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| 1 | Glycosylation engineering of therapeutic IgG antibodies: challenges for the safety, functionality and efficacy显示文摘IgG 的 Fc 区域的 Glycosylation 在安全和治疗学的抗体的临床的功效上有深刻影响。当复杂类型的 oligosaccharide 纳入了 Fc 的 Asn297 的 biantennary 为抗体受动器功能是必要的时,海藻糖和外部手臂的糖属于核心 heptasaccharide 产生结构的异质(glycoforms ) 展出唯一的生物活动。因此,有效、量的 glycan 分析技术为治疗学的抗体的发展和质量控制是日益重要的,并且 Fc 的 glycan 侧面作为批评优秀属性被认出。在过去的十年,我们 IgG-Fc 的结构 / 功能上的 glycosylation 的影响的理解通过 X 光检查结晶、原子的磁性的回声研究很快成长了,它为新奇抗体治疗学的设计提供可能性。而且,用基于 endoglycosidase 的 glycosynthases 的 chemoenzymatic glycoengineering 途径可以作为下一代的治疗学的抗体与理想的功能便于同类的 IgG glycoforms 的发展。因此, Fc glycans 是在精确药的时代的治疗学的 IgG 抗体的安全,功能,和功效的改进的肥沃的地面。 | Yusuke Mimura Toshihiko Katoh Radka Saldova Roisin O'Flaherty Tomonori Izumi Yuka Mimura-Kimura Toshiaki Utsunomiya Yoichi Mizukami Kenji Yamamoto Tsuneo Matsumoto Pauline M. Rudd | 2018 | Protein & Cell2018，9，1： | 2 |
| 2 | Greedy feature se- lection for glycan chromatography data with the generalized Dirichlet distribution 显示文摘 | Galligan M C Saldova R Campbell M P | 2013 | BMC Bioinformatics2013，14，1： | 1 |
| 3 | Evaluationof the serum N-linked glycome for the diagnosis ofcancer and chronic inflammation显示文摘 | ArnoldJN Saldova R Hamid UM | 2008 | Proteomics2008，8，16： | 1 |
| 4 | A strategy to reveal potential giycan markers from serum glycoproteins associated with breast cancer progression显示文摘 | Abd Hamid U M Royle L Saldova R | 2008 | Glycobiology2008，18，： | 1 |
| 5 | Levels of specific serum N-glycans identify breast cancer patients with higher circulating tumor counts显示文摘 | SALDOVA R REUBEN J M ABD HAMID U M | 2011 | Ann Oncol2011，22，5： | 1 |
| 6 | Ovarian cancer is associated with changes in glycosylation in both acute-phase proteins and IgG显示文摘 | Saldova R Royle L Radcliffe CM | 2007 | Glyeobiology2007，17，： | 1 |
| 7 | 5 AZA-2 '- deoxycytidine induced demethylation influences N glyeosylation of secreted glycoproteins in ovarian caneer显示文摘 | Saldova R Dempsey E Pfirez-Garay M | 2011 | Epigenetics2011，6，11： | 1 |
| 8 | Glycosylation changes on serum glycoproteins in ovarian cancer may contribute to disease pathogenesis 显示文摘 | Saldova R Wormald MR Dwek RA | 2008 | Disasse Markers2008，25，： | 1 |
| 9 | Evaluationof the serum N-linked glycome for the diagnosis ofcancer and chronic inflammation显示文摘 | ArnoldJN Saldova R Hamid UM | 2008 | Proteomics2008，8，16： | 1 |
| 10 | A strategy to reveal po-tential glycan markers from serum glycoproteins associated with breastcancer progression显示文摘 | Abd Hamid UM Royle L Saldova R | 2008 | Glycobiology2008，18，12： | 1 |
| 11 | Ovarian cancer is associated with changes in glycosylation in both acutephase proteins and Ig G显示文摘 | Saldova R Royle L Radclife C M | 2007 | Glycobiology2007，17，12： | 1 |
| 12 | Levels of specificserum N-glycans identify breast cancer patients with higher circu-lating tumor cell counts显示文摘 | Saldova K Reuben JM Abd Hamid DM | 2010 | Ann Oncol2010，22，5： | 1 |
| 13 | Ovarian cancer is associated with changes in glycosylation in both acute-phase proteins and IgG显示文摘 | Saldova R Royle L Radcliffe C M | 2007 | Glycobiology2007，17，12： | 1 |
| 14 | A strategy to reveal potential giycan markers from serum glycoproteins associated with breast cancer progression显示文摘 | Abd Hamid U M Royle L Saldova R | | 0，，： | 1 |
| 15 | Glycosylation chan- ges on serum glycoproteins in ovarian cancer may contribute to dis- ease pathogenesis 显示文摘 | Saldova R Worma/d M R Dwek R A | 2008 | Dis Markers2008，25，45： | 1 |
| 16 | Levels of specific serum N-glycans identify breast cancer patients with higher circulating tumor cell counts 显示文摘 | Saldova R Reuben JM Abd Harold UM | 2011 | Ann Oncol2011，22，5： | 1 |
| 17 | Core fucosyla- tion and alpha2-3 sialylation in serum N-glycome is signifi- cantly increased in prostate cancer comparing to benign pros- tate hyperplasia 显示文摘 | Saldova R Fan Y Fitzpatrick JM etal | 2011 | Glyeobiology2011，21，2： | 1 |
| 18 | A strategy to reveal potential glycan markers from serum glycoproteins associated with breast cancer progression显示文摘 | Abd Hamid U M Royle L Saldova R | 2008 | Glycobiology2008，18，： | 1 |
| 19 | Glycosylation of liver acute-phase proteins in pancreatic cancer and chronic panereatitis 显示文摘 | Sarrats A Saldova R Pla E | 2010 | Proteomics Clin Appl2010，4，4： | 1 |
| 20 | Exploring the Gly- cosylation of Serum CA125 显示文摘 | Saldova R Struwe WB Wynne K | 2013 | Int J Mol Sci2013，4，15： | 1 |
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