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| 1 | Clinical characteristics and type of antithrombotic treatment in a Spanish cohort of elderly patients with atrial fibrillation according to dependency, frailty and cognitive impairment显示文摘根据相关性,脆弱和认知缺陷与 atrial 纤维性颤动(AF ) 考虑老病人的临床的侧面和管理的 BackgroundAvailable 数据是少见的。学习的目的是根据相关性分析 biodemographic 数据,临床的侧面和 antithrombotic 治疗,吗在patients.MethodsCross部分的老 AF 和学习在 75 年与 3 个月在 Spain.ResultsA 在内部药部门出席了的口头的抗凝剂对待的连续 AF 病人执行了的多中心的脆弱和认知缺陷 837 总计病人( 83.0 ???????????????????吗???????????????????￡?? | Jose Maria Mostaza Manuel Jesús Romero Jiménez Fernando José Ruiz Laiglesia José Antonio Díaz Peromingo Manuel Beltrán Robles Ernesto Guevara Sierra Ana Santander Bilbao Carmen Suárez | 2018 | Journal of Geriatric Cardiology2018，15，4： | 2 |
| 2 | Oral cancer susceptibility associated with the CYP1A1 and GSTM1 genotypesin Chilean individuals显示文摘 | Karina Cordero Iris Espinoza Dante Caceres Angela Roco Carla Miranda Valentina Squicciarini Paula Santander Kuen Lee Iván Saavedra Luis Qui?ones | 2010 | Oncology Letters2010，，3： | 1 |
| 3 | Performance optimization of a passive silicon-based micro-direct methanol full Cell 显示文摘 | Tortes N Santander J Esquivel J P | 2008 | Sensors and Actuators B: Chemical2008，132，2： | 1 |
| 4 | Multi-Range Silicon Micromachined Flow Sensor显示文摘 | Sabate N Santander J Fonseca L | 2004 | Sensors and actuators A2004，110，13： | 1 |
| 5 | Muhi-Rangesilicon Micro-Ma- chined Flow Sensor显示文摘 | N Sabate J Santander L Fonseca et 2 | 2004 | Sensor and Actuators A2004，110，： | 1 |
| 6 | Characterization of thermal conductivity in thin film multilayered membranes显示文摘 | SABATE N SANTANDER J GRACIA I | 2005 | Thin Solid Films2005，484，： | 1 |
| 7 | Familial risk factors for suicide among adolescents with depression 显示文摘 | Pavez P Santander N Carranza J | 2009 | Rev Med Chil2009，137，2： | 1 |
| 8 | The solubility of copper in fayalite slag at 1300 ℃ 显示文摘 | Toguri J M Santander N H | 1969 | Canadian Metallurgical Quarterly1969，8，： | 1 |
| 9 | Electrochemical reduction of Cr(Ⅵ)in the presence of sodium alginate and its application in water purification显示文摘Chromium(Cr)is used in many manufacturing processes,and its release into natural waters is a major environmental problem today.Low concentrations of Cr(Ⅵ)are toxic to human health and living organisms due to the carcinogenic and mutagenic nature of this mineral.This work examined the conversion of Cr(Ⅵ)to Cr(Ⅲ)via electrochemical reduction using gold electrode in an acidic sodium alginate(SA)solution and subsequent removal of the produced Cr(Ⅲ)-SA by the polymer-enhanced ultrafiltration(PEUF)technique.A solution of SA in nitric acid was used both as an electrolytic medium during the voltammetric measurements and bulk electrolysis and as an extracting agent during the PEUF technique.The electroanalysis of Cr(Ⅵ)was performed by linear sweep voltammetry in the presence of acidic SA solution to study its voltammetric behavior as a function of the Cr(Ⅵ)concentration,pH,presence of Cr(Ⅲ),SA concentration and scan rate.In addition,the quantitative reduction of Cr(Ⅵ)to Cr(Ⅲ)was studied through the bulk electrolysis technique.The results showed efficient reduction with well-defined peaks at approximately 0.3 V vs.Ag/AgCl,using a gold working electrode.As the pH increased,the reduction signal strongly decreased until its disappearance.The optimum SA concentration was 10 mmol/L,and it was observed that the presence of Cr(Ⅲ)did not interfere in the Cr(Ⅵ)electroanalysis.Through the quantitative reduction by bulk electrolysis in the presence of acidic SA solution,it was possible to reduce all Cr(Ⅵ)to Cr(Ⅲ)followed by its removal via PEUF. | Bryan Butter Paola Santander Guadalupe del CPizarro Diego POyarzún Federico Tasca Julio Sánchez | 2021 | Journal of Environmental Sciences2021，33，3： | 1 |
| 10 | Performance optimization of a passive silicon-based micro-direct methanol fuel cell 显示文摘 | Tones N Santander J Esquivel J P | 2008 | Sensors and Actuators B : Chemical2008，132，2： | 1 |
| 11 | Influence of current collectors design on the performance of a silicon- based passive micro direct methanol fuel cell显示文摘 | Esquivel J P Sabat6 N Santander J | 2009 | J Power Sources2009，194，1： | 1 |
| 12 | Diacylglycerol pyrophosphate: a novel metabolite in the Trypanosoma cruzi phosphatidic acid metabolism 显示文摘 | Marchesini N Santander V Machado-Domenech E | 1998 | FEBS Lett1998，436，3： | 1 |
| 13 | Indomethacin but not a selective cyclooxygenase-2 inhibitor inhibits esophageal adenocarcinogenesis in rats显示文摘AIM:To evaluate the effects of indomethacin [dual cyclooxygenase(COX)-1/COX-2 inhibitor] and 3-(3,4-difluorophenyl)-4-(4-(methylsulfonyl) phenyl)2-(5H)-furanone(MF-tricyclic)(COX-2 selective inhibitor) in a rat experimental model of Barrett's esophagus and esophageal adenocarcinoma.METHODS:A total of 112 surviving post-surgery rats were randomly divided into three groups:the control group(n = 48),which did not receive any treatment;the indomethacin group(n = 32),which were given 2 mg/kg per day of the COX-1/COX-2 inhibitor;and the MF-tricyclic group(n = 32),which received 10 mg/kg per day of the selective COX-2 inhibitor.Randomly selected rats were killed either 8 wk or 16 wk after surgery.The timing of the deaths was in accordance with a previous study performed in our group.Only rats that were killed at the times designated by the protocol were included in the study.We then assessed the histology and prostaglandin E2(PGE2) expression levels in the rat esophagi.An additional group of eight animals that did not undergo esophagojejunostomy were included in order to obtain normal esophageal tissue as a control.RESULTS:Compared to a control group with no treatment(vehicle-treated rats),indomethacin treatment was associated with decreases in ulcerated esophageal mucosa(16% vs 35% and 14% vs 17%,2 mo and 4 mo after surgery,respectively;P = 0.021),length of intestinal metaplasia in continuity with anastomosis(2 ± 1.17 mm vs 2.29 ± 0.75 mm and 1.25 ± 0.42 mm vs 3.5 ± 1.54 mm,2 mo and 4 mo after surgery,respectively;P = 0.007),presence of intestinal metaplasia beyond anastomosis(20% vs 71.4% and 0% vs 60%,2 mo and 4 mo after surgery,respectively;P = 0.009),severity of dysplasia(0% vs 71.4% and 20% vs 85.7% high-grade dysplasia,2 mo and 4 mo after surgery,respectively;P = 0.002),and adenocarcinoma incidence(0% vs 57.1% and 0% vs 60%,2 mo and 4 mo after surgery,respectively;P < 0.0001).Treatment with the selective COX-2 inhibitor,MF-tricyclic,did not prevent development of intestinal metaplasia or adenocarcinoma.In parallel,we observed a significant decrease in PGE2 levels in indomethacin-treated rats,but not in those treated with MF-tricyclic,at both 2 mo and 4 mo.Compared to control rats that did not undergo surgery(68 ± 8 ng/g,P = 0.0022 Kruskal-Wallis test) there was a significant increase in PGE2 levels in the esophageal tissue of the rats that underwent surgery either 2 mo(1332 ± 656 ng/g) or 4 mo(1121 ± 1015 ng/g) after esophagojejunostomy.However,no differences were found when esophageal PGE2 levels were compared 2 mo vs 4 mo post-esophagojejunostomy.At both the 2-and 4-mo timepoints,we observed a significant decrease in PGE2 levels in indomethacin-treated rat esophagi compared to those in either the control or MF-tricyclic groups(P = 0.049 and P = 0.017,respectively).No differences in PGE2 levels were found when we compared levels in rats treated with MF-tricyclic to not-treated rats.CONCLUSION:In this rat model of gastrointestinal reflux,indomethacin was associated with a decrease in the severity of esophagitis and reduced development of esophageal intestinal metaplasia and adenocarcinoma. | Paula Esquivias Antonio Morandeira Alfredo Escartín Carmelo Cebrián Sonia Santander Francisco Esteva María Asunción García-González Javier Ortego Angel Lanas Elena Piazuelo | 2012 | World Journal of Gastroenterology2012，18，35： | 0 |
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