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| 1 | Biomarkers in triple negative breast cancer:A review显示文摘Breast cancer is an intrinsically heterogeneous disease. In the world about 1 million cases of breast cancer are diagnosed annually and more than 170000 are triplenegative. Characteristic feature of triple negative breast cancer(TNBC) is that it lacks expression of oestrogen,progesterone and human epidermal growth factor receptor-2/neu receptors. They comprise 15%-20% of all breast cancers. We did a systematic review of Pub Med and conference databases to identify studies published on biomarkers in TNBC. We included studies with biomarkers including: Epidermal growth factor receptor,vascular endothelial growth factor,c-Myc,C-kit and basal cytokeratins,Poly(ADP-ribose) polymerase-1,p53,tyrosinase kinases,m-TOR,heat and shock proteins and TOP-2A in TNBC. We also looked for studies published on synthetic lethality and inhibition of angiogenesis,growth,and survival pathways. TNBC is a complex disease subtype with many subclasses. Majority TNBC have a basal-like molecular phenotype by gene expression profiling. Their clinical and pathologic features overlap with hereditary BRCA1 related breast cancers. Management of these tumours is a challenge to the clinician because of its aggressive behaviour,poor outcome,and absence of targeted therapies. As the complexity of this disease is being simplified over time new targets are also being discovered for the treatment of this disease. There are many biomarkers in TNBC being used in clinical practice. Biomarkers may be useful as prognostic or predictive indicators as well as suggest possible targets for novel therapies. Many targeted agents are being studied for treatment of TNBC. | Budhi S Yadav Priyanka Chanana Swaty Jhamb | 2015 | World Journal of Clinical Oncology2015，6，6： | 13 |
| 2 | Inhibition of methionine adenosyltransferase II induces FasL expression, Fas-DISC formation and caspase-8-dependent apoptotic death in T leukemic cells显示文摘蛋氨酸 adenosyltransferase II (地席 II ) 是在细胞的新陈代谢的关键酶并且从 L 蛋氨酸和 ATP 催化 S-adenosylmethionine (一样) 的形成。正常休息 T 淋巴细胞举办最小的地席 II 活动,而白血病的房间显著地显示出的激活的增殖的 T 淋巴细胞和转变 T 提高了地席 II 活动。这个工作被执行在白血病的 T 房间的幸存检验地席 II 活动和一样的生合成的角色。在一样的层次的地席 II 和结果的减少的抑制提高了 FasL mRNA 和蛋白质的表示,并且导致了圆盘(导致发信号的建筑群的死亡) 有 FADD (联系船边交货的死亡域) 和 procaspase-8 招募的形成,以及 caspase-8 激活的伴随物增加和在 c 扭动的减少铺平。开始船边交货的发信号由地席 II 抑制导致了被观察经由出价劈开连接到 mitochondrial 小径并且最终在这些房间导致增加的 caspase-3 激活和 DNA 破碎。而且,堵住地席 2A mRNA 表示,它编码地席 II 的催化子单元,用一条小介入的 RNA 途径提高了 FasL 表示和房间死亡,验证在 T 白血病的房间的幸存的地席 II 活动的必要性质。 | Tanvi S Jani Leila Gobejishvili Prachi T Hote Aditya S Barve Swati Joshi-Barve Giorgi Kharebava Jill Suttles Theresa Chen Craig J McClain Shirish Barve | 2009 | Cell Research2009，19，3： | 5 |
| 3 | Influence of annealing temperature on the structural, mechanical and wetting property of TiOz films deposited by Rf magnetron sputtering显示文摘 | Swati S P Sambita S Pradhan S K | 2010 | Thin Solid Films2010，518，： | 1 |
| 4 | Use of novel hydro-gels based on modified cellulosics and methacrylamide for separation of metal ions from water systems显示文摘 | CHAUHAN Ghanshyam S MAHAJAN Swati | 2002 | Appl Polym Sci2002，86，： | 1 |
| 5 | Genetic diversity of oilseed Brassica napusinbred lines based on sequence-related amplified polymorphism and its relation to hybrid performance 显示文摘 | RIAZ A LI G QURESH Z SWATI M S QUIROS C F | 2001 | Plant Breeding2001，120，5： | 1 |
| 6 | Chronic Hepatitis B Virus Infection and Pregnancy 显示文摘 | Manoj K Tarandeep S Swati S | 2012 | Journal of Clinical and Experimental Hepatology2012，2，4： | 1 |
| 7 | Interactions between auxin transport and the actin cytoskeleton in developmental polarity of fucus distichus embryos in response to light显示文摘 | HAIGUO S SWATI B SHARI R B | 2004 | Plant Physiology2004，135，： | 1 |
| 8 | Feature selection for medical diagnosis: Evaluation for cardiovascular diseases 显示文摘 | SWATI S GHATOL A ASHOK C | 2013 | Expert Systems with Applications2013，40，10： | 1 |
| 9 | Genetic diversity of oilseed Brassica napus inbred lines based on sequence-related amplified polymorphism and its relation to hybrid performance显示文摘 | Riaz A Li G Quresh Z Swati M S | 2001 | Plant Breeding2001，120，5： | 1 |
| 10 | Evaluation of Cytotoxic Effects of Bevacizumab on Human Corneal Cells显示文摘 | Kakarla V Shalam Swati Agarwal Vikram S Brar Ravi K Murthy Rajesh K Sharma | 2009 | Cornea2009，，3： | 1 |
| 11 | Muncl8c provides stimulus-selective regula- tion of GLUT4 but not fatty acid transporter trafficking in skeletal muscle显示文摘 | Swati S J Laelie A S Jan F C | 2012 | FEBS let- ters2012，586，16： | 1 |
| 12 | Microwave-assisted synthesis of fine particle oxides employing wet redox mixtures显示文摘 | Swati Sigamani J P | 2002 | Journal of the America ceramic society2002，85，10： | 1 |
| 13 | Egr - 1 predicts PTEN and survival in patients with non - small - cell lung cancer显示文摘 | Bernadette F Gerold B Swati S | 2005 | J Clin Oncol2005，23，9： | 1 |
| 14 | Formulation,development,and evaluation of floating pulsatile drug delivery system of atenolol显示文摘 | Swati C J Monali S S Ajay L B | 2013 | PDA J Pharm Sci and Tech2013，67，3： | 1 |
| 15 | Thrombotic thrombocytopenic purpura and Systemic Luplus Erythematosus显示文摘 | SWATI V ABUL-EZZ S ELEANOR L | 2001 | Scand J Rheumatol2001，30，1： | 1 |
| 16 | Thrombotic thrombocytopenic purpura and systemic luplus erythematosus 显示文摘 | Swati V Abul-ezz S Eleanor L | 2001 | Scand J Rheumatol2001，30，5： | 1 |
| 17 | Management of chemotherapy-induced nausea and vomiting显示文摘 | Pooja D Swati S Deepika H | 2010 | Indian Pediatrics2010，47，2： | 1 |
| 18 | Fractional order PID controller for load frequency control 显示文摘 | Swati S Yogesh V H | 2014 | Energy Conversion and Management2014，85，6： | 1 |
| 19 | Genetic diversity of oilseed brassica napu inbred lines based on sequence-related amplified polymorphism and its relation to hybrid performance显示文摘 | RIAZ A LI G QURESH Z SWATI M S | 2001 | Plant Breeding2001，120，5： | 1 |
| 20 | Preliminary phytochemical screening, antibacterial and nitric oxide radical scaveng- ing activities of reinwardtia indica leaves extract显示文摘 | Abha S Swati V Shukla RK | 2013 | Int J PharmTech Res2013，5，： | 1 |
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