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| 1 | The recommendations of Chinese Parkinson’s disease and movement disorder society consensus on therapeutic management of Parkinson’s disease显示文摘Background:Parkinson’s disease(PD)is a chronic,progressive and debilitating disease,which affects over 2.5 million people in China.PD is characterized clinically by resting tremor,muscular rigidity,bradykinesia and postural instability.As the disease progresses,additional complications can arise such as non-motor and neurobehavioral symptoms.Pharmacological treatment and surgical intervention for PD have been implemented in China.Until 10 years ago,there was lack of standardization for the management of PD in different regions and among different physicians,leading to different treatment levels in different regions and different physicians.Since then,the Chinese Parkinson’s Disease and Movement Disorder Society have published three versions of guidelines for the management of PD in China,in 2006,2009 and 2014,respectively.Correspondingly,the overall level of treatment for PD in China improved.Objectives:To update the treatment guidelines based on current foreign and domestic practice guidelines and clinical evidence,and to improve the treatment options available to physicians in the management of PD.Summary:A variety of treatment recommendations in the treatment guidelines have been proposed,including physical activity and disease-modifying medication,which should be initiated at the early-stage of the disease.The principles of dosage titration should be followed to avoid acute adverse reactions to the drugs,to achieve a satisfactory clinical effect with a low dose and to reduce the incidence of long-term motor complications.Moreover,different treatment strategies should be considered at different stages of the disease.Importantly,treatment guidelines and personalized treatments should be valued equally.A set of treatment recommendations has been developed to assist physicians to improve and optimize clinical outcomes for patients with PD in China. | Shengdi Chen Piu Chan Shenggang Sun Haibo Chen Baorong Zhang Weidong Le Chunfeng Liu Guoguang Peng Beisha Tang Lijuan Wang Yan Cheng Ming Shao Zhenguo Liu Zhenfu Wang Xiaochun Chen Mingwei Wang Xinhua Wan Huifang Shang Yiming Liu Pingyi Xu Jian Wang Tao Feng Xianwen Chen Xingyue Hu Anmu Xie Qin Xiao | 2016 | Translational Neurodegeneration2016，5，1： | 23 |
| 2 | WDR26 promotes mitophagy of cardiomyocytes induced by hypoxia through Parkin translocation显示文摘心肌的局部缺血是血流动的减小引起到心的一个心条件,阻止心收到足够的氧。心肌的局部缺血全球性是死亡的最普通的原因。心 ischemic preconditioning (欧洲电脑生产厂商) 对局部缺血和 ischemia-reperfusion 损害导致的心肌的房间死亡有保护的效果。WDR26 最近作为蛋白质被识别了被增加后面的老鼠心脏的欧洲电脑生产厂商。WDR26 能支持 H9c2 房间的增长并且通过禁止 apoptosis.?However 保护 cardiomyocytes 免于氧化应力,它在心肌的局部缺血的角色是不清楚的。这研究的目的是在心肌的局部缺血和 H9c2 房间组织缺氧探索 WDR26 的角色。我们的结果证明 WDR26 被心肌的局部缺血和 H9c2 房间组织缺氧导致。WDR26 通过禁止保护 H9c2 房间免于组织缺氧损害 ? LDH 版本和增加的房间生存能力。WDR26 在 H9c2 房间的组织缺氧支持导致组织缺氧的 autophagy。我们进一步证明在 H9c2 房间组织缺氧, WDR26 增加 mitochondrial 膜潜力,从而线粒体的增加 Parkin translocation。在 Parkin 是在线粒体的 translocated 以后, WDR26 能在 H9c2 房间的组织缺氧增加 mitochondrial 蛋白质 ubiquitination。WDR26 是对组织缺氧的反应的一个调停人,并且 WDR26 在调停组织缺氧的 autophagy 和 mitophagy 起一个重要作用。这研究在组织缺氧期间在 cardiomyocyte 损害提供新奇卓见进 WDR26 的保护的角色。WDR26 可以为心肌的局部缺血的处理用作一个潜在的目标。 | Yansheng Feng Jia Zhao Huifang Hou Hui Zhang Yunjuan Jiao Jiangang Wang Yongling Wang Yinping Sun | 2016 | Acta Biochimica et Biophysica Sinica2016，48，12： | 13 |
| 3 | Precambrian Geochronology, Chronotectonic Framework and Model of Chronocrustal Structure of the Zhongtiao Mountains显示文摘The Zhongtiao Mountains, a typical exposure area of Precambrian rocks, are a concentration area of vari-ous types of copper deposit. The rocks were dated using several dating methods. Based on the age data ob-tained by means of three methods, several aspects are dealt with: (1) the dating results obtained by differentmethods and their geological implications have been compared; (2) a chronotectonic framework has been con-structed by means of these reliable ages, which indicates that the ages of the rocks of the Proterozoic mobilebelt fall in a time span of 2400 to 2000 Ma during which global magmatic records are lacking and reflects theages of important events in the mobile belt; (3) according to the ages of inherited zircons, neodymium modelage of the depleted mantle sources (TDM) and geochemical and geological data, a model of Precambrianchronocrustal structure has been constructed, representing a typical for the North China craton. | Sun Dazhong Li Huimin Lin Yuanxian Zhou Huifang Zhao Fengqing Tang Min Tianjin Institute of Geology and Mineral Resources, Chinese Academy of Geological Sciences, Tianjin Fei Zhenbi | 1992 | Acta Geologica Sinica(English Edition)1992，66，1： | 10 |
| 4 | Nano-sized graphitic carbon in authigenic tube pyrites from offshore southwest Taiwan, South China Sea, and its implication for tracing gas hydrate显示文摘Gas hydrates are a significant energy resource and are usually detected by bottom simulating reflection and submarine geochemical anomalies. Authigenic minerals are related to gas hydrates, with carbonates, sulfates and sulfides being important tracing minerals. Authigenic tubular pyrites were collected from offshore southwest Taiwan in the South China Sea, and were investigated by scanning electron microscopy(SEM) and high-resolution transmission electron microscopy (HRTEM). Authigenic tubular pyrite was composed of framboidal pyrite, within which nanosized graphitic carbon of low crystallinity was discovered. The graphitic carbon coexisted with pyrite and had a texture similar to carbon nanotubes and nanocones, indicating that they likely precipitated from carbon supersaturated C-H-O fluid. Pyrite may act as a catalyst for the conversion of CH 4 to C. The discovery of nanosized graphitic carbon in pyrite indicated it was deposited in sediments that were supersaturated with methane fluid. Thus, nanosized graphitic carbon may be another tracing species for submarine gas hydrates. The discovery of nanosized graphitic carbon deposited in a low temperature environment will enlighten our understanding of the laboratory synthesis and industrial production of graphitic carbon. | ZHANG Mei SUN XiaoMing XU Li XU HuiFang KONISHI Hirom LU Yang LU HongFeng WU ZhongWei | 2011 | Chinese Science Bulletin2011，56，19： | 8 |
| 5 | Studies of the Genotoxicity of Glycidyl Methacrylate (GMA)显示文摘The following experiments were conducted to evaluate the genotoxic effects of GMA (glycidyl methacrylale) on mammalian and human cells.(1) Using the absorption spectrum shift method in vitro, we observed that the maximums of calf thymus DNA and GMA were shifted toward longer wavelengths (a change of more than 15nm) and the absorbance decreased after incubation at room temperature for 15min or more.The result indicates that binding of DNA and GMA had occurred.The binding force is strong, not affected by the addition of concentrated sodium chloride solution, and only slightly decreased by the addition of 8 M urea solution.Therefore the bond between DNA and GMA might be covalent.(2) In cell cultures, unscheduled DNA synthesis (UDS) in human and/or rat lymphocyte was induced and DNA semiconserva-tive replication was inhibited by GMA at concentrations of less than 5.2 mM.(3) Sperm abnormality tests and assays of UDS in germ cells of male mice were conducted to study the in vivo genotoxicity of GMA.The results revealed that GMA could damage DNA, increase sperm abnormality frequency, and reduce the number of sperm cells, 1990 Academic Press.Inc. | DAYING XIE, WEI ZHANG, LAIFU CAO, WENQING SUN, ZHONGSHENG LI, QING GAO, YILI WU, HUILAN GAO, HUIFANG YANG, JIM ZUO,~* AND FUDE FANG~* Institute oF Occupational Medicine. Chinese Academy ol Preventive Medicine. Beijing 100050. and *Institute of Basic Medical Sciences, Chinese Academy ol Medical Sciences. Beijing 100730, China | 1990 | Biomedical and Environmental Sciences1990，3，3： | 7 |
| 6 | High-performance asymmetric electrodes photodiode based on Sb/WSe2 heterostructure显示文摘Two-dimensional (2D) van der Waals (vdWs) metal-semiconductor heterostructures with atomically sharp interface and matched work functions have recently attracted great attention due to their unique electronic and optoelectronic properties. Here we report the vapor phase epitaxial growth of large-scale vertical Sb/WSe2 metal-semiconductor vdWs heterostructures with uniform stacking orientation. Compared with the growth on S1O2/S1 substrate, the thick ness of Sb nan osheet on WSe2 can be reduced effectively to mono layer. We con struct Sb-WSe2-Au asymmetric electrodes photodiode based on the Sb/WSe2 heterostructures. Electrical transport measurements indicate that the photodiode show obvious rectifying effect. Optoelectronic characterizations show prominent photoresponse with a high photoresposivity of 364 mA/W, a fast response time of less than 8 ms, a large open-circuit voltage of 0.27 V and a maximum electrical power output of 0.11 nW. The direct growth of high-quality metal-semiconductor vdWs heterostructures may open up new realms in 2D functional electronics and optoelectronics. | Xiao Liu Guangzhuang Sun Peng Chen Junchi Liu Zhengwei Zhang Jia Li Huifang Ma Bei Zhao Ruixia Wu Weiqi Dang Xiangdong Yang Chen Dai Xuwan Tang Zhuojun Chen Lili Miao Xingqiang Liu Bo Li Yuan Liu Xidong Duan | 2019 | Nano Research2019，12，2： | 5 |
| 7 | Effects of Waxy Maize Relay Intercropping and Residue Retention on Rhizosphere Microbial Communities and Vegetable Yield in a Continuous Cropping System显示文摘Intercropping and residue retention contribute to high yield and quality of crops. However, their coupled effects on rhizospheric microbial communities under a continuous vegetable cropping system have not been adequately addressed. The objective of the present study was to assess the effects on soil microbial community and yields of waxy maize(Zea mays L.) intercropped with or without residue retention in a continuous broccoli(Brassica oleracea L.) cropping system, i.e., relay intercropping of broccoli and waxy maize(B/M-B), relay intercropping of broccoli and waxy maize with residue retention(B/MR-B), and broccoli monoculture(B-B). The biomass yields of spring and autumn vegetables in B/MR-B were 16.3%–32.5% and 30.1%–46.1% higher than those of B-B,respectively. Autumn vegetable economic yields of B/MR-B were 28.2%–40.3% higher than B-B. The average well color development followed the order: B/MR-B > B/M-B > B-B. The Shannon index, Simpson index, and Mc Intosh index were higher in B/MR-B than under monoculture. A principal component analysis showed that microbial communities of B/MR-B soils differed from those of B/M-B and B-B soils. Carbon(C) sources utilized by the rhizosphere microorganisms were mainly carbohydrates, carboxylic acids, amino acids, and polymers; however, the C sources for the soil microbial community differed between intercropping and monoculture. The communities from B/MR-B preferred amino acids and polymers. Available nitrogen(N), potassium(K), and phosphorus(P) had an obvious impact on soil microbial community. Additionally, the C source utilization by microorganisms was significantly affected by p H and available K and P. Cropping system diversification through relay intercropping and residue retention effectively improved the functional diversity of the soil microbial communities and increased the yields of vegetables. | ZHANG Xuepeng NING Tangyuan HAN Huifang SUN Tao LI Geng LI Zengjia Rattan LAL | 2018 | Pedosphere2018，28，1： | 5 |
| 8 | Deciphering primate retinal aging at single-cell resolution显示文摘Dear Editor, The retina is a light-sensitive highly-organized tissue,which is vulnerable to aging and age-related retinal diseases.Specifically,progressive retinal degeneration leads to visual function deterioration and vision impairment in the elderly(Lin et al.,2016).In diseases such as age-related macular degeneration(AMD),retinitis pigmentosa(RP)and diabetic retinopathy(DR),pathological process lacking effective treatments profoundly and negatively impact on the quality of life in the elderly(Lin et al.,2016;Chen et al.,2019).Thus,an in-depth molecular assessment of the mechanisms driv-ing retinal aging is of urgent scientific and medical importance. | Si Wang Yuxuan Zheng Qingqing Li Xiaojuan He Ruotong Ren Weiqi Zhang Moshi Song Huifang Hu Feifei Liu Guoqiang Sun Shuhui Sun Zunpeng Liu Yang Yu Piu Chan Guo-Guang Zhao Qi Zhou Guang-Hui Liu Fuchou Tang Jing Qu | 2021 | Protein & Cell2021，12，11： | 4 |
| 9 | The efficacy and safety of pramipexole ER versus IR in Chinese patients with Parkinson’s disease: a randomized, double-blind, double-dummy, parallel-group study显示文摘Objective:To evaluate the non-inferiority of pramipexole extended-release(ER)versus immediate-release(IR)in Chinese patients with Parkinson’s disease(PD)in a double-blind,randomized,parallel-group study.Methods:Subjects were Chinese patients with idiopathic PD with diagnosis≥2 years prior to trial,age≥30 years old at diagnosis,and Modified Hoehn and Yahr score 2-4 during‘on’-time.Subjects received treatment with pramipexole ER(n=234)or IR(n=239).Non-inferiority was based on the primary endpoint,the change from baseline to end of maintenance(week 18)in the UPDRS(Parts II+III)total score.Results:For the primary endpoint,the adjusted mean changes(standard error)of UPDRS Parts II+III at week 18 were−13.81(0.655)and−13.05(0.643)for ER and IR formulations,respectively,using ANCOVA adjusted for treatment and centre(fixed effect)and baseline(covariate).The adjusted mean between group difference was 0.8 for the 2-sided 95%CI(−1.047,2.566).Since the lower limit of the 2-sided 95%CI(−1.047)for treatment difference was higher than the non-inferiority margin of−4,non-inferiority between pramipexole ER and IR was demonstrated.The incidence of adverse events(AEs)was 68.8%in the ER arm and 73.6%in the IR arm with few severe AEs(ER:2.1%;IR:3.8%).Conclusion:Based on the UPDRS II+III score,pramipexole ER was non-inferior to pramipexole IR.The safety profiles of pramipexole ER and IR were similar.These results were based on comparable mean daily doses and durations of treatment for both formulations. | Ying Wang Shenggang Sun Suiqiang Zhu Chunfeng Liu Yiming Liu Qing Di Huifang Shang Yan Ren Changhong Lu Mark Forrest Gordon Nolwenn Juhel Shengdi Chen for the Pramipexole ER Study Team | 2014 | Translational Neurodegeneration2014，3，1： | 3 |
| 10 | Magnetostrictive and Kinematic Model Considering the Dynamic Hysteresis and Energy Loss for GMA显示文摘Due to the influence of magnetic hysteresis and energy loss inherent in giant magnetostrictive materials(GMM), output displacement accuracy of giant magnetostrictive actuator(GMA) can not meet the precision and ultra precision machining. Using a GMM rod as the core driving element, a GMA which may be used in the field of precision and ultra precision drive engineering is designed through modular design method. Based on the Armstrong theory and elastic Gibbs free energy theory, a nonlinear magnetostriction model which considers magnetic hysteresis and energy loss characteristics is established.Moreover, the mechanical system differential equation model for GMA is established by utilizing D'Alembert's principle. Experimental results show that the model can preferably predict magnetization property, magnetic potential orientation, energy loss for GMM. It is also able to describe magnetostrictive elongation and output displacement of GMA. Research results will provide a theoretical basis for solving the dynamic magnetic hysteresis,energy loss and working precision for GMA fundamentally. | Huifang LIU Xingwei SUN Yifei GAO Hanyu WANG Zijin GAO | 2017 | Chinese Journal of Mechanical Engineering2017，30，2： | 3 |
| 11 | Study on Ni/C catalysts for vapor phase carbonylation of ethanol显示文摘激活支持碳的 Ni 催化剂让乙醇的蒸汽阶段 carbonylation 当倡导者被调查,面对乙醇碘化物支撑离子的酸。在最佳反应条件下面,当时,碳一氧化物和乙醇的变换被测量分别地,是 81.4% 和 98.4% 选择为支撑离子的酸被发现是 98.65% 。催化剂在溪流上的 48 h 以内是稳定的。XRD 和 XPS 方法被用来描绘结构和新鲜、测试的催化剂的表面性质。描述结果显示镍粒子和催化剂表面上的镍碘化物的形成的聚集应该为催化剂的释放负责。 | Qing Zhang Huifang Wang Guosong Sun Kelin Huang Weiping Fang Yiquan Yang | 2008 | Journal of Natural Gas Chemistry2008，17，4： | 3 |
| 12 | Gear Fault Diagnosis Based on Rough Set and Support Vector Machine显示文摘By introducing Rough Set Theory and the principle of Support vector machine,a gear fault diagnosis method based on them is proposed.Firstly,diagnostic decision-making is reduced based on rough set theory,and the noise and redundancy in the sample are removed,then,according to the chosen reduction,a support vector machine multi-classifier is designed for gear fault diagnosis.Therefore,SVM’training data can be reduced and running speed can quicken.Test shows its accuracy and effi- ciency of gear fault diagnosis. | TIAN Huifang SUN Shanxia School of Mechanical and Electrical Engineering,Wuhan University of Technology,Wuhan 430070,China, | 2006 | 武汉理工大学学报2006，28，S3： | 3 |
| 13 | Application of intraoperative O-arm-assisted real-time navigation technique for spinal fixation显示文摘This study explored the combined use of the O-arm and real-time navigation during spinal fixation. The clinical data for 60 patients undergoing spinal fixation, at Beijing Tsinghua Chang Gung Hospital between May 5, 2015 and May 1, 2017, were retrospectively analyzed. Pre-, intra-, and postoperative imaging findings were assessed. The patients were classified into the occipitocervical fusion(32 cases) and thoracic/lumbar/sacral spine fixation(28 cases, including 6 cases of percutaneous pedicle screw) groups. Lesion resections were performed microscopically. An O-arm, combined with real-time navigation, was used to assess spinal fixation. Efficacy was evaluated using operative times, X-ray times, screw positioning, and complications. Within the occipitocervical fusion group, 182 screws were placed in the cervical spine and 96 in the occipital bone. However, 6 screws penetrated the bone cortex and were adjacent to the vertebral arteries, based on O-arm three-dimensional imaging; therefore, the precision rate was 96.7%. Within the thoracic/lumbar/sacral spine fixation group, 148 pedicle screws were implanted, with 4 initially outside the vertebral body,yielding a precision rate of 97.3%. Ten percutaneous pedicle screws were implanted and well positioned. O-arm scans were performed 3 times/patient, with an average of 20–30 min/time. Screw implantation times were 5–7 min(cervical spine), 8–10 min(thoracic spine), and 6–8 min(lumbar spine). Intraoperative O-arm scans, combined with real-time navigation technology, allow real-time observation of screw angles and depths, improving the accuracy and safety of posterior screw fixations and reducing the radiation dose and frequency experienced by patients and surgeons. | Zhenxing Sun Dan Yuan Yaxing Sun Zhanquan Zhang Guihuai Wang Yi Guo Guoqin Wang Dongkang Liu Peng Chen Linkai Jing Feng Yang Peihai Zhang Huifang Zhang Youtu Wu Wei Shi James Wang | 2017 | Translational Neuroscience and Clinics2017，3，3： | 2 |
| 14 | Direct van der Waals epitaxial growth of 1D/2D Sb2Se3/WS2 mixed-dimensional p-n heterojunctions显示文摘The mixed-dimensional integration of two-dimensional (2D) materials with non-2D materials can give rise to prominent advances in performance or function.To date,the mixed-dimensional one-dimensional (1D)/2D heterostructures have been fabricated using various physical assembly approaches.However,direct epitaxial growth method which has notable advantages in preparing large-scale products and obtaining perfect interfaces is rarely investigated.Herein,we demonstrate for the first time the direct synthesis of the 1D/2D mixed-dimensional heterostructures by sequential vapor-phase growth of Sb2Se3 nanowires on WS2 monolayers.X-ray diffraction (XRD) pattern and Raman spectrum confirm the composition of the Sb2Se3/NS2 heterostructures.Transmission electron microscope (TEM) measurement demonstrates high quality of the heterostructures.Electrical transport characterization reveals that Sb2Se3 nanowire exhibits p-type characteristic and that WS2 monolayer exhibits n-type behavior,and that the p-n diode from 1D/2D mixed-dimensional Sb2Se3/WS2 heterostructure possesses obvious current rectification behavior.Optoelectronic measurements of the heterostructures show apparent photovoltaic response with an open-circuit voltage of 0.19 V,photoresponsivity of 1.51 A/W (Vds =5 V) and fast response time of less than 8 ms.The van der Waals epitaxial growth mode of Sb2Se3 nanowires on WS2 monolayers is verified by stripping the Sb2Se3 nanowire from the heterostructures using tape.Together,the direct van der Waals epitaxy opens a facile pathway to 1D/2D mixed-dimensional heterostructures for functional electronic and optoelectronic devices. | Guangzhuang Sun Bo Li Jia Li Zhengwei Zhang Huifang Ma Peng Chen Bei Zhao Ruixia Wu Weiqi Dang Xiangdong Yang Xuwan Tang Chen Dai Ziwei Huang Yuan Liu Xidong Duan Xiangfeng Duan | 2019 | Nano Research2019，12，5： | 2 |
| 15 | Transformation relationship among different magnetic minerals within loess-paleosol sediments of the Chinese Loess Plateau显示文摘The dominant magnetic minerals and carriers of magnetic signals within the Chinese Loess Plateau are magnetite, maghemite, hematite, and goethite. In this study, we investigated the provenance and evo- lution of magnetic minerals during loess pedogenesis, using X-ray diffraction (XRD) and optical and electron microscopy, including field emission scanning electron microscopy (FESEM) and high- resolution transmission electron microscopy (HRTEM). Our results reveal that single- and multiphase mineral assemblages among magnetic minerals in the loess-paleosol sequence have been formed. Partial oxidation of coarse eolian magnetite has occurred in the desert source area and the oxidation degree is enhanced after deposition of the dust upon the Chinese Loess Plateau. This mode of origin resulted in a microtexture consisting of an inner magnetite core surrounded by a hematite rim, and strongly affected the magnetic characteristics of the loess. Goethite coexists with hematite in the loess and paleosol, and nanometer-scale hematite is formed upon goethite rims via dehydration. Our study provides direct mineralogical evidence of the magnetic record and paleoclimatic implications of the loess–paleosol sequence of the Chinese Loess Plateau. | XIE QiaoQin CHEN TianHu XU XiaoChun QING ChengSong XU HuiFang SUN YuBing JI JunFeng | 2009 | Science China Earth Sciences2009，52，3： | 2 |
| 16 | Microstructure Design of High-Entropy Alloys Through a Multistage Mechanical Alloying Strategy for Temperature-Stable Megahertz Electromagnetic Absorption显示文摘Developing megahertz(MHz)electromagnetic wave(EMW)absorption materials with broadband absorption,multi-temperature adaptability,and facile preparation method remains a challenge.Herein,nanocrystalline FeCoNiCr_(0.4)Cu_(0.2) high-entropy alloy powders(HEAs)with both large aspect ratios and thin intergranular amorphous layers are constructed by a multistage mechanical alloying strategy,aiming to achieve excellent and temperature-stable permeability and EMW absorption.A single-phase face-centered cubic structure with good ductility and high crystallinity is obtained as wet milling precursors,via precisely controlling dry milling time.Then,HEAs are flattened to improve aspect ratios by synergistically regulating wet milling time.FeCoNiCr_(0.4)Cu_(0.2) HEAs with dry milling 20 h and wet milling 5 h(D20)exhibit higher and more stable permeability because of larger aspect ratios and thinner intergranular amorphous layers.The maximum reflection loss(RL)of D20/SiO_(2) composites is greater than-7 dB with 5 mm thickness,and EMW absorption bandwidth(RL<-7 dB)can maintain between 523 and 600 MHz from-50 to 150℃.Furthermore,relying on the“cocktail effect”of HEAs,D20 sample also exhibits excellent corrosion resistance and high Curie temperature.This work provides a facile and tunable strategy to design MHz electromagnetic absorbers with temperature stability,broadband,and resistance to harsh environments. | Xiaoji Liu Yuping Duan Yuan Guo Huifang Pang Zerui Li Xingyang Sun Tongmin Wang | 2022 | Nano-Micro Letters2022，14，9： | 2 |
| 17 | Elevated miR-10a-5p facilitates cell cycle and restrains adipogenic differentiation via targeting Map2k6 and Fasn,respectively显示文摘miRNAs are a small class of noncoding RNAs that perform biological functions by regulating the stability or translation of target genes in various biological processes.This study illustrated the role of miR-10a-5p,which is relatively enriched in adipose tissues,using primary mouse preadipocytes as model.With elevated miR-10a-5p expression,the proliferative ability of mouse preadipocytes was significantly enhanced,indicated by increased EdU+cells and G1/S transition,accompanied by upregulated Cyclin B,Cyclin D and PCNA and downregulated p21 and p27.Meanwhile,the adi-pogenic differentiation was significantly attenuated by elevated miR-10a-5p,supported by Oil Red 0 staining and suppressed PPARγand aP2 expression.Furthermore,Map2k6 and Fasn were pre-dicted to be the target genes of miR-10a-5p in silico,and dual luciferase reporter assay confirmed the direct targeting effects.Western blot analysis results showed that miR-10a-5p specially reduced Map2k6 expression at the proliferative stage without affecting Fasn expression,while significantly restrained Fasn expression with unchanged Map2k6 expression during adipogenic differentiation.Taken together,these results revealed a potential role of miR-10a-5p in adipogenesis and in the treatment of obesity. | Xiaoyu Wang Huifang Zhang Meixue Xu Xin'E Shi Gongshe Yang Shiduo Sun Xiao Li | 2020 | Acta Biochimica et Biophysica Sinica2020，52，11： | 2 |
| 18 | Bacterial community of biofilms developed under different water supply conditions in a distribution system 显示文摘 | SUN Huifang SHI Baoyou BAI Yaohui | 2013 | Science of the Total Environment2013，472，： | 1 |
| 19 | Video transcoding architectures and techniques: an overview显示文摘 | VETRO A CHRISTOPOUI OS C SUN Huifang | 2003 | IEEE Signal Processing Magazine2003，20，3： | 1 |
| 20 | Biological characteristics of a denitrifying phosphorus-accumulating bacterium显示文摘 | Sun Ling Zhao Xinxin Zhang Huifang | 2015 | Ecological Engineering2015，81，： | 1 |
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