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| 1 | Determinant-Based Classification of Acute Pancreatitis Severity: An International Multidisciplinary Consultation显示文摘 | E. Patchen Dellinger Christopher E. Forsmark Peter Layer Philippe Lévy Enrique Maraví-Poma Maxim S. Petrov Tooru Shimosegawa Ajith K. Siriwardena Generoso Uomo David C. Whitcomb John A. Windsor | 2012 | Annals of Surgery2012，，6： | 7 |
| 2 | Quality of life assessment in patients with chronic pancreatitis receiving antioxidant therapy显示文摘AIM:To undertake a baseline study comparing quality of life(QoL) in patients with chronic pancreatitis(CP) on Antox to those with CP,matched for disease duration,who were not on this medication.METHODS:CP was defined according to the Zurich classification.Sixty eight consecutive patients with CP who were taking Antox(antioxidants) were compared with 69 consecutive control CP patients not on Antox.European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core questions 30 and Pancreatic Modification(28 questions) were used to assess QoL.Out of a total of 137 patients 28 in each group were matched for disease duration(within 12 mo).Median disease duration was 8(1-22) years in the Antox group and 7(1-23) years in the Non-Antox cohort(P = NS,Mann-Whitney U-test).Other parameters(age,gender,etiology,endocrine and exocrine insufficiency) were similar between groups.RESULTS:Median visual analogue pain score in the Antox group was 3(0-8) compared with 6(0-8) in the Non-Antox group(P < 0.01).Perceptions of cognitive,emotional,social,physical and role function were impaired in the Non-Antox group compared to Antox patients(P < 0.0001,P = 0.0007,P = 0.0032 and P < 0.005 and P < 0.001,respectively).Analgesics and opiate usage was significantly lower in the Antox group(P < 0.01).Overall physical health and global QoL was better in the Antox group(P < 0.0001,95% CI:1.5-3).CONCLUSION:Contemporary quality of life assessments show that after correction for disease duration and cigarette smoking,patients with CP taking antox had better scores than non-antox controls. | Nehal S Shah Alistair J Makin Aali J Sheen Ajith K Siriwardena | 2010 | World Journal of Gastroenterology2010，16，32： | 4 |
| 3 | Reappraisal of xenobiotic-induced,oxidative stress-mediated cellular injury in chronic pancreatitis:A systematic review显示文摘AIM:To reappraise the hypothesis of xenobiotic induced,cytochrome P450-mediated,micronutrient-deficient oxidative injury in chronic pancreatitis.METHODS:Individual searches of the Medline and Embase databases were conducted for each component of the theory of oxidative-stress mediated cellular injury for the period from 1st January 1990 to 31st December2012 using appropriate medical subject headings.Boolean operators were used.The individual components were drawn from a recent update on theory of oxidative stress-mediated cellular injury in chronic pancreatitis.RESULTS:In relation to the association between exposure to volatile hydrocarbons and chronic pancreatitis the studies fail to adequately control for alcohol intake.Cytochrome P450(CYP)induction occurs as a diffuse hepatic and extra-hepatic response to xenobiotic exposure rather than an acinar cell-specific process.GSH depletion is not consistently confirmed.There is good evidence of superoxide dismutase depletion in acute phases of injury but less to support a chronic intraacinar depletion.Although the liver is the principal siteof CYP induction there is no evidence to suggest that oxidative by-products are carried in bile and reflux into the pancreatic duct to cause injury.CONCLUSION:Pancreatic acinar cell injury due to short-lived oxygen free radicals(generated by injury mediated by prematurely activated intra-acinar trypsin)is an important mechanism of cell damage in chronic pancreatitis.However,in contemporary paradigms of chronic pancreatitis this should be seen as one of a series of cell-injury mechanisms rather than a sole mediator. | Ajith K Siriwardena | 2014 | World Journal of Gastroenterology2014，20，11： | 2 |
| 4 | Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis: the New EPOC randomised controlled trial显示文摘 | John Primrose Stephen Falk Meg Finch-Jones Juan Valle Derek O’Reilly Ajith Siriwardena Joanne Hornbuckle Mark Peterson Myrddin Rees Tim Iveson Tamas Hickish Rachel Butler Louise Stanton Elizabeth Dixon Louisa Little Megan Bowers Sian Pugh O James Garden D | 2014 | Lancet Oncology2014，，6： | 2 |
| 5 | Systematic review of carbohydrate antigen (CA 19-9) as a biochemical marker in the diagnosis of pancreatic cancer显示文摘 | K.S. Goonetilleke A.K. Siriwardena | 2006 | European Journal of Surgical Oncology2006，，3： | 2 |
| 6 | Pro/con debate: antifungal prophylaxis is important to prevent fungal infection in patients with acute necrotizing pancreatitis receiving broad-spectrum antibiotics显示文摘 | Eggimann P Jamdar S Siriwardena A K | 2006 | Crit Care2006，10，5： | 1 |
| 7 | Systematic review of perioperative nutritional supplementation in patients undergoing pancreaticoduodenectomy显示文摘 | Goonetilleke KS Siriwardena AK | 2006 | J OP2006，7，1： | 1 |
| 8 | Antibiotic prophy- laxis in the initial management of severe acute pancreations显示文摘 | POWELL J J MILES R SIRIWARDENA AK | | Br J Surg0，85，5： | 1 |
| 9 | Understand- ing the colonic complications of pancreatitis 显示文摘 | Mohamed SR Siriwardena AK | 2008 | Pancreatology2008，8，2： | 1 |
| 10 | Contemporary management of infected necrosis complicating severe acute pancreatitis 显示文摘 | Jamdar S Siriwardena AK | 2006 | Crit Care2006，10，1： | 1 |
| 11 | VEGF-C is associated with lymphatic status and invasion in oral cancer显示文摘 | SIRIWARDENA B S KUDO Y OGAWA I | | 0，，01： | 1 |
| 12 | Role of tumor necrosis factor-alpha in acute pancreatitis:from biological basis to clinical evidence显示文摘 | Malleo G Mazzon E Siriwardena AK | 2007 | Shock2007，28，2： | 1 |
| 13 | A comparison of white rice husk ash and silica as fillers in ethylene-propylene-diene terpolymer vulcanizates显示文摘 | Siriwardena S Ismail H Ishiaku U S | 2000 | Polymer International2000，50，6： | 1 |
| 14 | Systematic review of peri- operative nutritional supplementation in patients undergoing pancreaticoduodenectomy显示文摘 | Goonetilleke K S Siriwardena A K | 2006 | J OP2006，7，1： | 1 |
| 15 | Systematic review of carbohydrateantigen (CA 19-9) as a biochemical marker in the diagnosis of pan-creatic cancer 显示文摘 | Goonetilleke K Siriwardena A | 2007 | European Journal of Surgical Oncology (EJSO)2007，33，3： | 1 |
| 16 | Systematic review of carbohydrate antigen (CA 19-9) as a biochemical marker in the diagnosis of pancreatic cancer显示文摘 | Goonetilleke KS Siriwardena AK | 2007 | Eur J Surg Oncol2007，33，： | 1 |
| 17 | Antibiotic prophylaxis in the initial management of severe acute pancreatitis显示文摘 | Powell JJ Miles R Siriwardena AK | 1998 | Br J Surg1998，85，5： | 1 |
| 18 | Wound healing modulation after glaucoma surgery显示文摘 | Cordeiro MF Siriwardena D Chang L | 2000 | Curr Opin Ophthalmology2000，11，2： | 1 |
| 19 | The impact of land use change on catchment hydrology in large catchments: The Comet River, Central Queensland, Australia显示文摘 | Siriwardena L Finlayson B L McMahon T A | 2006 | Journal of Hydrology2006，326，14： | 1 |
| 20 | ETANERCEPT ATTENUATES THE DEVELOPMENT OF CERULEIN-INDUCED ACUTE PANCREATITIS IN MICE: A COMPARISON WITH TNF-α GENETIC DELETION显示文摘 | Giuseppe Malleo Emanuela Mazzon Tiziana Genovese Rosanna Di Paola Carmelo Muià Tommaso Centorrino Ajith K. Siriwardena Salvatore Cuzzocrea | 2007 | Shock2007，，5： | 1 |
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