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| 1 | Treatment strategies using adefovir dipivoxil for individuals with lamivudine-resistant chronic hepatitis B显示文摘AIM:To investigate retrospectively the long-term efficacy of various treatment strategies using adefovir dipivoxil(adefovir) in patients with lamivudine-resistant chronic hepatitis B.METHODS:We included 154 consecutive patients in two treatment groups:the 'add-on' group(n = 79),in which adefovir was added to ongoing lamivudine treatment due to lamivudine resistance,and the 'switch/combination' group(n = 75),in which lamivudine was first switched to adefovir and then re-added later as needed.The 'switch/combination' group was then divided into two subgroups depending on whether participants followed(group A,n = 30) or violated(group B,n = 45) a proposed treatment strategy that determined whether to add lamivudine based on the serum hepatitis B virus(HBV) DNA levels(< 60 IU/mL or not) after 6 mo of treatment(roadmap concept).RESULTS:The cumulative probability of virologic response(HBV DNA < 60 IU/mL) was higher in group A than in the 'add-on' group and in group B(P < 0.001).In contrast,the cumulative probability of virologic breakthrough was lower in the 'add-on' group than in group B(P = 0.002).Furthermore,the risk of virologic breakthrough in the multivariate analysis was significantly lower in the 'add-on' group than in group A(hazard ratio = 0.096;95%CI,0.015-0.629;P = 0.015).CONCLUSION:The selective combination of adefovir with lamivudine based upon early treatment responses increased the odds of virologic breakthrough relative to the use of uniform combination therapy from the beginning of treatment. | Tae Jung Yun Jin Yong Jung Chang Ha Kim Soon Ho Um Hyonggin An Yeon Seok Seo Jin Dong Kim Hyung Joon Yim Bora Keum Yong Sik Kim Yoon Tae Jeen Hong Sik Lee Hoon Jai Chun Chang Duck Kim Ho Sang Ryu | 2012 | World Journal of Gastroenterology2012，18，47： | 19 |
| 2 | Computed tomography findings for predicting severe acute hepatitis with prolonged cholestasis显示文摘AIM: To evaluate the significance of computed tomography (CT) findings in relation to liver chemistry and the clinical course of acute hepatitis. METHODS: Four hundred and twelve patients with acute hepatitis who underwent enhanced CT scanning were enrolled retrospectively. Imaging findings were analyzed for the following variables: gallbladder wall thickness (GWT), arterial heterogeneity, periportal tracking, number and maximum size of lymph nodes, presence of ascites, and size of spleen. The serum levels of alanine aminotransferase, alkaline phosphatase, bilirubin, albumin, and prothrombin time were measured on the day of admission and CT scan, and laboratory data were evaluated every 2-4 d for all subjects during hospitalization. RESULTS: The mean age of patients was 34.4 years, and the most common cause of hepatitis was hepatitis A virus (77.4%). The mean GWT was 5.2 mm. The number of patients who had findings of arterial heterogeneity, periportal tracking, lymph node enlargement > 7 mm, and ascites was 294 (80.1%), 348 (84.7%), 346 (84.5%), and 56 (13.6%), respectively. On multivariate logistic regression, male gender [odds ratio (OR) = 2.569, 95%CI: 1.477-4.469, P = 0.001], toxic hepatitis (OR = 3.531, 95%CI: 1.444-8.635, P = 0.006), level of albumin (OR = 2.154, 95%CI: 1.279-3.629, P = 0.004), and GWT (OR = 1.061, 95%CI: 1.015-1.110, P = 0.009) were independent predictive factors for severe hepatitis. The level of bilirubin (OR = 1.628, 95%CI: 1.331-1.991, P < 0.001) and GWT (OR = 1.172, 95%CI: 1.024-1.342,P = 0.021) were independent factors for prolonged cholestasis in multivariate analysis. CONCLUSION: In patients with acute hepatitis, GWT on CT scan was an independent predictor of severe hepatitis and prolonged cholestasis. | Sang Jung Park Jin Dong Kim Yeon Seok Seo Beom Jin Park Min Ju Kim Soon Ho Um Chang Ha Kim Hyung Joon Yim Soon Koo Baik Jin Yong Jung Bora Keum Yoon Tae Jeen Hong Sik Lee Hoon Jai Chun Chang Duck Kim Ho Sang Ryu | 2013 | World Journal of Gastroenterology2013，19，16： | 4 |
| 3 | Prospects for the therapeutic development of umbilical cord bloodderived mesenchymal stem cells显示文摘Umbilical cord blood(UCB)is a primitive and abundant source of mesenchymal stem cells(MSCs).UCB-derived MSCs have a broad and efficient therapeutic capacity to treat various diseases and disorders.Despite the high latent selfrenewal and differentiation capacity of these cells,the safety,efficacy,and yield of MSCs expanded for ex vivo clinical applications remains a concern.However,immunomodulatory effects have emerged in various disease models,exhibiting specific mechanisms of action,such as cell migration and homing,angiogenesis,anti-apoptosis,proliferation,anti-cancer,anti-fibrosis,anti-inflammation and tissue regeneration.Herein,we review the current literature pertaining to the UCB-derived MSC application as potential treatment strategies,and discuss the concerns regarding the safety and mass production issues in future applications. | Soyoun Um Jueun Ha Soo Jin Choi Wonil Oh Hye Jin Jin | 2020 | World Journal of Stem Cells2020，12，12： | 4 |
| 4 | Broadband omnidirectional light detection in flexible and hierarchical ZnO/Si heterojunction photodiodes显示文摘灵活光电探测器的开发包括灵活图象传感器,生物医学的成像,和聪明的、便携系统为未来 optoelectronic 应用程序收到了大注意。以前,全向的光电探测器由多重光电探测器上的一个半球的 microlens 集会的集成仅仅是可完成的。此处,组织蜂房的 Si ( H-Si )膜上的 ZnO nanowires ( NW )的一个层次光电二极管图案被表明展出优秀全向的轻吸收的能力并且因此在女人上维持高光电流光谱为宽事件角度的范围( 365~1,100 nm )( 0io 是超过 6.00~10 个病人和 35 age-/gender-matched 控制吗(吝啬的 s ?? | Seongdong Lim Doo-Seung Um Minjeong Ha Qianpeng Zhang Youngsu Lee Yuanjing Lin Zhiyong Fan Hyunhyub Ko | 2017 | Nano Research2017，10，1： | 2 |
| 5 | Hypolipidaemic effects of cyanidin 3-glucoside rich extract from black rice through regulating hepatic lipogenic enzyme activities 显示文摘 | Min Young Um Jiyun Ahn Tae You1 Ha | 2013 | Journal of the Science of food and agriculture2013，93，12： | 1 |
| 6 | Physical properties of silk fibroin/chitosan blend films 显示文摘 | KWEON H HA H C UM I C | 2001 | Journal of Applied Polymer Science2001，80，7： | 1 |
| 7 | Psychometric Hepatic Encephalopathy Score for the detection of minimal hepatic encephalopathy in Korean patients with liver cirrhosis显示文摘 | Yeon Seok Seo Sun Young Yim Jin Yong Jung Chang Ha Kim Jin Dong Kim Bora Keum Hyonggin An Hyung Joon Yim Hong Sik Lee Chang Duck Kim Ho Sang Ryu Soon Ho Um | 2012 | Journal of Gastroenterology and Hepatology2012，，11： | 1 |
| 8 | The compound isolated from the leaves of Phyllostachys nigra protects oxidative stress-induced retinal ganglion cells death显示文摘 | Hee Ju Lee Kyung-A Kim Kui Dong Kang Eun Ha Lee Chul Young Kim Byung Hun Um Sang Hoon Jung | 2010 | Food and Chemical Toxicology2010，，6： | 1 |
| 9 | Prognosis of hepatitis B‐related liver cirrhosis in the era of oral nucleos(t)ide analog antiviral agents显示文摘 | Chang Ha Kim Soon Ho Um Yeon Seok Seo Jin Yong Jung Jin Dong Kim Hyung Joon Yim Bora Keum Yong Sik Kim Yoon Tae Jeen Hong Sik Lee Hoon Jai Chun Chang Duck Kim Ho Sang Ryu | 2012 | Journal of Gastroenterology and Hepatology2012，，10： | 1 |
| 10 | Physical properties of silk fibroin/chitosan blend films 显示文摘 | Kweon H Ha H C Um I C | 2001 | J Appl Polyrn Sci2001，80，7： | 1 |
| 11 | Physical properties of silk fi- broin/chitosan blend films显示文摘 | Kweon H Ha HC Um IC | 2001 | J Applied Polymer Sci2001，80，7： | 1 |
| 12 | Physical properties of silk fibroin/chitosan blend films显示文摘 | KWEON H HA H C UM I C | 2001 | J Appl Polym Sci2001，80，7： | 1 |
| 13 | Pentoxifylline versus corticosteroid to treat severe alcoholic hepatitis: A randomised, noninferiority, open trial显示文摘 | Seung Ha Park Dong Joon Kim Young Seok Kim Hyung Joon Yim Won Young Tak Heon Ju Lee Joo Hyun Sohn Ki Tae Yoon In Hee Kim Hyoung Su Kim Soon Ho Um Soon Koo Baik June Sung Lee Ki Tae Suk Sang Gyune Kim Sang Jun Suh Soo Young Park Tae Yeob Kim Jae Young Jang | 2014 | Journal of Hepatology2014，，： | 1 |
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