | Model Characterizes Transmission-Line Trans- formers 显示文摘 | ENZO C | 1996 | Microwaves&RF1996，35，11： | 1 |
| 4 | HOMA-estimated insulin resistance is an independent predictor of cardiovascular disease in type 2 diabetic subjects显示文摘 | ENZO B GISNNI F FRANCESCO C | 2002 | Diabetes Care2002，25，： | 1 |
| 5 | An inter- laboratory study to test the ability of amendments to reduce the availability of Cd, Pb, and Zn in situ 显示文摘 | Sally B Barbara C Enzo L | 2005 | Environmental Pollution2005，138，： | 1 |
| 6 | Kinetic study of microwave-assisted Wittig reaction of stabilized Ylides with aromatic aldehydes显示文摘 | Monica Q Enzo C | 2001 | Tetrahedron Letters2001，42，39： | 1 |
| 7 | Arsenic fractionation in soils using an improved sequential extraction procedure显示文摘 | Walter W Wenzel Natalie Kirchbaumer Thomas Prohaska Gerhard Stingeder Enzo Lombi Domy C Adriano | 2001 | Analytica Chimica Acta2001，，2： | 1 |
| 8 | Supercritical CO2 extraction of lycopene and β-carotene from ripe tomatoes 显示文摘 | Enzo C Gorgi G R D Elena M | 2000 | Dys Pigments2000，，44： | 1 |
| 9 | Randomised trial of nadolol alone or with isosobide mononitrate for primary prophylaxis of variceal bleeding in cirrhosis Gruppo-Triveneto per L'ipertensione portale (GTIP)显示文摘 | MERKEL C MARIN R ENZO E | 1996 | Lancet1996，348，9043： | 1 |
| 10 | Supercritical CO2 extraction of lycopene β-carotene from ripe tomotoes显示文摘 | Giorgi G R D Elena M | 2000 | Dys Pigments2000，44，： | 1 |
| 11 | Diabetes mellitus and sperm,parameters显示文摘 | Sro V Rosita C Enzo V | 2012 | J Androl2012，33，2： | 1 |
| 12 | 2002 HOMA-estimated insulin resistance is an independent predictor of cardiovascular disease in type 2 diabetic subjects显示文摘 | Enzo B Gisnni F Francesco C | 2002 | Diabetes Care2002，15，25： | 1 |
| 13 | Circulating cell-free DNA: a promising marker of regional lymphonode metastasis in breast cancer patients 显示文摘 | Agostini M Enzo M V Bedin C | 2012 | Cancer Biomark2012，11，23： | 1 |
| 14 | Supereritieal CO2 extraction of lycopene and β-carotene from ripe tomatoes显示文摘 | Enzo C Giorgi M R D Elena M | 1999 | Dyes and Pigments1999，44，1： | 1 |
| 15 | A hypothesis on the evolution of isoprenoid emission by oaks based on the correlation between emission type and Quercus taxonomy显示文摘 | Francesco L Paolo C Enzo B | 1998 | Oecologia1998，115，： | 1 |
| 16 | Toxicity evaluation of surface water treated with different disinfectants in HepG2 ceils 显示文摘 | LAURA M SILVIA F ENZO C | 2006 | Water Res2006，40，2： | 1 |
| 17 | Supercritical CO2 extraction of lycopene and β-carotene from ripe tomatoes显示文摘 | ENZO C M RITA D G | 2000 | Dyes and Pigments2000，，44： | 1 |
| 18 | Predictors of local recurrence after conservative surgery and whole-breast irradiation显示文摘 | Giampiero Ausili Cèfaro Domenico Genovesi Rita Marchese Lucia Anna Ursini Ettore Cianchetti Enzo Ballone Marta Di Nicola | 2006 | Breast Cancer Research and Treatment2006，，3： | 1 |
| 19 | Parenteral administration of different amounts of branch- chain amino acids in septic patients: clinical and metabolic aspects 显示文摘 | GARCiA-DE-LOR ENZO A ORTIZ-LEYBA C PLANAS M | 1997 | Crit Care Med1997，25，3： | 1 |
| 20 | Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS显示文摘 | ENZO N CRISTINA T Annalisa C | 2005 | Science2005，310，： | 1 |
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